Tracking the intracellular dynamics of HIV-1 proteins

• Project/Area Number: 20390136
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: RYO Akihide National Institute of Infectious Diseases, 医学研究科, 教授 (20363814)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Naoki 国立感染症研究所, エイズ研究センター, センター長 (00094053)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: ヒト免疫不全ウイルス / エイズ / 宿主因子 / 細胞内輸送 / レトロウイルス / 翻訳後修飾 / タンパク質輸送 / 細胞 / HIV

Research Abstract

Human immunodeficiency virus type 1 (HIV-1) utilizes the macromolecular machinery of the infected host cell to produce progeny virus. We have identified suppressor of cytokine signaling 1 (SOCS1) as a host factor that positively regulates the intracellular trafficking and stability of HIV-1 Gag. SOCS1 can directly bind to Gag and enhance its stability and trafficking, resulting in the efficient production of HIV-1 particles. We found also that SOCS1 can enhance the ubiqtuitintion of Gag and facilitate its interaction with microtubule network. These findings will be useful for developing a new anti-HIV therapy.

Research Products

• [Journal Article] Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G. (2011)
  • Author(s): Sugiyama R, Nishitsuji H, Furukawa A, Katahira M, Habu Y, Takeuchi H, Ryo A, Takaku H.
  • Journal Title: J Biol Chem. 286(12) Pages: 10051-10057
• [Journal Article] Vaccination with human induced pluripotent stem cells creates an antigen-specific immune response against HIV-1 gp160. (2011)
  • Author(s): Yoshizaki S, Nishi M, Kondo A, Kojima Y, Yamamoto N, Ryo A.
  • Journal Title: Frontiers in Microbiology 2 Pages: 27-27
• [Journal Article] A distinct role for Pin1 in the induction and maintenance of pluripotency. (2011)
  • Author(s): Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A.
  • Journal Title: J Biol Chem 286(13) Pages: 11593-11603
• [Journal Article] Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G (2011)
  • Author(s): Sugiyama R
  • Journal Title: J Biol Chem Volume: 286(12) Pages: 10051-7
  • Peer Reviewed
• [Journal Article] Vaccination with human induced pluripotent stem cells creates an antigen-specific immune response against HIV-1 gp160 (2011)
  • Author(s): 吉崎慎二
  • Journal Title: Frontiers in Microbiology Pages: 2-27
  • Peer Reviewed
• [Journal Article] A distinct role for Pin1 in the induction and maintenance of pluripotency (2011)
  • Author(s): 西真由子
  • Journal Title: J Biol Chem Volume: 286(13) Pages: 11593-603
  • Peer Reviewed
• [Journal Article] HIV感染と宿主因子-エイズ制圧にむけて (2011)
  • Author(s): 梁明秀
  • Journal Title: 横浜医学 Volume: 62 Pages: 35-41
  • NAID: 40018817247
  • Peer Reviewed
• [Journal Article] A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins. (2010)
  • Author(s): Inagaki N, Takeuchi H, Yokoyama M, Sato H, Ryo A, Yamamoto H, Kawada M, Matano T.
  • Journal Title: Retrovirology 7 Pages: 90-90
• [Journal Article] Pinning down viral proteins : A new prototype for virus-host cell interaction. (2010)
  • Author(s): Kojima Y, Ryo A.
  • Journal Title: Frontiers in MICROBIOLOGY. 1 Pages: 107-107
• [Journal Article] DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity. (2010)
  • Author(s): Shimada M, Yoshizaki S, Jounai N, Kondo A, Ichino M, Ryo A, Okuda K.
  • Journal Title: Vaccine. 28(31) Pages: 4920-4927
• [Journal Article] Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML. (2010)
  • Author(s): Pulikkan JA, Dengler V, Peer Zada AA, Kawasaki A, Geletu M, Pasalic Z, Bohlander SK, Ryo A, Tenen DG, Behre G.
