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Role of PDGF signal in normal and injured brain.

Research Project

Project/Area Number 20390108
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionUniversity of Toyama

Principal Investigator

SASAHARA Masakiyo  富山大学, 大学院・医学薬学研究部(医学), 教授 (20154015)

Co-Investigator(Kenkyū-buntansha) MORI Hisashi  富山大学, 大学院・医学薬学研究部(医学), 教授 (00239617)
ISHII Yoko  富山大学, 大学院・医学薬学研究部(医学), 准教授 (00361949)
HAMASHIMA Takeru  富山大学, 大学院・医学薬学研究部(医学), 助教 (80467092)
Co-Investigator(Renkei-kenkyūsha) FUKUNAGA Kohji  東北大学, 大学院・薬学研究科, 教授 (90136721)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords血小板由来増殖因子 / 神経 / 虚血 / 行動 / 血管 / グリア細胞 / 神経幹細胞 / ノックアウトマウス / 高次脳機能 / PDGF / 受容体 / 修復 / 疾患モデル動物
Research Abstract

We analyzed the conditional knockout model of platelet-derived growth factor receptorβ(PDGFR-β). PDGFR-βpromoted the development of hippocampal pyramidal neurons and GABA neurons, and were involved in the development of cognitive ability and social behavior. PDGFR-βimproved the ischemic brain lesions, and was involved in neuroprotection, maturation of newly-formed blood vessels, the activation of neural stem cells and glial cell reaction. We established double knockout mouse model of PDGFR-αand-βgene for further PDGF research.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (139 results)

All 2012 2011 2010 2009 2008 Other

All Journal Article (73 results) (of which Peer Reviewed: 72 results) Presentation (64 results) Remarks (2 results)

  • [Journal Article] PDGFR-βas a positive regulator of tissue repair in a mouse model of focal cerebral ischemia2012

    • Author(s)
      Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, Matsushima T, Yamamoto S, Hattori Y, Takatsuru Y, Nabekura J, Sasahara M.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 32 Pages: 353-367

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant hippocampal spine morphology and impaired memory formation in neuronal platelet-derived growth factor beta-receptor lacking mice2012

    • Author(s)
      Shioda N, Moriguchi S, Oya T, Ishii Y, Shen J, Matsushima T, Nishijo H, Sasahara M, Fukunaga K.
    • Journal Title

      Hippocampus

      Volume: 22 Pages: 1371-1378

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-derived growth factor and renal disease2012

    • Author(s)
      Nakagawa T, Inoue H, Sasahara M.
    • Journal Title

      Curr Opin Nephrol Hypertens

      Volume: 21 Pages: 80-85

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet2012

    • Author(s)
      Yonezawa R, Wada T, Matsumoto N, Morita M, Sawakawa K, Ishii Y, Sasahara M, Tsuneki H, Saito S, Sasaoka T.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 303 Issue: 4 Pages: 445-456

    • DOI

      10.1152/ajpendo.00638.2011

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] SRT1720, A SIRT1 Activator, Aggravates Bleomycin-Induced Lung Injury in Mice2012

    • Author(s)
      Imanishi S, Hayashi R, Ichikawa T, Suzuki K, Sasahara M, Kondo T, Ogawa H, Tobe K.
    • Journal Title

      Food and Nutrition Sciences

      Volume: 3 Pages: 157-163

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Measuring CREB activation using bioluminescence probes that detect KID-KIX interaction in living cells2012

    • Author(s)
      Ishimoto T, Mano H, Ozawa T, Mori H.
    • Journal Title

      Bioconjug Chem

      Volume: 23 Pages: 923-932

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Serine Racemase in Behavioral Sensitization in Mice after Repeated Administration of Methamphetamine2012

    • Author(s)
      Horio M, Kohno M, Fujita Y, Ishima T, Inoue R, Mori H, Hashimoto K.
    • Journal Title

      PLoS ONE

      Volume: 7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of a truncated form of the endoplasmic reticulum chaperone protein, sigma-1 receptor, promotes mitochondrial energy depletion and apoptosis.2012

    • Author(s)
      Norifumi Shioda
    • Journal Title

      J Biol Chem.

      Volume: 287(28) Issue: 28 Pages: 23318-23331

    • DOI

      10.1074/jbc.m112.349142

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel dopamine D2 receptor signaling through proteins interacting with the third cytoplasmic loop2012

    • Author(s)
      Fukunaga K, Shioda N.
    • Journal Title

      Mol Neurobiol

      Volume: 45 Pages: 144-152

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice2012

    • Author(s)
      Moriguchi S, Yabuki Y, Fukunaga K.
    • Journal Title

      J Neurochem

      Volume: 120 Pages: 541-551

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting nitrosative stress for neurovascular protection : new implications in brain diseases2012

    • Author(s)
      Tao RR, Ji YL, Lu YM, Fukunaga K, Han F.
    • Journal Title

      Curr Drug Targets

      Volume: 13 Pages: 272-284

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PDGFR-βas a positive regulator of tissue repair in a mouse model of focal cerebral ischemia2012

    • Author(s)
      Shen J.
    • Journal Title

      J Cereb.Blood Flow Metab.

