Importance of host response for the development of chronic gastritis induced by infection with Helicobacter pylori.
Project/Area Number |
20390129
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Hyogo College of Medicine |
Principal Investigator |
TSUTSUI Hiroko Hyogo College of Medicine, 医学部, 教授 (40236914)
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Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Kenji 兵庫医科大学, 医学部, 教授 (60172350)
HAYASHI Shuhei 兵庫医科大学, 医学部, 講師 (40322185)
UCHIYAMA Ryousuke 兵庫医科大学, 医学部, 助教 (20456891)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 感染免疫 / ヘリコバクター・ピロリ / 好酸球 / インターロイキン33(IL-33) / IL-33 / 受容体 / 胃粘膜上皮細胞 / 好中球 / インターロイキン33 / ST2(IL-33受容体) / Toll様受容体 / カスパーゼ1 / NOD様受容体 / 胃上皮細胞 / 慢性感染 |
Research Abstract |
Helicobacter pylori is a Gram-negative, extracellular bacterium and is involved in the development of chronic gastritis and gastric cancer. We now know that the standard therapy against H.pylori using antibiotics and proton pomp inhibitor are beneficial for prevention of the gastric diseases. However, we have faced upon many cases that are resistant to the therapy and suffer from the re-infection. Here, we investigated whether and how host responses against H.pylori are involved in the development of those diseases. And we found that many eosinophils are infiltrated in the inflammatory sites of chronic gastritis in H. pylori-infected mice. Furthermore, IL-33, a potent cytokine triggering activation and recruitment of eosinophils via induction of IL-13/IL-5 and chemokines for eosinophils, is essentially required for the development of chronic gastritis. Indeed, Il33r^<-/-> mice are resistant to chronic gastritis induced by infection with H. pylori and are impaired in the clearance of the bacterium. These results indicated IL-33 as a potent target for protection against the chronic gastritis and plausibly gastric cancer.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] IFN-γ is a master regulator of endotoxin shock syndrome inmice primed with heat-killed Propionibacterium acnes.2010
Author(s)
Kawa, K., Tsutsui, H., Uchiyama, R., Kato, J., Matsui, K., Iwakura, Y., Matsumoto, T., Nakanishi, K.
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Journal Title
Int.Immunol. 22
Pages: 157-166
Related Report
Peer Reviewed
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[Journal Article] Neutrophil-dominant psoriasis-like inflammation induced by epidermal-specific expression of Raf in mice.2010
Author(s)
Tarutani, M., Imai, Y., Yasuda, K., Tsutsui, H., Nakanishi, K., Yamanishi K.
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Journal Title
J.Dermatol. Sci. 58
Pages: 28-35
Related Report
Peer Reviewed
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[Journal Article] Role of ASC in the mouse model of Helicobacter pylori infection.2009
Author(s)
Benoit, B.N., Kobayashi, M., Kawakubo, M., Takeoka, M., Sano, K., Zou, J., Itano, N., Tsutsui, H., Noda, T., Fukuda, M., Nakayama, J., Taniguchi, S.
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Journal Title
J.Histochem, Cytochem. 57
Pages: 327-338
Related Report
Peer Reviewed
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[Journal Article] Contribution of TIR domain-containing adapter inducing IFN-β-mediated IL-18 release to LPS-induced liver injury inmice.2009
Author(s)
Imamura, M., Tsutsui, H., Yasuda, K., Uchiyama, R., Yumikura-Futatsugi, S., Mitani, K., Hayashi, S., Akira, S., Taniguchi, S., Van Rooijen, N., Tschopp, J., Yamamoto, T., Fujimoto, J., Nakanishi, K.
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Journal Title
J.Hepatol. 51
Pages: 333-341
Related Report
Peer Reviewed
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[Journal Article] Contribution of TIR domain-containing adapter inducing IFN-β-mediated IL-18 release to LPS-induced liver injury in mice2009
Author(s)
Imamura, M., Tsutsui, H., Yasuda, K., Uchiyama, R., Yumikura-Futatsugi, S., Mitani, K., Hayashi, S., Akira, S., Taniguchi, S., Van Rooijen, N., Tschopp, J., Yamamoto, T., Fujimoto, J., Nakanishi K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Demonstration of cooperative contribution of MET- and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings2008
Author(s)
Seki E., Kondo, Y., Iimuro, Y., Naka, T., Son, G., Kishimoto, T., Fujimoto, J., Tsutsui, H., Nakanishi K.
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Journal Title
J. Hepatol. 48
Pages: 237-245
Related Report
Peer Reviewed
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[Journal Article] Vaginal infection with Ureaplasma urealyticum accounts for preterm delivery via induction of inflammatory responses2008
Author(s)
Harada, K., Tanaka, H., Komori, S., Tsuji, Y., Nagata, K., Tsutsui, H., Koyama K.
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Journal Title
Microbial. Immunol. 52
Pages: 297-304
Related Report
Peer Reviewed
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[Journal Article] Freshly isolated Langerhans cells negatively regulate naive T cell activation in response to peptide antigen through cell-to-cell contact2008
Author(s)
Imai, Y., Hayashi, N., Yasuda, K., Tsutsui, H., Mizutani, H., Nakanishi K.
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Journal Title
J. Dermatol. Sci. 51
Pages: 19-29
NAID
Related Report
Peer Reviewed
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[Journal Article] Role of ASC in the mouse model of Helicobacter pylori infection2008
Author(s)
Benoit, B. N., Kobayashi, M., Kawakubo, M., Takeoka, M., Sano, K., Zou, J., Itano, N., Tsutsui, H., Noda, T., Fukuda, M., Nakayama, J., Taniguchi, S.
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Journal Title
J. Histochem. Cytochem. 57
Pages: 327-338
Related Report
Peer Reviewed
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[Presentation] Requirement of MyD88 and TRIF but not ATP signaling for TLR4-mediated caspase-1 activation2008
Author(s)
Imamura, M., Tsutsui, H., Yasuda, K., Akira, S., Fujimoto, J., Nakanishi K.
Organizer
The 8^<th> Awaji International Forum on Infection and Immunity
Place of Presentation
兵庫
Related Report
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[Presentation] TLR3-dependent IFN-β production induced by commensal bacteria2008
Author(s)
Kosaka, A., Kawashima, T., Tsutsui, H., Kaisho, T., Uematsu, S., Saito, T., Nishimura, I., Tsuji N. M.
Organizer
第38回日本免疫学会総会・学術集会
Place of Presentation
京都
Related Report
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[Presentation] Vibrio vulnificus activates Nalp3 inflammasome via the synergistic action of pore formation toxins.2008
Author(s)
Toma, C., Higa, N., Nakasone, N., Koizumi, Y., McCoy, A. J., Ogura, Y., Tsutsui, H., Matsumoto, J., Franchi, L., Nunez, T., Suzuki, T.
Organizer
第38回日本免疫学会総会・学術集会
Place of Presentation
京都
Related Report
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[Presentation] Requirement of MyD88 and TRIF for TLR4-mediated caspase-1 activation2008
Author(s)
Imamura, M., Tsutsui, H., Yasuda, K., Akira, S., Fujimoto, J., Nakanishi K.
Organizer
第38回日本免疫学会総会・学術集会
Place of Presentation
京都
Related Report
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