ROLE OF SCAVENGER RECEPTORS IN MACROPHAGE ACTIVATION AND THEIR APPLICATION FOR DIAGNOSIS AND THERAPY

• Project/Area Number: 20390113
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kumamoto University
• Principal Investigator: TAKEYA Motohiro Kumamoto University, 大学院・生命科学研究部, 教授 (90155052)
• Co-Investigator(Kenkyū-buntansha): SAKASHITA Naomi 熊本大学, 大学院・生命科学研究部, 准教授 (90284752) ; KOMOHARA Yoshihiro 熊本大学, 大学院・生命科学研究部, 助教 (40449921) ; FUJIWARA Yukio 熊本大学, 大学院・生命科学研究部, 助教 (70452886)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000); Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2008: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: マクロファージ / オルタナティブ活性化 / クラスAスカベンジャー受容体(SR-A, CD204) / ヘモグロビンスカベンジャー受容体(CD163) / 腫瘍内浸潤マクロファージ / STAT3 / 天然化合物 / マクロファージの活性化 / オルタナティブ活性化マクロファージ / corosolic acid / CDI63 / CD204 / クラスAスカベンジャー受容体(CD204) / マクロファージ活性化 / 慢性炎症性疾患 / 腫傷内浸潤マクロファージ / 破骨細胞分化 / CD204欠損マウス / 免疫組織化学 / 炎症制御 / 急性冠症候群 / LOX-1

Research Abstract

Using class A scavenger receptor (SR-A, CD204)-deficient macrophages, we disclosed that SR-A suppresses the macrophage activation by inhibiting the binding of LPS to TLR4 in a competitive manner. The result indicates SR-A plays a pivotal role in the regulation of the LPS-induced inflammatory response. Density of CD163-positive macrophages in tumors positively correlated with the malignant grade of glioma and epithelial ovarian cancer. It was found that M2 macrophages and tumor cells interact via STAT3. By screening natural compounds, corosolic acid was found to suppress M2 polarization of macrophages. This compound could be a potentially new tool for tumor prevention and therapy.

Research Products

• [Journal Article] Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma. (2011)
  • Author(s): Komohara Y, Hasita H, Ohnishi K, Fujiwara Y, Suzu S, Eto M, Takeya M
  • Journal Title: Cancer Sci in press
  • NAID: 10029295791
  • Peer Reviewed
• [Journal Article] マクロファージの活性化制御による生活習慣病治療戦略 (2011)
  • Author(s): 藤原章雄、菰原義弘、池田剛、竹屋元裕
  • Journal Title: 日本体質医学会雑誌 73(1) Pages: 67-71
• [Journal Article] Triterpenoids isolated from zizyphus jujuba inhibit foam cell formation in macrophages. (2011)
  • Author(s): Fujiwara Y, Hayashida A, Tsurushima K, Nagai R, Yoshitomi M, Daiguji N, Sakashita N, Takeya M, Tsukamoto S, Ikeda T
  • Journal Title: J Agric Food Chem 59 Pages: 4544-4552
  • Peer Reviewed
• [Journal Article] Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of STAT3 and NF-κB in tumor cells and tumor-associated macrophages. (2011)
  • Author(s): 藤原章雄, 菰原義弘, 池田剛, 竹屋元裕
  • Journal Title: Cancer Sci 102 Pages: 206-211
  • Peer Reviewed
• [Journal Article] Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages (2011)
  • Author(s): Fujiwara Y, et al.
  • Journal Title: Cancer Sci Volume: 102 Pages: 206-211
  • NAID: 10029289102
  • Peer Reviewed
• [Journal Article] Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation. (2010)
  • Author(s): Takaishi K, Komohara Y, Tashiro H, Ohtake H, Nakagawa T, Katabuchi H, Takeya M
  • Journal Title: Cancer Sci 101 Pages: 2128-2136
  • NAID: 10027832147
  • Peer Reviewed
• [Journal Article] Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. (2010)
  • Author(s): Higashi-Kuwata N, Masatoshi J, Makino T, Fukushima S, Inoue Y, Muchemwa FC, Yonemura Y, Komohara Y, Takeya M, Mitsuya H, Ihn H.
