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Metagenomic diagnosis of bacterial infections

Research Project

Project/Area Number 20390128
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionOsaka University

Principal Investigator

IIDA Tetsuya  Osaka University, 微生物病研究所, 特任教授 (90221746)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords次世代シーケンサ / 細菌感染症 / 迅速診断法 / 検出 / 下痢症 / 診断 / メタゲノム
Research Abstract

We have been applying so-called "high-throughput DNA sequencers" to the analysis of infectious diseases, especially enteric bacterial infections. The approach is in principle a method that does not depend on the type of target pathogens, so that it is possible to analyze various microorganisms with a single common protocol. The approach enables us to conduct an unbiased analysis of dynamics of the pathogen and associated microbiota in human specimens during the course of infectious diseases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (29 results)

All 2011 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 10 results) Presentation (11 results) Book (4 results)

  • [Journal Article] Metagenomic analysis of bacterial infections by means of high-throughput DNA sequencing.2011

    • Author(s)
      Nakamura S., Nakaya T., Iida T.
    • Journal Title

      Exp.Biol.Med. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metagenomic analysis of bacterial infections by means of high-throughput DNA sequencing2011

    • Author(s)
      Nakamura, S., Iida, T., et al.
    • Journal Title

      Exp.Biol.Med.

      Volume: (未定 印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 次世代シーケンサを用いた細菌感染症のメタゲノミック診断2010

    • Author(s)
      飯田哲也
    • Journal Title

      Medical Technology 38

      Pages: 227-229

    • Related Report
      2010 Final Research Report
  • [Journal Article] 次世代シーケンサを用いた細菌感染症のメタゲノミック診断2010

    • Author(s)
      飯田哲也
    • Journal Title

      Medical Technology

      Volume: 38 Pages: 227-229

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Two regulators of Vibrio parahaemolyticus play important roles in enterotoxicity by controlling the expression of genes in the Vp-PAI region.2010

    • Author(s)
      Kodama, et al.
    • Journal Title

      PLoS One 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Vibrio parahaemolyticus thermostable direct hemolysin with lipid rafts is essential for its exerting cytotoxic effect but not its he molvtic activity.2010

    • Author(s)
      Matsuda, et al.
    • Journal Title

      Infect.Immun. 78

      Pages: 603-610

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Metagenomic Detection of Viral Pathogens in Nasal and Fecal Specimens using an Unbiased High-throughput Sequencing Approach.2009

    • Author(s)
      Nakamura S., Yang C.-S., Sakon N., Ueda M., Tougan T., Yamashita A., Goto N., Takahashi K., Yasunaga T., Ikuta K., Mizutani T., Okamoto Y., Tagami M., Morita R., Maeda N., Kawai J., Hayashizaki Y., Nagai Y., Horii T., Iida T., Nakaya T.
    • Journal Title

      PLoS One 4

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 次世代シーケンサを用いた細菌感染症のメタゲノミック診断2009

    • Author(s)
      飯田哲也
    • Journal Title

      JVM 62

      Pages: 819-820

    • Related Report
      2010 Final Research Report
  • [Journal Article] 次世代シーケンサーを用いた微生物・感染症解析2009

    • Author(s)
      飯田哲也
    • Journal Title

      医学のあゆみ 231

      Pages: 180-181

    • NAID

      10029759115

    • Related Report
      2010 Final Research Report
  • [Journal Article] Genomic taxonomy of vibrios.2009

    • Author(s)
      Thompson, et al.
    • Journal Title

      BMC Evol.Biol. 9

      Pages: 258-258

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct metagenomic detect ion of viral pathogens in nasal and fecal specimens using an unbiased high-throughput seauencing approach2009

    • Author(s)
      Nakamura, et al.
    • Journal Title

      PLoS One 4

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metagenomic diagnosis of bacterial infections.2008

    • Author(s)
      Nakamura, S., Maeda, N., Miron, I.M., Yoh, M., Izutsu, K., Kataoka, C., Honda, T., Yasunaga, T., Nakaya, T., Kawai, J., Hayashizaki, Y., Horii, T., Iida T.
    • Journal Title

      Emerg.Infect.Dis. 14

      Pages: 1784-1786

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metagenomic diagnosis of bacterial infections2008

    • Author(s)
      Nakamura, et al.
    • Journal Title

      Emerg. Infect. Dis. 14

      Pages: 1784-1786

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential replication dynamics for large and smal1 Vibriochromosomes affect gene dosage, expression and location.2008

