Identification of Genes for Cognition and Their Functional Analysis

• Project/Area Number: 20390099
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human genetics
• Research Institution: Osaka University
• Principal Investigator: TODA Tatsushi Osaka University, 大学院・医学研究科, 教授 (30262025)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 分子遺伝学 / 認知機能 / IQ / 一卵性双生児 / 網羅的遺伝子発現解析 / 網羅的DNAメチル化解析 / g因子 / 行動解析 / 炎症性サイトカイン / エピゲノム / 精神発達遅滞 / CNV / GEMCA / Sotos症候群 / 22q11.2欠失症候群 / Potocki-Lupski症候群

Research Abstract

By microarray analysis, we detected copy number abnormality in MR patients. We also found that inflammatory cytokines had different expression between IQ-discordant monozygotic twins.

Research Products

• [Journal Article] Genetic and clinical analysis in a Chinese parkinsonism- predominant spinocerebellar ataxia type 2 family. (2011)
  • Author(s): Sun H, Satake W, Zhang C, Nagai Y, Tian Y, Fu S, Yu J, Qian Y, Qian Y, Chu J, Toda T
  • Journal Title: J Hum Genet 56(4) Pages: 330-334
  • NAID: 10030659058
  • Peer Reviewed
• [Journal Article] Defective glycosylation of α-dystroglycan contributes to podocyte flattening. (2011)
  • Author(s): Kojima K, Nosaka H, Kishimoto Y, Nishiyama Y, Fukuda S, Shimada M, Kodaka K, Saito F, Matsumura K, Shimizu T, Toda T, Takeda S, Kawachi H, Uchida S.
  • Journal Title: Kidney Int 79 Pages: 311-316
  • Peer Reviewed
• [Journal Article] Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. (2011)
  • Author(s): Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Toda T, Yamamura T.
  • Journal Title: Proc Natl Acad Sci U S A 108 Pages: 3701-3706
  • Peer Reviewed
• [Journal Article] A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. (2011)
  • Author(s): Kruger R
  • Journal Title: Neurobiol Aging Volume: (In press)
  • Peer Reviewed
• [Journal Article] Defective glycosylation of α-dystroglycan contributes to podocyte flattening. (2011)
  • Author(s): Kojima K
  • Journal Title: Kidney Int Volume: 79 Pages: 311-316
  • Peer Reviewed
• [Journal Article] Post- translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. (2010)
  • Author(s): Kanagawa M, Omori Y, Sato S, Kobayashi K, Miyagoe-Suzuki Y, Takeda S, Endo T, Furukawa T, Toda T
  • Journal Title: J Biol Chem 285 Pages: 31208-31216
  • Peer Reviewed
• [Journal Article] Screening of genes involved in chromosome segregation during meiosis I : toward the identification of genes responsible for infertility in humans. (2010)
  • Author(s): Kogo H
  • Journal Title: J Hum Genet Volume: 55 Pages: 293-299
  • Peer Reviewed
• [Journal Article] Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus. (2010)
  • Author(s): Tan EK
  • Journal Title: Neurology Volume: 75 Pages: 508-512
  • Peer Reviewed
• [Journal Article] Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. (2010)
  • Author(s): Kanagawa M
  • Journal Title: J Biol Chem Volume: 85 Pages: 31208-31216
