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Elucidation of the pathogenic mechanism and the clinical spectrum of disorders associated with imprinted genes on human chromosome 14

Research Project

Project/Area Number 20390101
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionNational Research Institute for Child Health and Development

Principal Investigator

KAGAMI Masayo  National Research Institute for Child Health and Development, 分子内分泌研究部, 上級研究員 (70399484)

Co-Investigator(Kenkyū-buntansha) OGATA Tsutomu  独立行政法人国立成育医療研究センター, 分子内分泌研究部, 部長 (40169173)
YAMAZAWA Kazuki  独立行政法人国立成育医療研究センター, 分子内分泌研究部, 共同研究員 (10338113)
TAKADA Shuji  独立行政法人国立成育医療研究センター, システム発生・再生医学研究部, 室長 (20382856)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywordsインプリンティング / エピジェネティクス / 成長障害 / 胎盤 / 臨床像 / 遺伝子調節
Research Abstract

We identified two 14q32.2 imprinting centers in the body and the placenta, respectively. The germline-derived primary DLK1-MEG3 intergenic differentially methylated region (IG-DMR) acts as an upstream regulator for the methylation pattern of the postfertilization-derived secondary MEG3-DMR in the body but not in the placenta, and that the IG-DMR and the MEG3-DMR function as imprinting control centers in the placenta and the body, respectively. This is the first study demonstrating an essential long-range imprinting regulatory function for the secondary DMR.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (51 results)

All 2011 2010 2009 2008 Other

All Journal Article (24 results) (of which Peer Reviewed: 23 results) Presentation (24 results) Remarks (3 results)

  • [Journal Article] Radiological evaluation of dysmorphic thorax of paternal uniparental disomy 14.2011

    • Author(s)
      Miyazaki O, Nishimura G, Kagami M, Ogata T.
    • Journal Title

      Pediatric Radiology. Epub ahead of print

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal findings of paternal uniparental disomy 14 : Delineation of further patient.2010

    • Author(s)
      Suzumori N, Ogata T, Mizutani E, Hattori Y, Matsubara K, Kagami M, Sugiura-Ogasawara M.
    • Journal Title

      American Journal Medical Genetics A. 152A(12)

      Pages: 3189-3192

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2 : Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers.2010

    • Author(s)
      Kagami M, J O'Sullivan M, Green AJ, Watabe Y, Arisaka O, Masawa N, Matsuoka K, Fukami M, Matsubara K, Kato F, Ferguson-Smith AC, Ogata T.
    • Journal Title

      PLoS Genetics 6(6)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Parthenogenetic Female with a Silver-Russell Syndrome-like Phenotype and a 45, X Cell Lineage Accompanied by Biparentally Derived Autosomes.2010

    • Author(s)
      Yamazawa K, Nakabayashi K, Kagami M, Satoh T, Hata K, Saitoh S, Nagai T, Horikawa R, Hizuka N, Ogata T.
    • Journal Title

      Journal of Medical Genetics Epub ahead of print

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The 1G-DMR and the MEG3-DMR at Human Chromosome 14q32.2 : Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers.2010

    • Author(s)
      Kagami M, J O'Sullivan M, Green AJ, Watabe Y, Arisaka O, Masawa N, Matsuoka K, Fukami M, Matsubara K, Kato F, Ferguson-Smith AC, Ogata T.
    • Journal Title

      PLoS Genetics

      Volume: 6(6)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal findings of paternal uniparental disomy 14 : Delineation of further patient.2010

    • Author(s)
      Suzumori N, Ogata T, Mizutani E, Hattori Y, Matsubara K, Kagami M, Sugiura-Ogasawara M.
    • Journal Title

      American Journal Medical Genetics A.

      Volume: 152A(12) Pages: 3189-3192

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Parthenogenetic Female with a Silver-Russell Syndrome-like Phenotype and a 45,X Cell Lineage Accompanied by Biparentally Derive Autosomes.2010

    • Author(s)
      Yamazawa K, Nakabayashi K, Kagami M, Satoh T, Hata K, Saitoh S, Nagai T, Horikawa R, Hizuka N, Ogata T.A
    • Journal Title

      Journal of Medical Genetics

      Volume: 47(11) Pages: 782-785

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal uniparental disomy 14 syndrome demonstrates Prader-Willi syndrome-like phenotype.2009

    • Author(s)
      Hosoki K, Kagami M, Tanaka T, Kubota M, Kurosawa K, Kato M, Uetake K, Tohyama J, Ogata T, Saitoh S.
    • Journal Title

      Journal of Pediatrics 155(6)

      Pages: 900-903

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2.2009

    • Author(s)
      Kobayashi H, Yamada K, Morita S, Hiura H, Fukuda A, Kagami M, Ogata T, Hata K, Sotomaru Y, Kono T.
    • Journal Title

