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Resistance genes to collagen disease in a wild mice-derived inbred strain MSM/Ms

Research Project

Project/Area Number 20390112
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionEhime University

Principal Investigator

NOSE Masato  Ehime University, プロテオ医学研究センター, 教授 (70030913)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Tatsuhiko  愛媛大学, 大学院・医学系研究科, 准教授 (80239384)
SOGA Yoshiko  愛媛大学, 医学部附属病院, 助教 (10549182)
小森 浩章  愛媛大学, 大学院・医学系研究科, 講師 (30372725)
Co-Investigator(Renkei-kenkyūsha) ONO Masao  東北大学, 大学院・医学系研究科, 教授 (20302218)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
KeywordsMRL / lpr / MSM / Ms / 糸球体腎炎 / QTL解析 / 位置的候補遺伝子 / Cd59a / プロモーター多型 / リコンビナントコンジェニックマウス / MRL/lpr / MSM/Ms / 血管炎 / リコンビナント温ジェニックマウス / 系球体腎炎 / 抗Cd59a抗体 / 1pr / CD59 / ルチフェラーゼアッセイ
Research Abstract

This study attempted to elucidate the polygenic genetic resistance of a wild mice-derived inbred strain MSM/Ms, having a larger gene pools than commonly used laboratory mouse strains, to glomerulonephritis in an MRL/Mp-lpr/lpr (MRL-Fas^<lpr>) lupus strain of mice and thereby to understand the steps controlling development of lupus nephritis. A genome wide scan for glomerulonephritis resistance loci in a dominant inheritance form was carried out by using MRL-Fas^<lpr> x (MRL-Fas^<lpr> x MSM/Ms) F1 backcross mice. Three dominant MSM/Ms resistance loci were mapped on chromosomes 2, 13 and 4. One of the candidate genes for the locus Agnmrl was Cd59a, encoding an glycosyl phosphatidylinositol-anchored glycoprotein inhibiting the membrane attack complex of complement. Expression of Cd59a in the glomeruli was higher in MSM/Ms than in MRL-Fas^<lpr>. Different transcriptional activity of the Cd59a promoter region was observed between the parental strains of mice. Then, the recombinant congenic strain of mice MRL-Fas^<lpr>-Cd59a^<MSM> was newly established, which was significantly decreased in severity of glomerulonephritis and also renal vasculitis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (40 results)

All 2010 2009 2008

All Journal Article (23 results) (of which Peer Reviewed: 21 results) Presentation (16 results) Book (1 results)

  • [Journal Article] Evaluating the role of rheumatoid factors in the development of rheumatoidarthritis in a mouse model with a newly established ELISA system.2010

    • Author(s)
      Tanaka Y, Komori H, Mori S, Soga Y, Tsubaki T, Terada M, Miyazaki T, Fujino T, Nakamura S, Kanno H, Sawasaki T, Endo Y, Nose M.
    • Journal Title

      Tohoku J Exp Med. 220

      Pages: 199-206

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simple screening method for autoantigen proteins using the N-terminal biotinylated protein library produced by wheat Cell-Free synthesis.2010

    • Author(s)
      Matsuoka K, Komori H, Nose M, Endo Y, Sawasaki T.
    • Journal Title

      J Proteome Res. 9

      Pages: 4264-4273

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating the role of rheumatoid factors in the development of rheumatoidarthritis in a mouse model with a newly established ELISA system.2010

    • Author(s)
      Tanaka Y, Komori H, Mori S, Soga Y, Tsubaki T, Terada M, Miyazaki T, Fujino T, Nakamura S, Kanno H, Sawasaki T, Endo Y, Nose M.
    • Journal Title

      Tohoku J Exp Med.

      Volume: 220 Pages: 199-206

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple screening method for autoantigen proteins using the N-terminal biotinylated protein library produced by wheat Cell-Free synthesis.2010

    • Author(s)
      Matsuoka K, Komori H, Nose M, Endo Y, Sawasaki T.
    • Journal Title

      J Proteome Res.

      Volume: 9 Pages: 4264-4273

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating the role of rheumatoid factors in the development of rheumatoidarthritis in a mouse model with a newly established ELISA system2010

    • Author(s)
      Tanaka Y, Komori H, Mori S, Soga Y, Tsubaki T, Terada M, Miyazaki T, Fujino T, Nakamura S, Kanno H, Sawasaki T, Endo Y, Nose M.
    • Journal Title

      Tohoku J Exp Med 220

      Pages: 199-206

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of SLAM-associated protein in the pathogenesis of autoimmune diseases and immunological disorders2010

    • Author(s)
      Furukawa H, Tohma, S Kitazawa H, Komori H, Nose M, Ono M.
    • Journal Title