  • Journal Title: Leukemia. 24(5) Pages: 914-923
• [Journal Article] Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells. (2010)
  • Author(s): Yashima S, Yoshizaki S, Shinoda K, Yoshida A, Kondo A, Mizuguchi H, Ryo A, Okuda K, Shimada M.
  • Journal Title: Vaccine. 28(18) Pages: 3257-3264
• [Journal Article] A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins (2010)
  • Author(s): Inagaki N
  • Journal Title: Retrovirology Pages: 7-90
  • Peer Reviewed
• [Journal Article] Pinning down viral proteins : A new prototype for virus-host cell interaction (2010)
  • Author(s): 小島良績
  • Journal Title: Frontiers in MICROBIOLOGY Pages: 1-107
  • Peer Reviewed
• [Journal Article] DNA vaccine expressing HIV-1 gp120/immunoglobulin fusion protein enhances cellular immunity (2010)
  • Author(s): 島田勝
  • Journal Title: Vaccine Volume: 28(31) Pages: 4920-27
  • Peer Reviewed
• [Journal Article] Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML (2010)
  • Author(s): Pulikkan JA
  • Journal Title: Leukemia Volume: 24(5) Pages: 914-23
  • Peer Reviewed
• [Journal Article] Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells (2010)
  • Author(s): 八島さやか
  • Journal Title: Vaccine Volume: 28(18) Pages: 3257-64
  • Peer Reviewed
• [Journal Article] Pin1 promotes transforming growth factor-beta-induced migration and in vasion (2010)
  • Author(s): Matsuura Isao
  • Journal Title: The journal of biological chemistry 285 Pages: 1754-1764
  • Peer Reviewed
• [Journal Article] Postinfection passive transfer of KD-247 protects against simian/human immunodeficiency virus-induced CD4+ T-cell loss in macaque lymphoid tissue. (2009)
  • Author(s): Murakami T, Eda Y, Nakasone T, Ami Y, Someya K, Yoshino N, Kaizu M, Izumi Y, Matsui H, Shinohara K, Yamamoto N, Honda M.
  • Journal Title: AIDS. 23(12) Pages: 1485-1494
• [Journal Article] The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection : comparative studies with AMD3100. (2009)
  • Author(s): Murakami T, Kumakura S, Yamazaki T, Tanaka R, Hamatake M, Okuma K, Huang W, Toma J, Komano J, Yanaka M, Tanaka Y, Yamamoto N.
  • Journal Title: Antimicrob Agents Chemother. 53(7) Pages: 2940-2948
• [Journal Article] Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1. (2009)
  • Author(s): Ohba K, Ryo A, Dewan MZ, Nishi M, Naito T, Qi X, Inagaki Y, Nagashima Y, Tanaka Y, Okamoto T, Terashima K, Yamamoto N.
  • Journal Title: J Immunol. 183(1) Pages: 524-532
• [Journal Article] Pinning down HER2-ER crosstalk in SMRT regulation. (2009)
  • Author(s): Ryo A, Wulf G, Lee TH, Lu KP.
  • Journal Title: Trends Biochem Sci. 34(4) Pages: 162-165
• [Journal Article] Selective transmission of R5 HIV-1 over X4 HIV-1 at the dendritic cell-T cell infectious synapse is determined by the T cell activation state. (2009)
  • Author(s): Yamamoto T, Tsunetsugu-Yokota Y, Mitsuki YY, Mizukoshi F, Tsuchiya T, Terahara K, Inagaki Y, Yamamoto N, Kobayashi K, Inoue J.
