Metagenomic diagnosis of bacterial infections
| Project/Area Number |
20390128
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Osaka University |
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Principal Investigator |
IIDA Tetsuya Osaka University, 微生物病研究所, 特任教授 (90221746)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 次世代シーケンサ / 細菌感染症 / 迅速診断法 / 検出 / 下痢症 / 診断 / メタゲノム |
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| Research Abstract |
We have been applying so-called "high-throughput DNA sequencers" to the analysis of infectious diseases, especially enteric bacterial infections. The approach is in principle a method that does not depend on the type of target pathogens, so that it is possible to analyze various microorganisms with a single common protocol. The approach enables us to conduct an unbiased analysis of dynamics of the pathogen and associated microbiota in human specimens during the course of infectious diseases.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Direct Metagenomic Detection of Viral Pathogens in Nasal and Fecal Specimens using an Unbiased High-throughput Sequencing Approach.2009
Author(s)
Nakamura S., Yang C.-S., Sakon N., Ueda M., Tougan T., Yamashita A., Goto N., Takahashi K., Yasunaga T., Ikuta K., Mizutani T., Okamoto Y., Tagami M., Morita R., Maeda N., Kawai J., Hayashizaki Y., Nagai Y., Horii T., Iida T., Nakaya T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Metagenomic diagnosis of bacterial infections.2008
Author(s)
Nakamura, S., Maeda, N., Miron, I.M., Yoh, M., Izutsu, K., Kataoka, C., Honda, T., Yasunaga, T., Nakaya, T., Kawai, J., Hayashizaki, Y., Horii, T., Iida T.
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Journal Title
Emerg.Infect.Dis. 14
Pages: 1784-1786
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Peer Reviewed
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[Book] Direct Metagenomic Detection of Viral Pathogens in Human Specimens using an Unbiased High-throughput Sequencing Approach. In: Handbook of Molecular Microbial Ecology II: Metagenomics in Different Habitats(Ed. Frans J. de Bruijn. Wiley-Blackwell)Hoboken, NJ, USA.2011
Author(s)
Nakaya T., Nakamura S., Okamoto Y., Nagai Y., Kawai J., Hayashizaki Y., Iida T., Horii, T.
Publisher
an imprint of John Wiley & Sons Ltd in press
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