  • Journal Title: Arthritis Res Ther 12
  • Peer Reviewed
• [Journal Article] Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma. (2010)
  • Author(s): Hasita H, Komohara Y, Okabe H, Masuda T, Ohnishi K, Lei XF, Beppu T, Baba H, Takeya M
  • Journal Title: Cancer Sci 101 Pages: 1913-1919
  • NAID: 10027831002
  • Peer Reviewed
• [Journal Article] Ratio of M2 macrophage expression is closely associated with poor prognosis for angioimmunoblastic T-cell lymphoma (AITL). (2010)
  • Author(s): Niino D, Komohara Y, Murayama T, Aoki R, Kimura Y, Hashikawa K, Kiyasu J, Takeuchi M, Suefuji N, Sugita Y, Takeya M, Ohshima K.
  • Journal Title: Pathol Int 60 Pages: 278-283
  • NAID: 10029331443
  • Peer Reviewed
• [Journal Article] Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype : their possible involvement in pathological processes. (2010)
  • Author(s): Ohnishi K, Komohara Y, Sakashita N, Iyama K, Murayama T, Takeya M
  • Journal Title: Pathol Int 60 Pages: 27-34
  • NAID: 10027382665
  • Peer Reviewed
• [Journal Article] Class A scavenger receptor promotes osteoclast differentiation via the enhanced expression of receptor activator of NF-kappaB (RANK). (2010)
  • Author(s): Takemura K, Sakashita N, Fujiwara Y,Komohara Y, Lei X, Ohnishi K, Suzuki H, Kodama T, Mizuta H, Takeya M
  • Journal Title: Biochem Biophys Res Commun 391 Pages: 1675-1680
  • Peer Reviewed
• [Journal Article] Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma (2010)
  • Author(s): Hasita H, et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 1913-1919
  • Peer Reviewed
• [Journal Article] Involvement of M2-polarized macrophages in the ascites from advanced epithelial ovarian carcinoma in tumor progression via Stat3 activation (2010)
  • Author(s): Takaishi K, et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 2128-2136
  • Peer Reviewed
• [Journal Article] Ratio of M2 macrophage expression is closely associated with poor prognosis for Angioimmunoblastic T-cell lymphoma(AITL) (2010)
  • Author(s): Niino D, et al.
  • Journal Title: Pathol Int Volume: 60 Pages: 278-283
  • Peer Reviewed
• [Journal Article] Nifedipine induces peroxisome proliferator-activated receptor-{gamma}activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice (2010)
  • Author(s): Ishii N, et al.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 30 Pages: 1598-1605
  • Peer Reviewed
• [Journal Article] Association of ACAT1-positive vesicles with late endosomes/lysosomes in cholesterol-rich human macrophages (2010)
  • Author(s): Lei X, et al.
  • Journal Title: J Atheroscler Thromb Volume: 17 Pages: 740-750
  • Peer Reviewed
• [Journal Article] Onionin A from allium cepa inhibits macrophage activation (2010)
  • Author(s): El-Aasr M, et al.
  • Journal Title: J Nat Prod Volume: 73 Pages: 1306-1308
  • Peer Reviewed
• [Journal Article] Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis (2010)
  • Author(s): Higashi-Kuwata N, et al.
  • Journal Title: Arthritis Res Ther Volume: 12
  • Peer Reviewed
• [Journal Article] Effect of natural compounds on human macrophage activation (2010)
  • Author(s): Fujiwara Y, et al.
  • Journal Title: Inflammation and Regeneration Volume: 30 Pages: 520-523
  • NAID: 10027813189
  • Peer Reviewed
• [Journal Article] Class A scavenger receptor promotes osteoclast differentiation vi a the enhanced expression of receptor activator of NF-kappa B(RANK) (2010)
  • Author(s): Takemura K, Sakashita N, Fujiwara Y, Komohara Y, Lei X, Ohnishi K, Suzuki H, Kodama T, Mizuta H, Takeya M.
  • Journal Title: Biochem Biophys Res Commun 391 Pages: 1675-1680
  • Peer Reviewed
• [Journal Article] Macrophages in Langerhans cell histiocytosis are differentiated toward M2 phenotype : their possible involvement in pathological processes (2010)
  • Author(s): Ohnishi K, Komohara Y, Sakashita N, Iyama K, Murayama T, Takeya M.