  • Journal Title: PLoS Pathog. 5(1)
• [Journal Article] BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction (2009)
  • Author(s): 宮川敬
  • Journal Title: PLoS Pathogens 5
  • Peer Reviewed
• [Journal Article] Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process (2009)
  • Author(s): Wei Zhou
  • Journal Title: The journal of biological chemistry 284 Pages: 23980-23988
  • Peer Reviewed
• [Journal Article] Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1 (2009)
  • Author(s): 大庭賢二
  • Journal Title: Journal of immunology 183 Pages: 524-532
  • Peer Reviewed
• [Journal Article] The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1(HTLV-1)Tax oncoprotein and promotes malignant transformation (2009)
  • Author(s): Soo-Jin Jeong
  • Journal Title: Biochemical and biophysical research communications 381 Pages: 294-299
  • Peer Reviewed
• [Journal Article] Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag (2009)
  • Author(s): 西真由子
  • Journal Title: FEBS letters 583 Pages: 1243-1250
  • Peer Reviewed
• [Journal Article] Pinning down HER2-ER crosstalk in SMRT regulation (2009)
  • Author(s): 梁明秀
  • Journal Title: Trens in biochemical sciences 34 Pages: 162-165
  • Peer Reviewed
• [Journal Article] The prolyl isomerase Pin 1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation (2009)
  • Author(s): Jeong SJ., et al.
  • Journal Title: Biochem Biophys Res Commun. 381 Pages: 294-299
  • Peer Reviewed
• [Journal Article] Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag (2009)
  • Author(s): Nishi M., et al.
  • Journal Title: FEBS Lett. 583 Pages: 1243-1250
  • Peer Reviewed
• [Journal Article] Substitution of the myristoylation signal of human immunodeficiency virus type 1 Pr55Gag with the phospholipase C delta 1 pleckstrin homology domain results in infectious pseudovirion production. (2008)
  • Author(s): Urano, E., T. Aoki, Y. Futahashi, T. Murakami, Y. Morikawa, N. Yamamoto, J. Komano
  • Journal Title: J.Gen.Virol. 89 Pages: 3144-3149
• [Journal Article] Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells. (2008)
  • Author(s): Urano E, Kariya Y, Futahashi Y, Ichikawa R, Hamatake M, Fukazawa H, Morikawa Y, Yoshida T, Koyanagi Y, Yamamoto N, Komano J.
  • Journal Title: FEBS Lett. 582(29) Pages: 4053-4058
• [Journal Article] Loss of Atg16L1, an autophagy regulator, enhances endotoxin-induced IL-1β production Nature (2008)
  • Author(s): Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.
  • Journal Title: 456(7219) Pages: 264-268
• [Journal Article] Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. (2008)
  • Author(s): Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez Bruyn VJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S.
  • Journal Title: Blood. 111(10) Pages: 5118-5129
• [Journal Article] Cyclin K/CPR4 inhibits primate lentiviral replication by inactivating Tat/positive transcription elongation factor b-dependent long terminal repeat transcription. (2008)
  • Author(s): Urano E, Shimizu S, Futahashi Y, Hamatake M, Morikawa Y, Takahashi N, Fukazawa H, Yamamoto N, Komano J.
  • Journal Title: AIDS. 22(9) Pages: 1081-1083
• [Journal Article] SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag (2008)
  • Author(s): Ryo A., et al.
