Visualization of molecular dynamics of epithelial-mesenchymal and mesenchymal-epithelial transition

• Project/Area Number: 20390107
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Hokkaido University
• Principal Investigator: OHBA Yusuke Hokkaido University, 大学院・医学研究科, 准教授 (30333503)
• Co-Investigator(Renkei-kenkyūsha): TSUDA Masumi 北海道大学, 大学院・医学研究科, 助教 (30431307)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2008: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
• Keywords: 血管新生 / EMT / MET / バイオイメージング / 腫瘍微小環境

Research Abstract

We have hereby identified transcription factor 8 (TCF8) as a regulator of epithelial-mesenchymal transition, a critical process in cancer invasion/metastasis and endothelial mobilization to tumor angiogenesis. The molecular mechanisms by which TCF8 governs EMT were also revealed in both cancer cells and endothelial cells. In addition, novel evidence that the difference in the tumor microenvironment yields distinct feature of cancer malignancy is also provided, which might lead to the development of new strategies to cancer development.

Research Products

• [Journal Article] The Ras-PI3K Signaling Pathway Is Involved in Clathrin-Independent Endocytosis and the Internalization of Influenza Viruses (2011)
  • Author(s): Y. Fujioka, M. Tsuda, T. Hattori, J. Sasaki, T. Sasaki, T. Miyazaki, Y. Ohba
  • Journal Title: PLoS One 6(1)
  • NAID: 120002834740
• [Journal Article] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species (2011)
  • Author(s): K. Atarashi, T. Tanoue, T. Shima, A. Imaoka, T. Kuwahara, Y. Momose, G. Cheng, S. Yamasaki, T. Saito, Y. Ohba, T. Taniguchi, K. Takeda, S. Hori, I.I. Ivanov, Y. Umesaki, K. Itoh, K. Honda
  • Journal Title: Science 331(6015) Pages: 337-341
• [Journal Article] ZAPS is a potent stimulator of RIG-I-mediated signaling for antiviral response (2011)
  • Author(s): S. Hayakawa, S. Shiratori, H. Yamato, T. Kameyama, C. Kitatsuji, F. Kashigi, S. Goto, S. Kameoka, D. Fujikura, T. Yamada, T. Mizutani, M. Kazumata, M. Sato, J. Tanaka, M. Asaka, Y. Ohba, T. Miyazaki, M. Imamura, A. Takaoka
  • Journal Title: Nat.Immunol. 12(1) Pages: 37-44
• [Journal Article] RANKL expression specifically observed in vivo promotes epithelial mesenchymal transition and tumor progression (2011)
  • Author(s): T.Yamada, et al.
  • Journal Title: Am.J.Pathol Volume: In press
  • Peer Reviewed
• [Journal Article] IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension (2011)
  • Author(s): K.Tsushima, et al.
  • Journal Title: FASEB J. Volume: In press
  • Peer Reviewed
• [Journal Article] The Ras-PI3K signaling pathway is involved in clathrin-independent endocytosis and the internalization of influenza viruses (2011)
  • Author(s): Y.Fujioka, et al.
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species (2011)
  • Author(s): K.Atarashi, et al.
  • Journal Title: Science Volume: 6331 Pages: 337-341
  • Peer Reviewed
• [Journal Article] ZAPS is a potent stimulator of RIG-I-mediated signaling for antiviral response (2011)
  • Author(s): S.Hayakawa, et al.
  • Journal Title: Nat.Immunol. Volume: 12 Pages: 37-44
  • Peer Reviewed
• [Journal Article] Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21 (2011)
  • Author(s): Y.Saito, et al.
  • Journal Title: J.Exp.Med. Volume: 6
  • Peer Reviewed
• [Journal Article] Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21. (2010)
  • Author(s): Y. Saito, N. Murata-Kamiya, Y. Ohba, M. Hatakeyama
  • Journal Title: J.Exp.Med. 207(10) Pages: 2157-2174
• [Journal Article] A novel FRET-based biosensor for the measurement of BCR?ABL activity and its response to drugs in living cells (2010)
  • Author(s): T. Mizutani, T. Kondo, S. Darmanin, M. Tsuda, S. Tanaka, M. Tobiume, M. Asaka, Y. Ohba
  • Journal Title: Clin.Cancer Res. 16(15) Pages: 3964-3975
  • NAID: 120003207587
• [Journal Article] A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells (2010)
  • Author(s): T.Mizutani, et al.
