Mechanisms of Helicobacter pylori infection and inflammation in gastric mucosa

• Project/Area Number: 20390123
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: The University of Tokyo
• Principal Investigator: MIMURO Hitomi The University of Tokyo, 医科学研究所, 講師 (80396887)
• Co-Investigator(Kenkyū-buntansha): OGAWA Michinaga 東京大学, 医科学研究所, 助教 (80361624)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 細菌 / 感染 / 微生物 / ヘリコバクターピロリ

Research Abstract

The aim of this study was to obtain a comprehensive understanding of the mechanisms underlying Helicobacter pylori-induced inflammation. We focused on three aspects of the interplay between H. pylori and the host : macroscopic, macrophages and dendritic cells, and peyer's patch analyses. As a result, we found that H. pylori modulates both bacteria and host adherence factors during the course of infection in vivo.

Research Products

• [Journal Article] Autophagy targeting of Listeria monocytogenes and the bacterial countermeasure. (2011)
  • Author(s): Ogawa M, Yoshikawa Y, Mimuro H, Hain T, Chakraborty T, Sasakawa C.
  • Journal Title: Autophagy. 7(3) Pages: 310-314
  • Peer Reviewed
• [Journal Article] Shigella deploy multiple countermeasures against host innate immune responses. (2011)
  • Author(s): Ashida H, Ogawa M, Kim M, Suzuki S, Sanada T, Punginelli C, Mimuro H, Sasakawa C.
  • Journal Title: Curr Opin Microbiol. 14(1) Pages: 16-23
  • Peer Reviewed
• [Journal Article] Reinforcement of epithelial cell adhesion to basement membrane by a bacterial pathogen as a new infectious stratagem. (2010)
  • Author(s): Kim M, Ogawa M, Mimuro H, Sasakawa C.
  • Journal Title: Virulence. 1(1) Pages: 52-55
  • Peer Reviewed
• [Journal Article] Bacterial interactions with the host epithelium. (2010)
  • Author(s): Kim M, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Sasakawa C.
  • Journal Title: Cell Host Microbe. 8(1) Pages: 20-35
  • Peer Reviewed
• [Journal Article] The bacterial eftector Cif interferes with SCF ubiquitin hgase function by inhibiting deneddylation of Cullinl (2010)
  • Author(s): Morikawa, H., et al.
  • Journal Title: Biochem. Biophys. Res.Commun. Volume: 401 Pages: 268-274
  • Peer Reviewed
• [Journal Article] Autophagy targeting Listeris monocytogenes and the bacterial countermeasure. (2010)
  • Author(s): Ogawa, M., et al.
  • Journal Title: Autophagy Volume: 7(掲載確定)
  • Peer Reviewed
• [Journal Article] Reinforcement of epithelial cell adhesion to basement membrane by a bacterial pathogen as a new infectious stratagem. (2010)
  • Author(s): Kim, M., et al.
  • Journal Title: Virulence Volume: 12 Pages: 52-55
  • Peer Reviewed
• [Journal Article] Shigella deploy multiple countermeasures against host innate immune responses. (2010)
  • Author(s): A.shida, H., et al.
  • Journal Title: Curr Opin Microbiol Volume: 14 Pages: 16-23
  • Peer Reviewed
• [Journal Article] Bacterial interactions with the host epithelium : bacterial countermeasures that disrupt intrinsic epithelial barrier function. (2010)
  • Author(s): Kim, M., et al.
  • Journal Title: Cell Host Microbe Volume: 8 Pages: 20-35
  • Peer Reviewed
• [Journal Article] Shigella infection of intestinal epithelium and circumvention of the host innate defense system. (2009)
  • Author(s): Ashida H, Ogawa M, Mimuro H, Sasakawa C.
  • Journal Title: Curr Top Microbiol Immunol. 337 Pages: 231-255
  • Peer Reviewed
• [Journal Article] Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN. (2009)
  • Author(s): Nagamatsu K, Kuwae A, Konaka T, Nagai S, Yoshida S, Eguchi M, Watanabe M, Mimuro H, Koyasu S, Abe A.
  • Journal Title: J Exp Med. 206(13) Pages: 3073-3088
  • Peer Reviewed
• [Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition. (2009)