      Volume: 32 Issue: 2 Pages: 353-367

    • DOI

      10.1038/jcbfm.2011.136

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-derived growth factor and renal disease2012

    • Author(s)
      Nakagawa T.
    • Journal Title

      Curr.Opin.Nephrol.Hypertens.

      Volume: 21 Issue: 1 Pages: 80-85

    • DOI

      10.1097/mnh.0b013e32834db4d3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells2011

    • Author(s)
      Xue Y, Lim S, Yang Y, Wang Z, Jensen LD, Hedlund EM, Andersson P, Sasahara M, Larsson O, Galter D, Cao R, Hosaka K, Cao Y.
    • Journal Title

      Nat Med

      Volume: 18 Pages: 100-110

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of platelet-derived growth factor receptor-βimproves diabetic nephropathy in Ca2+/calmodulin-dependent protein kinase IIα(Thr286Asp) transgenic mice2011

    • Author(s)
      Suzuki H, Usui I, Kato I, Oya T, Kanatani Y, Yamazaki Y, Fujisaka S, Senda S, Ishii Y, Urakaze M, Mahmood A, Takasawa S, Okamoto H, Kobayashi M, Tobe K, Sasahara M.
    • Journal Title

      Diabetologia

      Volume: 54 Pages: 2953-262

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice2011

    • Author(s)
      Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I.
    • Journal Title

      Hippocampus

      Volume: 21 Pages: 678-687

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive and Socio-Emotional Deficits in Platelet-Derived Growth Factor Receptor-βGene Knockout Mice2011

    • Author(s)
      Nguyen PT, Nakamura T, Hori E, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus2011

    • Author(s)
      Nakagawa T, Izumino K, Ishii Y, Oya T, Hamashima T, Jie S, Ishizawa S, Tomoda F, Fujimori T, Nabeshima Y, Inoue H, Sasahara M.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26 Pages: 458-468

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Levels of D-serine in the brain and peripheral organs of serine racemase(Srr) knock-out mice2011

    • Author(s)
      Horio M, Kohno M, Fujita Y, Ishima T, Inoue R, Mori H, Hashimoto K.
    • Journal Title

      Neurochem. Int

      Volume: 59 Pages: 853-859

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of autoantibody against extracellular epitopes of N-methyl-D-aspartate receptor by cell-based assay2011

    • Author(s)
      Takano S, Takahashi Y, Kishi H, Taguchi Y, Takashima S, Tanaka K, Muraguchi A, Mori H.
    • Journal Title

      Neurosci Res

      Volume: 71 Pages: 294-302

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation2011

    • Author(s)
      Oyagi A, Moriguchi S, Nitta A, Murata K, Oida Y, Tsuruma K, Shimazawa M, Fukunaga K, Hara H.
    • Journal Title

      Brain Res

      Volume: 1419 Pages: 97-104

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CaMKIIδB mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart2011

    • Author(s)
      Lu YM, Huang J, Shioda N, Fukunaga K, Shirasaki Y, Li XM, Han F.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice2011

    • Author(s)
      Moriguchi S, Yamamoto Y, Ikuno T, Fukunaga K.
    • Journal Title

      J Neurochem

      Volume: 117 Pages: 879-891

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant calcium/calmodulin-dependent protein kinase II(CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain2011

    • Author(s)
      Shioda N, Beppu H, Fukuda T, Li E, Kitajima I, Fukunaga K.
    • Journal Title

      J Neurosci Res

      Volume: 31 Pages: 346-358

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Melatonin ameliorates ischemic-like injury-evoked nitrosative stress : Involvement of HtrA2/PED pathways in endothelial cells2011

    • Author(s)
      Han F, Tao RR, Zhang GS, Lu YM, Liu LL, Chen YX, Lou YJ, Fukunaga K, Hong ZH.
    • Journal Title

      J Pineal Res

      Volume: 50 Pages: 281-291

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sigma-1 receptor stimulation with fluvoxamine activates Akt-eNOS signaling in the thoracic aorta of ovariectomized rats with abdominal aortic banding2011

    • Author(s)
      Bhuiyan MS, Tagashira H, Fukunaga K.
    • Journal Title

      Eur J. Pharmacol

      Volume: 650 Pages: 621-628

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells.2011

    • Author(s)
      Xue Y.
    • Journal Title

      Nat.Med.

