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Clinocopathological analysis of HTLV-I associated genes of HBZ and tax in the tumor genesis of ATLL

Research Project

Project/Area Number 20390104
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKurume University

Principal Investigator

KOICHI Ohshima  Kurume University, 医学部, 教授 (50203766)

Co-Investigator(Kenkyū-buntansha) SUGITA Yasuo  久留米大学, 医学部, 教授 (80216316)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Keywordsウイルス / 病理学 / ATLL / HTLV-I / 腫瘍 / HBZ / HTLV-1
Research Abstract

Adult T-cell leukemia/lymphoma (ATLL) is a T-cell malignancy associated with human T-cell leukemia virus type 1 (HTLV-1). The HTLV-1 provirus genome has the pX region which encodes tax and HTLV-1 basic leucine zipper factor (HBZ). The previous studies have reported that the tax gene is expressed in few ATLL cases, but the HBZ gene in all ATLL cases. In this study, HBZ-expression was demonstrated in all cases of ATLL cell line and ATLL model mouse, and human ATLL cases. However, Tax expression was rare. In addition,we analyzed the expression of FOXP3, a key molecule of regulatory T cells. The expression was detected in about one third of ATLL. And FOXP3 expression is associated with an immunosuppressive state.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (60 results)

All 2010 2009 2008

All Journal Article (59 results) (of which Peer Reviewed: 28 results) Book (1 results)

  • [Journal Article] Regression of rectal mucosa-associated lymphoid tissue (MALT) lymphoma after antibiotic treatments.2010

    • Author(s)
      Niino D, Yamamoto K, Tsuruta O, Maeda T, Yakushijin Y, Aoki R, Kimura Y, Hashikawa K, Kiyasu J, Takeuchi M, Sugita Y, Ohshima K
    • Journal Title

      Pathol Int. 60(6)

      Pages: 438-42

    • NAID

      10029332141

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL)2010

    • Author(s)
      Niino D, Komohara Y, Murayama T, Aoki R, Kimura Y, Hashikawa K, Kiyasu J, Takeuchi M, Suefuji N, Sugita Y, Takeya M, Ohshima K
    • Journal Title

      Pathol Int. 60(4)

      Pages: 278-83

    • NAID

      10029331443

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ueda RPhase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody2010

    • Author(s)
      Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K,Nakamura S, Inagaki H, Ohshima K, Kiyoi H, Ishida T, Matsushima K, Akinaga S, Ogura M, Tomonaga M
    • Journal Title

      in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma J Clin Oncol. 20;28(9)

      Pages: 1591-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Linkage of expression of chemokine receptors (CXCR3 and CCR4) and cytotoxic molecules in Peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell Lymphoma.2010

    • Author(s)
      Asano N, Suzuki R, Ohshima K, Kagami Y, Ishida F, Yoshino T, Ogawa H,Morishima Y, Nakamura S
    • Journal Title

      Int J Hematol. 91(3)

      Pages: 26-35

    • NAID

      10026401157

    • Related Report
      2010 Final Research Report
  • [Journal Article] Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma.2010

    • Author(s)
      Sato H, Oka T, Shinnou Y, Kondo T, Washio K, Takano M, Takata K, Morito T, Huang X, Tamura M, Kitamura Y, Ohara N, Ouchida M, Ohshima K, Shimizu K, Tanimoto M, Takahashi K, Matsuoka M, Utsunomiya A, Yoshino T
    • Journal Title

      Am J Pathol. 176(1)

      Pages: 402-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Linkage of expression of chemokine receptors (OXCR3 and CCR4) and cytotoxic molecules in Peripheral T cell lymphoma, not otherwise specified and ALK-negative anaplastic large cell Lymphoma.2010

    • Author(s)
      Asano N, Ohshima K, et al.
    • Journal Title

      Int J Hematol.

      Volume: 91 Pages: 426-435

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I study of KW-0761 a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma2010

    • Author(s)
      Yamamoto K, Ohshima K, et al.
    • Journal Title

      J Clin Oncol.

      Volume: 28 Pages: 1591-1598

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma (AITL).2010

    • Author(s)
      Niino D, Ohshima K, et al.
    • Journal Title

      Pathol Int.