    • Author(s)
      Dryselius, et al.
    • Journal Title

      BMC Genomics 9

      Pages: 559-559

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 次世代DNAシーケンサの細菌感染症への応用2010

    • Author(s)
      飯田哲也
    • Organizer
      特別講演日本細菌学会中国四国支部総会
    • Place of Presentation
      松山大学
    • Year and Date
      2010-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 次世代DNAシーケンサの細菌感染症への応用2010

    • Author(s)
      飯田哲也
    • Organizer
      日本細菌学会中国四国支部総会
    • Place of Presentation
      松山大学(招待講演)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Metagenomic analysis of infectious diseases.2010

    • Author(s)
      飯田哲也
    • Organizer
      The 10th Japan-Korea International Symposium on Microbiology
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2010-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Metagenomic analysis of enteric infections.2010

    • Author(s)
      飯田哲也
    • Organizer
      14^<th> International Conference on Emerging Infectious Diseases in the Pacific Rim : Next Generation Diagnostics for Infectious Diseases.
    • Place of Presentation
      Penang, Malaysia
    • Related Report
      2010 Final Research Report
  • [Presentation] I believe in sequencing. Symposium : Future high-throughput microbiology laboratory.2010

    • Author(s)
      飯田哲也
    • Organizer
      20th ECCMID, European Cngress of Clinical Microbiology and Infectious Diseases
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2010 Final Research Report
  • [Presentation] Metagenomic analysis of intestinal microbiota in infections.国際シンポジウムGut defense and microbial infections2010

    • Author(s)
      飯田哲也
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Metagenomic diagnosis of infectious diseases.2009

    • Author(s)
      Tetsuya Iida
    • Organizer
      12^<th> ISTC-SAC Seminar -Combatine Global Infections-
    • Place of Presentation
      Irkutsk, Russia
    • Year and Date
      2009-09-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 次世代シーケンサを用いた感染症のメタゲノミツク診断2009

    • Author(s)
      飯田哲也
    • Organizer
      第3回日本ゲノム微生物学会
    • Place of Presentation
      中央大学理工学部
    • Year and Date
      2009-03-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 次世代シーケンサを用いた微生物・感染症解析2009

    • Author(s)
      飯田哲也
    • Organizer
      特別講演.日本微生物資源学会第16回大会
    • Place of Presentation
      大阪大学銀杏会館
    • Related Report
      2010 Final Research Report
  • [Presentation] Metagenomic diagnosis of infectious diseases.2009

    • Author(s)
      飯田哲也
    • Organizer
      12^<th> ISTC-SAC Seminar. Combating Global Infections-
    • Place of Presentation
      Irkutsk, Russia
    • Related Report
      2010 Final Research Report
  • [Presentation] Metagenomic approach for detection of bacterial pathogens.2008

    • Author(s)
      飯田哲也
    • Organizer
      2008 International Symposium & Annual Meeting of the Korean Society for Microbiology and Biotechnology.
    • Place of Presentation
      Seoul KyoYuk MunHwa HoeKwan, Seoul, Korea
    • Related Report
      2010 Final Research Report
  • [Book] Direct Metagenomic Detection of Viral Pathogens in Human Specimens using an Unbiased High-throughput Sequencing Approach. In: Handbook of Molecular Microbial Ecology II: Metagenomics in Different Habitats(Ed. Frans J. de Bruijn. Wiley-Blackwell)Hoboken, NJ, USA.2011

    • Author(s)
      Nakaya T., Nakamura S., Okamoto Y., Nagai Y., Kawai J., Hayashizaki Y., Iida T., Horii, T.
    • Publisher
      an imprint of John Wiley & Sons Ltd in press
    • Related Report
      2010 Final Research Report
  • [Book] Handbook of Molecular Microbial Ecology II : Metagenomics in Different Habitats2011

    • Author(s)
      Nakaya, T., Iida, T., et al.
    • Publisher
      Wiles-Blackwell(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] 次世代シークエンサーを用いた感染症の診断と解析メタゲノム解析技術の最前線2010

    • Author(s)
      中村昇太、中屋隆明、飯田哲也
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Final Research Report
  • [Book] メタゲノム解析技術の最前線2010

    • Author(s)
      中村昇太、飯田哲也、, 他
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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