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Development of novel diagnosis and therapy against human oncogene hWAPL

Research Project

Project/Area Number 20390116
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionTokyo Medical University

Principal Investigator

KURODA Masahiko  Tokyo Medical University, 医学部, 主任教授 (80251304)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
KeywordshWAPL / 子宮頚癌 / miRNA / 分子標的治療 / 細胞診 / siRNA
Research Abstract

Human WAPL (hWAPL) gene is human homologue of wings apart-like (wapl) gene which encodes a protein that regulates heterochromatin structure of Drosophilia. Our previous study demonstrated that the novel human gene hWAPL showed the unscheduled high level expression in cervical dysplasia and carcinoma. In addition, NIH3T3 cells overexpressing hWAPL developed into tumours upon injection into nude mice, suggesting that hWAPL plays a significant role in cervical carcinogenesis and tumour progression as an oncogene. Because the repression of hWAPL by RNA interference (RNAi) using small interfering RNA (siRNA) decrease the tumor growth, the possibility that it becomes the target of the molecular target therapy is assumed. We identified the microRNA which regulated the expression of hWAPL gene this time. These microRNAs bound to 3'UTR of hWAPL gene and were shown to participate in repression of hWAPL mRNA and protein. We push forward analysis more and will investigate usefulness of the treatment of uterine cervical cancer with microRNA in future.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (106 results)

All 2011 2010 2009 2008 Other

All Journal Article (41 results) (of which Peer Reviewed: 41 results) Presentation (55 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (7 results)

  • [Journal Article] Anthocyanidins-enriched bilberry extracts inhibit 3T3-L1 adipocyte differentiation via the insulin pathway.2011

    • Author(s)
      Suzuki R, Tanaka M, Takanashi M, Hussain A, Yuan B, Toyoda H, Kuroda M
    • Journal Title

      Nutr Metab (Lond). 8

      Pages: 14-14

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families.2011

    • Author(s)
      Murakami Y, Toyoda H, Tanaka M, Kuroda M, Harada Y, Matsuda F, Tajima A, Kosaka N, Ochiya T, Shimotohno K
    • Journal Title

      PLoS One. 6(1)

    • NAID

      120002871278

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Impact of Down-regulated Plasma miR-92a Levels in Non-Hodgkin's Lymphoma.2011

    • Author(s)
      Ohyashiki K, Umezu T, Yoshizawa S, Ito Y, Ohyashiki M, Kawashima H, Tanaka M, Kuroda M, Ohyashiki JH
    • Journal Title

      PLoS ONE. 6(2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families.2011

    • Author(s)
      Murakami Y
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Impact of Down-regulated Plasma miR-92a Levels in Non-Hodgkin's Lymphoma.2011

    • Author(s)
      Ohyashiki K
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact on cell to plasma ratio of miR-92a in patients with acute leukemia : in vivo assessment of cell to plasma ratio of miR-92a.2010

    • Author(s)
      Ohyashiki JH, Umezu T, Kobayashi C, Hamamura RS, Tanaka M, Kuroda M, Ohyashiki K
    • Journal Title

      BMC Res Notes. 3

      Pages: 347-347

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development.2010

    • Author(s)
      Shigoka M, Tsuchida A, Matsudo T, Nagakawa Y, Saito H, Suzuki Y, Aoki T, Murakami Y, Toyoda H, Kumada T, Bartenschlager R, Kato N, Ikeda M, Takashina T, Tanaka M, Suzuki R, Oikawa K, Takanashi M, Kuroda M
    • Journal Title

      Pathol Int. 60(5)

      Pages: 351-357

    • NAID

      10029331782

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of Experimental Autoimmune Uveoretinitis by Inducing Differention of Regulatory T Cells via Activation of Aryl Hydrocarbon Receptor.2010

    • Author(s)
      Zhang L, Ma J, Takeuchi M, Usui Y, Hattori T, Okunuki Y, Yamakawa N, Kezuka T, Kuroda M, Goto H
    • Journal Title