      Volume: 18 Issue: 1 Pages: 100-110

    • DOI

      10.1038/nm.2575

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca^<2+>/calmodulin-dependent protein kinase IIα (Thr286Asp) transgenic mice2011

    • Author(s)
      Suzuki H.
    • Journal Title

      Diabetologia

      Volume: 54 Issue: 11 Pages: 2953-2962

    • DOI

      10.1007/s00125-011-2270-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.Nephrol2011

    • Author(s)
      Nakagawa T.
    • Journal Title

      Dial.Transplant.

      Volume: 26 Issue: 2 Pages: 458-468

    • DOI

      10.1093/ndt/gfq468

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.Nephrol.2011

    • Author(s)
      Nogami T.
    • Journal Title

      Hippocampus

      Volume: 21 Issue: 6 Pages: 678-687

    • DOI

      10.1002/hipo.20782

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.Nephrol.2011

    • Author(s)
      Hasegawa T.
    • Journal Title

      J.Obstet.Gynaecol.Res.

      Volume: 37 Issue: 6 Pages: 650-655

    • DOI

      10.1111/j.1447-0756.2010.01412.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.Nephrol.2011

    • Author(s)
      Nguyen PT.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 3 Pages: 244-253

    • DOI

      10.1371/journal.pone.0018004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive and Socio-Emotional Deficits in Platelet-Derived Growth Factor Receptor-β Gene Knockout Mice.2011

    • Author(s)
      Nguyen PT, Nakamura T, HoriE, Urakawa S, Uwano T, Zhao J, Li R, Bac ND, Hamashima T, Ishii Y, Matsushima T, Ono T, Sasahara M, Nishijo H.
    • Journal Title

      PLoS One. 6(3)

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.2011

    • Author(s)
      Nakagawa T, Izumino K, Ishii Y, Oya T, Hamashima T, Jie S, Ishizawa S, Tomoda F, Fujimori T, Nabeshima Y, Inoue H, Sasahara M.
    • Journal Title

      Nephrol Dial Transplant. 26(2)

      Pages: 458-68

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cognitive and Socio-Emotional Deficits in Platelet-Derived Growth Factor Receptor-β Gene Knockout Mice.2011

    • Author(s)
      Nguyen PT.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of PDGF receptor-beta in the structure and function of postnatal kidney glomerulus.2011

    • Author(s)
      Nakagawa T.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26 Pages: 458-468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATBF1 inhibits estrogen receptor(ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells2010

    • Author(s)
      Dong XY, Sun X, Guo P, Li Q, Sasahara M, Ishii Y, Dong JT.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 32801-32809

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of platelet-derived growth factor-BB and its receptor-beta in hypoxia-induced depression of excitatory synaptic transmission in the nucleus tractus solitarius of mice2010

    • Author(s)
      Ohi Y, Ishii Y, Sasahara M, Haji A.
    • Journal Title

      J Pharmacol Sci

      Volume: 112 Pages: 477-481

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved2010

    • Author(s)
      Zheng L, Ishii Y, Tokunaga A, Hamashima T, Shen J, Zhao QL, Ishizawa S, Fujimori T, Nabeshima Y, Mori H, Kondo T, Sasahara M.
    • Journal Title

      J Neurosci Res

      Volume: 88 Pages: 1273-1284

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serine racemase knockout mice2010

    • Author(s)
      Mori H, Inoue R.
    • Journal Title

      Chem Biodivers

      Volume: 7 Pages: 1573-1578

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of Tpl2 protein kinase suppresses RANKL-induced osteoclastogenesis through down-regulation of the c-Fos and NFATc1 genes2010

    • Author(s)
      Hirata K, Taki H, Shinoda K, Hounoki H, Miyahara T, Tobe K, Ogawa H, Mori H, Sugiyama E.
    • Journal Title

      Biol Pharm Bull

      Volume: 33 Pages: 133-137

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiling of Ca(2+)/calmodulin-dependent signaling molecules in the rat dorsal and ventral hippocampus after acute lead exposure2010

    • Author(s)
      Zhang GS, Ye WF, Tao RR, Lu YM, Shen GF, Fukunaga K, Huang JY, Ji YL, Han F.
    • Journal Title

      Exp Toxicol Pathol

      Volume: 64 Issue: 6 Pages: 619-624

    • DOI

      10.1016/j.etp.2010.12.004

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of platelet-derived growth factor-BB and its receptor-beta in hypoxia-induced depression of excitatory synaptic transmission in the nucleus tractus solitarius of mice.2010

    • Author(s)
      Ohi Y, Ishii Y, Sasahara M, Haji A.
    • Journal Title

      J Pharmacol Sci. 112(4)

      Pages: 477-481

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved.2010

    • Author(s)
      Zheng L, Ishii Y, Tokunaga A, Hamashima T, Shen J, Zhao QL, Ishizawa S, Fujimori T, Nabeshima Y, Mori H, Kondo T, Sasahara M.
    • Journal Title

      J Neurosci Res. 88(6)