  • Journal Title: Proc Natl Acad Sci USA. 105 Pages: 294-299
  • Peer Reviewed
• [Presentation] Evaluating HIV-1 reverse transcriptase inhibitor resistance by in vitro enzymatic assay using a wheat-germ cell-free translation system. (2011)
  • Author(s): Masaoka T, Morishita R, Sawasaki T, Sugiura W, Yamamoto N, Ryo A
  • Organizer: 18^<th> Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: America
• [Presentation] Evaluating HIV-1 reverse transcriptase inhibitor resistance by in vitro enzymatic assay using a wheat-germ cell-free translation system (2011)
  • Author(s): 正岡崇志
  • Organizer: 18th Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Hynes Convention Center, America
• [Presentation] Identification of a Host Factor Antagonizung Vpu-Mediated Tetherin Down-Regulation (2010)
  • Author(s): 宮川敬
  • Organizer: 第50回米国細胞生物学会
  • Place of Presentation: Pennsylvania Convention Center, America
  • Year and Date: 2010-12-13
• [Presentation] 革新的技術を応用した次世代エイズ研究の展望 (2010)
  • Author(s): 梁明秀
  • Organizer: 日本エイズ学会学術集会・総会
  • Place of Presentation: グランドプリンスホテル高輪、東京(招待講演)
  • Year and Date: 2010-11-25
• [Presentation] 包括的キノーム解析によるHIV-1 Vpuのリン酸化調節機構の解明 (2010)
  • Author(s): 宮川敬
  • Organizer: 第58回 日本ウイルス学会学術集会
  • Place of Presentation: 徳島あわぎんホール、徳島
  • Year and Date: 2010-11-08
• [Presentation] A New Host Restriction Factor Promoting HIV-1 Particle Destruction (2010)
  • Author(s): 宮川敬
  • Organizer: 第5回日独エイズシンポジウム
  • Place of Presentation: 慶応大学、神奈川
  • Year and Date: 2010-05-11
• [Presentation] Identification of host proteins required for HIV-1 infection (2010)
  • Author(s): 梁明秀
  • Organizer: 第3回日中科学フォーラム
  • Place of Presentation: 東湖賓館
  • Year and Date: 2010-03-16
• [Presentation] Novel High-throughput HIV-1 Protease-resistance Phenotypic Assay Using Cell-free Protein Production System (2010)
  • Author(s): 正岡崇志
  • Organizer: the 17th Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Moscone Center West San Francisco, CA, US
  • Year and Date: 2010-02-19
• [Presentation] BCA2/Rabring7 Promotes Tetherin-Dependent HIV-1 Restriction (2010)
  • Author(s): 宮川敬
  • Organizer: the 17th Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: Moscone Center West San Francisco, CA, US
  • Year and Date: 2010-02-17
• [Presentation] 宿主蛋白質BCA2/Rabring7は tetherin と協調してHIV-1粒子産生を抑制する (2010)
  • Author(s): 宮川敬
  • Organizer: 第3回 先端医科学研究センター国際学術フォーラム
  • Place of Presentation: 県民共済みらいホール
  • Year and Date: 2010-02-03
• [Presentation] Identification of a Host Factor Antagonizing Vpu-Mediated Tetherin Down-Regulation. (2010)
  • Author(s): 宮川敬, 澤崎達也, 松永智子, 山本直樹, 梁明秀
  • Organizer: The American Society for Cell Biology 50th Annual Meeting
  • Place of Presentation: Philadelphia
• [Presentation] 革新的技術を応用した次世代エイズ研究の展望 (2010)
  • Author(s): 梁明秀
  • Organizer: 第24回日本エイズ学会学術集会・総会
  • Place of Presentation: 東京