      Genomics 93(5)

      Pages: 461-472

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maternal uniparental disomy 14 syndrome demonstrates Prader-Willi syndrome-like phenotype2009

    • Author(s)
      Hosoki K, Kagami M, Tanaka T, Kubota M, Kurosawa K, Kato M, Uetake K, Tohyama J, Ogata T, Saitoh S.
    • Journal Title

      Journal of Pediatrics 155(6)

      Pages: 900-903

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 22009

    • Author(s)
      Kobayashi H, Yamada K, Morita S, Hiura H, Fukuda A, Kagami M, Ogata T, Hata K, Sotomaru Y, Kono T.
    • Journal Title

      Genomics 93(5)

      Pages: 461-472

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 22009

    • Author(s)
      Kobayashi H, Yamada K, Morita S, Hiura H, Fukuda A, Kagami M, Ogata T, Hata K, Sotomaru Y, Kono T.
    • Journal Title

      Genomics 93

      Pages: 461-472

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Placentomegaly in paternal uniparental disomy for human chromosome 14.2008

    • Author(s)
      Kagami M, Yamazawa K, Matsubara K, Matsuo N, Ogata T.
    • Journal Title

      Placenta 29(8)

      Pages: 760-761

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epimutation (hypomethylation) affecting the chromosome 14q32.2 imprinted region in a girl with upd(14)mat-like phenotype.2008

    • Author(s)
      Hosoki K, Ogata T, Kagami M, Tanaka T, Saitoh S.
    • Journal Title

      European Journal of Human Genetics 16(8)

      Pages: 1019-1023

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and clinical findings and their correlations in Silver-Russell syndrome : implications for a positive role of IGF2 in growth determination and differential imprinting regulation of the IGF2-H19 domain in bodies and placentas.2008

    • Author(s)
      Yamazawa K, Kagami M, Nagai T, Kondoh T, Onigata K, Maeyama K, Hasegawa T, Hasegawa Y, Yamazaki T, Mizuno S, Miyoshi Y, Miyagawa S, Horikawa R, Matsuoka K, Ogata T.
    • Journal Title

      Journal of Molecular Medicine 86(10)

      Pages: 1171-1181

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monozygotic female twins discordant for Silver-Russell syndrome and hypomethylation of the H19-DMR.2008

    • Author(s)
      Yamazawa K, Kagami M, Fukami M, Matsubara K, Ogata T.
    • Journal Title

      Journal of Human Genetics 53(10)

      Pages: 950-955

    • NAID

      10022603248

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 142008

    • Author(s)
      Ogata T, Kagami M, Ferguson-Smith AC.
    • Journal Title

      Epigenetics 3

      Pages: 181-187

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Placentomegaly in paternal uniparental disomy for human chromosome 142008

    • Author(s)
      Kagami M, Yamazawa K, Matsubara K, Matsuo N, Ogata T.
    • Journal Title

      Placenta 29

      Pages: 760-761

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epimutation (hypomethylation) affecting the chromosome 14q32. 2 imprinted region in a girl with upd (14) mat-like phenotype2008

    • Author(s)
      Hosoki K, Ogata T, Kagami M, Tanaka T, Saitoh S.
    • Journal Title

      Eur J Hum Genet 16

      Pages: 1019-1023

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and clinical findings and their correlations in Silver-Russell syndrome : implications for a positive role of IGF2 in growth determination and differential imprinting regulation of the IGF2-H19 domain in bodies and placentas2008

    • Author(s)
      Yamazawa K, Kagami M, Nagai T, Kondoh T, Onigata K, Maeyama K, Hasegawa T, Hasegawa Y, Yamazaki T, Mizuno S, Miyoshi Y, Miyagawa S, Horikawa R, Matsuoka K, Ogata T.
    • Journal Title

      J Mol Med. 86

      Pages: 1171-1181

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Placental hypoplasia in maternal uniparental disomy for chromosome 72008

    • Author(s)
      Yamazawa K, Kagami M, Ogawa M, Horikawa R, Ogata T.
    • Journal Title

      Am J Med Gent A. 146A

      Pages: 514-516

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monozygotic female twins discordant for Silver-Russell syndrome and hypomethylation of the H19-DMR2008

    • Author(s)
      Yamazawa K, Kagami M, Fukami M, Matsubara K, Ogata T.
    • Journal Title

      J Hum Genet 53

      Pages: 950-955

    • NAID

      10022603248

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2 : Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers

    • Author(s)
      Kagami M, J O'Sullivan M, Green AJ, Watabe Y, Arisaka O, Masawa N, Matsuoka K, Fukami M, Matsubara K, Kato F, Ferguson-Smith AC, Ogata T.
    • Journal Title