      Investigative Ophthalmology & Visual Science. 51(4)

      Pages: 2109-2117

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.2010

    • Author(s)
      Iejima D, Minegishi Y, Takenaka K, Siswanto A, Watanabe M, Huang L, Watanabe T, Tanaka F, Kuroda M, Gotoh N
    • Journal Title

      Oncogene. 29(21)

      Pages: 3087-3099

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective Effect of Imatinib Mesylate in Non-BCR-ABL-expressing Cells and Autophagosome Formation.2010

    • Author(s)
      Ohtomo T, Miyazawa K, Naito M, Moriya S, Kuroda M, Itoh M, Tomoda A
    • Journal Title

      BBRC. 391(1)

      Pages: 310-315

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells.2010

    • Author(s)
      Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, Umezawa K, Tojo A, Aburatani Hand Gotoh N
    • Journal Title

      British journal of cancer. 102(1)

      Pages: 206-212

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact on cell to plasma ratio of miR-92a in patients with acute leukemia : in vivo assessment of cell to plasma ratio of miR-92a.2010

    • Author(s)
      Ohyashiki JH
    • Journal Title

      BMC Res Notes

      Volume: 3 Pages: 347-347

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development.2010

    • Author(s)
      Shigoka M
    • Journal Title

      Pathology International

      Volume: 60 Pages: 351-357

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.2010

    • Author(s)
      Iejima D
    • Journal Title

      Oncogene

      Volume: 29 Pages: 3087-3099

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of Experimental Autoimmune Uveoretinitis by Inducing Differentiation of Regulatory T Cells via Activation of Aryl Hydrocarbon Receptor.2010

    • Author(s)
      Zhang L
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 51 Pages: 2109-2117

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.2010

    • Author(s)
      Iejima D
    • Journal Title

      Oncogene (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptor.2010

    • Author(s)
      Zhang L
    • Journal Title

      Invest Ophthalmol Vis Sci. 51

      Pages: 2109-2117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective Effect of Imatinib Mesylate in Non-BCR-ABL-expressing Cells and Autophagosome Formation.2010

    • Author(s)
      Ohtomo T
    • Journal Title

      Biochem Biophys Res Commun 1

      Pages: 310-315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells.2010

    • Author(s)
      Murohashi M
    • Journal Title

      British journal of cancer 5

      Pages: 206-212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma.2009

    • Author(s)
      Yamamoto Y, Kosaka N, Tanaka M, Koizumi F, Kanai Y, Mizutani T, Murakami Y, Kuroda M, Miyajima A, Kato T, Ochiya T
    • Journal Title

      Biomarkers. 14(7)

      Pages: 529-538

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mucinous Carcinoma of the Rectosigmoid Colon, Transforming from a Pedunculated (Ip type) Polypoid Cancer in about One Year, Report of a Case.2009

    • Author(s)
      Higuchi R, Nakamura F, Matsuura Y, Hattori K, Suda H, Kawazaki H, Ohta A, Kuroda M, Matsubayashi J
    • Journal Title

      Stomach and Intestine (Tokyo). 44(11)

      Pages: 1777-1784

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis.2009

    • Author(s)
      Xu M, Takanashi M, Oikawa K, Tanaka M, Nishi H, Isaka K, Kudo M, Kuroda M
    • Journal Title

      Biochem Biophys Res Commun. 388(2)

      Pages: 366-371

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic silencing of an endogenous gene by the siRNA cream in an arthritis model mouse.2009

    • Author(s)
      Takanashi M, Oikawa K, Sudo K, Tanaka M, Fujita K, Kasper R, Matsuzaki M, Kuoda M
    • Journal Title

      Gene Therapy. 16(8)

      Pages: 982-989

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients.2009

    • Author(s)
      Tanaka M, Oikawa K, Takanashi M, Kudo M, Ohyashiki J, Ohyashiki K, Kuroda M
    • Journal Title

