Analysis of efficacy of a vaccine inducing confined avirulent virus replication against immunodeficiency virus infection

• Project/Area Number: 20390131
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases (2010); The University of Tokyo (2008-2009)
• Principal Investigator: MATANO Tetsuro National Institute of Infectious Diseases, エイズ研究センター, センター長 (00270653)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000); Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
• Keywords: ウイルス / 感染症 / ワクチン2HIV / エイズ / 細胞傷害性Tリンパ球 / エイズワクチン / DNAワクチン / 弱毒化生ワクチン / HIV / SIV / 変異 / サルエイズモデル / マウスレトロウイルス

Research Abstract

We analyzed the effect of a prophylactic AIDS vaccine inducing confined replication of an avirulent virus on cytotoxic T lymphocyte (CTL) responses in macaques after simian immunodeficiency virus (SIV) challenge. Our analysis revealed that prophylactic vaccination results in dominant induction of vaccine antigen-specific CTL responses post-viral exposure but delays SIV non-vaccine antigen-specific CTL responses. These results imply a significant influence of prophylactic vaccination on CTL immunodominance post-viral exposure, providing insights into antigen design in development of a CTL-inducing AIDS vaccine.

Research Products

• [Journal Article] Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge. (2011)
  • Author(s): Takahara Y、Matano T, 他(責任著者)
  • Journal Title: Biochem Biophys Res Commun 408 Pages: 615-619
  • Peer Reviewed
• [Journal Article] Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications. Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications. (2011)
  • Author(s): Saito A、Matano T、Akari H, 他
  • Journal Title: Microbes Infect 13 Pages: 58-64
  • Peer Reviewed
• [Journal Article] Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications (2011)
  • Author(s): Saito A, Nomaguchi M, Iijima S, Kuroishi A, Yoshida T, Lee Y-J, Hayakawa T, Kono K, Nakayama EE, Shioda T, Yasutomi Y, Adachi A, Matano T, Akari H
  • Journal Title: Microbes Infect Volume: 13 Pages: 58-64
  • NAID: 120002723147
  • Peer Reviewed
• [Journal Article] A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins. (2010)
  • Author(s): Inagaki N、Matano T, 他(責任著者)
  • Journal Title: Retrovirology 7 Pages: 90-90
  • Peer Reviewed
• [Journal Article] Broadening of CD8^+ cell responses in vaccine-based simian immunodeficiency virus controllers. (2010)
  • Author(s): Iwamoto N、Matano T, 他(責任著者)
  • Journal Title: AIDS 24 Pages: 2777-2787
  • Peer Reviewed
• [Journal Article] Diversity of MHC class I genes in Burmese-origin rhesus macaques. (2010)
  • Author(s): Naruse TK、Matano T、Kimura A, 他
  • Journal Title: Immunogenetics 62 Pages: 601-611
  • Peer Reviewed
• [Journal Article] Neutralizing antibodies in SIV control : co-impact with T cells. (2010)
  • Author(s): Yamamoto H、Matano T(責任著者)
  • Journal Title: Vaccine 28S
  • Peer Reviewed
• [Journal Article] Broadening of CD8^+ cell responses in vaccine-based simian immunodeficiency virus controllers (2010)
  • Author(s): Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T
  • Journal Title: AIDS Volume: 24 Pages: 2777-2787
  • Peer Reviewed
• [Journal Article] A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins. (2010)
  • Author(s): Inagaki N, Takeuchi H, Yokoyama M, Sato H, Ryo A, Yamamoto H, Kawada M, Matano T
  • Journal Title: Retrovirology Volume: 7 Pages: 90-90
  • Peer Reviewed
• [Journal Article] Neutralizing antibodies in SN control : co-impact with T cells (2010)
  • Author(s): Yamamoto H, Matano T
  • Journal Title: Vaccine Volume: 28S
  • Peer Reviewed
• [Journal Article] Diversity of MHC class I genes in Burmese-origin rhesus macaques (2010)
  • Author(s): Naruse TK, Chen Z, Yanagida R, Yamashita T, Saito Y, Mori K, Akari H, Yasutomi Y, Miyazawa M, Matano T, Kimura A
  • Journal Title: Immunogenetics Volume: 62 Pages: 601-611
  • Peer Reviewed
• [Journal Article] Neutralizing antibodies in SIV control : co-impact with T cells (2010)
  • Author(s): Hiroyuki Yamamoto, et al.
  • Journal Title: Vaccine (accepted, in press)
  • Peer Reviewed
• [Journal Article] Impact of cytotoxic-T-lymphocyte memory induction without virus-specific CD4+ T-cell help on control of a simian immunodeficiency virus challenge in rhesus macaques. (2009)
