Molecular basis of immune evasion of malaria parasites
Project/Area Number |
20390121
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Parasitology (including Sanitary zoology)
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Research Institution | Kyushu University |
Principal Investigator |
HISAEDA Hajime Kyushu University, 大学院・医学系研究科, 教授 (50243689)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|
Keywords | マラリア / 制御性T細胞 / TLR9 / 赤血球 / CD8T細胞 / 防御免疫 / 免疫回避 / 腸管寄生性蠕虫 / 病原性 / 寄生適応 / マラリア原虫 / 樹状細胞 |
Research Abstract |
Mechanisms underlying immune evasion due to activation of regulatory T cells during blood-stage malaria have been carefully analyzed. Stimulation of dendritic cells with parasitized red blood cells through TLR9 resulted in activation of regulatory T cells. Furthermore, mice deficient in TLR9 were partially resistant to lethal malaria because of a failure of activating regulatory T cells. It was suggested that hemozoin, malaria pigment, is involved in activation of regulatory T cells as TLR9 ligand. We also analyzed "suppressed" protective immunity to malaria, and found protective roles of CD8 T cells previously supposed to be unlike to contribute to protection to blood-stage malaria.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Development of experimental cerebral malaria is independent of IL-23 and IL-17.2010
Author(s)
Ishida H, Matsuzaki-Moriya C, Imai T, Yanagisawa K, Nojima Y, Suzue K, Hirai M, Iwakura Y, Yoshimura A, Hamano S, Shimokawa C, Hisaeda H
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Journal Title
Biochem. Biophys. Res.Commun. 402
Pages: 790-795
Related Report
Peer Reviewed
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[Journal Article] Involvement of CD8^+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain.2010
Author(s)
Imai T, Shen J, Chou B, Duan X, Tu L, Tetsutani K, Moriya C, Ishida H, Hamano S, Shimokawa C, Hisaeda H, Himeno K
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Journal Title
Eur.J.Immunol. 40
Pages: 1053-1061
Related Report
Peer Reviewed
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[Journal Article] Critical role for immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection.2009
Author(s)
Tu L, Moriya C, Imai T, Ishida H, Tetsutani K, Duan X, Murata S, Tanaka K, Shimokawa C, Hisaeda H, Himeno K
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Journal Title
Eur.J.Immunol. 39
Pages: 3385-3394
Related Report
Peer Reviewed
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[Journal Article] Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.2008
Author(s)
Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
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Journal Title
J Immunol 180
Pages: 2496-2503
Related Report
Peer Reviewed
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