      Pages: 1273-1284

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice.2010

    • Author(s)
      Nogami T.
    • Journal Title

      Hippocampus

      Volume: 21巻

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells.2010

    • Author(s)
      Dong XY.
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 32801-32809

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of platelet-derived growth factor-BB and its receptor-beta in hypoxia-induced depression of excitatory synaptic transmission in the nucleus tractus solitarius of mice.2010

    • Author(s)
      Ohi Y.
    • Journal Title

      J Pharmacol Sci

      Volume: 112 Pages: 477-481

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet.2010

    • Author(s)
      Wada T.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 2040-2049

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved.2010

    • Author(s)
      Zheng L.
    • Journal Title

      J Neurosci Res

      Volume: 88 Pages: 1273-1284

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves2009

    • Author(s)
      Yamazaki T, Sabit H, Oya T, Ishii Y, Hamashima T, Tokunaga A, Ishizawa S, Jie S, Kurashige Y, Matsushima T, Furuta I, Noguchi M, Sasahara M.
    • Journal Title

      J Peripher Nerv Syst

      Volume: 14 Pages: 165-176

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxic ventilatory response in platelet-derived growth factor receptor-beta-knockout mice2009

    • Author(s)
      Tsunekawa S, Ohi Y, Ishii Y, Sasahara M, Haji A.
    • Journal Title

      J Pharmacol Sci

      Volume: 110 Pages: 270-275

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of NMDA receptors enhances the excitability of hippocampal CA3 neurons2009

    • Author(s)
      Fukushima F, Nakao K, Shinoe T, Fukaya M, Muramatsu S-I, Sakimura K, Kataoka H, Mori H, Watanabe M, Manabe T, Mishina M.
    • Journal Title

      PLoS ONE

      Volume: 4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus2009

    • Author(s)
      Kishioka A, Fukushima F, Ito T, Kataoka H, Mori H, Ikeda T. Itohara S, Sakimura K, Mishina M.
    • Journal Title

      PLoS ONE

      Volume: 4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves.2009

    • Author(s)
      Yamazaki T, Sabit H, Oya T, Ishii Y, Hamashima T, Tokunaga A, Ishizawa S, Jie S, Kurashige Y, Matsushima T, Furuta I, Noguchi M, Sasahara M.
    • Journal Title

      J Peripher Nerv Syst. 14(3)

      Pages: 165-176

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Hypoxic ventilatory response in platelet-derived growth factor receptor-beta-knockout mice.2009

    • Author(s)
      Tsunekawa S, Ohi Y, Ishii Y, Sasahara M, Haji A.
    • Journal Title

      J Pharmacol Sci. 110(3)

      Pages: 270-275

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves.2009

    • Author(s)
      Yamazaki T.
    • Journal Title

      J.Peripher.Nerv.Syst. 14

      Pages: 165-176

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxic ventilatory response in platelet-derived growth factor receptor-beta-knockout mice.2009

    • Author(s)
      Tsunekawa S.
    • Journal Title

      J.Pharmacol.Sci. 110

      Pages: 270-275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan attenuates progression of steatohepatitis in mice : role of hepatic macrophage infiltration and effects on adipose tissue.2009

    • Author(s)
      Kudo H
    • Journal Title

      Liver Int. 29

      Pages: 988-996

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice.2009

    • Author(s)
      Suzuki H.
    • Journal Title

      Biochem.Biophys.Res.Commun. 379

      Pages: 38-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothermia during Ischemia Protects against Neuronal Death but Not Acute Brain Edema following Transient Forebrain Ischemia in Mice.2009

    • Author(s)
      Doshi M.
    • Journal Title

      Biol.Pharm.Bull. 32

      Pages: 1957-1961

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDGF receptor beta is a potent regulator of mesenchymal stromal cell function2008

    • Author(s)
      Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A, Kanamori M, Kimura T, Sasahara M.
    • Journal Title

      J Bone Miner Res

      Volume: 23 Pages: 1519-1528

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice2008

    • Author(s)
      Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima Y, Sasahara M, Funa K.
    • Journal Title

      Mol Cell Neurosci

      Volume: 37 Pages: 507-518

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] NMDA-andβ-amyloid_<1-42>-induced neurotoxicity is attenuated in serine racemase knock-out mice2008

    • Author(s)
      Inoue R, Hashimoto K, Harai T, Mori H.
    • Journal Title

      J Neurosci Res

      Volume: 28 Pages: 14486-14491

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serine racemase is predominantly localized in neurons in mouse brain2008

    • Author(s)
      Miya K, Inoue R, Takata Y, Abe M, Natsume R, Sakimura K, Hongou K, Miyawaki T, Mori H.
    • Journal Title