      Volume: 60 Pages: 278-283

    • NAID

      10029331443

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regression of rectal mucosa-associated lymphoid tissue (MALI) lymphoma after antibiotic treatments.2010

    • Author(s)
      Niino D, Ohshima K, et al.
    • Journal Title

      Pathol Int

      Volume: 60 Pages: 438-442

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma2010

    • Author(s)
      Sato H, Ohshima K, et al.
    • Journal Title

      Am J Pathol. 176

      Pages: 402-15

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of S-phase kinase-associated protein 2 and p27kip1 in patients with diffuse large B-cell lymphoma : effects of rituximab.2009

    • Author(s)
      Seki R, Ohshima K, Fujisaki T, Uike N, Kawano F, Gondo H, Makino S, Eto T, Moriuchi Y, Taguchi F, Kamimura T, Tsuda H, Shimoda K, Okamura T
    • Journal Title

      Ann Oncol. 4(Epub ahead of print)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis.2009

    • Author(s)
      Nomura Y, Takeuchi M, Yoshida S, Sugita Y, Niino D, Kimura Y, Shimizu K, Aoki R, Suefuji N, Hirose S, Kikuchi M, Ohshima K.
    • Journal Title

      Pathol Int. 59(9)

      Pages: 631-5

    • NAID

      10027381460

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era.2009

    • Author(s)
      Seki R, Ohshima K, Fujisaki T, Uike N, Kawano F, Gondo H, Makino S, Eto T, Moriuchi Y, Taguchi F, Kamimura T, Tsuda H, Ogawa R, Shimoda K, Yamashita K, Suzuki K, Suzushima H, Tsukazaki K, Higuchi M, Utsunomiya A, Iwahashi M, Imamura Y, Tamura K, Suzumiya J, Yoshida M, Abe Y, Matsumoto T, Okamura T
    • Journal Title

      Cancer Sci. 100(10)

      Pages: 1842-7

    • NAID

      10027195531

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phase I/II Study of Concurrent Chemoradiotherapy for Localized Nasal Natural Killer/T-Cell Lymphoma : Japan Clinical Oncology Group Study JCOG0211.2009

    • Author(s)
      Yamaguchi M, Tobinai K, Oguchi M, Ishizuka N, Kobayashi Y, Isobe Y, Ishizawa K, Maseki N, Itoh K, Usui N, Wasada I, Kinoshita T, Ohshima K, Matsuno Y, Terauchi T, Nawano S, Ishikura S, Kagami Y, Hotta T, Oshimi K
    • Journal Title

      J Clin Oncol. 5(Epub ahead of print)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hepatocellular apoptosis associated with cytotoxic T/natural killer-cell infiltration in chronic active EBV infection.2009

    • Author(s)
      Nomura Y, Kimura H, Karube K, Yoshida S, Sugita Y, Niino D, Shimizu K, Kimura Y, Aoki R, Kiyasu J, Takeuchi M, Hashikawa K, Hirose S, Ohshima K
    • Journal Title

      Pathol Int. 59(7)

      Pages: 438-42

    • NAID

      10027380607

    • Related Report
      2010 Final Research Report
  • [Journal Article] Clinical significance of co-expression of CD21 and LFA-1 in B-cell lymphoma.2009

    • Author(s)
      Tanimoto K, Yakushijin Y, Fujiwara H, Otsuka M, Ohshima K, Sugita A, Sakai A, Hato T, Hasegawa H, Yasukawa M
    • Journal Title

      Int J Hematol. 89(4)

      Pages: 497-507

    • NAID

      10025161350

    • Related Report
      2010 Final Research Report
  • [Journal Article] Oncogene associated cDNA microarray analysis shows PRAME gene expression is a marker for response to anthracycline containing chemotherapy in patients with diffuse large B-cell lymphoma.2009

    • Author(s)
      Kawano R, Karube K, Kikuchi M, Takeshita M, Tamura K, Uike N, Eto T, Ohshima K, Suzumiya J
    • Journal Title

      J Clin Exp Hematop. 49(1)

      Pages: 1-7

    • NAID

      10025683555

    • Related Report
      2010 Final Research Report
  • [Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.2009

    • Author(s)
      Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
    • Journal Title

      Int J Cancer. 1;124(11)

      Pages: 2607-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression of CXCL12 on pseudopalisading cells and proliferating microvessels in glioblastomas : an accelerated growth factor in glioblastomas.2009

    • Author(s)
      Komatani H, Sugita Y, Arakawa F, Ohshima K, Shigemori M
    • Journal Title

      Int J Oncol. 34(3)

      Pages: 665-72

    • Related Report
      2010 Final Research Report
  • [Journal Article] Correlation of decreased survival and IL-18 in bone metastasis.2009

    • Author(s)
      Okamoto M, Azuma K, Hoshino T, Imaoka H, Ikeda J, Kinoshita T, Takamori S, Ohshima K, Edakuni N, Kato S, Iwanaga T, Aizawa H
    • Journal Title

