| Project/Area Number |
20390106
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
IWABUCHI Kazuya (2009-2010) Hokkaido University, 医学部, 教授 (20184898)
小野江 和則 (2008) Hokkaido University, 遺伝子病制御研究所, 教授 (40002117)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Kazunori 北海道大学, 遺伝子病制御研究所, 教授 (40002117)
YANAGAWA Yoshiki 北海道医療大学, 薬学部, 講師 (20322852)
岩渕 和也 北海道大学, 遺伝子病制御研究所, 准教授 (20184898)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Keywords | 樹状細胞 / NK-T細胞 / ネガティブフィードバック / 免疫制御 / 病態モデル / 生活習慣病 / 動脈硬化症 / 自然免疫 / NKT細胞 / サイトカイン / TLR / オステオポンチン |
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| Research Abstract |
We demonstrated that balances of cytokines are negatively or positively regulated in dendritic cells with a unique combination such as IL-12/23 production by prostaglandin E2, IL-10 by TNF-α, and IL-33 by noradrenalin. We also found that NK-T cells (especially type II subset) play an accelerating role in visceral fat syndrome. In atherosclerotic model, CD1d-restricted NKT cell subset seemed to be negatively regulated by MR1-restricted NKT cell subset.
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