      J Comp Neurol

      Volume: 510 Pages: 641-654

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin2008

    • Author(s)
      Takeuchi T, Ohtsuki G, Yoshida T, Fukaya M, Wainai T, Yamashita M, Yamazaki Y, Mori H, Sakimura K, Kawamoto S, Watanabe M, Hirano T, Mishina M.
    • Journal Title

      PLoS ONE

      Volume: 3

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effects of FAK ablation on cerebellar foliation, Bergmann glia positioning and climbing fiber territory on Purkinje cells2008

    • Author(s)
      Watanabe F, Miyazaki T, Takeuchi T, Fukaya M, Nomura T, Noguchi S, Mori H, Sakimura K, Watanabe M, Mishina M.
    • Journal Title

      Eur J. Neurosci

      Volume: 27 Pages: 836-854

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] PDGF receptor beta is a potent regulator of mesenchymal stromal cell function.2008

    • Author(s)
      Tokunaga A, Oya T, Ishii Y, Motomura H, Nakamura C, Ishizawa S, Fujimori T, Nabeshima Y, Umezawa A, Kanamori M, Kimura T, Sasahara M.
    • Journal Title

      J Bone Miner Res. 23(9)

      Pages: 1519-1528

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice.2008

    • Author(s)
      Ishii Y, Matsumoto Y, Watanabe R, Elmi M, Fujimori T, Nissen J, Cao Y, Nabeshima Y, Sasahara M, Funa K.
    • Journal Title

      Mol Cell Neurosci. 37(3)

      Pages: 507-518

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Characterization of neuroprogenitor cells expressing the PDGF β-receptor within the subventricular zone of postnatal mice2008

    • Author(s)
      Ishii Y.
    • Journal Title

      Mol. Cell. Neurosci. 37

      Pages: 507-518

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDGF receptor β is a potent regulator of mesenchymal stromal cell function.2008

    • Author(s)
      Tokunaga A.
    • Journal Title

      J. Bone Miner. Res 23

      Pages: 1519-1528

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKII-alpha (Thr286Asp) in pancreatic beta-cells.2008

    • Author(s)
      Kato I.
    • Journal Title

      Diabetes Metab. Res. Rev. 24

      Pages: 486-497

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation-, aging-, and gene-dosage-dependent accumulation of FENIB-type neuroserpin (G392E) in ERs and lysosomes of neurons in transgenic mice.2008

    • Author(s)
      Takasawa A.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 35606-35613

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.2008

    • Author(s)
      Kagawa S.
    • Journal Title

      Endocrinology 149

      Pages: 642-650

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tufted angiomaとの鑑別が問題となったKaposiform hemangioendotheliomaの1例2011

    • Author(s)
      濱島丈
    • Organizer
      第23回北陸病理集談会
    • Place of Presentation
      富山大学(富山)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Eplerenone improves insulin sensitivity by suppressing inflammation in both liver and adipose tissue of NASH model mice2011

    • Author(s)
      Sasaki M.
    • Organizer
      The 4^<th> International Aldosterone Forum in Japan
    • Place of Presentation
      Royal Park Hotel (Tokyo)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規NASHモデルマウスに対するエプレレノンの治療効果の検討2011

    • Author(s)
      佐々木元大
    • Organizer
      第83回日本糖尿病学会中部地方会
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2011-04-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neuroprotective Effects of PDGF Against Oxidative Stress and the Signaling Pathway Involved2011

    • Author(s)
      Ishii Y, Zheng L Sasahara M.
    • Organizer
      The 6th International conference of Neurons and Brain Diseases in Toyama
    • Place of Presentation
      Toyama
    • Related Report
      2011 Final Research Report
  • [Presentation] Functional analysis of plated-derived growth factorβreceptor in neural stem cells2011

    • Author(s)
      Xu G, Ishii Y, Shen J, Sasahara M.
    • Organizer
      The 6th International conference of Neurons and Brain Diseases in Toyama
    • Place of Presentation
      Toyama
    • Related Report
      2011 Final Research Report
  • [Presentation] PDGFR-βis essential recruitment but not for survival of pericyte in adult mouse brain2011

    • Author(s)
      Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, Matsushima T, Yamamoto S, Hattori Y, Takatsuru Y, Nabekura J, Sasahara M.
    • Organizer
      The 6th International conference of Neurons and Brain Diseases in Toyama
    • Place of Presentation
      Toyama
    • Related Report
      2011 Final Research Report
  • [Presentation] PDGFR-βsignal promotes repair process after cerebral ischemia2011

    • Author(s)
      申杰,石井陽子,徐桂華,濱島丈,松島貴子,山本誠士,高鶴祐介,鍋倉淳一,笹原正清
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 血小板由来増殖因子β受容体の神経幹細胞の増殖と分化に対する役割の検討2011

    • Author(s)
      徐桂華,石井陽子,申杰,濱島丈,石澤伸,笹原正清
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Neuroprotective Effects of PDGF Against Oxidative Stress and the Signaling Pathway Involved2011