      PLoS Genetics (accepted)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Parthenogenetic Female with a Silver-Russell Syndrome-like Phenotype and a 45,X Cell Lineage Accompanied by Biparentally Derived Autosomes

    • Author(s)
      Yamazawa K, Nakabayashi K, Kagami M, Satoh T, Hata K, Saitoh S, Nagai T, Horikawa R, Hizuka N, Ogata T.
    • Journal Title

      Journal of Medical Genetics (accepted)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2 : Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers2010

    • Author(s)
      Masayo Kagami, Maureen J O' Sullivan, Andrew J Green, Yoshiyuki Watabe, Osamu Arisaka, Nobuhide Masawa, Kentarou Matsuoka, Maki Fukami, Keiko Matsubara, Fumiko Kato, Anne C Ferguson-Smith, Tsutomu Ogata.
    • Organizer
      International Symposium on Epigenome Network , Development and Reprograming of Germ Cells
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] RTL1 plays a key role in human placental development.2010

    • Author(s)
      Masayo Kagami, Kentaro Matsuoka, Keiko Matsubara, Tomoko Sato, Michiko Yamanaka, Nobuhiro Suzumori, Tsutomu Ogata.
    • Organizer
      International Symposium on Epigenome Network , Development and Reprograming of Germ Cells
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-11-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト14q32.2のインプリンティング領域においてIG-DMRとMEG3-DMRは異なった役割をはたす2010

    • Author(s)
      鏡雅代、高田修治、加藤芙弥子、Anne C Ferguson-Smith、緒方勤
    • Organizer
      第4回エピジェネティクス研究会
    • Place of Presentation
      鳥取
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hierarchical interaction and distinct functional properties of the IG-DMR and the MEG3-DMR at the human chromosome 14q32.2 imprinted region.2010

    • Author(s)
      Masayo Kagami, Maureen J O'Sullivan, Andrew J Green, Yoshiyuki Watabe, Osamu Arisaka, Toshiro Nagai, Shuji Takada, Maki Fukami, Kazuki Yamazawa, Keiko Matsubara, Fumiko Kato, Anne C Ferguson-Smith, Tsutomu Ogata.
    • Organizer
      14^<th> International Congress of Endocrinology
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hierarchical interaction and distinct functional properties of the IG-DMR and the MEG3-DMR at the human chromosome 14q32.2 imprinted region.2010

    • Author(s)
      Masayo Kagami, Maureen J O'Sullivan, Andrew J Green, Yoshiyuki Watabe, Osamu Arisaka, Toshiro Nagai, Shuji Takada, Maki Fukami, Kazuki Yamazawa, Keiko Matsubara, Fumiko Kato, Anne C Ferguson-Smith, Tsutomu Ogata
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] Hierarchical interaction and distinct functional properties of the IG-DMR and the MEG3-DMR at the human chromosome 14q32.2 imprinted region.2010

    • Author(s)
      Masayo Kagami, Maureen J O'Sullivan, Andrew J Green, Yoshiyuki Watabe , Osamu Arisaka, Toshiro Nagai, Shuji Takada, Maki Fukami, Kazuki Yamazawa, Keiko Matsubara, Fumiko Kato, Anne C Ferguson-Smith, Tsutomu Ogata
    • Organizer
      International Snmposium on Pediatric Endocrinology
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒト14q32.2のインプリンティング領域において、IG-DMRとMEG3-DMRは異なった役割をはたす2010

    • Author(s)
      鏡雅代、高田修治、加藤芙弥子、Anne C Ferguson-Smith、緒方勤
    • Organizer
      第4回エピジェネティクス研究会
    • Place of Presentation
      鳥取
    • Related Report
      2010 Final Research Report
  • [Presentation] 14番染色体インプリンティング遺伝子の胎盤における機能の解明2010

    • Author(s)
      鏡雅代、加藤芙弥子、宮戸真美、高田修治、松岡健太郎、山中美智子、金子さおり、松原圭子、佐藤智子、緒方勤
    • Organizer
      第44回日本小児内分泌学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ヒト14番染色体インプリンティング異常症発症機序の解明2010

    • Author(s)
      鏡雅代
    • Organizer
      第55回日本人類遺伝学会奨励賞受賞講演
    • Place of Presentation
      大宮
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 14番染色体父親性ダイソミー症候群の病因別頻度の解明2010

    • Author(s)
      鏡雅代、加藤芙弥子、松原圭子、佐藤智子、緒方勤
    • Organizer
      第55回日本人類遺伝学会学術集会
    • Place of Presentation
      大宮
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] The IG-DMR and the MEG3-DMR at Human Chromosome 14q32.2 : Hierarchical Interaction and Distinct Functional Properties as Imprinting Control Centers, International Symposium on Epigenome Network2010

