Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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Research Abstract |
We identified LUBAC ubiquitin ligase, which composed of SHARPIN, HOIL-1L, and HOIP, forms a novel type of linear polyubiquitin chain. LUBAC regulates NF-κB system, a critical transcription factor for inflammation and immune regulation. Furthermore, we revealed that cpdm mice, which lack Sharpen by a spontaneous mutation, induce dermatitis by the reduction of LUBAC and NF-κB activity. These results indicate that linear polyubiquitination is an indispensable post-transcription modification for NF-κB activation.
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