    • Author(s)
      Ishii Y.
    • Organizer
      The 6^<th> International conference of Neurons and Brain Diseases in Toyama
    • Place of Presentation
      ANAクラウンプラザホテル富山(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional analysis of plated-derived growth factor β receptor in neural stem cells2011

    • Author(s)
      Xu G.
    • Organizer
      The 6^<th> International conference of Neurons and Brain Diseases in Toyama
    • Place of Presentation
      ANAクラウンプラザホテル富山(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PDGFR-β is essential recruitment but not for survival of pericyte in adult mouse brain2011

    • Author(s)
      Shen J.
    • Organizer
      The 6^<th> International conference of Neurons and Brain Diseases in Toyama
    • Place of Presentation
      ANAクラウンプラザホテル富山(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PDGF-β受容体の欠損は,インスリン分泌低下型糖尿病モデルマウスの糖尿病腎症を改善する2011

    • Author(s)
      石井陽子
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腸管出血性大腸菌感染後に急性壊死性脳症を来たした1剖検例2011

    • Author(s)
      濱島丈
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Annual Research Report
  • [Presentation] PDGFR-β signal promotes repair process after cerebral ischemia2011

    • Author(s)
      申杰
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血小板由来増殖因子β受容体の神経幹細胞の増殖と分化に対する役割の検討2011

    • Author(s)
      徐桂華
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 富山県神通川流域に発生したイタイイタイ病における病理学的特徴の体系化2011

    • Author(s)
      矢崎めぐみ
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 視床下部ニューロンでのSHIP2の発現が,摂食シグナルとインスリン感受性,エネルギー代謝に与える影響の解明2011

    • Author(s)
      市原克則
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規NASHモデルマウスの作成と,抗アルドステロン薬の治療効果の検討2011

    • Author(s)
      佐々木元大
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Related Report
      2011 Annual Research Report
  • [Presentation] リピッドホスファターゼSHIP2が中枢性エネルギー代謝に与える影響2011

    • Author(s)
      市原克則
    • Organizer
      第12回Pharmaco-Hematology Symposium
    • Place of Presentation
      富山国際会議場(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特徴的な画像所見を呈した石灰化を伴う転移性脳腫瘍の1剖検例2011

    • Author(s)
      猪又峰彦
    • Organizer
      第67回呼吸器合同北陸地方会
    • Place of Presentation
      富山国際会議場(富山)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝特異的SREBP1cトランスジェニックマウスを用いた新規NAS且モデルマウスに対する、エプレレノンの改善作用の検討2010

    • Author(s)
      和田努
    • Organizer
      第22回分子糖尿病学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Establishment of a novel mouse model of diet-induced metabolic syndrome with non-alcoholic steatohepatitis (NASH), and the therapeutic impact of MR antagonism in the mice.2010

    • Author(s)
      Wada T.
    • Organizer
      The 3rd Insulin Resistance in Metabolic Disease Forum
    • Place of Presentation
      福岡
    • Year and Date
      2010-11-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規NASHモデルマウスにおける抗アルドステロン薬の治療効果2010

    • Author(s)
      佐々木元大
    • Organizer
      第10回日本内分泌学会北陸支部学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] PDGFの病態生理学~発生生物学から臨床医学へ~2010

    • Author(s)
      笹原正清
    • Organizer
      第53回NPO法人日本口腔科学会中部地方部会
    • Place of Presentation
      富山
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝特異的SREBP1cトランスジェニックマウスを用いた新規NAS且モデルマウスの作成と、エプレレノンによる改善効果の検討2010

    • Author(s)
      和田努
    • Organizer
      第29回北陸合同内分泌代謝談話会
    • Place of Presentation
      金沢
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neurovascular signaling of PDGF receptor beta protects CNS from insults, a study using conditional knockout mouse2010

    • Author(s)
      Sasahara M, Ishii Y, Shen J, Hamashima T.
    • Organizer
      BIT's 1st Annual World Congress of NeuroTalk-2010
    • Place of Presentation
      Singapore.(Invited lecture)
    • Related Report
      2011 Final Research Report
  • [Presentation] The Role for PDGFR-s as a Positive Regulator of Vessels Maturation after Focal Cerebral Ischemia in Mice2010

    • Author(s)
      Shen J, Ishii Y, Hamashima T, Sasahara M.
    • Organizer
      BIT's 1st Annual World Congress of NeuroTalk-2010
    • Place of Presentation
      Singapore
    • Related Report
      2011 Final Research Report
  • [Presentation] PDGFR-βdeletion improves diabetic nephropathy in CaM Kinase IIα(Thr286Asp) Transgenic Mice2010

    • Author(s)
      Suzuki H, Usui I, Kato I, Kanatani Y, Yamazaki Y, Fujisaka S, Senda S, Urakaze M, Sasahara M, Takasawa S, Okamoto H, Kobayashi M, Tobe K.
    • Organizer
      American Diabetes Association(ADA) 70th Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The Involvement of PDGFR-βin the Maturation of Blood Vessel after Focal Cerebral Ischemia2010