      PloS ONE 4(5)

    • NAID

      120005341007

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] HPly epigenetically regulates cell differentiation and exhibits potential as a therapeutic target for various types of cancers.2009

    • Author(s)
      Takanashi M, Oikawa K, Fujita K, Kudo M, Kinoshita M, Kuroda M
    • Journal Title

      Am J Pathol. 174(1)

      Pages: 309-316

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Environmental Chemicals on Cell Division and Chromosomal Positioning.2009

    • Author(s)
      Oikawa K
    • Journal Title

      Reproductive Immunology and Biology 24

      Pages: 70-76

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma.2009

    • Author(s)
      Yamamoto Y
    • Journal Title

      Biomarkers 14

      Pages: 529-538

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis.2009

    • Author(s)
      Xu M
    • Journal Title

      Biochem Biophys Res Commun 14

      Pages: 529-538

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic silencing of an endogenous gene by the siRNA cream in an arthritis model mouse.2009

    • Author(s)
      Takanashi M
    • Journal Title

      Gene Therapy 16

      Pages: 982-989

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Dioxin on Vascular Endothelial Growth Factor(VEGF) Production in the Retina Associated with Chroidal Neavascularization.2009

    • Author(s)
      Takeuvhi A
    • Journal Title

      Invest Ophthalmol Vis Sci. 50

      Pages: 3410-3416

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of miR-92 in human plasma is a novel marker foracute leukemia patients.2009

    • Author(s)
      Tanaka M
    • Journal Title

      PloS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dioxin promotes vascular endothelial growth factor (VEGF) production in the retina and enhances choroidal neovascularization.2009

    • Author(s)
      Takeuchi A
    • Journal Title

      Invest. Ophthalmol. Vis. Sci. in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic silencing of an endogenous gene by the siRNA cream in an arthritis model mouse.2009

    • Author(s)
      Takanashi M
    • Journal Title

      Gene Therapy in press

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HP1γ epigenetically regulates cell differentiation and exhibits potential as a therapeutic target for various types of cancers.2009

    • Author(s)
      Takanashi M
    • Journal Title

      Am J Pathol 174

      Pages: 309-316

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of G-protein-coupled receptor kinase 4 is associated with breast cancer tumorigenesis.2008

    • Author(s)
      Matsubayashi J, Takanashi M, Oikawa K, Mingli Xu, Mukai K, Kuroda M, Mukai K
    • Journal Title

      J Pathol. 216

      Pages: 317-327

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia.2008

    • Author(s)
      Oikawa K, Akiyoshi A, Tanaka M, Takanashi M, Nishi H, Isaka K, Kiseki H, Idei T, Tsukahara Y, Hashimura N, Mukai K, Kuroda M
    • Journal Title

      Gene. 423(1)

      Pages: 57-62

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor.2008

    • Author(s)
      Oikawa K, Yoshida K, Takanashi M, Tanabe H, Kiyuna T, Ogura M, Saito A, Umezawa A, Kuroda M
    • Journal Title

      Biochem Biophys Res Commun. 374(2)

      Pages: 361-364

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of G-protein-coupled receptor kinase 4 is associated with breast cancer tumorigenesis.2008

    • Author(s)
      Matsubayashi J
    • Journal Title

      J Pathol 216

      Pages: 317-327

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia.2008

    • Author(s)
      Oikawa K
    • Journal Title

      Gene 423

      Pages: 57-62

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor.2008

    • Author(s)
      Oikawa K
    • Journal Title

      Biochem Biophys Res Commun 374

      Pages: 361-364

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development.