  • Peer Reviewed
• [Journal Article] 孤発性パーキンソン病のリスク遺伝子 (2010)
  • Author(s): 戸田達史
  • Journal Title: 最新医学 Volume: 65 Pages: 806-813
• [Journal Article] ゲノムワイド関連解析によるパーキンソン病リスク遺伝子の同定 (2010)
  • Author(s): 戸田達史
  • Journal Title: 医学のあゆみ Volume: 233 Pages: 640-642
• [Journal Article] パーキンソン病のGWAS (2010)
  • Author(s): 戸田達史
  • Journal Title: Bio Clinica Volume: 25 Pages: 477-482
• [Journal Article] 福山型先天性筋ジストロフィーについて (2010)
  • Author(s): 戸田達史
  • Journal Title: 厚生労働科学研究事業 こころの健康科学研究 Pages: 9-10
• [Journal Article] 福山型筋ジストロフィーの治療戦略 (2010)
  • Author(s): 戸田達史
  • Journal Title: 難病と在宅のケア Volume: 16 Pages: 41-43
• [Journal Article] 福山型筋ジストロフィー (2010)
  • Author(s): 戸田達史
  • Journal Title: JFNMH Newsletter Volume: 7 Pages: 2-6
• [Journal Article] 疾患感受性遺伝子 (2010)
  • Author(s): 戸田達史
  • Journal Title: Current Therapy Volume: 28 Pages: 859-860
• [Journal Article] 抗aquaporin-4抗体陽性症例の治療経験 (2010)
  • Author(s): 小田哲也
  • Journal Title: 神経内科 Volume: 73 Pages: 194-198
• [Journal Article] パーキンソン病 (2010)
  • Author(s): 徳田隆彦
  • Journal Title: Clinical Neuroscience Volume: 28 Pages: 1405-1409
• [Journal Article] パーキンソン病の遺伝的背景 (2010)
  • Author(s): 佐竹渉
  • Journal Title: 綜合臨牀 Volume: 59 Pages: 2388-2391
• [Journal Article] Mutation analysis for DJ-1 in sporadic and familial parkinsonism : screening strategy in parkinsonism. (2009)
  • Author(s): Tomiyama H, Li Y, Yoshino H, Mizuno Y, Kubo S, Toda T, Hattori N.
  • Journal Title: Neurosci Lett 455 Pages: 159-161
  • Peer Reviewed
• [Journal Article] Fukutin gene retrotransposal insertion in a non-Japanese Fukuyama congenital muscular dystrophy (FCMD) patient. (2009)
  • Author(s): Xiong H, Wang S, Kobayashi K, Jiang Y, Wang J, Chang X, Yuan Y, Liu J, Toda T, Fukuyama Y, Wu X.
  • Journal Title: Am J Med Genet 149A Pages: 2403-2408
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (2009)
  • Author(s): Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
  • Journal Title: Nature Genet 41 Pages: 1303-1307
  • Peer Reviewed
• [Journal Article] Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. (2009)
  • Author(s): Sidransky E, Nalls MA, Aasly JO, ...Toda T, et al.
  • Journal Title: N Engl J Med 361 Pages: 1651-1661
  • Peer Reviewed
• [Journal Article] Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice. (2009)
  • Author(s): Popiel HA, Nagai Y, Fujikake N, Toda T
  • Journal Title: Neurosci Lett 449 Pages: 87-92
  • Peer Reviewed
• [Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinson disease. (2009)
  • Author(s): Mitsui J, Mizuta I, Toyoda A, Ashida R, Takahashi Y, Goto J, Fukuda Y, Date H, Iwata A, Yamamoto M, Hattori N, Murata M, Toda T, Tsuji S.
  • Journal Title: Arch Neurol 66 Pages: 571-576
  • Peer Reviewed
• [Journal Article] Is g an entity? A Japanese twin study using syllogisms and intelligence tests. (2009)
  • Author(s): Shikishima C, Hiraishi K, Yamagata S, Sugimoto Y, Takemura R, Ozaki K, Okada M, Toda T, Ando J.