  • Author(s): Yoshikawa Y, Ogawa M, Hain T, Yoshida M, Fukumatsu M, Kim M, Mimuro H, Nakagawa I, Yanagawa T, Ishii T, Kakizuka A, Sztul E, Chakraborty T, Sasakawa C.
  • Journal Title: Nat Cell Biol. 11(10) Pages: 1233-1240
  • Peer Reviewed
• [Journal Article] Strategy of Helicobacter pylori to enhance colonization of the stomach. (2009)
  • Author(s): Mimuro H.Nippon Saikingaku Zasshi.
  • Journal Title: 64(2-4) Pages: 311-317
  • NAID: 10027208568
• [Journal Article] Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. (2009)
  • Author(s): Suzuki M, Mimuro H, Kiga K, Fukumatsu M, Ishijima N, Morikawa H, Nagai S, Koyasu S, Gilman RH, Kersulyte D, Berg DE, Sasakawa C.
  • Journal Title: Cell Host Microbe. 5(1) Pages: 23-34
  • Peer Reviewed
• [Journal Article] Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. (2009)
  • Author(s): Bronte-Tinkew DM, Terebiznik M, Franco A, Ang M, Ahn D, Mimuro H, Sasakawa C, Ropeleski MJ, Peek RM Jr, Jones NL.
  • Journal Title: Cancer Res. 69(2) Pages: 632-639
  • Peer Reviewed
• [Journal Article] Shigella infection of intestinal epithelium and circumvention of the host innate defense system. (2009)
  • Author(s): Ashida, H., et al.
  • Journal Title: Curr.Top.Microbiol.Immunol. 337 Pages: 231-255
  • Peer Reviewed
• [Journal Article] Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN. (2009)
  • Author(s): Nagamatsu, K., et al.
  • Journal Title: J.Exp. Med. 206 Pages: 3073-3088
  • Peer Reviewed
• [Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition. (2009)
  • Author(s): Yoshikawa, Y., et al.
  • Journal Title: Nat. Cell Biol. 11 Pages: 1233-1240
  • Peer Reviewed
• [Journal Article] Strategy of Helicobacter pylori to enhance colonization of the stomach. (2009)
  • Author(s): Mimuro, H.
  • Journal Title: Nippon Saikingaku Zasshi 64 Pages: 311-317
  • NAID: 10027208568
• [Journal Article] Helicobacter pylori-induced interleukin-12 p40 expression. (2009)
  • Author(s): Takeshima, E., et al.
  • Journal Title: Infect. Immun. 77 Pages: 1337-1348
  • Peer Reviewed
• [Journal Article] Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo. (2009)
  • Author(s): Bronte-Tinkew, D.M. et al.
  • Journal Title: Cancer Res. 69 Pages: 632-639
  • Peer Reviewed
• [Journal Article] NF-kappaB activation by Helicobacter pylori requires Akt-med iated phosphorylation of p65. (2009)
  • Author(s): Takeshima, E. et al
  • Journal Title: BMC Microbiol. 9 Pages: 36-45
  • Peer Reviewed
• [Journal Article] Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation. (2008)
  • Author(s): Suzuki M, et al.
  • Journal Title: Cell Host Microbe 5 Pages: 23-34
  • Peer Reviewed
• [Journal Article] Helicobacter pyloriの胃上皮感染戦略と.病原因子CagAの生物活性 (2008)
  • Author(s): 三室仁美
  • Journal Title: Helicobacter Research 12 Pages: 259-265
• [Presentation] Regulation of bacterial colonization on gastric epithelium by Helicobacter pylori virulence factors (2010)
  • Author(s): 三室仁美, et al.
  • Organizer: 第10回あわじしま感染症・免疫フォーラム (The 10th Awaji International Forum on Infection and Immunity)
  • Place of Presentation: 淡路夢舞台国際会議場, 兵庫県
  • Year and Date: 2010-09-08
• [Presentation] Regulation of bacterial colonization on gastric epithelium by Helicobacter pylon virulence factors (2010)
  • Author(s): Mimuro, H., et al.
  • Organizer: 第10回あわじしま感染症・免疫フォーラム(The 10th Awaji International Forum on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2010-09-08
• [Presentation] Effect of Helicobacter pylori's BabA adhesion on the pathogenicity in gastric epithelial cells (2010)
  • Author(s): 三室仁美, et al.
  • Organizer: 第10回日韓国際微生物学シンポジウム(The 10th Japan-Korea international symposium on microbiology, JKISM10)
  • Place of Presentation: パシフィコ横浜, 神奈川県
