| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Research Abstract |
From the Genome-Wide Association Study of human genetic polymorphisms of HIV-1-infected and non-HIV-1-infected individuals, we were able to identify several single nucleotide polymorphisms which are potentially involved in natural HIV-1 resistance. Furthermore, we have shown that the anti-retroviral factor TRIM5 ・binds to TAB2, which also binds to a signal transducer TAK1. These host factors involved in HIV-1 replication may be potential targets for developing novel anti-HIV-1 therapy.
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