Analysis of efficacy of a vaccine inducing confined avirulent virus replication against immunodeficiency virus infection
| Project/Area Number |
20390131
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | National Institute of Infectious Diseases (2010)
The University of Tokyo (2008-2009) |
|---|
Principal Investigator |
MATANO Tetsuro National Institute of Infectious Diseases, エイズ研究センター, センター長 (00270653)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
|---|
| Keywords | ウイルス / 感染症 / ワクチン2HIV / エイズ / 細胞傷害性Tリンパ球 / エイズワクチン / DNAワクチン / 弱毒化生ワクチン / HIV / SIV / 変異 / サルエイズモデル / マウスレトロウイルス |
|---|
| Research Abstract |
We analyzed the effect of a prophylactic AIDS vaccine inducing confined replication of an avirulent virus on cytotoxic T lymphocyte (CTL) responses in macaques after simian immunodeficiency virus (SIV) challenge. Our analysis revealed that prophylactic vaccination results in dominant induction of vaccine antigen-specific CTL responses post-viral exposure but delays SIV non-vaccine antigen-specific CTL responses. These results imply a significant influence of prophylactic vaccination on CTL immunodominance post-viral exposure, providing insights into antigen design in development of a CTL-inducing AIDS vaccine.
|
Report
(4 results)
Research Products
(51 results)
-
-
-
[Journal Article] Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications2011
Author(s)
Saito A, Nomaguchi M, Iijima S, Kuroishi A, Yoshida T, Lee Y-J, Hayakawa T, Kono K, Nakayama EE, Shioda T, Yasutomi Y, Adachi A, Matano T, Akari H
-
Journal Title
Microbes Infect
Volume: 13
Pages: 58-64
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Diversity of MHC class I genes in Burmese-origin rhesus macaques2010
Author(s)
Naruse TK, Chen Z, Yanagida R, Yamashita T, Saito Y, Mori K, Akari H, Yasutomi Y, Miyazawa M, Matano T, Kimura A
-
Journal Title
Immunogenetics
Volume: 62
Pages: 601-611
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