      Arch Immunol Ther Exp 58

      Pages: 37-44

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-Like receptor 3 signaling induces chronic pancreatitis through the Fas/Fas ligand-mediated cytotoxicity.2009

    • Author(s)
      Soga Y, Komori H, Miyazaki T, Arita N, Terada M, Kamada K, Tanaka Y, Fujino T, Hiasa Y, Matsuura B, Onji M, Nose M.
    • Journal Title

      Tohoku J Exp Med. 217(3)

      Pages: 175-184

    • NAID

      10025105148

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic dissociation of dacryoadenitis and sialadenitis in a sjogren's syndrome mouse model with common and different susceptibility gene loci.2009

    • Author(s)
      Kamao T, Miyazaki T, Soga Y, Komori H, Terada M, Ohashi Y, Nose M.
    • Journal Title

      Invest Ophthalmol Vis Sci. 50

      Pages: 3257-3265

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll-Like receptor 3 signaling induces chronic pancreatitis through the Fas/Fas ligand-mediated cytoxicity2009

    • Author(s)
      Soga Y, Komori H, Miyazaki T, Arita N, Terada M, Kamada K, Tanaka Y, Fujino T, Hiasa Y, Matsuura B, Onji M, Nose M.
    • Journal Title

      Tohoku J.Exp. Med. 217

      Pages: 175-184

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic dissociation of dacryoadenitis and sialadenitis in a sjogren's syndrome mouse model with common and different susceptibility gene loci2009

    • Author(s)
      Kamao T, Miyazaki T, Soga Y, Komori H, Terada M, Ohashi Y, Nose M.
    • Journal Title

      Invest Ophthalmol Vis Sci. 50

      Pages: 3257-3265

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] モデルマウスから学ぶ血管炎のゲノム的仕組み2009

    • Author(s)
      能勢眞人, 小森浩章
    • Journal Title

      J Jpm Coll Angiol 49

      Pages: 11-16

    • NAID

      10025626686

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 血管炎発症のポリジーンネットワークモデル2009

    • Author(s)
      能勢眞人, 小森浩章
    • Journal Title

      リウマチ科 42

      Pages: 337-343

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Toll-Like receptor 3 signaling induces chronic pancreatitis through the Fas/Fas ligand-mediated cytotoxicity.2009

    • Author(s)
      Soga Y, Komori H, Nose M, et al
    • Journal Title

      Tohoku J. Exp. Med 217

      Pages: 175-184

    • NAID

      10025105148

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.2008

    • Author(s)
      Hasegawa H, Inoue A, Kohno M, Lei J, Miyazaki T, Yoshie O, Nose M, Yasukawa M.
    • Journal Title

      Gene Ther. 15

      Pages: 171-182

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dcir deficiency causes development of autoimmune diseases in mice due to excess expanision of dendritic cells.2008

    • Author(s)
      Fujikado N, Saijo S, Yonezawa T, Shimamori K, Ishii A, Sugai S, Kotaki H, Sudo K, Nose M, Iwakura Y.
    • Journal Title

      Nature medicine. 14

      Pages: 176-180

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel recombinant congenic mouse strain developing arthritis with enthesopathy.2008

    • Author(s)
      Mori S, Tanda N, Ito R.M, Oishi H, Tsubaki T, Komori H, Zhang MC, Ono M, Nishimura M, Nose M.
    • Journal Title

      Pathology Int. 58

      Pages: 407-414

    • NAID

      10027377068

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the ameliorative effects of immunosuppressants on crescentic giomerulonephritis in SCG/Kj mice.2008

    • Author(s)
      Saiga K, Yoshida M, Nakamura I, Toyoda E, Tokunaka K, Morihashi H, Abe F, Nemoto K, Nose M.
    • Journal Title

      Int Immunopharmacol. 8

      Pages: 1183-1189

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice.2008

    • Author(s)
      Zhang MC, Furukawa H, Tokunaka K, Saiga K, Date F, Owada Y, Nose M, Ono M.
    • Journal Title

      Immunogenetics. 60

      Pages: 599-607

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model.2008

    • Author(s)
      Hasegawa H, Inoue A, Nose M, et al
    • Journal Title

      Gene Ther. 15

      Pages: 171-182

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dcir deficiency causes development of autoimmune diseases in mice due to excess expanision of dendritic cells.2008

    • Author(s)
      Fujikado N, Saijo S, Nose M, et al
    • Journal Title

      Nature medicine. 14

      Pages: 176-180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel recombinant congenic mouse strain developing arthritis with enthesopathy.2008

    • Author(s)
      Mori S, Tanda N, Nose M, et al
    • Journal Title

      Pathology Int. 58

      Pages: 407-414

    • NAID

      10027377068

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the ameliorative effects of immunosuppressants on crescentic giomerulonephritis in SCG/Kjmice.2008