  • Journal Title: Intelligence 37 Pages: 256-267
  • Peer Reviewed
• [Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation in novel model mice to dystroglycanopathy. (2009)
  • Author(s): Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T
  • Journal Title: Hum Mol Genet 18 Pages: 621-631
  • Peer Reviewed
• [Journal Article] Delivery of the aggregate inhibitor peptide QBP1 into the mouse brain using PTDs and its therapeutic effect on polyglutamine disease mice (2009)
  • Author(s): Popiel HA
  • Journal Title: Neurosci Lett 449 Pages: 87-92
  • Peer Reviewed
• [Journal Article] Surface plasmon resonance characterization of specific binding of polyglutamine aggregate inhibitors to the expanded polyglutamine stretch (2009)
  • Author(s): Okamoto Y
  • Journal Title: Biochem Biophys Res Commun 378 Pages: 634-639
  • Peer Reviewed
• [Journal Article] Structure-activity relationship study on polyglutamine binding peptide QBP1 (2009)
  • Author(s): Tomita K
  • Journal Title: Bioorg Med Chem 17 Pages: 1259-1263
  • Peer Reviewed
• [Journal Article] A locus for ophthalmo-acromelic syndrome mapped to 10p11.23 (2009)
  • Author(s): Hamanoue H
  • Journal Title: Am J Med Genet 149A Pages: 336-342
  • Peer Reviewed
• [Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation in novel model mice to dystroglycanopathy (2009)
  • Author(s): Kanagawa M
  • Journal Title: Hum Mol Genet 18 Pages: 621-631
  • Peer Reviewed
• [Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinson disease (2009)
  • Author(s): 三井純
  • Journal Title: Arch Neurol 66 Pages: 571-576
  • Peer Reviewed
• [Journal Article] Is g an entity? A Japanese twin study using syllogisms and intelligence tests (2009)
  • Author(s): Shikishima C
  • Journal Title: Intelligence 37 Pages: 256-267
  • Peer Reviewed
• [Journal Article] Characterization of the complex 7q21.3 rearrangement in a patient with bilateral split-foot malformation and hearing loss (2009)
  • Author(s): Saitsu H
  • Journal Title: Am J Med Genet 149A Pages: 1224-1230
  • Peer Reviewed
• [Journal Article] Fukutin gene retrotransposal insertion in a non-Japanese Fukuyama congenital muscular dystrophy(FCMD)patient (2009)
  • Author(s): Xiong H
  • Journal Title: Am J Med Genet 149A Pages: 2403-2408
  • Peer Reviewed
• [Journal Article] Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease (2009)
  • Author(s): Sidransky E
  • Journal Title: N Engl J Med 361 Pages: 1651-1661
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease (2009)
  • Author(s): Satake W
  • Journal Title: Nature Genet 41 Pages: 1303-1307
  • Peer Reviewed
• [Journal Article] 家族性パーキンソン病は孤発性パーキンソンのモデルになるか? (2009)
  • Author(s): 水田依久子
  • Journal Title: Frontiers in Parkinson Disease 2 Pages: 79-87
• [Journal Article] パーキンソン病関連遺伝子の全ゲノム関連解析 (2009)
  • Author(s): 戸田達史
  • Journal Title: 最新医学 64 Pages: 872-879
• [Journal Article] パーキンソン病のゲノムワイド関連解析 (2009)
  • Author(s): 戸田達史
  • Journal Title: 細胞 41 Pages: 198-202
• [Journal Article] 孤発性パーキンソン病の分子遺伝学 (2009)
  • Author(s): 三井純, 戸田達史
  • Journal Title: 実験医学 増刊 27 Pages: 1854-1859
• [Journal Article] 福山型先天性筋ジストロフィー (2009)