  • Author(s): Tsukamoto T、Matano T, 他(責任著者)
  • Journal Title: J Virol 83 Pages: 9339-9346
  • Peer Reviewed
• [Journal Article] Polyfunctional CD4^+ T-cell induction in neutralizing antibody-triggered control of simian immunodeficiency virus infection. (2009)
  • Author(s): Yamamoto T、Matano T, 他(責任著者)
  • Journal Title: J Virol 83 Pages: 5514-5524
  • Peer Reviewed
• [Journal Article] Impact of cytotoxic-T-lymphocyte memory induction without virus-specific CD4+ T-cell help on control of a simian immunodeficiency virus challengein rhesus macaques (2009)
  • Author(s): Tetsuo Tsukamoto, et al.
  • Journal Title: J.Virol. 83 Pages: 9339-9346
  • Peer Reviewed
• [Journal Article] Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques. (2008)
  • Author(s): Takeda A、Matano T, 他(責任著者)
  • Journal Title: Vaccine 26 Pages: 6839-6843
  • Peer Reviewed
• [Journal Article] Gag-specific cytotoxic T lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial. (2008)
  • Author(s): Kawada M、Matano T, 他(責任著者)
  • Journal Title: J Virol 82 Pages: 10199-10206
  • Peer Reviewed
• [Journal Article] Gag-specific cytotoxic T lymphocyte-based control of primary simian immunodeficiency virus replication in a vaccine trial (2008)
  • Author(s): Miki Kawada, et al.
  • Journal Title: J.Virol. 82 Pages: 10199-10206
  • Peer Reviewed
• [Journal Article] Evaluation of the immunogenicity of replication-competent V-knocked-out and replication-defective F-deleted Sendai virus vector-based vaccines in macaques (2008)
  • Author(s): Akiko Takeda, et al.
  • Journal Title: Vaccine 26 Pages: 6839-6843
  • Peer Reviewed
• [Presentation] エイズワクチン開発:HIV感染症克服への挑戦 (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第24回日本エイズ学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] エイズワクチン開発:HIV感染症克服への挑戦 (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第24回日本エイズ学会学術集会
  • Place of Presentation: グランドプリンスホテル高輪(東京都)
  • Year and Date: 2010-11-26
• [Presentation] エイズワクチン開発:国際共同臨床試験プロジェクト (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第13回ヒューマンサイエンス総合研究ワークショップ
  • Place of Presentation: 国際研究交流会館国際会議場(東京都)
  • Year and Date: 2010-11-25
• [Presentation] サルエイズモデルにおけるHAART実施前後のCTL反応の比較 (2010)
  • Author(s): 高原悠佑、松岡佐織、石井洋、堀池麻里子、三浦智行、五十嵐樹彦、俣野哲朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-08
• [Presentation] 自然感染で優位なGag特異的CTLが誘導されないMHC-Iハプロタイプ共有サル群におけるGag特異的CTL誘導ワクチン効果の解析 (2010)
  • Author(s): 高橋尚史、石井洋、高原悠佑、成瀬妙子、木村彰方、俣野哲朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-08
• [Presentation] サルエイズモデルにおけるHAART実施前後のCTL反応の比較 (2010)
  • Author(s): 高原悠佑、松岡佐織、石井洋、堀池麻里子、三浦智行、五十嵐樹彦、俣野哲朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2010-11-08
• [Presentation] 自然感染で優位なGag特異的CTLが誘導されないMHC-Iハプロタイプ共有サル群におけるGag特異的CTL誘導ワクチン効果の解析 (2010)
  • Author(s): 高橋尚史、石井洋、高原悠佑、成瀬妙子、木村彰方、俣野哲朗
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: あわぎんホール(徳島市)
  • Year and Date: 2010-11-08
• [Presentation] The effect of prophylactic vaccination on CTL dominancy post-SIV exposure in rhesus macaques (2010)
  • Author(s): Matano T
  • Organizer: 11th Kumamoto AIDS Seminar
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル(阿蘇市)
  • Year and Date: 2010-10-07
• [Presentation] Alteration of CTL dominancy post-viral exposure by prophylactic AIDS vaccination (2010)
  • Author(s): Ishii H, Matano T
  • Organizer: AIDS Vaccine 2010
  • Place of Presentation: Omni Hotel at CNN Center(アトランタ市)
  • Year and Date: 2010-09-30
• [Presentation] Functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins (2010)
  • Author(s): Inagaki N, Takeuchi H, Matano T
  • Organizer: The 10th Awaji International Fonun on Infection and Immunity
  • Place of Presentation: 淡路夢舞台国際会議場(淡路市)
  • Year and Date: 2010-09-08
• [Presentation] Vaccine-based simian immunodeficiency virus controllers acquire broader CD8^+ cell responses able to suppress multiple escape mutant virus replication. (2010)
  • Author(s): Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-26
• [Presentation] Vaccine-based simian immunodeficiency virus controllers acquire broader CD8^+cell responses able to suppress multiple escape mutant virus replication (2010)