    • Author(s)
      Saiga K, Yoshida M, Nose M, et al
    • Journal Title

      International Immunopharmacology. 8

      Pages: 1183-1189

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants, of lupus-prone mice.2008

    • Author(s)
      Zhang M-C, Furukawa H, Nose M, et al
    • Journal Title

      Immunogenetics. 60

      Pages: 599-607

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Common and different gene loci susceptible to sialoadenitis and dacryoadenitis in a sjogen's syndrome mouse model.2010

    • Author(s)
      Kamao T, Miyazaki T, Soga Y, Komori H, Terada M, Nose M
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] A novel mouse model for primary focal segmental glomerulosclerosis developing associated with insertional mutagenesis by transgene.2010

    • Author(s)
      Tanaka Y, Fujino T, Terada M, Ito M, Shudo M, Okabe M, Nose M
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] Allelic polymorphism of murine osteopontin implicates functional differences in antigen presentation by dendritic cells.2010

    • Author(s)
      Miyazaki T, Tanaka Y, Kurata M, Ono M, Nose M
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan.
    • Related Report
      2010 Final Research Report
  • [Presentation] オステオポンチン蛋白多型による樹状細胞抗原提示能修飾の新たなメカニズム2009

    • Author(s)
      宮崎龍彦、田中ゆき、小野栄夫、能勢眞人
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 血管炎に関する基礎研究の進歩2009

    • Author(s)
      能勢眞人
    • Organizer
      第50回日本脈管学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 膠原病のポリジーンネットワーク2009

    • Author(s)
      能勢眞人
    • Organizer
      第37回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] A simple capture ELISA for recombinant proteins synthesized in cell-free system : Genetic dissociation of rheumatoid factors from arthritis in MRL/lpr mice.2009

    • Author(s)
      田中ゆき, 曽我美子, 能勢眞人
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] オステオポンチン蛋白多型による樹状細胞抗原提示能修飾の新たなメカニズム2009

    • Author(s)
      宮崎龍彦, 田中ゆき, 小野栄夫, 能勢眞人
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都(国立京都国際会館)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管炎に関する基礎研究の進歩(シンポジウム)2009

    • Author(s)
      能勢眞人
    • Organizer
      第50回日本脈管学会総会
    • Place of Presentation
      東京(ハイアットリージェンシー東京)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膠原病のポリジーンネットワーク(シンポジウム)2009

    • Author(s)
      能勢眞人
    • Organizer
      第37回日本臨床免疫学会総会
    • Place of Presentation
      東京(東京ステーションコンファレンス)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Common and different gene loci susceptible to sialoadenitis and dacryoadenitis in a sjogren's syndrome mouse model.2008

    • Author(s)
      Kamao T, Miyazaki T, Soga Y, Komori H, Terada M, Nose M
    • Organizer
      6th International Congress on Autoimmunity
    • Place of Presentation
      Porto, Portugal.
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic basis of autoimmune pancreatitis induced by the stimulation through the toll-like receptor 3 signaling.2008

    • Author(s)
      Soga Y, Komori H, Terada T, Miyazaki T, Nose M
    • Organizer
      6th International Congress on Autoimmunity
    • Place of Presentation
      Porto, Portugal.
    • Related Report
      2010 Final Research Report
  • [Presentation] 自然免疫系刺激により誘導される自己免疫性膵炎の疾患感受性遺伝子解析2008

    • Author(s)
      小森浩章、曽我美子、能勢眞人
    • Organizer
      第97回日本病理学会総会(日本病理学会会誌第97巻第1号p169.)
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report
  • [Presentation] 血管炎発症のポリジーンネットワークモデル2008

    • Author(s)
      能勢眞人
    • Organizer
      第52回日本リウマチ学会総会・学術集会・第17回国際リウマチシンポジウム
    • Place of Presentation
      札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] Genetic basis of autoimmnune pancreatitis induced by the stimulation through the toll-like receptor 3 signaling.2008

    • Author(s)
      Soga Y, Komori H, Nose M, et al
    • Organizer
      6^<th> Intemational Congress on Autoimmunity
    • Place of Presentation
      Porto, Portugal.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Common and different gene loci susceptible to sialoadenitis and dacryoadenitis in a sjogern's syndrome mouse model.2008

    • Author(s)
      Kamao T, Miyazaki T, Nose M, et al
    • Organizer
      6^<th> International Congress on Autoimmunity
    • Place of Presentation
      Porto, Portugal.
    • Related Report
      2008 Annual Research Report
  • [Book] リウマチ病学テキスト2010

    • Author(s)
      能勢眞人
    • Total Pages
      8
    • Publisher
      診断と治癒社
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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