• [Presentation] 包括的キノーム解析によるHIV-1 Vpuのリン酸化調節機構の解明 (2010)
  • Author(s): 宮川敬, 澤崎達也, 松永智子, 山下暁朗, 山本直樹, 梁明秀
  • Organizer: 第58回日本ウイルス学会総会
  • Place of Presentation: 徳島
• [Presentation] A New Host Restriction Factor Promoting HIV-1 Particle Destruction. (2010)
  • Author(s): 宮川敬, 梁明秀
  • Organizer: 第5回日独エイズシンポジウム
  • Place of Presentation: 東京
• [Presentation] Indentification of host proteins required for HIV-1 infection. (2010)
  • Author(s): 梁明秀
  • Organizer: 第3回日中科学フォーラム
  • Place of Presentation: 中国
• [Presentation] 宿主蛋白質BCA2/Rabring7はtetherinと協調してHIV-1粒子産生を抑制する (2010)
  • Author(s): 宮川敬, 梁明秀
  • Organizer: 第3回先端医科学研究センター国際学術フォーラム
  • Place of Presentation: 神奈川
• [Presentation] BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. (2010)
  • Author(s): Kei Miyakawa, Akihide Ryo, Tsutomu Murakami, John Guatelli, Naoki Yamamoto
  • Organizer: The 17^<th> Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: USA
• [Presentation] Novel High-throughput HIV-1 Protease-resistance Phenotypic Assay Using Cell-free Protein Production System. (2010)
  • Author(s): Takashi Masaoka, Ryo Akihide
  • Organizer: The 17^<th> Conference on Retroviruses and Opportunistic Infections
  • Place of Presentation: USA
• [Presentation] 滑膜細胞におけるc/EBP-βに対するPin1の効果 (2009)
  • Author(s): 小島良績
  • Organizer: 第32回分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-10
• [Presentation] 免疫抑制受容体PD-1を阻害する新規抗体の作製 (2009)
  • Author(s): 熱田翠薫
  • Organizer: 第32回分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] Atypical protein kinase C positively regulates the Vpr incorporation into HIV-1 particles by phosphorylating Gag p6 (2009)
  • Author(s): 高濱正吉
  • Organizer: The 10^<th> Kumamoto AIDS Seminar
  • Place of Presentation: ホテル日航熊本
  • Year and Date: 2009-09-28
• [Presentation] Identification of a tetherin-interacting protein that restricts HIV-1 particle production (2009)
  • Author(s): 宮川敬
  • Organizer: 第9回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2009-09-10
• [Presentation] ペプチジルプロリルイソメラーゼPin1:疾患や分化を司る新しいリン酸化後修飾因子 (2009)
  • Author(s): 梁明秀
  • Organizer: 日本ヒトプロテオーム機構(JHUPO)第7回大会
  • Place of Presentation: 北里大学薬学部
  • Year and Date: 2009-07-27
• [Presentation] The peptidyl-prolyl isomerase Pin1 : A novel post-phosphorylation modifier indevelopment and diseases (2009)
  • Author(s): 梁明秀
  • Organizer: 先端融合領域イノベーション創出拠点の形成翻訳後修飾プロテオミクス医療研究拠点の形成 第1回公開シンポジウム「分析技術の発達により見えてきた蛋白質の翻訳後修飾とその異常」
  • Place of Presentation: 港南区民文化センター ひまわりの郷
  • Year and Date: 2009-06-19
• [Presentation] HIV-1 Gagタンパク質の細胞内ダイナミクス関連因子の同定とその制御機構の解明 (2009)
  • Author(s): 梁明秀
  • Organizer: 第9回日本蛋白質科学会年会
  • Place of Presentation: 熊本全日空ホテルニュースカイ
  • Year and Date: 2009-05-22
• [Presentation] 滑膜細胞におけるC/EBP-βに対するPin1の効果 (2009)
  • Author(s): 小島良績, 後藤さやか, 近藤麻美, 木下茂美, 梁明秀
  • Organizer: 第32回分子生物学会年会
  • Place of Presentation: 神奈川
