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Epstein-Barr virus lytic replication and host factors supporting its replication

Research Project

Project/Area Number 20390137
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

TSURUMI Tatsuya  Aichi Cancer Center Research Institute, 部長 (90172072)

Co-Investigator(Renkei-kenkyūsha) KANDA Teru  愛知県がんセンター(研究所), 室長 (50333472)
ISOMURA Hiroki  愛知県がんセンター(研究所), 室長 (20294415)
MURATA Takayuki  愛知県がんセンター(研究所), 研究員 (30470165)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
KeywordsEBV / 複製 / 転写 / 溶解感染 / 構造 / 機能 / 宿主 / 変異 / 増殖 / EBウイルス / 複製蛋白質 / TORC / 再活性化
Research Abstract

Epstein-Barr virus (EBV) is a DNA tumor virus、possessing two alternative life cycle ; latent and lytic. EBV genome replication is occurred in nuclei of the infected cells. In this study we have revealed that TORC2 (Transducer of Regulated CREB 2) and HIF-2αis involved in the reactivation from the latency. Furthermore, We have showed the three dimensional structure of BMRF1, one of EBV replication proteins, and its relationship with its functions on DNA binding, polymerase processivity, and lytic replication.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (73 results)

All 2011 2010 2009 2008 Other

All Journal Article (27 results) (of which Peer Reviewed: 9 results) Presentation (39 results) Remarks (4 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Noise Cancellation : Viral Fine Tuning of the Cellular Environment for its Own Genome Replication.2010

    • Author(s)
      Sato Y Tsurumi T.
    • Journal Title

      PLos Pathog 6

      Pages: 1001158-1001158

    • Related Report
      2010 Final Research Report
  • [Journal Article] Tetrameric Ring Formation of EBV Polymerase Processivity Factor is Crucial for Viral Replication.2010

    • Author(s)
      Nakayama S, Murata T, Yasui Y,Murata T Isomura HH, Kanda T, Tsurumi T.
    • Journal Title

      J.Virol. 84

      Pages: 12589-12598

    • Related Report
      2010 Final Research Report
  • [Journal Article] Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase.2010

    • Author(s)
      Murata T, Hotta N, Toyama S, Nakayama S, Chiba S, Isomura HH, Ohshima T, Kanda T, Tsurumi T.
    • Journal Title

      J Biol Chem 285

      Pages: 23925-23935

    • Related Report
      2010 Final Research Report
  • [Journal Article] Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication.2010

    • Author(s)
      Sato Y, Shirata N, Murata T, Nakasu S, Kudoh A, Iwahori S, Nakayama S, Chiba S, Isomura H, Kanda T, Tsurumi T.
    • Journal Title

      Cell Cycle 9

      Pages: 807-814

    • Related Report
      2010 Final Research Report
  • [Journal Article] The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene.2010

    • Author(s)
      Isomura H, Stinski MF, Murata T, Nakayama S, Chiba S, Akatsuka Y, Kanda T, Tsurumi T.
    • Journal Title

      PLoS One. 5

      Pages: 11901-11901

    • Related Report
      2010 Final Research Report
  • [Journal Article] Noise Cancellation : Viral Fine Tuning of the Cellular Environment for its Own Genome Replication.2010

    • Author(s)
      Sato Y, et al.
    • Journal Title

      PLos Pathog.

      Volume: 6 Pages: 1001158-1001158

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tetrameric Ring Formation of EBV Polymerase Processivity Factoris Crucial for Viral Replication.2010

    • Author(s)
      Nakayama S, et al.
    • Journal Title

      J.Virol.

      Volume: 84 Pages: 12589-12598

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ranscriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase.2010

    • Author(s)
      Murata T, et al
    • Journal Title

      J.Biol.Chem.

