| Project/Area Number |
20390120
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Osaka University |
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Principal Investigator |
TANABE Kazuyuki Osaka University, 微生物病研究所, 招へい教授 (40047410)
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| Co-Investigator(Kenkyū-buntansha) |
YASUNAGA Teruo 大阪大学, 微生物病研究所, 教授 (20260630)
KAWAI Satoru 獨協医科大学, 医学部, 准教授 (70275733)
HAYAKAWA Toshiyuki 京都大学, 霊長類研究所, 特任助教 (80418681)
SAWAI Hiromi 東京大学, 大学院・医学研究科, 特任研究員 (60377124)
TOYAMA Tomoko 大阪大学, 微生物病研究所, 特任研究員 (40456934)
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| Research Collaborator |
TACHIBANA Shin-Ichiro 大阪大学, 微生物病研究所, 特任研究員 (90414630)
NAKAMURA Shota 大阪大学, 微生物病研究所, 特任助教 (90432434)
GOTO Naohisa 大阪大学, 微生物病研究所, 助教 (60448157)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2008: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
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| Keywords | マラリア / 三日熱マラリア原虫 / サルマラリア原虫 / ゲノム / 進化 / 寄生 / ゲノム解読 / Plasmodium cynomolgi / Plasmodium vivax / 比較ゲノム解析 |
|---|
| Research Abstract |
Plasmodium vivax infects only humans, although it is closely related to Old World monkey malaria parasites. In order to reveal genetic backgrounds of host switch and human infection of P. vivax, genome sequencing of P. cynomolgi and comparative genomic analyses were performed. Results revealed that about 10% of genes of the genomes are species-specific and belong to multigene families. Intriguingly, the number of genes in the DBP and RBP families, which encode parasite's ligands for the recognition of host erythrocytes, differed between P. vivax and related monkey malaria parasites.
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