    • Author(s)
      Shigoka M
    • Journal Title

      Pathology International. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ビルベリー抽出液による脂肪分化阻害効果2010

    • Author(s)
      鈴木理英子
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] The PRG4 variants associated with sarcoma development have a potential to be therapeutic targets.2010

    • Author(s)
      Kosuke Oikawa
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] microRNAプロファイルとC型慢性肝炎へのインターフェロン治療効果2010

    • Author(s)
      田中正視
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 前立腺癌患者における血清マイクロRNA解析2010

    • Author(s)
      佐竹直哉
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌研究の新展開2010

    • Author(s)
      黒田雅彦
    • Organizer
      第165回東京医科大学医学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 髄間葉系幹細胞による皮膚炎モデルマウスへの症状の抑制効果について2010

    • Author(s)
      高梨正勝
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Potential roles of NF-kaooa B pathways in breast cancer-initiating cells.2010

    • Author(s)
      Kunihiko Hinohara
    • Organizer
      AACR, 101^<st> Annual Meeting
    • Place of Presentation
      Washington, DC USA
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development2010

    • Author(s)
      Masami Tanaka
    • Organizer
      AACR, 101^<st> Annual Meeting
    • Place of Presentation
      Washington, DC USA
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Deregulation of miR-92a expression is implicated in colon cancer development.2010

    • Author(s)
      Ohno S, Tanaka M, Suzuki R, Naraso, Go I, Fujita K, Takanashi M, Kuroda M.
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] エキソソーム内のマイクロRNAによる細胞間情報伝達効率2010

    • Author(s)
      田中正視、上田しのぶ、大野慎一郎、高梨正勝、柴田篤志、黒田雅彦
    • Organizer
      第33回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 大腸癌におけるmiR-17-92クラスターの解析2010

    • Author(s)
      那日蘇、呉偉紅、藤田浩司、松山永久、田中正視、鈴木理英子、高梨正勝、大野慎一郎、倉田厚、黒田雅彦
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] miR-92aの発現は大腸癌の増殖に関与する2010

    • Author(s)
      大野慎一郎、田中正視、鈴木理英子、那日蘇、呉偉紅、藤田浩司、高梨正勝、黒田雅彦
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] microRNAプロファィルとC型慢性肝炎へのインターフェロン治療効果2010

    • Author(s)
      田中正視、村上善基、下遠野邦忠、田嶋敦、高梨正勝、大野慎一郎、鈴木理英子、黒田雅彦
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] EGFR遺伝子を標的とするmiRNAの単離と解析2010

    • Author(s)
      山口学、大平達夫、黒田雅彦、田中正視、高梨正勝、大野慎一郎、片場寛明、吉田浩一、垣花昌俊、臼田実男、梶原直央、内田修、池田徳彦
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 骨髄間葉系幹細胞による皮膚炎モデルマウスへの症状の抑制効果について2010

    • Author(s)
      高梨正勝、須藤カツ子、石川章夫、黒田雅彦
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] LNA probeを用いたin situ hybridizationによるmiRNAの検出2010

    • Author(s)
      藤田浩司、田中正視、高梨正勝、黒田雅彦
    • Organizer
      第99回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Potential roles of NF kaooa B pathways in breast cancer-initiating cells.2010

    • Author(s)
      Hinohara K, Murohashi M, Kuroda M., Isagawa T, Tsuji S, Kobayashi S, Umezawa K, Tojo A, Aburatani H, Goto N
    • Organizer
      AACR, 101^<st> Annual Meeting
    • Place of Presentation
      Washington, DC USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development.2010

    • Author(s)
      Tanaka M, Tsuchida A, Shigoka M, Aoki T, Takashina T, Takanashi M, Murakami Y, Kuroda M.
    • Organizer
      AACR, 101^<st> Annual Meeting
    • Place of Presentation
      Washington, DC USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規バイオマーカーとしての血清中microRNA.2009

    • Author(s)
      田中正視
    • Organizer
      第32回日本分子生物学会年会(MBSJ2009)
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Oncofetal microRNA as a potential diagnostic marker for hepatocellular carcinoma.2009

    • Author(s)
      小坂展慶
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Autophagy Inducing Effect of Imatinib Mesylate in Non-BCR-ABL Expressing Cells along with Suppression of ER Stress.2009