  • Journal Title: Clin.Cancer Res. Volume: 16 Pages: 3964-3975
  • Peer Reviewed
• [Journal Article] Increased motility and invasiveness of tumor cells that survived 10 Gy irradiation. (2009)
  • Author(s): K. Tsutsumi, M. Tsuda, N. Yazawa, H. Nakamura, S. Ishihara, H. Haga, M. Yasuda, R. Yamazaki, H. Shirato, H. Kawaguchi, T. Nishioka, Y. Ohba.
  • Journal Title: Cell Struct.Funct. 34(2) Pages: 89-96
  • NAID: 40017160767
• [Journal Article] The adaptor protein Crk induces Src-dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation. (2009)
  • Author(s): T. Watanabe, M. Tsuda, S. Tanaka, Y. Ohba, H. Kawaguchi, T. Majima, H. Sawa, A. Minami.
  • Journal Title: Mol.Cancer Res. 7(9) Pages: 1582-1592
• [Journal Article] Visualization of Ras-PI3K interaction in the endosome using BiFC. (2009)
  • Author(s): K. Tsutsumi, Y. Fujioka, M. Tsuda, H. Kawaguchi, Y. Ohba.
  • Journal Title: Cell.Signal. 21(11) Pages: 1672-1679
  • NAID: 120005367445
• [Journal Article] Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability. (2009)
  • Author(s): M. Umeda, N. Murata-Kamiya, Y. Saito, Y. Ohba, M. Takahashi, M. Hatakeyama
  • Journal Title: J.Biol.Chem. 284(33) Pages: 22166-22172
• [Journal Article] Parkin stabilizes PINK1 through direct interaction (2009)
  • Author(s): K. Shiba, T. Arai, S. Sato, SI. Kubo, Y. Ohba, Y. Mizuno, N. Hattori
  • Journal Title: Biochem.Biophys.Res.Commun. 383(3) Pages: 331-335
• [Journal Article] Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis (2009)
  • Author(s): T. Inuzuka, M. Tsuda, S. Tanaka, H. Kawaguchi, Y. Higashi, Y. Ohba
  • Journal Title: Cancer Res. 69(4) Pages: 1678-1684
  • NAID: 120005367446
• [Journal Article] Transcription factor 8 activates R-Ras to regulate angiogenesis. Biochem. (2009)
  • Author(s): T. Inuzuka, M. Tsuda, H. Kawaguchi, Y. Ohba
  • Journal Title: Biophys.Res.Commun. 379(2) Pages: 510-513
• [Journal Article] Parkin stabilizes PINK1 through direct interaction (2009)
  • Author(s): K.Shiba, T.Arai, S.Sato, SI, Kubo, Y.Ohba, Y.Mizuno, N.Hattori.
  • Journal Title: Biochem.Biophys.Res.Commun 383 Pages: 331-5
  • Peer Reviewed
• [Journal Article] Helicobacter pylori CagA causes mitotic impairment and induces chromosomal instability (2009)
  • Author(s): M.Umeda, N.Murata-Kamiya, Y.Satio, Y.Ohba. M.Takahashi, M.Hatakeyama
  • Journal Title: J.Biol.Chem 284 Pages: 22166-72
  • Peer Reviewed
• [Journal Article] Visualization of Ras-PI3K interaction in the endosome using BiFC (2009)
  • Author(s): K.Tsusumi, Y.Fujioka, M.Tsuda, H.Kawaguchi, Y.Ohba
  • Journal Title: Cell.Singnal. 21 Pages: 1672-9
  • NAID: 120005367445
  • Peer Reviewed
• [Journal Article] The adaptor protein Crk induces Src-dependent activation of p38 MARK in regulation of synovial sarcoma cell proliferation (2009)
  • Author(s): T.Watanabe, M.Tsuda, S.Tanaka, Y.Ohba, H.Kawagushi, T.Majima, H.Sawa, A.Minami
  • Journal Title: Mol.Cancer Res. 7 Pages: 1582-92
  • Peer Reviewed
• [Journal Article] Increased motility and invasiveness of tumor cells that survived 10Gy irradiation (2009)
  • Author(s): K.Tsusumi, M.Tsuda, N.Yazawa, H.Nakamura, S.Ishihara, H.Haga, M.Yasuda, R.Yamazaki, H.Shirato, H.Kawaguchi, T.Nishioka, Y.Ohba.