  • Journal Title: Pathol Int 60 Pages: 27-34
  • NAID: 10027382665
  • Peer Reviewed
• [Journal Article] Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages. (2009)
  • Author(s): Komohara Y, Takemura K, Lei XF, Sakashita N, Harada M, Suzuki H, Kodama T, Takeya M
  • Journal Title: Cancer Sci 100 Pages: 2160-2166
  • Peer Reviewed
• [Journal Article] Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors. (2009)
  • Author(s): Kawamura K, Komohara Y, Takaishi K, Katabuchi H, Takeya M
  • Journal Title: Pathol Int 59 Pages: 300-305
  • NAID: 10027380027
  • Peer Reviewed
• [Journal Article] Alternatively activated macrophages (M2 macrophages) in the skin of patient with localized scleroderma. (2009)
  • Author(s): Higashi-Kuwata N, Makino T, Inoue Y, Takeya M, Ihn H.
  • Journal Title: Exp Dermatol 18 Pages: 727-729
  • Peer Reviewed
• [Journal Article] Alternatively activated macrophages(M2 macrophages)in the skin of patient with localized scleroderma (2009)
  • Author(s): Higashi-Kuwata N, Makino T, Inoue Y, Takeya M, Ihn H.
  • Journal Title: Exp Dermatol 18 Pages: 727-729
  • Peer Reviewed
• [Journal Article] Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors (2009)
  • Author(s): Kawamura K, Komohara Y, Takaishi K, Katabuchi H, Takeya M.
  • Journal Title: Pathol Int 59 Pages: 300-305
  • NAID: 10027380027
  • Peer Reviewed
• [Journal Article] Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to upregulation of nitric oxide and interferon-gamma production by tumor-associated macrophages (2009)
  • Author(s): Komohara Y, Takemura K, Lei XF, Sakashita N, Harada M, Suzuki H, Kodama T, Takeya M.
  • Journal Title: Cancer Sci 100 Pages: 2160-2166
  • Peer Reviewed
• [Journal Article] Expression and localization of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in murine and human placentas. (2008)
  • Author(s): Satoh H, Kiyota E, Terasaki Y, Sawamura T, Takagi K, Mizuta H, Takeya M
  • Journal Title: J Histochem Cytochem 56 Pages: 773-784
  • Peer Reviewed
• [Journal Article] Class A macrophage scavenger receptor gene expression levels in peripheral blood mononuclear cells specifically increased in patients with acute coronary syndrome. (2008)
  • Author(s): Nakayama M, Kudoh T, Kaikita K, Yoshimura M, Oshima S, Miyamoto Y, Takeya M, Ogawa H.
  • Journal Title: Atherosclerosis 198 Pages: 426-433
  • Peer Reviewed
• [Journal Article] Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. (2008)
  • Author(s): Komohara Y, Ohnishi K, Kuratsu J, Takeya M
  • Journal Title: J Pathol 216 Pages: 15-24
  • Peer Reviewed
• [Journal Article] Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas. (2008)
  • Author(s): Komohara Y
  • Journal Title: J Pathol 216 Pages: 15-24
  • Peer Reviewed
• [Journal Article] Expression and Localization of Lectin-like Oxidized Low-Density Lipop rotein Receptor-1(LOX-1)in Murine and Human Placentas. (2008)
  • Author(s): Satoh H
  • Journal Title: J Histochem Cytochem 56 Pages: 773-784
  • Peer Reviewed
• [Journal Article] Class A Macrophage Scavenger receptor Gene Expression Levels in Perip heral Blood Mononuclear Cells Specifically Increased in Patients with Acute Coronary Syndrome. (2008)
  • Author(s): Nakayama M
  • Journal Title: Atherosclerosis 198 Pages: 426-433
  • Peer Reviewed
• [Presentation] M2 type of macrophages and tumor microenvironment. (2010)
  • Author(s): 竹屋元裕
  • Organizer: Zhejiang University-Kumamoto University Life Science Symposium
  • Place of Presentation: Zhejiang University (Hangzhou, China)
  • Year and Date: 2010-12-13
• [Presentation] M2 type of macrophages and tumor microenvironment (2010)
  • Author(s): Takeya M, et al.