    • Author(s)
      大友理
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular signatures of tumor-intiating cells in human breast cancer cell lines.2009

    • Author(s)
      室橋道子
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Down-regulation of miR- in human plasma is a novel marker for acureleukemia patients.2009

    • Author(s)
      田中正視
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] miRNAによる癌診断の臨床応用(招待講演)2009

    • Author(s)
      黒田雅彦
    • Organizer
      第1回日本RNA研究会
    • Place of Presentation
      広島
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 乳癌におけるG protein-coupled Receptor Kinase 4の役割とその関連分子の同定2009

    • Author(s)
      黒田雅彦、高梨正勝、工藤玄恵、松林純、長尾俊孝、斉藤彰、田伏洋、木下雅雄
    • Organizer
      第5回日本臨床プロテオーム研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-09
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Potential roles of NF-kB pathways in breast cancer-initiating cells.2009

    • Author(s)
      Hinohara K, Murohashi M, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, Umehara K, Tojo A, Aburatani H, Gotoh N
    • Organizer
      第32回日本分子生物学会年会(MBSJ2009)
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Circulating microRNAs in plasma as novel biomarkers.2009

    • Author(s)
      Tanaka M, Suzuki R, Murakami Y, Toyoda H,Matsudo T, Shigoka M, Tsutida A, Aoki T, Ohyashiki J, Ohyashiki K, Kuroda M.
    • Organizer
      第32回日本分子生物学会年会(MBSJ2009)
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] The chimeric oncoprotein TLS-CHOP represses the expression of an anticancer molecule through induction of specific microRNAs.2009

    • Author(s)
      Oikawa K, Tanaka M, Ito S, Takanashi M, Uetani K, Muragaki Y, Kuroda M.
    • Organizer
      第32回日本分子生物学会年会(MBSJ2009)
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Therapic silencing of an endogenous gene by siRNA cream in an arthritis model mouse.2009

    • Author(s)
      Takanashi M, Oikawa K, Sudo K, Tanaka M, Nakae S, Kuroda M.
    • Organizer
      第32回日本分子生物学会年会(MBSJ2009)
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Bilberry extract inhibits adipocyte diffentiation.2009

    • Author(s)
      Suzuki R, Tanaka M, Toyoda H, Kuroda M.
    • Organizer
      第32回日本分子生物学会年会(MBSJ2009)
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Down-regulation of miR-in human plasma is a novel marker for acure leukemia patients.2009

    • Author(s)
      Talcnaka M, Oikawa K, Ohyashiki K, Ohyashiki J, Kuroda M.
    • Organizer
      68^<th> Annual Meeting ofthe Japanese Cancer Association.
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Molecular signatures of tumor-intiating cells in human breast cancer cell lines.2009

    • Author(s)
      Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Aburatani H, Gotoh N
    • Organizer
      68^<th> Annual Meeting of the Japanese Cancer Association.
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Oncofetal microRNA as a potential diagnostic marker for hepatocellularcarcinoma.2009

    • Author(s)
      Kosaka N, Yamamoto Y, Murakami Y, Kuroda M, Ochiya T
    • Organizer
      68^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Autophagy Inducing Effect of Imatinib Mesylate in Non-BCR-ABL Expressing Cells along with Suppression of ER Stress.2009

    • Author(s)
      Ohtomo T, Miyazawa K, Kuroda M, Tomoda A
    • Organizer
      68^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト血漿におけるmiR-92の下方制御は急性白血病の新規マーカーである2009

    • Author(s)
      田中正視、及川恒輔、大屋敷一馬、大屋敷純子、黒田雅彦
    • Organizer
      日本癌学会総会記事(0546-0476)68回Page145
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of Dioxin on Vascular Endothelial Growth Factor(VEGF) Production in the Retina Associated with Chroidal Neavascularization.2009