  • Journal Title: Cell Struct.Funct. 34 Pages: 89-96
  • NAID: 40017160767
  • Peer Reviewed
• [Journal Article] Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis (2009)
  • Author(s): T. Inuzuka, et.al.
  • Journal Title: Cancer Res. 69 Pages: 1678-1684
  • Peer Reviewed
• [Journal Article] Transcription factor 8 activates R-Ras to regulate angiogenesis (2009)
  • Author(s): T. Inucuka, et.al.
  • Journal Title: Biochem. Biophys. Res. Commun. 379 Pages: 510-513
  • Peer Reviewed
• [Journal Article] Clinicopathological significance of expression of p-c-Jun, TCF4 and β-Catenin in colorectal tumors (2008)
  • Author(s): K. Takeda, I. Kinoshita, Y. Shimizu, Y. Ohba, T. Itoh, Y. Matsuno, H. Dosaka-Akita
  • Journal Title: BMC-Cancer 8 Pages: 328-328
• [Journal Article] PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling (2008)
  • Author(s): T. Yamada, M. Tsuda, Y. Ohba, H. Kawaguchi, Y. Totsuka, M. Shindoh
  • Journal Title: Biochem.Biophys.Res.Commun. 368(3) Pages: 575-581
  • NAID: 120005367448
• [Journal Article] Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. (2008)
  • Author(s): T. Mizutani, K. Tsuji, Y. Ebihara, S. Taki, Y. Ohba, T. Taniguchi, K. Honda
  • Journal Title: Exp.Hematol. 36(3) Pages: 255-264
• [Journal Article] Clinicopathological significance of expression of p-c-Jun,TCF 4 and β-Catenin in colorectal tumors (2008)
  • Author(s): K. Takeda, et.al.
  • Journal Title: BMC-Cancer 368 Pages: 328-328
  • Peer Reviewed
• [Journal Article] 細胞内シグナル伝達の可視化とその創薬への応用 (2008)
  • Author(s): 大場雄介、津田真寿美
  • Journal Title: 実験医学 26
• [Journal Article] RANKL expression specifically observed in vivo promotes epithelial mesenchymal transition and tumor progression
  • Author(s): T. Yamada, M. Tsuda, T. Takahashi, Y. Totsuka, M. Shindoh, Y. Ohba
  • Journal Title: Am.J.Pathol. (in press)
  • NAID: 120005367443
• [Journal Article] IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension
  • Author(s): K. Tsushima, T. Osawa, H. Yanai, A. Nakajima, A. Takaoka, I. Manabe, Y. Ohba, Y. Imai, T. Taniguchi, R. Nagai
  • Journal Title: FASEB J. (in press)
• [Presentation] 細胞機能に光をあてる-蛍光バイオイメージング技術とその応用- (2011)
  • Author(s): 大場雄介
  • Organizer: 第8回がんとハイポキシア研究会
  • Place of Presentation: 北海道大学学術交流会館
  • Year and Date: 2011-01-29
• [Presentation] 細胞機能に光をあてる-蛍光バイオイメージング技術とその応用- (2011)
  • Author(s): 大場雄介
  • Organizer: 第8回がんとハイボシア研究会
  • Place of Presentation: 北海道大学学術交流会館 招待講演
  • Year and Date: 2011-01-29
• [Presentation] RANKL発現は腫瘍形成とEMTを亢進する (2010)
  • Author(s): 山田珠希
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] RANKL発現は腫瘍形成とEMTを亢進する (2010)
  • Author(s): 山田珠希, 他
  • Organizer: 69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] RANKLは微小環境特異的に発現し細胞接着・EMT・腫瘍形成を促進する生体内特異的機能マーカーである (2010)
  • Author(s): 大場雄介
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-21
• [Presentation] Ras-PI3Kシグナル経路がエンドサイトーシスとインフルエンザ感染を調節する (2010)
  • Author(s): 藤岡容一朗
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-21
• [Presentation] エンドソームにおけるアンジオテンシン2型受容体による1型受容体シグナリングの抑制機構 (2010)
  • Author(s): 津田真寿美
  • Organizer: 第62回日本細胞生物学会大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-05-19