  • Organizer: Zhejiang University-Kumamoto University Life Science Symposium
  • Place of Presentation: Zhejiang University, Hangzhou, China(招待講演)
  • Year and Date: 2010-12-13
• [Presentation] 特別講演「腫瘍内浸潤マクロファージとその活性化」 (2010)
  • Author(s): 竹屋元裕
  • Organizer: 第16回福島免疫細胞療法研究会
  • Place of Presentation: 福島県立医科大学、福島(招待講演)
  • Year and Date: 2010-12-07
• [Presentation] マクロファージの活性化制御による生活習慣病治療戦略 シンポジウム2「体質改善を主眼においた最新の生活習慣病治療法開発」 (2010)
  • Author(s): 竹屋元裕
  • Organizer: 第60回日本体質医学会総会
  • Place of Presentation: 熊本パレアホール(熊本)
• [Presentation] CD163 as a marker for M2 macrophages in human tissues. (2010)
  • Author(s): 竹屋元裕
  • Organizer: CD163 AND INFLAMMATION, WORKSHOP2010
  • Place of Presentation: The Sandbjerg Estate (Denmark)
• [Presentation] 脳原発悪性リンパ腫におけるマクロファージ浸潤と臨床予後に関する解析 (2010)
  • Author(s): 菰原義弘、大西紘二、竹屋元裕
  • Organizer: 第50回日本リンパ網内系学会総会
  • Place of Presentation: 朱鷺メッセ(新潟)
• [Presentation] Significance of M2 macrophage infiltration in human malignant tumors. Symposium 6 : Tumor Microenvironments. (2010)
  • Author(s): 菰原義弘, 竹屋元裕
  • Organizer: 18th International Symposium on Molecular Cell Biology of macrophages 2010
  • Place of Presentation: Kumamoto Parea Hall (Kumamoto)
• [Presentation] Corosolic acidのマクロファージ活性化制御作用について (2010)
  • Author(s): 藤原章雄, 菰原義弘、池田剛、坂下直実、竹屋元裕
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] CD163 as a marker for M2 macrophages in human tissues (2010)
  • Author(s): Takeya M, et al.
  • Organizer: CD163 AND INFLAMMATION, WORKSHOP2010
  • Place of Presentation: The Sandbjerg Estate, Denmark(招待講演)
• [Presentation] Significance of M2 macrophage infiltration in human malignant tumors Symposium 6 : Tumor Microenvironments (2010)
  • Author(s): Komohara Y, et al.
  • Organizer: 18th International Symposium on Molecular Cell Biology of macrophages 2010
  • Place of Presentation: Kumamoto Parea Hall, Kumamoto, Japan(招待講演)
• [Presentation] Suppression of TLR4-mediated inflammatory response by macrophage class A scavenger receptor(CD204) (2010)
  • Author(s): Ohnishi K, et al.
  • Organizer: 18th International Symposium on Molecular Cell Biology of macrophages 2010
  • Place of Presentation: Kumamoto Parea Hall, Kumamoto, Japan
• [Presentation] Translocation of ACAT1 from ER to late endosomal associated membranes in cholesterol-rich human macrophage (2010)
  • Author(s): Lei X, et al.
  • Organizer: 18th International Symposium on Molecular Cell Biology of macrophages 2010
  • Place of Presentation: Kumamoto Parea Hall, Kumamoto, Japan
• [Presentation] Involvement of M2 macrophages in the ascites of advanced epithelial ovarian cancer in tumor progression via Stat3 activation (2010)
  • Author(s): Takaishi K, et al.
