Regulation of acquired immunity via negative feedback mechanism between dendritic cells and NK-T cells
Project/Area Number |
20390106
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Hokkaido University |
Principal Investigator |
IWABUCHI Kazuya (2009-2010) Hokkaido University, 医学部, 教授 (20184898)
小野江 和則 (2008) Hokkaido University, 遺伝子病制御研究所, 教授 (40002117)
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Co-Investigator(Kenkyū-buntansha) |
ONO Kazunori 北海道大学, 遺伝子病制御研究所, 教授 (40002117)
YANAGAWA Yoshiki 北海道医療大学, 薬学部, 講師 (20322852)
岩渕 和也 北海道大学, 遺伝子病制御研究所, 准教授 (20184898)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
|
Keywords | 樹状細胞 / NK-T細胞 / ネガティブフィードバック / 免疫制御 / 病態モデル / 生活習慣病 / 動脈硬化症 / 自然免疫 / NKT細胞 / サイトカイン / TLR / オステオポンチン |
Research Abstract |
We demonstrated that balances of cytokines are negatively or positively regulated in dendritic cells with a unique combination such as IL-12/23 production by prostaglandin E2, IL-10 by TNF-α, and IL-33 by noradrenalin. We also found that NK-T cells (especially type II subset) play an accelerating role in visceral fat syndrome. In atherosclerotic model, CD1d-restricted NKT cell subset seemed to be negatively regulated by MR1-restricted NKT cell subset.
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Report
(4 results)
Research Products
(102 results)
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[Journal Article] CSF-1-dependent red pulp macro phages regulate CD4 T cell responses.2011
Author(s)
Kurotaki D, Kon S, Bae K, Ito K, Matsui Y, Nakayama Y, Kanayama M, Kimura C, Narita Y, Nishimura T, Iwabuchi K, Mack M, van Rooijen N, Sakaguchi S, Uede T, Morimoto J.
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Journal Title
J Immunol 186(4)
Pages: 2229-2237
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Peer Reviewed
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[Journal Article] Identification of INAM, a polyI:C-inducible membrane protein, that participates in dendritic cellmediated natural killer cell activation.2010
Author(s)
Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T.
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Journal Title
J Exp Med 207(12)
Pages: 2675-2687
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Peer Reviewed
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[Journal Article] Differential enhancement of T helper type 1 (Th1)/Th2 cytokine production by natural killer T cells through negative feedback regulation with pre-treated dendritic cells.2010
Author(s)
Iwabuchi K, Yanagawa Y, Minami K, Mizuuchi K, Maeda K, Ogura H, Satou S, Iwata D, Hirata H, Iwabuchi C, Onoe K.
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Journal Title
Curr Immunol Rev 6(2)
Pages: 78-87
Related Report
Peer Reviewed
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[Journal Article] Nuclear factor-κB (NF-κB) inhibitor, Dehydroxymethylepoxyquinomicin( DHMEQ) ameliorates experimental autoimmune uveoreitnitis (EAU) in mice.2010
Author(s)
Iwata D, Kitaichi N, Ebihara A, Iwabuchi K, Yoshida K, Namba K, Ozaki M, Ohno S, Umezawa K, Yamashita K-i, Todo S, Ishida S, Onoe K.
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Journal Title
Invest Ophthalmol Vis Sci 51(4)
Pages: 2077-2084
Related Report
Peer Reviewed
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[Journal Article] Dendritic cellderived TNF-α is responsible for development of IL-10-producing CD4^+ T cells.2010
Author(s)
Hirata N, Yanagawa Y, Satoh M, Ogura H, Ebihara T, Noguchi M, Matsumoto M, Togashi H, Seya T, Onoe K, Iwabuchi K.
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Journal Title
Cell Immunol 261(1)
Pages: 37-41
NAID
Related Report
Peer Reviewed
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[Journal Article] Natural killer T cells are involved in adipose tissue inflammation and glucose intolerance in diet-induced obese mice.2010
Author(s)
Ohmura K, Ishimori N, Ohmura Y, Tokuhara S, Nozawa A, Hori S, Andoh Y, Fujii S, Iwabuchi K, Onoe K, Tsutsui H.
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Journal Title
Arterioscler Thromb Vasc Biol 30
Pages: 193-199
NAID
Related Report
Peer Reviewed
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[Journal Article] Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA.2010
Author(s)
Iwata D, Kitamura M, Kitaichi N, Saito Y, Kon S, Morimoto J, Miyazaki A, Kitamei H, Namba K-i, Yoshida K, Ohno S, Uede T, Onoe K, Iwabuchi K.
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Journal Title
Exp Eye Res 90(1)
Pages: 41-48
NAID
Related Report
Peer Reviewed
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[Journal Article] Expansion of CD4^+CD28^- T cells producing high levels of interferon-γ in peripheral blood of patients with multiple sclerosis.2008
Author(s)
Miyazaki Y, Iwabuchi K, Iwata D, Miyazaki A, Kon Y, Niino M, Kikuchi S, Yanagawa Y, Van Kaer L, Sasaki H, Onoe K.
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Journal Title
Multiple Sclerosis 14
Pages: 1044-1055
Related Report
Peer Reviewed
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[Journal Article] Osteopontin regulates development and function of invariant natural killer T cells.2008
Author(s)
Diao H, Iwabuchi K, Li L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt D, Rittling S, Uede T.
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Journal Title
Proc Natl Acad Sci USA 105
Pages: 15884-15889
Related Report
Peer Reviewed
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[Presentation] Amelioration of experimental autoimmune uveoretinitis by blockade of osteopontin with antibody or small interfering RNA.2010
Author(s)
Iwabuchi K, Iwata D, Kitamura M, Kitaichi N, Kon S, Kitamei H, Namba K, Yoshida K, Ishida S, Ohno S, Rittling SR, Denhardt DT, Uede T, Onoe K.
Organizer
14^<th> International Congress of Immunology
Place of Presentation
Kobe
Year and Date
2010-08-27
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