      Volume: 285 Pages: 23925-23935

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of Epstein-Barr virus DNA polymerase processivity factor BMRF1.2009

    • Author(s)
      Murata T Nakayama S, Kato-Murayama, M, Akasaka R, Ohbayashi N Kamewari-Hayami Y, Terada T, Shirouzu M, Tsurumi T, Yokoyama S.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 35896-35905

    • Related Report
      2010 Final Research Report
  • [Journal Article] Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex. PLoS Pathog.2009

    • Author(s)
      Sato Y, Kamura T,Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura HH, Nishiyama Y, Tsurumi T.
    • Journal Title

      PLoS Pathog. 5

      Pages: 1000530-1000530

    • Related Report
      2010 Final Research Report
  • [Journal Article] Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 immediate-early protein.2009

    • Author(s)
      Nakayama S, Murata T,Murata T Yasui Y, Sato Y, Kudoh A, Iwahori S, Isomura, H, Kanda T Tsurumi T.
    • Journal Title

      J Biol Chem. 284

      Pages: 21557-21568

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication.2009

    • Author(s)
      Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T Tsurumi T.
    • Journal Title

      J Biol Chem. 284

      Pages: 18923-18931

    • Related Report
      2010 Final Research Report
  • [Journal Article] Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr irus replication compartments2009

    • Author(s)
      Kudoh A, Iwahori S, Sato Y, Nakayama S, Isomura HH, Murata T Tsurumi T.
    • Journal Title

      J Virol. 83

      Pages: 6641-6651

    • Related Report
      2010 Final Research Report
  • [Journal Article] ORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein.2009

    • Author(s)
      Murata T, Sato Y, Nakayama S, Kudoh A, Iwahori S, Isomura HH, Tajima M, Hishiki T, Ohshima T, Hijikata M, Shimotohno K Tsurumi T
    • Journal Title

      J Biol Chem. 284

      Pages: 8033-8041

    • Related Report
      2010 Final Research Report
  • [Journal Article] Efficient Production of infectious viruses requires enzymatic activity of Epstein-Barr virus protein kinase.2009

    • Author(s)
      Murata T, Isomura HH, Yamashita Y, Toyama S, Sato Y, Nakayama S, Kudoh A, Iwahori S, Kanda T Tsurumi T
    • Journal Title

      Virology 389

      Pages: 75-81

    • Related Report
      2010 Final Research Report
  • [Journal Article] Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr virus replication compartments.2009

    • Author(s)
      Kudoh A, Iwahori S, Sato Y, Nakayama S, Isomura HH, Murata T Tsurumi T.
    • Journal Title

      J Virol. 83

      Pages: 6641-6651

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription.2009

    • Author(s)
      Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura HH, Nishiyama Y Tsurumi T.
    • Journal Title

      Virology. 388

      Pages: 204-211

    • Related Report
      2010 Final Research Report
  • [Journal Article] TORC2, a Coactivator of cAMP-response Element-binding Protein, Promotes Epstein-Barr Virus Reactivation from Latency through Interaction with Viral BZLF1 Protein.2009

    • Author(s)
      Murata T, et al
    • Journal Title

      J.Biol.Chem. 284

      Pages: 8033-8041

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.2009

    • Author(s)
      Sato Y, et al.
    • Journal Title

      PLoS Pathog 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 immediate-early protein.2009

    • Author(s)
      Nakayama S, et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 21557-21568

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TORC2, a Coactivator of cAMP-response Element-binding Protein, Promotes Epstein-Barr Virus Reactivation from Latency through Interaction with Viral BZLF1 Protein2009

    • Author(s)
      Murata T, et al
    • Journal Title

      J. Biol. Chem. 284

      Pages: 8033-8041

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites.2008

    • Author(s)
      Iwahori S, Yasui Y, Kudoh A, Sato Y, Nakayama S, Murata T, Isomura HH, Tsurumi T.
    • Journal Title

      Cell Signal. 10

      Pages: 1795-803

    • Related Report
      2010 Final Research Report
  • [Journal Article] A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication.2008

    • Author(s)
      Isomura HH, Stinski MF, Kudoh A, Nakayama S, Murata T, Sato Y, Iwahori S, Tsurumi T.
    • Journal Title