  • Author(s): 戸田達史
  • Journal Title: 小児科 50 Pages: 899-906
  • NAID: 10008311277
• [Journal Article] パーキンソン病のゲノミックス (2009)
  • Author(s): 戸田達史
  • Journal Title: 老年精神医学雑誌 20 Pages: 973-979
• [Journal Article] 福山型筋ジストロフィーおよび類縁疾患の病態・治療戦略 (2009)
  • Author(s): 戸田達史
  • Journal Title: 臨床神経学 49 Pages: 859-862
  • NAID: 10026290982
• [Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylationby LARGE in novel model mice to dystroglycanopathy. (2009)
  • Author(s): Kanagawa M
  • Journal Title: Hum Mol Genet 18 Pages: 621-631
  • Peer Reviewed
• [Journal Article] Surface plasmon resonance characterization of specific binding ofpolyglutamine aggregate inhibitors to the expanded polyglutamine stretch. (2009)
  • Author(s): Okamoto Y
  • Journal Title: Biochem Biophys Res Commun 378 Pages: 634-639
  • Peer Reviewed
• [Journal Article] Structure-activity relationship study on polyglutamine binding peptideQBP1. (2009)
  • Author(s): Tomita K
  • Journal Title: Bioorg Med Chem 17 Pages: 1259-1263
  • Peer Reviewed
• [Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinsondisease. (2009)
  • Author(s): Mitsui J
  • Journal Title: Arch Neurol (In press)
  • Peer Reviewed
• [Journal Article] Is g an entity? A Japanese twin study using syllogisms and intelligencetests. (2009)
  • Author(s): Shikishima C
  • Journal Title: Intelligence (In press)
  • Peer Reviewed
• [Journal Article] Heat shock transcription factor 1 (HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones. (2008)
  • Author(s): Fujikake N, Nagai Y, Popiel HA, Okamoto Y, Yamaguchi M, Toda T
  • Journal Title: J Biol Chem 283 Pages: 26188-26197
  • Peer Reviewed
• [Journal Article] Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. (2008)
  • Author(s): Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.
  • Journal Title: Nature Neurosci 11 Pages: 923-931
  • Peer Reviewed
• [Journal Article] Calbindin 1, fibroblast growth factor 20, and ?-synuclein in Parkinson's disease. (2008)
  • Author(s): Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T
  • Journal Title: Hum Genet 124 Pages: 89-94
  • Peer Reviewed
• [Journal Article] 認知と遺伝子 (2008)
  • Author(s): 小林千浩, 戸田達史
  • Journal Title: Cognition and Dementia 7 Pages: 35-43
• [Journal Article] Mutation analysis of the PINK1 gene in 391 patients with Parkinsondisease. (2008)
  • Author(s): Kumazawa R
  • Journal Title: Arch Neurol 65 Pages: 802-808
  • Peer Reviewed
• [Journal Article] Calbindin 1, fibroblast growth factor 20, and a-synuclein in Parkinson'sdisease. (2008)
  • Author(s): Mizuta I
  • Journal Title: Hum Genet 124 Pages: 89-94
  • Peer Reviewed
• [Journal Article] Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbonsynapse formation. (2008)
  • Author(s): Sato S
  • Journal Title: Nature Neurosci 11 Pages: 923-931
  • Peer Reviewed
• [Journal Article] Heat shock transcription factor 1-activating compounds suppresspolyglutamine-induced neurodegeneration through induction of multiplemolecular chaperones. (2008)
  • Author(s): Fujikake N
  • Journal Title: J Biol Chem 283 Pages: 26188-26197
  • Peer Reviewed
