|Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
We analyzed the conditional knockout model of platelet-derived growth factor receptorβ(PDGFR-β). PDGFR-βpromoted the development of hippocampal pyramidal neurons and GABA neurons, and were involved in the development of cognitive ability and social behavior. PDGFR-βimproved the ischemic brain lesions, and was involved in neuroprotection, maturation of newly-formed blood vessels, the activation of neural stem cells and glial cell reaction. We established double knockout mouse model of PDGFR-αand-βgene for further PDGF research.