    • Author(s)
      Shen J, Ishii Y, Xu G, Hamashima T, Matsushima T, Yamamoto S, Takatsuru Y, Nabekura J, Sasahara M.
    • Organizer
      The 33rd Annual Meeting of the Japan Neuroscience Society(Neuro 2010)
    • Place of Presentation
      Kobe
    • Related Report
      2011 Final Research Report
  • [Presentation] Neurovascular signaling of PDGF receptor beta protects CNS from insults, a study using conditional knockout mouse.2010

    • Author(s)
      Sasahara M., Ishii Y., Shen J., Hamashima T.
    • Organizer
      BIT's 1st Annual World Congress of NeuroTalk-2010
    • Place of Presentation
      Singapore.(Invited lecture)
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] The Role for PDGFR-s as a Positive Regulator of Vessels Maturation after Focal Cerebral Ischemia in Mice.2010

    • Author(s)
      Shen J., Ishii Y., Hamashima T., Sasahara M.
    • Organizer
      BIT's 1st Annual World Congress of NeuroTalk-2010.
    • Place of Presentation
      Singapore.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] PDGFR-β deletion improves diabetic nephropathy in CaM Kinase II α(Thr286Asp) Transgenic Mice.2010

    • Author(s)
      Suzuki H., Usui I., Kato I., Kanatani Y., Yamazaki Y., Fujisaka S., Senda S., Urakaze M., Sasahara M., Takasawa S., Okamoto H., Kobayashi M., Tobe K.
    • Organizer
      American Diabetes Association (ADA) 70th Scientific Sessions(59(Suppl.1): A1, 2010)
    • Place of Presentation
      Orlando, USA.Diabetes
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] The Involvement of PDGFR-β in the Maturation of Blood Vessel after Focal Cerebral Ischemia.2010

    • Author(s)
      Shen J., Ishii Y., Xu G., Hamashima T., Matsushima T., Yamamoto S., Takatsuru Y., Nabekura J., Sasahara M.
    • Organizer
      The 33rd Annual Meeting of the Japan Neuroscience Society(Neuro 2010)(Res., 68(Suppl.1): e97, 2010)
    • Place of Presentation
      Kobe.Neurosci.
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Neurovascular signaling of PDGF receptor beta protects CNS from insults, a study using conditional knockout mouse.2010

    • Author(s)
      Sasahara M.
    • Organizer
      BIT's 1st Annual World Congress of NeuroTalk-2010
    • Place of Presentation
      Singapore
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Role for PDGFR-s as a Positive Regulator of Vessels Maturation after Focal Cerebral Ischemia in Mice.2010

    • Author(s)
      Shen J.
    • Organizer
      BIT's 1st Annual World Congress of NeuroTalk-2010
    • Place of Presentation
      Singapore
    • Related Report
      2010 Annual Research Report
  • [Presentation] Eplerenone ameliorates hepatic lipid accumulation, inflammation, and fibrosis induced by high-fat and high-fructose feeding in the liver specific SREBP1c transgenic mice.2010

    • Author(s)
      Wada T.
    • Organizer
      The 3rd International Aldosterone Forum in Japan
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Spironolactone improves glucose and lipid metabolism and ameliorates hepatic steatosis induced by high-fat and high-fructose diet.2010

    • Author(s)
      Wada T.
    • Organizer
      American Diabetes Association (ADA) 70th Scientific Sessions
    • Place of Presentation
      Orlando, USA.
    • Related Report
      2010 Annual Research Report
  • [Presentation] PDGFR-β deletion improves diabetic nephropathy in CaM Kinase IIα (Thr286Asp) Transgenic Mice.2010

    • Author(s)
      Suzuki H.
    • Organizer
      American Diabetes Association (ADA) 70th Scientific Sessions
    • Place of Presentation
      Orlando, USA.
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Involvement of PDGFR-β in the Maturation of Blood Vessel after Focal Cerebral Ischemia.2010

    • Author(s)
      Shen J.
    • Organizer
      The 33rd Annual Meeting of the Japan Neuroscience Society (Neuro 2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impaired Glomerular Adaptability Against Subtotal Nephrectomy after Conditional Knock-Out of Platelet-Derived Growth Factor Receptor (PDGFR)-β in Mice.2010

    • Author(s)
      Nakagawa T.
    • Organizer
      ASN Renal Week 2010.(43rd Annual Meeting & Scientific Exposition)
    • Place of Presentation
      Denver, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Blockade of mineralocorticoid receptor ameliorates glucose and lipid metabolism, steatohepatitis, and hepatic fibrosis in a novel mouse model of non-alcoholic steatohepatitis (NASH) utilizing liver-specific SREBP1c transgenic mice.2010