• [Journal Article] Reduced expression of sarcospan in muscles of Fukuyama congenitalmuscular dystrophy. (2008)
  • Author(s): Wakayama Y
  • Journal Title: Histol Histopathol 23 Pages: 1425-1438
  • Peer Reviewed
• [Journal Article] LRRK2 P755L variant in sporadic Parkinson's disease. (2008)
  • Author(s): Tomiyama H
  • Journal Title: J Hum Genet 53 Pages: 1012-1015
  • Peer Reviewed
• [Journal Article] Delivery of the aggregate inhibitor peptide QBP1 into the mouse brainusing PTDs and its therapeutic effect on polyglutamine disease mice. (2008)
  • Author(s): Popiel HA
  • Journal Title: Neurosci Lett 449 Pages: 87-92
  • Peer Reviewed
• [Journal Article] 福山型筋ジストロフィー (2008)
  • Author(s): 戸田達史
  • Journal Title: ビジュアル疾患解説 眼で見る遺伝病とターナ-症候群 2 Pages: 6-7
• [Journal Article] 孤発性パーキンソン病のゲノムワイドスクリーニング (2008)
  • Author(s): 戸田達史
  • Journal Title: ゲノム医学 8 Pages: 21-26
• [Journal Article] 認知と遺伝子 (2008)
  • Author(s): 小林千浩
  • Journal Title: Cognition and Dementia 7 Pages: 35-43
• [Journal Article] 筋ジストロフィー (2008)
  • Author(s): 谷口真理子
  • Journal Title: 小児内科 40 Pages: 1308-1314
• [Journal Article] 孤発性パーキンソン病のメカニズム (2008)
  • Author(s): 水田依久子
  • Journal Title: 成人病と生活習慣病 38 Pages: 887-892
• [Journal Article] Alzheimer病と遺伝 (2008)
  • Author(s): 戸田達史
  • Journal Title: 成人病と生活習慣病 38 Pages: 1205-1210
• [Journal Article] 福山型筋ジストロフィーの発見とその類縁疾患における病態 (2008)
  • Author(s): 戸田達史
  • Journal Title: 蛋白質 核酸 酵素 53 Pages: 1771-1780
  • NAID: 40016244595
• [Presentation] 認知能力の差が顕著な一卵性双生児のDNAメチル化解析 (2010)
  • Author(s): 小林千浩
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-07
• [Presentation] Genome-wide gene expression and DNA methylation analyses of significantly discordant monozygotic twins for cognitive ability. (2010)
  • Author(s): Kobayashi K
  • Organizer: American Society of Human Genetics 60th Annual Meeting
  • Place of Presentation: Washington Convention Center (Washington DC, 米国)
  • Year and Date: 2010-11-03
• [Presentation] 認知能力の差が顕著な一卵性双生児の分子遺伝学的解析 (2010)
  • Author(s): 小林千浩
  • Organizer: 日本人類遺伝学会第55回大会
  • Place of Presentation: 大宮ソニックシティ(埼玉県)
  • Year and Date: 2010-10-30
• [Presentation] 認知能力の差が顕著な一卵性双生児の網羅的遺伝子発現・DNAメチル化解析 (2010)
  • Author(s): 小林千浩
  • Organizer: 日本パーソナリティ心理学会第19回大会
  • Place of Presentation: 慶應義塾大学三田キャンパス(東京都)(招待講演)
  • Year and Date: 2010-10-11
• [Presentation] 認知能力の差が顕著な-卵性双生児の網羅的遺伝子発現・DNAメチル化解析. (2010)
  • Author(s): 小林千浩
  • Organizer: 日本パーソナリティ心理学会第19回大会(招待講演)
  • Place of Presentation: 慶應義塾大学三田キャンパス
• [Presentation] 認知能力の差が顕著な-卵性双生児の分子遺伝学的解析 (2010)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、瀬々潤、菅原裕子、岩本和也、加藤忠史、安藤寿康、戸田達史
  • Organizer: 日本人類遺伝学会第55回大会
  • Place of Presentation: 大宮ソニックシティ
• [Presentation] 認知能力の差が顕著な-卵性双生児のDNAメチル化解析 (2010)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、瀬々潤、菅原裕子、岩本和也、加藤忠史、安藤寿康、戸田達史
  • Organizer: 第33回日本分子生物学会年会第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Genome-wide gene expression and DNA methylation analyses of significantly discordant monozygotic twins for cognitive ability. (2010)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、瀬々潤、菅原裕子、岩本和也、加藤忠史、安藤寿康、戸田達史
  • Organizer: American Society of Human Genetics 60th Annual Meeting.
