Pathogenesis of atherothrombosis
| Project/Area Number |
20390102
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
ASADA Yujiro University of Miyazaki, 医学部, 教授 (70202588)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Yuichiro 宮崎大学, 医学部, 助教 (90347055)
YAMASHITA Atsushi 宮崎大学, 医学部, 助教 (90372797)
IMAMURA Takuroh 宮崎大学, 医学部, 准教授 (60203329)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | アテローム血栓症 / 血小板 / 凝固線溶系 / 炎症性サイトカイン / 血流解析 / 冠動脈アテレクトミー / 酸化ストレス |
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| Research Abstract |
Thrombus formation on a disrupted atherosclerotic plaque is the major cause that leads to the onset of cardiovascular events. However, the detail mechanisms of thrombogenesis and thrombus propagation have been remained unclear. The issue was investigated using human pathological samples, novel established animal model of atherothrombosis, and flow chamber system. The results showed that thrombus formation was enhanced by the thrombogenicity of exposed plaque constituents rather than systemic thrombogenicity. And blood flow alteration greatly promoted thrombus propagation, and also induced erosive injury of plaques. Taken together, a combination of these factors could induce the onset of cardiovascular events.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Human C -reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits.2011
Author(s)
Matsuda S, Yamashita A, Sato Y, Kitajima S, Koike T, Sugita C, Moriguchi-Goto S, Hatakeyama K, Takahashi M, Koshimoto C, Matsuura Y, Iwakiri T, Chen YE, Fan J, Asada Y.
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Journal Title
J Thromb Haemost. 9
Pages: 201-208
Related Report
Peer Reviewed
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[Journal Article] Disturbed blood flow induces erosive injury to smooth muscle cell-rich neointima and promotes thrombus formation in rabbit femoral artery.2010
Author(s)
Sumi T, Yamashita A, Matsuda S, Goto S, Nishihira K, Furukoji E, Sugimura H, Kawahara H, Imamura T, Kitamura K, Tamura S, Asada Y.
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Journal Title
J Thromb Haemost. 8
Pages: 1394-1402
Related Report
Peer Reviewed
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[Journal Article] Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits.2009
Author(s)
Yamashita A, Matsuda S, Matsumoto T, Moriguchi-Goto S, Takahashi M, Sugita C, Sumi T, Imamura T, Shima M, Kitamura K, Asada Y.
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Journal Title
Atherosclerosis. 206
Pages: 418-426
Related Report
Peer Reviewed
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[Presentation] Serotonin induces vasoconstriction of smooth muscle cell?rich neointima through 5?hydroxytryptamine 2A receptor in rabbit femoral arteries.2009
Author(s)
Nishihira K, Imamura T, Nakama T, Mine D, Shimomura M, Nomura K, Kuriyama N, Matsuyama A, Ishikawa T, Shibata Y, Kitamura K, Asada Y.
Organizer
The 73rd Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
大阪
Year and Date
2009-03-21
Related Report
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