      Intern Med. 48(10)

      Pages: 763-73

    • NAID

      130000121774

    • Related Report
      2010 Final Research Report
  • [Journal Article] for the International Peripheral T-cell Lymphoma Project. The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma : analysis of 126 patients from the International Peripheral T-cell Lymphoma Project.2009

    • Author(s)
      Suzumiya J, Ohshima K, Tamura K, Karube K, Uike N, Tobinai K, Gascoyne RD, Vose JM, Armitage JO, Weisenburger DD
    • Journal Title

      Ann Oncol. 20

      Pages: 715-721

    • Related Report
      2010 Final Research Report
  • [Journal Article] rray comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma.2009

    • Author(s)
      Nakagawa M, Nakagawa-Oshiro A, Karnan S, Tagawa H, Utsunomiya A, Nakamura S, Takeuchi I, Ohshima K, Seto M
    • Journal Title

      Clin Cancer Res. 1;15(1)

      Pages: 30-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma2009

    • Author(s)
      Nakagawa M, Ohshima K, et al.
    • Journal Title

      Clin Cancer Res 15

      Pages: 30-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The International Prognostic Index predicts outcome in aggressive adult T-cell leukemia/lymphoma : analysis of 126 patients from the International Peripheral T-cell Lymphoma Project2009

    • Author(s)
      Suzumiya J, Ohshima K, et al.
    • Journal Title

      Ann Oncol. 20

      Pages: 715-721

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of decreased survival and IL-18 in bone metastasis2009

    • Author(s)
      Okamoto M, Ohshima K, et al.
    • Journal Title

      Intern Med. 48

      Pages: 763-73

    • NAID

      130000121774

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of CXCL12 on pseudopalisading cells and proliferating micro vessels in glioblastomas : an accelerated growth factor in glioblastomas2009

    • Author(s)
      Komatani H, Ohshima K, et al.
    • Journal Title

      Int J Oncol. 34

      Pages: 665-72

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV 1-infected T cells through enhanced NF-kappaB activity2009

    • Author(s)
      Tomita M, Ohshima K, et al.
    • Journal Title

      Int J Cancer. 124

      Pages: 2607-15

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oncogene associated cDNA microarray analysis shows PRAME gene expression is a marker for response to anthracycine containing chemotherapy in patients with diffuse large B-cell lymphoma2009

    • Author(s)
      Kawano R, Ohshima K, et al.
    • Journal Title

      J Clin Exp Hematop. 49

      Pages: 1-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] linical significance of co-expression of CD21 and LFA-1 in B-cell lymphoma2009

    • Author(s)
      Tanimoto K, Ohshima K, et al.
    • Journal Title

      Int J Hematol. 89

      Pages: 497-507

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocellular apoptosis associated with cytotoxic T/natural killer-cell in filtration in chronic active EBV infection2009

    • Author(s)
      Nomura Y, Ohshima K, et al.
    • Journal Title

      Pathol Int. 59

      Pages: 438-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of immunohistochemical biomarkers in diffuse large B-cell lymphoma in the rituximab era2009

    • Author(s)
      Soki R, Ohshima K, et al.
    • Journal Title

      Cancer Sci. 100

      Pages: 1842-7

    • NAID

      10027195531

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotype for activated tissue macrophages in histiocytic necrotizing lymphadenitis2009

    • Author(s)
      Nomura Y, Ohshima K, et al.
    • Journal Title

      Pathol Int. 59

      Pages: 631-5

    • NAID

      10027381460

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes of 59 children with lymphoblastic lymphoma receiving an intensive AL-type therapy without prophlactic cranial irradiation.A report from Japanese children's cancer and leukemia study group NH 960 traial2009

    • Author(s)
      Tsurusawa M, Ohshima K, et al.
    • Journal Title

      日本小児血液学会誌 23

      Pages: 244-250

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      大島孝一、新野大介
    • Journal Title

      WHO分類第4版による白血病・悪性リンパ系腫瘍の病態学(押味和夫 木崎昌弘 田丸淳一編)(中外医学社)

      Pages: 250-268

    • Related Report
      2009 Annual Research Report
  • [Journal Article] IL-21 is expressed in Hodgkin lymphoma and activates STAT5 : evidence that activated STAT5 is required for Hodgkin lymphomagenesis.2008

    • Author(s)
      Scheeren FA, Diehl SA, Smit LA, Beaumont T, Naspetti M, Bende RJ, Blom B, Karube K, Ohshima K, van Noesel CJ, Spits H
    • Journal Title