• [Presentation] RANKL expression induced by the tumor microenvironment promotes epithelial mesenchymal transition and tumor progression in vivo (2010)
  • Author(s): 山田珠希
  • Organizer: The 8th AACR-JCA Joint Conference
  • Place of Presentation: Waikoloa, HI, USA
  • Year and Date: 2010-02-08
• [Presentation] RANKL expression induced by the tumor microenvironment promotes epithelial mesenchymal transition and tumor progression in vivo (2010)
  • Author(s): Y.T, M.Tsuda, H.Kawaguchi, Y.Totsuka, M.Shindoh, Y.Ohba
  • Organizer: The 8^<th> AACR-JCA Joint Conference
  • Place of Presentation: Hilton Waikoloa Village(USA)
  • Year and Date: 2010-02-08
• [Presentation] A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to molecular target drugs in living chronic myeloid leukemia cells (2010)
  • Author(s): 水谷龍明
  • Organizer: The 8th AACR-JCA Joint Conference
  • Place of Presentation: Waikoloa, HI, USA
  • Year and Date: 2010-02-06
• [Presentation] A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to molecular target drugs in living chronic myeloid leukemia cells (2010)
  • Author(s): T.Mizutani, T.Kondo, S.Darmanine, M.Tsuda, S.Tanaka, M.Asaka, Y.Ohba
  • Organizer: The 8^<th> AACR-JCA Joint Conference
  • Place of Presentation: Hilton Waikoloa Village(USA)
  • Year and Date: 2010-02-06
• [Presentation] Ras-PI3K signaling regulates influenza virus infection (2009)
  • Author(s): 藤岡容一朗
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-11
• [Presentation] Effect of Src family kinase inhibitor on proliferation and invasion in human synovial sarcoma in vivo. (2009)
  • Author(s): R.Arai, M.Tsuda, T.Watanabe, H.Kawaguchi, A.Minami, Y.Ohba
  • Organizer: 第32回日本分子生物会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-12-11
• [Presentation] Ras-PI3K signaling regulates influenza virus infection. (2009)
  • Author(s): Y.Fujioka, M.Tsuda, T.Hattori, J.Sasaki, H.Kawaguchi, T.Sasaki, T.Miyazaki, Y.Ohba
  • Organizer: 第32回日本分子生物会年会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-12-11
• [Presentation] Effect of Src family kinase inhibitor on proliferation and invasion in human synovial sarcoma in vivo (2009)
  • Author(s): 新井隆太
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] A FRET-based biosensor for the evaluation of the efficacy of molecular targeted drugs for chronic myeloid leukemia (2009)
  • Author(s): 水谷龍明
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] Requirement for tumor microenvironment-induced RANKL expression in the tumorigenesis in vivo (2009)
  • Author(s): 山田珠希
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] Requirement for tumor microenvironment-induced RANKL expression in the tumorigensis in vivo. (2009)
  • Author(s): T.Yamada, M.Tsuda, Y.Totsuka, M.Shindoh, Y.Ohba
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-10-03
• [Presentation] A FRET-based biosensor for the evaluation of the efficacy of molecular targeted drugs for chronic myeloid leukemia. (2009)
  • Author(s): T.Mizutani, T.Kondo, S.Darmanin, M.Tsuda, S.Tanaka, M.Asaka, Y.Ohba
  • Organizer: 第68回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-10-03
