|Budget Amount *help
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Using the real-time imaging system, we identified the site of HSV-1 final envelopment as trans-Golgi network. Moreover, we identified a binding partner of UL12, which is involved in nuclear egress pathway, as nucleolin and showed that nucleolin was required for efficient nuclear egress of HSV-1 capsids.