      Blood. 1;111(9)

      Pages: 4706-15

    • Related Report
      2010 Final Research Report
  • [Journal Article] Histological characteristics of 21 Papua New Guinean children with high-grade B-cell lymphoma, which is frequently associated with EBV infection.2008

    • Author(s)
      Nomura Y, Lavu EK, Muta K, Niino D, Takeshita M, Hirose S, Nakamura S, Yoshino T, Kikuchi M, Ohshima K
    • Journal Title

      Pathol Int. 58(11)

      Pages: 695-700

    • NAID

      10027378284

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes.2008

    • Author(s)
      Kikuchi A, Nakamura N, Kuze T, Sasaki Y, Abe M, Ohno H, Akasaka T, Nakamura S, Ohshima K, Ando K
    • Journal Title

      Leuk Res. 32(8)

      Pages: 1176-82

    • Related Report
      2010 Final Research Report
  • [Journal Article] Downregulation of RCAS1 and upregulation of cytotoxic T cells affects synovial proliferation and apoptosis in rheumatoid arthritis.2008

    • Author(s)
      Yoshida S, Higuchi F, Ishibashi Y, Goto M, Sugita Y, Nomura Y, Karube K, Shimizu K, Aoki R, Komatani H, Hashikawa K, Kimura Y, Nakashima M, Nagata K, Ohshima K
    • Journal Title

      J Rheumatol. 35(9)

      Pages: 1716-22

    • Related Report
      2010 Final Research Report
  • [Journal Article] Estimation of the relationship between caspase-3 expression and clinical outcome of Burkitt's and Burkitt-like lymphoma.2008

    • Author(s)
      Nomura Y, Yoshida S, Karube K, Takeshita M, Hirose S, Nakamura S, Yoshino T, Kikuchi M, Ohshima K
    • Journal Title

      Cancer Sci. 99(8)

      Pages: 1564-9

    • NAID

      10024009675

    • Related Report
      2010 Final Research Report
  • [Journal Article] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation.2008

    • Author(s)
      Karube K, Ying G, Tagawa H, Niino D, Aoki R, Kimura Y, Hashikawa K, Suefuji N, Sugita Y, Nomura Y, Shimizu K, Yoshida S, Seto M, Ohshima K
    • Journal Title

      Mod Pathol. 21(8)

      Pages: 973-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients.2008

    • Author(s)
      Yamaguchi M, Nakamura N, Suzuki R, Kagami Y, Okamoto M, Ichinohasama R, Yoshino T, Suzumiya J, Murase T, Miura I, Ohshima K, Nishikori M, Tamaru J, Taniwaki M, Hirano M, Morishima Y, Ueda R, Shiku H, Nakamura S
    • Journal Title

      Haematologica. 93(8)

      Pages: 1195-202

    • Related Report
      2010 Final Research Report
  • [Journal Article] Lymphoma Committee of Japanese Childhood Cancer and Leukemia.Favourable outcomes in children with diffuse large B-cell lymphoma treated by a short-term ALL-like regimen : a report on the NHL960 study from the Japanese Childhood Cancer and Leukemia Study Group.2008

    • Author(s)
      Tsurusawa M, Taga T, Horikoshi Y, Ogawa A, Kikuta A, Kanegane H, Matsushita T, Hyakuna N, Shimomura Y, Ohshima K
    • Journal Title

      Leuk Lymphoma. 49(4)

      Pages: 734-9

    • Related Report
      2010 Final Research Report
  • [Journal Article] High-grade mature B-cell lymphoma with Burkitt-like morphology : results of a clinicopathological study of 72 Japanese patients.2008

    • Author(s)
      Nomura Y, Karube K, Suzuki R, Ying G, Takeshita M, Hirose S, Nakamura S, Yoshino T, Kikuchi M, Ohshima K
    • Journal Title

      Cancer Sci. 99(2)

      Pages: 246-52

    • NAID

      10024002025

    • Related Report
      2010 Final Research Report
  • [Journal Article] CAEBV Study Group. Review : Proposed categorization of pathological states of EBV-associated T/natural killer-cell lymphoproliferative disorder (LPD) in children and young adults : overlap with chronic active EBV infection and infantile fulminant EBV T-LPD.2008

    • Author(s)
      Ohshima K, Kimura H, Yoshino T, Kim CW, Ko YH, Lee SS, Peh SC, Chan JK
    • Journal Title

      Pathol Int. 58(4)

      Pages: 209-17

    • Related Report
      2010 Final Research Report
  • [Journal Article] Estimation of apoptosis and cell proliferation in histiocytic necrotizing lymphadenitis using immunohistochemical double staining.2008

