| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Research Abstract |
Pericellular proteolysis has critical roles in homeostasis and disease progression in multicellular organisms. We analyzed roles for hepatocyte growth factor activator inhibitor type 1(HAI-1), a membrane-bound serine protease inhibitor expressed on the epithelial cell surface, and its target proteases(HGF activator, matriptase, etc) in processing of pericellular bioactive molecules, epithelial integrity, carcinogenesis and cancer progression. Our data uncovered critical roles of HAI-1 in normal regulated keratinization of epidermal keratinocytes, formation of hair cuticle and intestinal epithelial integrity. We also found that HAI-1 may be an important suppressor of epithelial carcinogenesis and cancer invasion.
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