      J Virol 82

      Pages: 849-858

    • Related Report
      2010 Final Research Report
  • [Journal Article] Noncanonical TATA Sequence in the UL44 Late Promoter of Human Cytomegalovirus is required for the accumulation of late viral transcripts.2008

    • Author(s)
      Isomura HH, Stinski MF, Kudoh A, Murata T, Nakayama S, Sato Y, Iwahori S, Tsurumi T.
    • Journal Title

      J Virol 82

      Pages: 1638-1646

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cell cycle arrest and lytic induction of EBV-transformed B lymphoblastoid cells by a histone deacetylase inhibitor, Trichostatin A.2008

    • Author(s)
      Seo JS, Cho NY, Kim HR, Tsurumi T, Jang YS, Lee WK, Lee SK.
    • Journal Title

      Oncol Rep. 19

      Pages: 93-98

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites2008

    • Author(s)
      Iwahori S, et al.
    • Journal Title

      Cell Signal 20

      Pages: 1795-1803

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts2008

    • Author(s)
      Isomura H, et al.
    • Journal Title

      J. Virol. 82

      Pages: 1638-1646

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Utilizing WT1-expressing lymphoblastoid cell lines for the induction of WT1-specific cell immunity2010

    • Author(s)
      神田輝、越智俊元、安川正貴、岡本幸子、峰野純一、葛島清隆、鶴見達也
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Screening of cellular factors that enhance reactivation of Epstein-Barr virus from latency2010

    • Author(s)
      村田貴之、鶴見達也
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Tail to tail contact for tetrameric ring formation of EBV BMRF1 is crucial for viral replication2010

    • Author(s)
      中山早苗、村田貴之、鶴見達也
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Screening of cellular factors that enhance reactivation from Epstein-Barr virus latency2010

    • Author(s)
      村田貴之, 鶴見達也
    • Organizer
      14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases
    • Place of Presentation
      Birmingham
    • Year and Date
      2010-09-07
    • Related Report
      2010 Final Research Report
  • [Presentation] The impact of viral repetitive sequences on the biological properties of Epstein-Barr virus recombinants12010

    • Author(s)
      Kanda T., Tsurumi T.
    • Organizer
      4th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases
    • Place of Presentation
      Birmingham
    • Year and Date
      2010-09-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Tail to tail contact for tetrameric ring formation of EBV processivity factor is crucial for viral replication The EMBO meeting 20102010

    • Author(s)
      鶴見達也, 中山早苗, 村田貴之
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-09-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Tail to tail contact for tetrameric ring formation of EBV BMRF 1 is crucial for viral replication.2010

    • Author(s)
      Tatsuya Tsurumi
    • Organizer
      EMBO Meeting 2010
    • Place of Presentation
      Palau de Congressos de Catalunya(Spain)
    • Year and Date
      2010-09-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Human Cytomegalovirus Late Transactivators Recruited to the Replication Compartments2010

    • Author(s)
      Isomura H., Stinski M.F., Murata T., Kanda T., Tsurumi T
    • Organizer
      35th Annua International Herpesvirus Workshop
    • Place of Presentation
      Salt Lake City
    • Year and Date
      2010-07-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 潜伏感染細胞中でEBNA1蛋白質と相互作用する細胞性因子の解析2010

    • Author(s)
      神田輝、鶴見達也
    • Organizer
      第7回EBウイルス研究会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] EBウイルスBZLF1はSUMO 化によりその転写活性を強く抑制される2010

    • Author(s)
      村田貴之、鶴見達也
    • Organizer
      第7回EBウイルス研究会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 潜伏感染EB ウイルスエピゾームの宿主染色体付着機構の解析2010

    • Author(s)
      神田輝、鶴見達也
    • Organizer
      第25回ヘルペスウイルス研究会
    • Place of Presentation
      浜松
    • Year and Date
      2010-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 純粋な組換えEBV を用いたエピトープタグ付加EBNA1蛋白質発現リンパ芽球様細胞株の樹立2009