    • Author(s)
      Nomura Y, Sugita Y, Yoshida S, Karube K, Shimizu K, Aoki R, Hirose S, Kikuchi M, Ohshima K
    • Journal Title

      Pathol Int. 58(2)

      Pages: 98-103

    • NAID

      10027375715

    • Related Report
      2010 Final Research Report
  • [Journal Article] The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma.2008

    • Author(s)
      Karube K, Aoki R, Sugita Y, Yoshida S, Nomura Y, Shimizu K, Kimura Y, Hashikawa K, Takeshita M, Suzumiya J, Utsunomiya A, Kikuchi M, Ohshima K
    • Journal Title

      Mod Pathol. 21(5)

      Pages: 617-25

    • Related Report
      2010 Final Research Report
  • [Journal Article] Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lymphomas : Analysis of 490 cases.2008

    • Author(s)
      Karube K, Aoki R, Nomura Y, Yamamoto K, Yoshida S, Shimizu K, Komatani H, Sugita Y, Ohshima K.
    • Journal Title

      Pathol Int. 58(2)

      Pages: 89-97

    • NAID

      10027375683

    • Related Report
      2010 Final Research Report
  • [Journal Article] Usefulness of flow cytometry for differential diagnosis of precursor and peripheral T-cell and NK-cell lyinphom as : Analysis of 490 cases.2008

    • Author(s)
      Karube K, Ohshima K., et al.
    • Journal Title

      Pathol Int. 58

      Pages: 89-97

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The relationship of FOXP3 expression and clinicopatholo gical characteristies in adult T-cell leukemia/lymphoma2008

    • Author(s)
      Karube K, Ohshima K., et al.
    • Journal Title

      Mod Pathol. 21

      Pages: 617-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of apoptosis and cell proliferation in histiocytic necrotizing lymphadenitis using immunohistochemical double staining.2008

    • Author(s)
      Nomura Y, Ohshima K., et al.
    • Journal Title

      Pathol Int. 58

      Pages: 98-103

    • NAID

      10027375715

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-grade mature B-cell lymphoma with Burkitt-like morphology : results of a clinicopathological study of 72 Japanese patients.2008

    • Author(s)
      Nomura Y, Ohshima K., et al.
    • Journal Title

      Cancer Sci. 99

      Pages: 246-52

    • NAID

      10024002025

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periostin and bone marrow fibrosis.2008

    • Author(s)
      Oku E, Ohshima K., et al.
    • Journal Title

      Int J Hematol. 88

      Pages: 57-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Favourable outcomes in children with diffuse large B-cell lymphoma treated by a short-term ALL-like regimen : a report on the NHL960 study from the Japanese Childhood Cancer and Leukemia Study Group.2008

    • Author(s)
      Tsurusawa M, Ohshima K., et al.
    • Journal Title

      Leuk Lymphoma. 49

      Pages: 734-739

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients.2008

    • Author(s)
      Yamaguchi M, Ohshima K., et al.
    • Journal Title

      Haematologica 93

      Pages: 1195-202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation.2008

    • Author(s)
      Karube K, Ohshima K, et al.
    • Journal Title

      Mod Pathol. 21

      Pages: 973-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of the relationship between caspase-3 expression and clinical outcome of Burkitt' s and Burkitt-like lymphoma.2008

    • Author(s)
      Nomura Y, Ohshima K, et al.
    • Journal Title

      Cancer Sci. 99

      Pages: 1564-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of RCASl and upregulati on of cytotoxic Tcells affects synovial proliferation and apoptosis in rheumatoid arthritis.2008

    • Author(s)
      Yoshida S Ohshima K, et al.
    • Journal Title

      J Rheumatol. 35

      Pages: 1716-22

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes.2008

    • Author(s)
      Kikuchi A Ohshima K, et al.
    • Journal Title

      Leuk Res. 32

      Pages: 1176-82

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological characteristics of 21 Papua New Guinean children with high-grade B-cell lymphoma, which is frequently associated with EBV infection.2008

    • Author(s)
      Nomura Y, Ohshima K., et al.
    • Journal Title

      Pathol Int. 58

      Pages: 695-700

    • NAID

      10027378284

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Book] Adult T-cell leukemia/lymphoma p281-4、Swerdlow SH, Campo E, Harris NL et al. . (eds)WHO classification of tumor, Tumours of haematopoietic and lymphoid tissues.2008

    • Author(s)
      K. Ohshima, ES Jaffe, M Kikuchi
    • Publisher
      WHO Lyon
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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