    • Author(s)
      Wada T.
    • Organizer
      NASH2010 The 9th Japan Society of Hepatology (JSH) Single Topic Conference
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス局所脳虚血後の修復過程を正に制御する因子としてのPDGFR-βの役割2010

    • Author(s)
      申杰
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎切除後の糸球体リモデリングに対すづ血小板由来増殖因子(PDGF)β受容体抑制の影響2010

    • Author(s)
      中川泰三
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Valsalva洞動脈瘤破裂による心タンポナーデの1剖検例2010

    • Author(s)
      尾矢剛志
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Shirt1活性化薬SRT1720は、OVA喘息マウスモデルの炎症反応を抑制する2010

    • Author(s)
      市川智巳
    • Organizer
      第22回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] PDGF-β受容体の欠損は、インスリン分泌低下型糖尿病モデルマウスの尿アルブミンを減少させる2010

    • Author(s)
      鈴木ひかり
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高脂質高フルクトース負荷マウスのメタボリックシンドローム病態に対する抗アルドステロン薬の改善効果2010

    • Author(s)
      宮下佑介
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山
    • Related Report
      2010 Annual Research Report
  • [Presentation] 5/6腎切除後の糸球体リモデリングに対する血小板由来増殖因子(PDGF)β受容体発現抑制の影響2010

    • Author(s)
      中川泰三
    • Organizer
      第53回日本腎臓学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Conditional depletion of PDGF-β receptor gene in the central nervous system induced deficits in higher brain functions in mice.2010

    • Author(s)
      Nguyen PTH.
    • Organizer
      第57回中部日本生理学会
    • Place of Presentation
      豊明
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of PDGFR-β in the postnatal kidney glomerulus.2009

    • Author(s)
      Nakagawa T.
    • Organizer
      ASN(American Society of Nephrology) Renal Week 2009
    • Place of Presentation
      San Diego, CA.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cultured neuron deficit in PDGF-bis vulnerable to oxidative stress.2009

    • Author(s)
      笹原正清
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 末梢神経の再生におけるPDGF受容体および細胞シグナル活性化の解析2009

    • Author(s)
      山崎隆志
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 条件的KOマウスを用いた成体期腎糸球体における血小板由来増殖因子(PDGF)beta受容体の役割2009

    • Author(s)
      中川泰三
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス脳虚血中の低体温が脳浮腫および海馬神経細胞死の発生に及ぼす影響2009

    • Author(s)
      道志勝
    • Organizer
      第12回日本脳低温療法学会
    • Place of Presentation
      札幌
    • Related Report
      2009 Annual Research Report
  • [Presentation] Changes in hippocampal spine morphology and synaptic plasticity induced by conditional loss of PDGFR-β are associated with memory impairment in mutant mice.2009

    • Author(s)
      Shioda N.
    • Organizer
      The 32nd Annual Meeting the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] インスリン分泌低下型糖尿病を発症するPDGF-R受容体conditional knockoutマウスを用いた、糖尿病性腎症の解析2009

    • Author(s)
      鈴木ひかり
    • Organizer
      第24回日本糖尿病合併症学会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] The platelet-derived growth factor-β receptor modulates the hypoxic ventilatory response in the mouse2008

    • Author(s)
      Tsunekawa S.
    • Organizer
      The 81th Annual Meeting of The Japanese Pharmacological Society
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] PDGF Receptor β is a Potent Regulator of Mesenchymal Stromal Cell Function.2008

    • Author(s)
      徳永綾乃
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] PDGFR-βは, 細胞内カルシウムイオン濃度上昇の抑制を介して, 酸化ストレス性細胞死から神経細胞を保護する.2008

    • Author(s)
      鄭蓮順
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cre-lox P系を用いた制限的ノックアウト(KO)による成体期の糸球体におけるPDGFR-βの機能解析2008

    • Author(s)
      中川泰三
    • Organizer
      第51回日本腎臓学学術総会
    • Place of Presentation
      福岡
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of PDGF β-receptor signaling in the neurogenesis of postnatal mouse brain.2008

    • Author(s)
      Ishii Y.
    • Organizer
      The 31st Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cultured neuron deficit in PDGF receptor is vulnerable to oxidative stress.2008

    • Author(s)
      Zheng L.
    • Organizer
      The 31st Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 腎症 : 基礎PDGF-beta受容体conditional knockoutマウスを用いた, 糖尿病性腎症発症におけるPDGF経路の役割についての検討.2008

    • Author(s)
      鈴木ひかり
    • Organizer
      第23回日本糖尿病合併症学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血小板由来増殖因子β受容体は, 間葉系間質細胞機能を強く制御する.2008

    • Author(s)
      徳永綾乃
    • Organizer
      第23回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.u-toyama.ac.jp/pathol2/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.u-toyama.ac.jp/patho12/index.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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