    • Author(s)
      神田輝、鶴見達也
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-27
    • Related Report
      2010 Final Research Report
  • [Presentation] EB ウイルスの再活性化-EBウイルスBZLF1 遺伝子産物はSUMO化によりその転写活性を抑制される2009

    • Author(s)
      村田貴之、鶴見達也
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-27
    • Related Report
      2010 Final Research Report
  • [Presentation] EBウイルス産生感染に伴うp27Kip1分解の分子機構2009

    • Author(s)
      岩堀聡子、村田貴之、藤田雅俊、清野透、鶴見達也
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-27
    • Related Report
      2010 Final Research Report
  • [Presentation] EB ウイルスの再活性化-TORC2はBZLF1 蛋白質と共同してEBウイルスの再活性化を促進する2009

    • Author(s)
      村田貴之、鶴見達也
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトサイトメガロウイルスUL76ORF内に存在するinternalentry ribosome site2009

    • Author(s)
      磯村寛樹、鶴見達也
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 変異EBV BMRF1蛋白質のウイルス産生感染に与える影響2009

    • Author(s)
      中山早苗、鶴見達也
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Human cytomegalovirus L76 gene regulates the level of xpression of the UL77 gene2009

    • Author(s)
      Isomura H, Stinski MF, Murata T, Nakayama S, Chiba S, Akatsuka Y, Kanda T, Tsurumi T
    • Organizer
      14th nternational Conference on mmunobiology and Prophylaxis of Human erpesvirus Infections
    • Place of Presentation
      Kobe
    • Year and Date
      2009-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Sumoylation of pstein-Barr virus BZLF1 viral protein ramatically inhibits its ranscriptional activity2009

    • Author(s)
      村田貴之, 鶴見達也
    • Organizer
      14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections
    • Place of Presentation
      Kobe
    • Year and Date
      2009-10-06
    • Related Report
      2010 Final Research Report
  • [Presentation] Single-step conversion of peripheral B-lymphocytes into B-lymphoblastoid cell lines expressing WT1 tumor antigen (末梢血Bリンパ球を材料としたWT1蛋白質高発現Bリンパ芽球様細胞株ワンステップ樹立法)2009

    • Author(s)
      Kanda T, Tsurumi T
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Human cytomegalovirus UL76 contains an internal ribosome entry site to facilitate UL77 translation2009

    • Author(s)
      磯村寛樹、鶴見達也
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Sumoylation of Epstein-Barr virus BZLF1 viral protein dramatically inhibits its transcriptional activity2009

    • Author(s)
      村田貴之、鶴見達也
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Epstein-Barr Virus Polymerase Processivity Factor Enhances BALF2 Promoter Transcription as a Coactivator for the BZLF1 Immediate-Early Protein.2009

    • Author(s)
      中山早苗、鶴見達也
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCF/Skp2 ubiquitin ligase2009

    • Author(s)
      岩堀聡子、村田貴之、藤田雅俊、清野透、鶴見達也
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Epstein-Barr virus polymerase processivity factor enhances BALF2 Promoter transcription as a coactivator for the BZLF12009

    • Author(s)
      中山早苗
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phosphorylation of p27Kip1 by Epstein-Barr Virus Protein Kinase Induces its Degradation through SCFSkp2 Ubiquitin Ligase Actions during Viral Lytic Replication2009

    • Author(s)
      Tsurumi T, Iwahori S., Murata T.
    • Organizer
      9th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji
    • Year and Date
      2009-09-09
    • Related Report
      2010 Final Research Report
  • [Presentation] TORC2 promotes EBV reactivation from latency through interaction with viral BZLF1 protein2009

    • Author(s)
      村田貴之, 鶴見達也
    • Organizer
      4th International Symposium on Nasopharyngeal Carcinoma
    • Place of Presentation
      Marrakech, Morocco
    • Year and Date
      2009-06-19
    • Related Report
      2010 Final Research Report
  • [Presentation] EBウイルスの再活性化:TORC2はBZLF1 蛋白質と共同してEBウイルスの再活性化を促進する2009

