Identification of Genes for Cognition and Their Functional Analysis
Project/Area Number |
20390099
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human genetics
|
Research Institution | Osaka University |
Principal Investigator |
TODA Tatsushi Osaka University, 大学院・医学研究科, 教授 (30262025)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
Keywords | 分子遺伝学 / 認知機能 / IQ / 一卵性双生児 / 網羅的遺伝子発現解析 / 網羅的DNAメチル化解析 / g因子 / 行動解析 / 炎症性サイトカイン / エピゲノム / 精神発達遅滞 / CNV / GEMCA / Sotos症候群 / 22q11.2欠失症候群 / Potocki-Lupski症候群 |
Research Abstract |
By microarray analysis, we detected copy number abnormality in MR patients. We also found that inflammatory cytokines had different expression between IQ-discordant monozygotic twins.
|
Report
(4 results)
Research Products
(97 results)
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[Journal Article] Genetic and clinical analysis in a Chinese parkinsonism- predominant spinocerebellar ataxia type 2 family.2011
Author(s)
Sun H, Satake W, Zhang C, Nagai Y, Tian Y, Fu S, Yu J, Qian Y, Qian Y, Chu J, Toda T
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Journal Title
J Hum Genet 56(4)
Pages: 330-334
NAID
Related Report
Peer Reviewed
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[Journal Article] Defective glycosylation of α-dystroglycan contributes to podocyte flattening.2011
Author(s)
Kojima K, Nosaka H, Kishimoto Y, Nishiyama Y, Fukuda S, Shimada M, Kodaka K, Saito F, Matsumura K, Shimizu T, Toda T, Takeda S, Kawachi H, Uchida S.
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Journal Title
Kidney Int 79
Pages: 311-316
Related Report
Peer Reviewed
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[Journal Article] Fukutin gene retrotransposal insertion in a non-Japanese Fukuyama congenital muscular dystrophy (FCMD) patient.2009
Author(s)
Xiong H, Wang S, Kobayashi K, Jiang Y, Wang J, Chang X, Yuan Y, Liu J, Toda T, Fukuyama Y, Wu X.
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Journal Title
Am J Med Genet 149A
Pages: 2403-2408
Related Report
Peer Reviewed
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[Journal Article] Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.2009
Author(s)
Satake W, Nakabayashi Y, Mizuta I, Hirota Y, Ito C, Kubo M, Kawaguchi T, Tsunoda T, Watanabe M, Takeda A, Tomiyama H, Nakashima K, Hasegawa K, Obata F, Yoshikawa T, Kawakami H, Sakoda S, Yamamoto M, Hattori N, Murata M, Nakamura Y, Toda T
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Journal Title
Nature Genet 41
Pages: 1303-1307
Related Report
Peer Reviewed
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[Journal Article] Mutations for Gaucher disease confer a high susceptibility to Parkinson disease.2009
Author(s)
Mitsui J, Mizuta I, Toyoda A, Ashida R, Takahashi Y, Goto J, Fukuda Y, Date H, Iwata A, Yamamoto M, Hattori N, Murata M, Toda T, Tsuji S.
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Journal Title
Arch Neurol 66
Pages: 571-576
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Peer Reviewed
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[Journal Article] Residual laminin-binding activity and enhanced dystroglycan glycosylation in novel model mice to dystroglycanopathy.2009
Author(s)
Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, Toda T
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Journal Title
Hum Mol Genet 18
Pages: 621-631
Related Report
Peer Reviewed
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[Journal Article] Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.2008
Author(s)
Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T.
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Journal Title
Nature Neurosci 11
Pages: 923-931
Related Report
Peer Reviewed
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[Journal Article] Calbindin 1, fibroblast growth factor 20, and ?-synuclein in Parkinson's disease.2008
Author(s)
Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T
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Journal Title
Hum Genet 124
Pages: 89-94
Related Report
Peer Reviewed
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