  • Place of Presentation: Washington D.C., 米国
• [Presentation] Expression analysis of monozygotic twins discordant for cognitive ability (2009)
  • Author(s): 古川真理
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜, (神奈川県)
  • Year and Date: 2009-12-12
• [Presentation] Genomic analysis of monozygotic twins discordant for cognitive ability (2009)
  • Author(s): 小林千浩
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-11
• [Presentation] Genetic Analysis of Monozygotic Twins Discordant for Cognitive Abilities (2009)
  • Author(s): 小林千浩
  • Organizer: 第59回米国人類遺伝学会年会
  • Place of Presentation: Hawaii, U.S.
  • Year and Date: 2009-10-22
• [Presentation] Genetic Analysis of Monozygotic Twins Discordant for Cognitive Abilities. (2009)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、安藤寿康、戸田達史
  • Organizer: 第59回米国人類遺伝学会年会
  • Place of Presentation: Hawaii, 米国
• [Presentation] Genomic analysis of monozygotic twins discordant for cognitive ability (2009)
  • Author(s): 小林千浩、古川真理、游智傑、敷島千鶴、安藤寿康、戸田達史
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Expression analysis of monozygotic twins discordant for cognitive ability. (2009)
  • Author(s): 古川真理、小林千浩、游智傑、瀬々潤、敷島千鶴、安藤寿康、戸田達史
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 精神発達道滞における500K SNP チップを用いたコピー数変化領域のスクV ーニングと原因遺伝子の同定 (2008)
  • Author(s): 小林千浩
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-11
• [Presentation] Copy number variation screening with the500k SNP array in patientswith mental retardation. (2008)
  • Author(s): Kobayashi K
  • Organizer: The American Society of Human Genetics58^<th> Annual Meeting
  • Place of Presentation: Pennsylvania Convention Center, Philadelphia
  • Year and Date: 2008-11-14
• [Presentation] 精神発達遅滞児(者)における500K SNPチップを用いたコピー数変化領域のスクリーニングと原因遺伝子の同定 (2008)
  • Author(s): 牟禮岳男
  • Organizer: 日本人類遺伝学会第53回大会
  • Place of Presentation: パシフイコ横浜
  • Year and Date: 2008-09-30
• [Presentation] 精神発達遅滞児(者)における500KSNPチップを用いたコピー数変化領域のスクリーニングと原因遺伝子の同定 (2008)
  • Author(s): 牟禮岳男、小林千浩、金城薫、千代延友裕、西村陽、平井清、森本昌史、松尾雅文、稲澤譲治、戸田達史
  • Organizer: 日本人類遺伝学会第53回大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 精神発達遅滞における500K SNPチップを用いたコピー数変化領域のスクリーニングと原因遺伝子の同定 (2008)
  • Author(s): 小林千浩、牟禮岳男、金城薫、千代延友裕、西村陽、平井清、森本昌史、松尾雅文、稲澤譲治、戸田達史
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド
• [Presentation] Copy number variation screening with the 500k SNP array in patients with mental retardation. (2008)
  • Author(s): 小林千浩、牟禮岳男、金城薫、千代延友裕、西村陽、平井清、森本昌史、松尾雅文、稲澤譲治、戸田達史
  • Organizer: The American Society of Human Genetics. 58th Annual Meeting.
  • Place of Presentation: Philadelphia, 米国
• [Book] Glycoscience Lab Manual (2008)
  • Author(s): Kanagawa M
  • Total Pages: 4
  • Publisher: Elsevier Japan
• [Remarks] ホームページ等
  • URL: http://www.med.kobe-u.ac.jp/im3/rinsyo/shinkei/index.html
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/clgene/
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/im3/rinsyo/shinkei/index.html
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/clgene/
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/im3/rinsyo/shinkei/index.html
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/clgene/
• [Remarks]
  • URL: http://www.clgene.med.osaka-u.ac.jp/www/gyoseki.html
• [Patent(Industrial Property Rights)] パーキンソン病発症リスクマーカー (2010)
  • Inventor(s): 戸田達史
  • Industrial Property Rights Holder: エーザイ・アール・アンド・デイーマネジメント株式会社
  • Filing Date: 2010-05-14