    • Author(s)
      Masayo Kagami, Maureen J O'Sullivan, Andrew J Green, Yoshiyuki Watabe, Osamu Arisaka, Nobuhide Masawa, Kentarou Matsuoka, Maki Fukami, Keiko Matsubara, Fumiko Kato, Anne C Ferguson-Smith, Tsutomu Ogata
    • Organizer
      Development and Reprograming of Germ Cells
    • Place of Presentation
      Fukuoka
    • Related Report
      2010 Final Research Report
  • [Presentation] RTL1 plays a key role in human placental development. International Symposium on Epigenome Network2010

    • Author(s)
      Masayo Kagami, Kentaro Matsuoka, Keiko Matsubara, Tomoko Sato, Michiko Yamanaka, Nobuhiro Suzumori, Tsutomu Ogata
    • Organizer
      Development and Reprograming of Germ Cells
    • Place of Presentation
      Fukuoka
    • Related Report
      2010 Final Research Report
  • [Presentation] Essential role of the MEG3-DMR in the regulation of the maternally inherited human chromosome 14q32.2 imprinting region2009

    • Author(s)
      Kagami M
    • Organizer
      The 24th Naito Conference
    • Place of Presentation
      Sapporo
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Essential role of the MEG3-DMR in the regulation of the maternally inherited human chromosome 14q32.2 imprinting region.2009

    • Author(s)
      Masayo Kagami, Maki Fukami, Maureen O'Sullivan, Andrew Green, Shuji Takada, Fumiko Kato, Anne Ferguson-Smith, Tsutomu Ogata
    • Organizer
      The 24th Naito Conference
    • Place of Presentation
      Sapporom
    • Related Report
      2010 Final Research Report
  • [Presentation] 14番染色体インプリンティング遺伝子群の調節において, IG-DMRとMEG3-DMRは異なった役割をはたす2009

    • Author(s)
      鏡雅代、高田修治、加藤芙弥子、Anne C Ferguson-Smith、緒方勤
    • Organizer
      第3回日本エピジェネティクス研究会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 14番染色体インプリンティング遺伝子群の調節において, IG-DMRとMEG3-DMRは異なった役割を果たす2009

    • Author(s)
      鏡雅代、高田修治、加藤芙弥子、Anne C Ferguson-Smith、緒方勤
    • Organizer
      第54回日本人類遺伝学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 14番染色体インプリンティング遺伝子群の調節において, IG-DMRとMEG3-DMRは異なった役割をはたす2009

    • Author(s)
      鏡雅代、高田修治、加藤芙弥子、Anne C Ferguson-Smith、緒方勤
    • Organizer
      第43回日本小児内分泌学会
    • Place of Presentation
      宇都宮
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Hierarchical interaction and distinct functional properties of the IG-DMR and the MEG3-DMR at the human chromosome 14q32.2 imprinted region.2009

    • Author(s)
      Masayo Kagami, Shuji Takada, Maki Fukami, Kazuki Yamazaw, Keiko Matsubara, Fumiko Kato, Anne C Ferguson-Smith, Tsutomu Ogata
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Hierarchical interaction and distinct functional properties of the IG-DMR and the MEG3-DMR at the human chromosome 14q32.2 imprinted region2009

    • Author(s)
      鏡雅代
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 14番染色体母性片親性ダイソミーは Prader-Willi 症候群の鑑別疾患である2008

    • Author(s)
      鏡雅代
    • Organizer
      第42回日本小児内分泌学会学術集会
    • Place of Presentation
      米子
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 14番染色体インプリンティング遺伝子群の調節にはGTL2-DMRが決定的な役割を果たす2008

    • Author(s)
      鏡雅代
    • Organizer
      第53回日本人類遺伝学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 14番染色体母性片親性ダイソミーはPrader-Willi症候群の鑑別疾患である。2008

    • Author(s)
      鏡雅代、斎藤伸治、高桑聖、田中藤樹、緒方勤
    • Organizer
      第42回日本小児内分泌学会学術集会
    • Place of Presentation
      米子
    • Related Report
      2010 Final Research Report
  • [Presentation] 14番染色体インプリンティング遺伝子群の調節にはGTL2-DMRが決定的な役割を果たす2008

    • Author(s)
      鏡雅代、加藤芙弥子、西村玄、緒方勤
    • Organizer
      第53回日本人類遺伝学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 14番染色体父親性ダイソミー、母親性ダイソミーの表現型を招く疾患発症機序の解明2008

    • Author(s)
      鏡雅代、加藤芙美子、西村玄、田中葉子、黒澤健司、石野史敏、緒方勤
    • Organizer
      第111回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.nch.go.jp/endocrinology/upd14/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.nch.go.jp/endocrinology/upd14/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.nch.go.jp/endocrinology/upd14/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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