• [Presentation] エンドゾームにおけるRas依存性PI3K活性化機構の時空間的解析 (2009)
  • Author(s): 藤岡容一朗
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-06-04
• [Presentation] エンドゾームにおけるRas依存性PI3K活性化機構の時空的解析 (2009)
  • Author(s): 藤岡容一郎、堤香織、津田真寿美、川口秀明、大場雄介
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-06-04
• [Presentation] Crkが制御するSrcを介したGab1 Y307のリン酸化は、細胞接着斑の形成と運動能の亢進に重要である (2009)
  • Author(s): 津田真寿美
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-06-02
• [Presentation] Crkが制御するSrcを介したGab1 Y307のリン酸化は、細胞接着斑の形成と運動能の亢進に重要である (2009)
  • Author(s): 津田真寿美、渡部琢哉、牧野吉倫、川口秀明、田中伸哉、大場雄介
  • Organizer: 第61回日本細胞生物学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2009-06-02
• [Presentation] TCF8は血管新生の負の制御因子である (2009)
  • Author(s): 犬塚貴之
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] Receptor activator of NF-KB ligand (RANKL)発現口腔癌細胞株の悪性形質に関する機能解析 (2009)
  • Author(s): 山田珠希
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-03
• [Presentation] Receptor activator of NF-KB ligand(RANKL)発現口腔癌細胞株の悪性形質に関する機能解析 (2009)
  • Author(s): 山田珠希、津田真寿美、川口秀明、戸塚靖則、進藤正信、大場雄介
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2009-05-03
• [Presentation] TCF8は血管新生の負の制御因子である (2009)
  • Author(s): 犬塚貴之、津田真寿美、田中伸哉、川口秀明、東雄二郎、大場雄介
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2009-05-03
• [Presentation] 慢性骨髄性白血病に対する分子標的治療薬の新たな薬効評価系の構築 (2009)
  • Author(s): 水谷龍明
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-05-01
• [Presentation] 慢性骨髄性白血病に対する分子標的治療薬の新たな薬効評価系の構築 (2009)
  • Author(s): 水谷龍明、近藤健、S.Darmanin、津田真寿美、甲斐原拓真、川口秀明、浅香正博、大場雄介
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2009-05-01
• [Presentation] 慢性骨髄性白血病に対する分子標的治療薬の新たな薬効評価系の構築 (2008)
  • Author(s): 水谷龍明
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-12-12
• [Presentation] 口腔癌細胞の接着に関連する分子の機能解析 (2008)
  • Author(s): 山田珠希
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-12-10
• [Presentation] TCF8は血管新生の負の制御因子である (2008)
  • Author(s): 犬塚貴之
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-12-10
• [Presentation] エンドゾームにおけるRas依存性PI3K活性化機構のイメージング手法を用いた解析 (2008)
  • Author(s): 藤岡容一朗
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2008-12-09
• [Presentation] Negative regulation of angiogenesis by zinc-finger transcription factor TCF8 (2008)
  • Author(s): 大場雄介
  • Organizer: The 25th Annual Meeting of ISHR Japanese Section
  • Place of Presentation: 横浜開港記念会館
  • Year and Date: 2008-12-06
• [Presentation] バイオイメージングの基礎と診断への応用 (2008)
  • Author(s): 大場雄介
  • Organizer: 日本病理学会
  • Place of Presentation: 松山市総合コミュニティセンター
  • Year and Date: 2008-11-19
• [Presentation] バイオイメージングの基礎と診断への応用 (2008)
  • Author(s): 大場雄介
  • Organizer: 日本病理学会
  • Place of Presentation: 松山市総合コミュニティ・センター
  • Year and Date: 2008-11-19
• [Presentation] SYT-SSX1トランスジェニックマウスはp53ヘテロ環境下で滑膜肉腫様腫瘍を発生する (2008)
  • Author(s): 津田真寿美
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-30
• [Presentation] 血管新生抑制性転写因子の機能解析 (2008)
  • Author(s): 犬塚貴之
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] 上皮細胞増殖因子(EGF)依存的なPTHrPの発現制御と口腔癌細胞の増殖能・局所浸潤能との関連性 (2008)
  • Author(s): 山田珠希
  • Organizer: 日本インターフェロンンサイトカイン学会
  • Place of Presentation: 北海道大学学術交流会館
  • Year and Date: 2008-07-11