    • Author(s)
      村田貴之、鶴見達也
    • Organizer
      第6回EBウイルス研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Calcineurin Promotes EBV Reactivation from Latency via TORC2 8th International Conference on Protein Phosphatases2008

    • Author(s)
      村田貴之, 鶴見達也
    • Place of Presentation
      Maebashi
    • Year and Date
      2008-11-12
    • Related Report
      2010 Final Research Report
  • [Presentation] ECS Ubiquitin complex is recruited by Epstein-Barr virus BZLF1 IE protein for degradation of the p53 tumor suppressor2008

    • Author(s)
      佐藤好隆、鶴見達也
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] TORC2 promotes EBV reactivation from latency by interacting with BZLF12008

    • Author(s)
      村田貴之、鶴見達也
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] TORC2 promotes EBV reactivation from latency by interacting with BZLF12008

    • Author(s)
      村田貴之
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] EBV BMRF1蛋白質は一本鎖DNA結合蛋白質をコードするBALF2遺伝子の発現を促進する2008

    • Author(s)
      中山早苗、岩堀聡子、鶴見達也
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Epstein-BarrウイルスBZLF1蛋白質は溶解感染期においてECSユビキチンE3リガーゼ複合体をリクルートしてp53を分解する2008

    • Author(s)
      佐藤好隆、西山幸廣、鶴見達也
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Degradation of phosphorylated p53 occurs through viral protein-ECS E3 ligase complex during Epstein-Barr virus lytic replication2008

    • Author(s)
      Tsurumi T, Yoshitaka S
    • Organizer
      The 8th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Hyogo
    • Year and Date
      2008-09-09
    • Related Report
      2010 Final Research Report
  • [Presentation] Open Reading frame 76 of human cytomegalovirus contains an internal ribosome entry site.2008

    • Author(s)
      Isomura H, Stinski M.F., Kumimoto H, Tsurumi T
    • Organizer
      33th International Herpesvirus Workshop, 2008
    • Place of Presentation
      Estoril, Portugal
    • Year and Date
      2008-07-29
    • Related Report
      2010 Final Research Report
  • [Presentation] EBウイルス溶解感染時にp53はBZLF1-ECSユビキチンリガーゼによって分解される2008

    • Author(s)
      佐藤好隆、鶴見達也
    • Organizer
      第5回EBウイルス研究会
    • Place of Presentation
      鳥取
    • Year and Date
      2008-07-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2

    • Author(s)
      Sato Y., Tsurumi T.
    • Organizer
      leading to repression of p53-mediated transcription. American Society for Microbiology Conference on Manipulation of Nuclear Processes by DNA Viruses Charleston
    • Related Report
      2010 Final Research Report
  • [Presentation] TORC promotes EBV reactivation from latency by interacting with BZLF1.

    • Author(s)
      村田貴之, 鶴見達也
    • Organizer
      American Society for Microbiology Conference on Manipulation of Nuclear Processes by DNA Viruses Charleston
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.pref.aichi.jp/cancer-center/h400/420/421/421-06.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-06.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-06.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.pref.aichi.jp/cancer-center/400/420/421/421-06.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 弱毒ヒトサイトメガロウイルス及びそのワクチンとしての使用2011

    • Inventor(s)
      鶴見達也, 磯村寛樹
    • Industrial Property Rights Holder
      愛知県
    • Filing Date
      2011-01-26
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 弱毒ヒトサイトメガロウイルス及びそのワクチンとしての使用2011

    • Inventor(s)
      鶴見達也, 磯村寛樹
    • Industrial Property Rights Holder
      愛知県
    • Industrial Property Number
      2011-014548
    • Filing Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 弱毒HCMV及びそのワクチンとしての使用2010

    • Inventor(s)
      鶴見達也, 磯村寛樹
    • Industrial Property Rights Holder
      愛知県
    • Industrial Property Number
      2010-042936
    • Filing Date
      2010-02-26
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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