  • Organizer: 18th International Symposium on Molecular Cell Biology of macrophages 2010
  • Place of Presentation: Kumamoto Parea Hall, Kumamoto, Japan
• [Presentation] マクロファージの活性化制御による生活習慣病治療戦略シンポジウム2「体質改善を主眼においた最新の生活習慣病治療法開発」 (2010)
  • Author(s): 竹屋元裕
  • Organizer: 第60回日本体質医学会総会
  • Place of Presentation: 熊本パレアホール、熊本(招待講演)
• [Presentation] 脳原発悪性リンパ腫におけるマクロファージ浸潤と臨床予後に関する解析 (2010)
  • Author(s): 菰原義弘, 他
  • Organizer: 第50回日本リンパ網内系学会総会
  • Place of Presentation: 朱鷺メッセ(新潟コンベンションセンター)、新潟
• [Presentation] 腎淡明細胞癌におけるM2マクロファージの解析 (2010)
  • Author(s): 大西紘二, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] 肝内胆管癌におけるM2マクロファージの役割 (2010)
  • Author(s): Horlad Hasita, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] Corosolic acidのマクロファージ活性化制御作用について (2010)
  • Author(s): 藤原章雄, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] Stat3を介したグリオーマ細胞とマクロファージの細胞間相互作用 (2010)
  • Author(s): 菰原義弘, 他
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] CD204 (class A scavenger receptor)はToll-like receptor 4のMyD88依存性及び非依存性シグナル伝達経路を抑制する (2009)
  • Author(s): 大西紘二、菰原義弘、藤原章雄、坂下直実、清田恵美、竹村健一、竹屋元裕
  • Organizer: 第49回日本リンパ網内系学会総会
  • Place of Presentation: 淡路夢舞台国際会議場(淡路島)
• [Presentation] 腫瘍内浸潤マクロファージにおけるCD204 (class A scavenger receptor)発現の意義 (2009)
  • Author(s): 菰原義弘、竹村健一、坂下直実、竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] CD204(クラスAスカベンジャー受容体)はMyD88依存性と非依存性のTLR4シグナル伝達経路を抑制する (2009)
  • Author(s): 大西紘二、菰原義弘、藤原章雄、竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] M2 anti-inflammatory macrophage phenotype and tumor microenvironment (2009)
  • Author(s): 竹屋元裕, 菰原義弘
  • Organizer: The Third Japanese-Chinese Symposium of Pathology
  • Place of Presentation: Shandon, China
• [Presentation] Effect of natural compounds on human macrophage activation (2009)
  • Author(s): Fujiwara Y, Komohara Y, Ikeda T, Sakashita N, Takeya M
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: Tokyo 京王プラザホテル
• [Presentation] CD204(class A scavenger receptor)は Toll-like receptor 4のMyD88依存性及び非依存性シグナル伝達経路を抑制する (2009)
  • Author(s): 大西紘二, 菰原義弘, 藤原章雄, 坂下直実, 清田恵美, 竹村健一, 竹屋元裕
  • Organizer: 第49回日本リンパ網内系学会総会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫)
• [Presentation] ランゲルハンス細胞組織球症に浸潤するM2マクロファージはIL-10の分泌を介して腫瘍細胞の増殖を抑制する (2009)
  • Author(s): 大西紘二, 菰厚義弘, 坂下直実, 猪山賢一, 村山寿彦, 竹屋元裕
  • Organizer: 第19回日本樹状細胞研究会
  • Place of Presentation: 淡路夢舞台国際会議場(兵庫)
• [Presentation] 血管免疫芽球性T細胞リンパ腫(AILT)におけるM2マクロファージの腫瘍内浸潤は予後不良となる (2009)
  • Author(s): 新野大介, 菰原義弘, 村山寿彦, 木村芳三, 青木良祐, 清水桂, 杉田保雄, 竹屋元裕, 大島孝一
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] 腫瘍内浸潤マクロファージにおけるCD204(class A scavenger receptor)発現の意義 (2009)
  • Author(s): 菰原義弘, 竹村健一, 坂下直実, 竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] CD204(クラスAスカベンジャー受容体)はMyD88依存性と非依存性のTLR4シグナル伝達経路を抑制する (2009)
  • Author(s): 大西紘二, 菰原義弘, 藤原章雄, 竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] 卵巣癌進行期の腹腔内微小環境におけるマクロファージの役割 (2009)
  • Author(s): 高石清美, 菰原義弘, 竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] クラスAスカベンジャー受容体(CD204)による破骨細胞分化制御の解析 (2009)
  • Author(s): 竹村健一, 坂下直実, 藤原章雄, 菰原義弘, 雷小峰, 大西紘二, 水田博志, 竹屋元裕
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 京都国際会館
• [Presentation] 炎症制御におけるマクロファージのオルタナティブ活性化とクラスAスカベンジャー受容体[ワークショップ1:炎症研究の新しい展開] (2008)
  • Author(s): 竹屋元裕
  • Organizer: 第97回日本病理学会
  • Place of Presentation: 石川県立音楽堂(金沢)
  • Year and Date: 2008-05-15
• [Presentation] 炎症制御におけるマクロファージのオルタナティブ活性化とクラスAスカベンジャー受容体[ワークショップ1 : 炎症研究の新しい展開] (2008)
  • Author(s): 竹屋元裕
  • Organizer: 第97回日本病理学会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-15
• [Remarks] ホームページ等
• [Remarks] 熊本大学・大学院生命科学研究部・細胞病理学分野
  • URL: http://www.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html
• [Remarks]
  • URL: http://srv02.medic.kumamoto-u.ac.jp/dept/patho2/patho2.html