• [Presentation] 免疫抑制受容体PD-1を阻害する新規抗体の作製 (2009)
  • Author(s): 熱田翠薫, 吉田篤司, 吉崎慎二, 八島さやか, 松永智子, 澤崎達也, 梁明秀
  • Organizer: 第32回分子生物学会年会
  • Place of Presentation: 神奈川
• [Presentation] 細胞極性制御キナーゼaPKCによるHIV-1 Gagのリン酸化及びその生理的意義 (2009)
  • Author(s): 高濱正吉, 澤崎達也, 岡山明子, 赤木達也, 遠藤弥重太, 山本直樹, 梁明秀
  • Organizer: 第23回日本エイズ学会学術集会・総会
  • Place of Presentation: 愛知
• [Presentation] Identification of a tetherin-interacting protein that restricts HIV-1 particle production. (2009)
  • Author(s): 宮川敬, 梁明秀, 大庭賢二, 西真由子, 村上努, John Guatelli, 山本直樹
  • Organizer: 第9回あわじしま感染症・免疫フォーラム
  • Place of Presentation: 兵庫
• [Presentation] Atypical protein kinase C positively regulates the Vpr incorporation into HIV-1 particles by phosphorylating Gag p6. (2009)
  • Author(s): Takahama S, Sawasaki T, Okayama A, Akagi T, Endo Y, Yamamoto N, Ryo A
  • Organizer: The 10^<th> Kumamoto AIDS Seminar
  • Place of Presentation: 熊本
• [Presentation] ペプチジルプロリルイソメラーゼPin1:疾患や分化を司る新しいリン酸化後修飾因子 (2009)
  • Author(s): 梁明秀
  • Organizer: 日本ヒトプロテオーム機構(JHUPO)第7回大会
  • Place of Presentation: 東京
• [Presentation] The peptidyl-prolyl isomerase Pin1 : A novel post-phosphorylation modifier indevelopment and diseases. (2009)
  • Author(s): 梁明秀
  • Organizer: 先端融合領域イノベーション創出拠点の形成翻訳後修飾プロテオミクス医療研究拠点の形成 第1回公開シンポジウム「分析技術の発達により見えてきた蛋白質の翻訳後修飾とその異常」
  • Place of Presentation: 神奈川
• [Presentation] 宿主蛋白質BCA2/Rabring7はtetherinと協調してHIV-1粒子産生を抑制する (2009)
  • Author(s): 宮川敬, 梁明秀, 山本直樹
  • Organizer: 第19回抗ウイルス療法研究会
  • Place of Presentation: 東京
• [Presentation] HIV-1産生を制御するtetherin相互作用蛋白の同定 (2009)
  • Author(s): 梁明秀, 山本直樹
  • Organizer: 特定領域研究「感染現象のマトリックス」縦糸研究会
  • Place of Presentation: 愛知
• [Presentation] HIV-1 Gagタンパク質の細胞内ダイナミクス関連因子の同定とその制御機構の解明 (2009)
  • Author(s): 梁明秀
  • Organizer: 第9回日本蛋白質科学会年会
  • Place of Presentation: 熊本
• [Presentation] HIV-1産生を制御する tetherin 相互作用蛋白の同定 (2009)
  • Author(s): 梁明秀
  • Organizer: 特定領域研究「感染現象のマトリックス」縦糸研究会
  • Place of Presentation: 名古屋大学
• [Presentation] 宿主蛋白質BCA2/Rabring7 は tetherin と協調してHIV-1粒子産生を抑制する (2009)
  • Author(s): 宮川敬
  • Organizer: 第19回抗ウイルス療法研究会
  • Place of Presentation: ホテルゆうぽうと
• [Presentation] 細胞極性制御キナーゼaPKCによるHIV1 Gagのリン酸化及びその生理的意義 (2009)
  • Author(s): 高濱正吉
  • Organizer: 第23回日本エイズ学会学術集会・総会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 無細胞タンパク質合成系を用いたHIV/AIDS研究の新たな展開 (2008)
  • Author(s): 梁明秀
  • Organizer: 第22回日本エイズ学会学術集会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2008-11-27
• [Presentation] 無細胞タンパク質合成系を用いたHIV/AIDS研究の新たな展開 (2008)
  • Author(s): 梁明秀
  • Organizer: 第22回日本エイズ学会学術集会
  • Place of Presentation: 大阪
• [Remarks]
  • URL: http://www-user.yokohama-cu.ac.jp/~saikin/gyoseki.html
• [Patent(Industrial Property Rights)] Method For Screening Anti-HIV Drugs and A Diagnostic Method of AIDS (2010)
  • Inventor(s): 梁明秀、山本直樹
  • Industrial Property Rights Holder: 国立感染症研究所、株式会社セルフリーサイエンス
  • Filing Date: 2010-02-11
  • Overseas