| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Research Abstract |
We have hereby identified transcription factor 8 (TCF8) as a regulator of epithelial-mesenchymal transition, a critical process in cancer invasion/metastasis and endothelial mobilization to tumor angiogenesis. The molecular mechanisms by which TCF8 governs EMT were also revealed in both cancer cells and endothelial cells. In addition, novel evidence that the difference in the tumor microenvironment yields distinct feature of cancer malignancy is also provided, which might lead to the development of new strategies to cancer development.
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