  • Year and Date: 2010-03-26
• [Presentation] Effect of Helicobacter pylori's BabA adhesion on the pathoge nicity in gastric epithelial cells (2010)
  • Author(s): Mimuro, H., et al.
  • Organizer: 第10回日韓国際微生物学シンポジウム(The 10th Japan-Korea international symposium on microbiology,JKISM10)
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-03-26
• [Presentation] Helicobacter pyloriの宿主感染戦略 (2009)
  • Author(s): 三室仁美
  • Organizer: 第92回日本細菌学会関東支部総会
  • Place of Presentation: 東京医科歯科大学, 東京都
  • Year and Date: 2009-11-06
• [Presentation] Helicobcter pyloriの宿主感染戦略 (2009)
  • Author(s): 三室仁美
  • Organizer: 第92回日本細菌学会関東支部総会
  • Place of Presentation: 東京医科歯科大学5号館講堂
  • Year and Date: 2009-11-06
• [Presentation] ヘリコバクターピロリ菌の宿主感染機構 (2009)
  • Author(s): 三室仁美, 笹川千尋
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: 大宮ソニックシティ, 埼玉県
  • Year and Date: 2009-05-16
• [Presentation] ヘリコバクターピロリ菌の宿主感染機構 (2009)
  • Author(s): 三室仁美, 笹川千尋
  • Organizer: 第56回日本実験動物学会総会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2009-05-16
• [Presentation] Control of epithelial cell by Helicobacter pylori infection (2009)
  • Author(s): 三室仁美, et al.
  • Organizer: 15th International Workshop on Campylobacter, Helicobacter, and related organisms (CHRO2009)
  • Place of Presentation: 朱鷺メッセ(新潟コンベンションセンター), 新潟市
• [Presentation] Control of Gastric Epithelial Cell by Helicobacter pylori infection (2009)
  • Author(s): 三室仁美, et al.
  • Organizer: American Society for Microbiology 109th General Meeting
  • Place of Presentation: ペンシルヴァニアコンベンションセンター,U.S.、ペンシルヴァニア州
• [Presentation] Control of gastric epithelial cell by Helicobacter pylori infection (2009)
  • Author(s): 三室仁美
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋国際会議場, 愛知県
• [Presentation] Control of epithelial cell by Helicobacter pylori infection (2009)
  • Author(s): Mimuro, H., et al.
  • Organizer: 15th International Workshop on Campylobacter, Helicobacter, and related organisms(CHR02009)
  • Place of Presentation: 朱鷺メッセ(新潟コンベンションセンター)、新潟市
• [Presentation] Control of Gastric Epithelial Cell by Helicobacter pylori in fection (2009)
  • Author(s): Mimuro, H., et al.
  • Organizer: American Society for Microbiology 109th General Meeting
  • Place of Presentation: ペンシルヴァニア コンベンションセンター, U.S.、ペンシルヴァニア州
• [Presentation] Control of gastric epithelial cell by infection (2009)
  • Author(s): 三室仁美
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Helicobacter pylori adaptive strategy to inffamed stomach via stimulation of IL lapha nuclear translocation in macrophage (2008)
  • Author(s): Nagamatsu, Kanna et al.
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji Yumebutai International Conference Center (あわじ夢舞台)
• [Presentation] Helicobacter pylori Dampens Gut Epithelial Self-Renewal by Inhibiting Apoptosis, a Bacterial Strategy to Enhance Colonization of the Stomach (2008)
  • Author(s): Mimuro, Hitomi et al.
  • Organizer: 9th Korea-Japan International Symposium on Microbiology (KJISM)
  • Place of Presentation: Seoul Kyoyuk Munhwa Hoekwan, Korea
• [Presentation] Control of gastric epithelium by Helicobacter pylori infection (2008)
  • Author(s): Mimuro, Hitomi
  • Organizer: 第3回感染症国際シンポジウム3rd symposium on emerging and reemerging infectious diseases
  • Place of Presentation: 東京大学医科学研究所
• [Presentation] Helicobacter pylori感染胃粘膜上皮細胞およびT細包におけるIL-12 p40発現機構(Helicobacter pylori-inuced interleukin-12 p40 expression in gastric enithelial cells and T cells) (2008)
  • Author(s): Takeshima, Eriko et al.
  • Organizer: 第38回、日本免疫学会総会・学術集会
  • Place of Presentation: 国立京都国際会館
• [Remarks] ホームページ等
  • URL: http://www.ims.u-tokyo.ac.jp/bac/hp/mainpage.html
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/bac/hp/mainpage.html