  • Author(s): Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-26
• [Presentation] Vaccine-based SIV control in a group of Burmese rhesus macaques sharing a MHC class I haplotype. (2010)
  • Author(s): 俣野哲朗
  • Organizer: 9th International Veterinary Immunology Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-08-19
• [Presentation] Vaccine-based SIV control in a grop of Burmese rhesus macaques sharing a MHC class I haplotype (2010)
  • Author(s): Matano T
  • Organizer: 9th International Veterinary Immunology Symposium
  • Place of Presentation: Tower Hall Funabori(東京都)
  • Year and Date: 2010-08-19
• [Presentation] Induction of broad CD8 cell responses effective against replication of a variant virus with multiple escape mutations in simian immunodeficiency virus controllers (2010)
  • Author(s): Iwamoto N, Tsukamoto T, Kawada M, Takeda A, Yamamoto H, Takeuchi H, Matano T
  • Organizer: VIII International A-DS Conference
  • Place of Presentation: Messe Wien(ウィーン市)
  • Year and Date: 2010-07-22
• [Presentation] The effect of prophylactic vaccination on CTL dominancy post-SIV exposure in rhesus macaques. (2010)
  • Author(s): 俣野哲朗
  • Organizer: 11th Kumamoto AIDS Seminar
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 2010-07-10
• [Presentation] センダイウイルスベクターを用いたエイズワクチン開発 (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-17
• [Presentation] センダイウイルスベクターを用いたエイズワクチン開発 (2010)
  • Author(s): 俣野哲朗
  • Organizer: 第26回日本DDS学会
  • Place of Presentation: 大阪国際交流センター(大阪市)
  • Year and Date: 2010-06-17
• [Presentation] Dynamics of cytotoxic T lymphocyte responses in simian immunodeficiency virus controllers. (2010)
  • Author(s): 俣野哲朗
  • Organizer: 2nd Symposium of the IMSUT & RCAST Global COE
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2010-03-02
• [Presentation] ビルマ産アカゲザルSIV感染により誘導されるCTLエピトープの探索 (2009)
  • Author(s): 高原悠佑、武内寛明、石井洋、高橋尚史、三浦智行、五十嵐樹彦、俣野哲朗
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] ピルマ産アカゲザルSIV感染により誘導されるCTLエピトープの探索 (2009)
  • Author(s): 高原悠佑, 他
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] Immunogenicity of an intranasal Sendai virus vector vaccine. (2009)
  • Author(s): 俣野哲朗
  • Organizer: Japan-France Vaccine and Infectious Diseases Workshop
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2009-10-10
• [Presentation] Immunogenicity of an intranasal Sendai virus vector vaccine (2009)
  • Author(s): Tetsuro Matano
  • Organizer: Japan-France Vaccine and Infectious Diseases Workshop
  • Place of Presentation: Osaka
  • Year and Date: 2009-10-10
• [Presentation] Effect of vaccine-induced memory T cells on HIV/SIV replication after virus exposure. (2009)
  • Author(s): 俣野哲朗
  • Organizer: The 9th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji, Japan
  • Year and Date: 2009-09-11
• [Presentation] Effect of vaccine-induced memory T cells on HIV/SIV replication aftervirus exposure (2009)
  • Author(s): Tetsuro Matano
  • Organizer: The 9th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji
  • Year and Date: 2009-09-11
• [Presentation] CTLのエイズウイルス複製抑制効果:サルエイズモデルにおける解析 (2009)
  • Author(s): 俣野哲朗
  • Organizer: 京都大学ウイルス研究所シンポジウム「霊長類を用いた生命科学研究」
  • Place of Presentation: 京都
  • Year and Date: 2009-02-18
• [Presentation] Induction of functional T-cell responses in neutralizing antibody-triggered SIV control. (2008)
  • Author(s): Matano T, Yamamoto T, Iwamoto N, Yamamoto H, Kawada M
  • Organizer: The 26th Annual Symposium on Nonhuman Primate Models for AIDS
  • Place of Presentation: San Juan, Puerto Rico
  • Year and Date: 2008-12-12
• [Presentation] サルエイズモデルにおける宿主MHC遺伝子多型の細胞性免疫誘導ワクチン効果への影響の解析 (2008)
  • Author(s): 桑野哲矢、川田真幹、塚本徹雄、岩本南、井上誠、飯田章博、朱亜峰、長谷川護、俣野哲朗
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2008-10-28
• [Presentation] Impact of vaccine-induced Gag-specific CTL responses on SIV control (2008)
  • Author(s): 桑野哲矢
  • Organizer: The 9th Kumamoto AIDS Seminar
  • Place of Presentation: Kumamoto
  • Year and Date: 2008-09-19
• [Book] 次世代ワクチンの産業技術応用(神谷齊監修)(エイズワクチン開発の問題点) (2010)
  • Author(s): 中根拓、俣野哲朗
  • Publisher: シーエムシー出版
• [Book] 臨床粘膜免疫学(清野宏編集)(AIDS) (2010)
  • Author(s): 塚本徹雄、俣野哲朗
  • Publisher: シナジー
• [Remarks] ホームページ等
  • URL: http://square.umin.ac.jp/arc/