• [Presentation] 血管新生を制御する新規遺伝子の同定とその機能解析 (2008)
  • Author(s): 犬塚貴之
  • Organizer: 日本インターフェロンンサイトカイン学会
  • Place of Presentation: 北海道大学学術交流会館
  • Year and Date: 2008-07-11
• [Presentation] 上皮細胞増殖因子(EGF)依存的なPTHrPの発現制御と口腔癌細胞の増殖能・局所浸潤能との・関連性 (2008)
  • Author(s): 山田珠希, 他
  • Organizer: 日本インターフェロンンサイトカイシ学会
  • Place of Presentation: 北海導大学学術交流会館
  • Year and Date: 2008-07-11
• [Book] 蛍光タンパク質を用いた白血病分子標的治療薬の効果判定技術.バイオインダストリー28(2) (2011)
  • Author(s): 大場雄介
• [Book] バイオイメージングの基礎と応用.細胞41(11) (2009)
  • Author(s): 津田真寿美,大場雄介
• [Book] 細胞内シグナル伝達の可視化とその創薬への応用.実験医学(増刊号)26 (2008)
  • Author(s): 大場雄介,津田真寿美
• [Remarks] ホームページ等
  • URL: http://www.cellsignal-imaging.com/
• [Remarks]
  • URL: http://www.cellsignal-imaging.com/
• [Remarks]
  • URL: http://www.med.hokudai.ac.jp/~clilab-w/
• [Remarks]
  • URL: http://www.med.hokudai.ac.jp/~clilab-w/
• [Patent(Industrial Property Rights)] ウイルス感染抑制および/または感染症治療剤、ならびにウイルスの感染を抑制および/または感染症を治療する方法 (2011)
  • Inventor(s): 大場雄介、宮崎忠昭
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2011-04-07
• [Patent(Industrial Property Rights)] ウイルスの感染を抑制する物質のスクリーニング方法およびウイルス感染抑制剤 (2010)
  • Inventor(s): 大場雄介、宮崎忠昭
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2010-10-14
• [Patent(Industrial Property Rights)] ウイルスの感染を抑制する物質のスクリーニング方法およびウイルス感染抑制剤 (2010)
  • Inventor(s): 大場雄介、宮崎忠昭
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2010-05-07
• [Patent(Industrial Property Rights)] ウイルス感染抑制および/または感染症治療剤 (2010)
  • Inventor(s): 大場雄介、宮崎忠昭
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2010-04-09
• [Patent(Industrial Property Rights)] ウイルス感染抑制および/または感染症治療剤 (2010)
  • Inventor(s): 大場雄介, 他
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2010-04-09
• [Patent(Industrial Property Rights)] ウイルスの感染を抑制する物質のスクリーニング方法およびウイルス感染抑制剤 (2010)
  • Inventor(s): 大場雄介, 他
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2010-10-14
  • Overseas
• [Patent(Industrial Property Rights)] ウイルスの感染を抑制する物質のスクリーニング方法およびウイルス感染抑制剤 (2009)
  • Inventor(s): 大場雄介、宮崎忠昭
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2009-10-14
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2009)
  • Inventor(s): 大場雄介
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2009-07-09
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2009)
  • Inventor(s): 大場雄介
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2009-07-09
  • Overseas
• [Patent(Industrial Property Rights)] ウイルスの感染を抑制する物質のスクリーニング方法およびウイルス感染抑制剤 (2009)
  • Inventor(s): 大場雄介, 宮崎忠昭
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2009-10-14
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2008)
  • Inventor(s): 大場雄介
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2008-07-09
• [Patent(Industrial Property Rights)] BCR-ABLチロシンキナーゼ活性測定試薬 (2008)
  • Inventor(s): 大場雄介、近藤健
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2008-05-23
• [Patent(Industrial Property Rights)] BCR-ABLチロシンキナーゼ活性測定用試薬 (2008)
  • Inventor(s): 大場雄介、近藤健
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2008-05-23
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2008)
  • Inventor(s): 大場雄介
  • Industrial Property Rights Holder: 北海道大学
  • Filing Date: 2008-07-09