| Budget Amount *help |
¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Research Abstract |
Thrombus formation on a disrupted atherosclerotic plaque is the major cause that leads to the onset of cardiovascular events. However, the detail mechanisms of thrombogenesis and thrombus propagation have been remained unclear. The issue was investigated using human pathological samples, novel established animal model of atherothrombosis, and flow chamber system. The results showed that thrombus formation was enhanced by the thrombogenicity of exposed plaque constituents rather than systemic thrombogenicity. And blood flow alteration greatly promoted thrombus propagation, and also induced erosive injury of plaques. Taken together, a combination of these factors could induce the onset of cardiovascular events.
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