| Budget Amount *help |
¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Research Abstract |
The major findings of this project are summarized as follows :(1) loss of chromatin remodeling factors, BRG1 and BRM, were closely correlated with and may be involved in EMT of lung adenocarcinomas ;(2) CTGF(connective tissue growth factor) was identified as a biomarker of lung adenocarcinomas with EMT features ; and (3) lung adenocarcinomas with EMT features were sensitive to cisplatin or one of the inhibitors for HDAC, Hsp 90, Proteasome, and Jak2.
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