| Project/Area Number |
20390111
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
MATSUKAWA Akihiro Okayama University, 大学院・医歯薬学総合研究科, 教授 (90264283)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Yasumasa 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30403489)
HIDA Akira 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10435026)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KUBO Masato 独立行政法人理化学研究所, チームリーダー (40277281)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
|
|---|
| Keywords | 敗血症 / 自然免疫 / サイトカイン / シグナル伝達 |
|---|
| Research Abstract |
T cells exist in the peritoneum under healthy conditions. Rag2Ko mice (T and B cell deficient) showed increased mortality rate during sepsis, which was recovered after adoptive transfer of T cells, but not B cells. Mice with overexpression of SOCS5 in T cells (SOCS5-cTg) demonstrated increased Th1 response in the peritoneum whereas SOCS3-cTg mice exhibited decreased systemic inflammatory response during septic peritonitis, leading to the increased survival rate during sepsis. Thus, T cells appear to be important in innate immunity, which can be controlled by SOCS3/5 in T cells. We also elucidated the crucial roles of T cells in different types of inflammation models, such as T cell-dependent hepatitis and arthritis.
|