    • Author(s)
      Takeuchi A, Takeuchi M, Oikawa K, Sonoda K, Usui Y, Okunuki Y, Takeda A, Oshima Y, Yoshida K, Usui M, Goto H, Kuroda M.
    • Organizer
      Invest Ophthalmol Vis Sci.(50(7) : 3410-6)
    • Related Report
      2010 Final Research Report
  • [Presentation] miRNAによる癌診断の臨床応用2009

    • Author(s)
      黒田雅彦
    • Organizer
      第1回日本RNAi研究会
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] A functional genomic screen identifies a role of USP15 and Septin 10 in spindle-checkpoint and Paclitaxel-resistance in human cancers.2009

    • Author(s)
      Xu M, Takanashi M, Oikawa K, Tanaka M, Nishi H, Isaka K, Kudo M, Kuroda M.
    • Organizer
      AACR, 100^<th> Annual Meeting
    • Place of Presentation
      Denver, Colorado USA
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Therapeutic Silencing of an Endogenous Gene by the siRNA Cream in an Arthritis model Mouse.2009

    • Author(s)
      黒田雅彦
    • Organizer
      KEYSTONE SYMPOSIA on Molecular and Cellular Biology, Therapeutic Modulation of RNA Using Oligonucleotides
    • Place of Presentation
      Canada
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Ip型ポリープから発育伸展した直腸粘液癌の1例2008

    • Author(s)
      樋口良太、可児希、橋本剛、戸田隆洋、中村文彦、松浦良徳、服部克哉、須田浩晃、太田昭彦、剛崎寛徳、黒田雅彦
    • Organizer
      早期胃癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-18
    • Related Report
      2010 Final Research Report
  • [Presentation] I p型ポリープから発育伸展した直腸粘液癌の1例2008

    • Author(s)
      黒田雅彦
    • Organizer
      早期胃癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脂肪細胞分化に関与するmicroRNAの探索2008

    • Author(s)
      鈴木理英子、及川恒輔、田中正視、高梨正勝、黒田雅彦
    • Organizer
      第31回日本分子生物学会年会(BMB2008)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] ヒト子宮頸部病変におけるWAPL遺伝子の多様な選択的スプライシングバリアントの発現2008

    • Author(s)
      及川恒輔、秋好歩美、田中正視、高梨正勝、黒田雅彦
    • Organizer
      第31回日本分子生物学会年会(BMB2008)
    • Place of Presentation
      神戸
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia.2008

    • Author(s)
      Oikawa K, Takanashi M, Kuroda M
    • Organizer
      67^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Analysis of tumor initiating cells/cancer stem cells in human breast cancer cell lines.2008

    • Author(s)
      Murohashi M, Kuroda M, Kobayashi S, Tojo A, Gotoh N
    • Organizer
      67^<th> Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Nagoya
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] HP1γ epigenetically regulates cell differentiation and exhibits potential as a therapeutic target for various types of cancers.2008

    • Author(s)
      Takanashi M, Oikawa K, Fujita K, Gotoh N, Kuroda M.
    • Organizer
      AACR-NCI-EORTC Symposium Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 軟部腫瘍の病理診断における免疫組織化学の新展開2008

    • Author(s)
      黒田雅彦、及川恒輔、服部宏行、山本謙吾、向井清
    • Organizer
      第41回日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      浜松
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 粘液型脂肪肉腫とPRG4の各スプライシングバリアントとの関わり2008

    • Author(s)
      鈴木理英子、及川恒輔、高梨正勝、黒田雅彦、向井清
    • Organizer
      第97回日本病理学会
    • Place of Presentation
      石川県
    • Related Report
      2010 Final Research Report
  • [Presentation] 粘液型及び円形細胞型脂肪肉腫におけるTLS-CHOPキメラ癌タンパク質の癌細胞増殖制御機構2008

    • Author(s)
      及川恒輔、高梨正勝、黒田雅彦、向井清
    • Organizer
      第97回日本病理学会
    • Place of Presentation
      石川県
    • Related Report
      2010 Final Research Report
  • [Presentation] 研究費申請書の書き方のポイント2008

    • Author(s)
      向井清、黒田雅彦
    • Organizer
      第97回日本病理学会
    • Place of Presentation
      石川県(特別発言)
    • Related Report
      2010 Final Research Report
  • [Presentation] FRS2beta adaptor is a novel tumor suppressor for breast cancer by attenuating ErbB signaling.2008

    • Author(s)
      Watanabe T, Kuroda M, Gotoh N
    • Organizer
      AACR, Annual meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] ヒト子宮頚部病変におけるWAPL遺伝子の多様な選択的スプライシングバリアントの発現2008

    • Author(s)
      黒田雅彦
    • Organizer
      第31回日本分子生物学会年会(BMB2008)
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Presentation] 粘液型脂肪肉腫とPRG4の各スプライシングバリアントとの関わり2008

    • Author(s)
      黒田雅彦
    • Organizer
      第97回日本病理学会
    • Place of Presentation
      石川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 粘液型及び円形細胞型脂s肪肉腫におけるTLS-CHOP キメラ癌タンパク質の癌細胞増殖制御機構2008

    • Author(s)
      黒田雅彦
    • Organizer
      第97回日本病理学会
    • Place of Presentation
      石川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 研究費申請書の書き方のポイント2008

    • Author(s)
      黒田雅彦
    • Organizer
      第97回日本病理学会
    • Place of Presentation
      石川
    • Related Report
      2008 Annual Research Report
  • [Book] がん転移研究の実験手法 転移研究を目的とした組織アレイの作製法2008

    • Author(s)
      済木育夫, 愛甲 孝
    • Publisher
      (株)金芳堂
    • Related Report
      2008 Annual Research Report
  • [Book] 研修医のための病理マニュアル2008

    • Author(s)
      梅澤明弘, 黒田雅彦, 大喜多肇
    • Publisher
      (株)診断と治療社
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.tokyo-med.ac.ip/molpathol/

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 新規な癌遺伝子、該癌遺伝子由来の組換えタンパク質、およびそれらの用途2011

    • Inventor(s)
      黒田雅彦、齋藤彰
    • Industrial Property Rights Holder
      東京医科大学、日本電気(株)
    • Acquisition Date
      2011-02-22
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 新規な癌遺伝子、該癌遺伝子由来の組換えタンパク質、およびそれらの用途2010

    • Inventor(s)
      黒田雅彦、齋藤彰
    • Industrial Property Rights Holder
      東京医科大学、日本電気(株)
    • Acquisition Date
      2010-06-09
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 発現ベクター、それを用いたキャリアの製造方法およびその用途2010

    • Inventor(s)
      黒田雅彦
    • Industrial Property Rights Holder
      黒田雅彦
    • Industrial Property Number
      2010-292542
    • Filing Date
      2010-12-28
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] キャリア、その製造方法およびその用途2010

    • Inventor(s)
      黒田雅彦
    • Industrial Property Rights Holder
      黒田雅彦
    • Industrial Property Number
      2009-262938
    • Filing Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規な癌遺伝子、該癌遺伝子由来の組換えタンパク質、およびそれらの用途2008

    • Inventor(s)
      黒田雅彦、齋藤彰
    • Industrial Property Rights Holder
      東京医科大学、日本電気(株)
    • Acquisition Date
      2008-10-07
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 新規な癌遺伝子、該癌遺伝子由来の組換えタンパク質、およびそれらの用途2008

    • Inventor(s)
      黒田雅彦、齋藤彰
    • Industrial Property Rights Holder
      東京医科大学、日本電気(株)
    • Acquisition Date
      2008-07-15
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 乳癌のマーカー、検査方法および検査用キット2008

    • Inventor(s)
      黒田雅彦
    • Industrial Property Rights Holder
      黒田雅彦
    • Industrial Property Number
      2008-119280
    • Filing Date
      2008-04-30
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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