Epstein-Barr virus lytic replication and host factors supporting its replication

• Project/Area Number: 20390137
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Virology
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: TSURUMI Tatsuya Aichi Cancer Center Research Institute, 部長 (90172072)
• Co-Investigator(Renkei-kenkyūsha): KANDA Teru 愛知県がんセンター(研究所), 室長 (50333472) ; ISOMURA Hiroki 愛知県がんセンター(研究所), 室長 (20294415) ; MURATA Takayuki 愛知県がんセンター(研究所), 研究員 (30470165)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2010: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: EBV / 複製 / 転写 / 溶解感染 / 構造 / 機能 / 宿主 / 変異 / 増殖 / EBウイルス / 複製蛋白質 / TORC / 再活性化

Research Abstract

Epstein-Barr virus (EBV) is a DNA tumor virus、possessing two alternative life cycle ; latent and lytic. EBV genome replication is occurred in nuclei of the infected cells. In this study we have revealed that TORC2 (Transducer of Regulated CREB 2) and HIF-2αis involved in the reactivation from the latency. Furthermore, We have showed the three dimensional structure of BMRF1, one of EBV replication proteins, and its relationship with its functions on DNA binding, polymerase processivity, and lytic replication.

Research Products

• [Journal Article] Noise Cancellation : Viral Fine Tuning of the Cellular Environment for its Own Genome Replication. (2010)
  • Author(s): Sato Y Tsurumi T.
  • Journal Title: PLos Pathog 6 Pages: 1001158-1001158
• [Journal Article] Tetrameric Ring Formation of EBV Polymerase Processivity Factor is Crucial for Viral Replication. (2010)
  • Author(s): Nakayama S, Murata T, Yasui Y,Murata T Isomura HH, Kanda T, Tsurumi T.
  • Journal Title: J.Virol. 84 Pages: 12589-12598
• [Journal Article] Transcriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase. (2010)
  • Author(s): Murata T, Hotta N, Toyama S, Nakayama S, Chiba S, Isomura HH, Ohshima T, Kanda T, Tsurumi T.
  • Journal Title: J Biol Chem 285 Pages: 23925-23935
• [Journal Article] Transient increases in p53-responsible gene expression at early stages of Epstein-Barr virus productive replication. (2010)
  • Author(s): Sato Y, Shirata N, Murata T, Nakasu S, Kudoh A, Iwahori S, Nakayama S, Chiba S, Isomura H, Kanda T, Tsurumi T.
  • Journal Title: Cell Cycle 9 Pages: 807-814
• [Journal Article] The human cytomegalovirus UL76 gene regulates the level of expression of the UL77 gene. (2010)
  • Author(s): Isomura H, Stinski MF, Murata T, Nakayama S, Chiba S, Akatsuka Y, Kanda T, Tsurumi T.
  • Journal Title: PLoS One. 5 Pages: 11901-11901
• [Journal Article] Noise Cancellation : Viral Fine Tuning of the Cellular Environment for its Own Genome Replication. (2010)
  • Author(s): Sato Y, et al.
  • Journal Title: PLos Pathog. Volume: 6 Pages: 1001158-1001158
  • Peer Reviewed
• [Journal Article] Tetrameric Ring Formation of EBV Polymerase Processivity Factoris Crucial for Viral Replication. (2010)
  • Author(s): Nakayama S, et al.
  • Journal Title: J.Virol. Volume: 84 Pages: 12589-12598
  • Peer Reviewed
• [Journal Article] ranscriptional repression by sumoylation of Epstein-Barr virus BZLF1 protein correlates with association of histone deacetylase. (2010)
  • Author(s): Murata T, et al
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 23925-23935
  • Peer Reviewed
• [Journal Article] Crystal structure of Epstein-Barr virus DNA polymerase processivity factor BMRF1. (2009)
  • Author(s): Murata T Nakayama S, Kato-Murayama, M, Akasaka R, Ohbayashi N Kamewari-Hayami Y, Terada T, Shirouzu M, Tsurumi T, Yokoyama S.
  • Journal Title: J. Biol. Chem. 284 Pages: 35896-35905
• [Journal Article] Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex. PLoS Pathog. (2009)
  • Author(s): Sato Y, Kamura T,Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura HH, Nishiyama Y, Tsurumi T.
  • Journal Title: PLoS Pathog. 5 Pages: 1000530-1000530
• [Journal Article] Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 immediate-early protein. (2009)
  • Author(s): Nakayama S, Murata T,Murata T Yasui Y, Sato Y, Kudoh A, Iwahori S, Isomura, H, Kanda T Tsurumi T.
  • Journal Title: J Biol Chem. 284 Pages: 21557-21568
• [Journal Article] Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCFSkp2 ubiquitin ligase actions during viral lytic replication. (2009)
  • Author(s): Iwahori S, Murata T, Kudoh A, Sato Y, Nakayama S, Isomura H, Kanda T Tsurumi T.
  • Journal Title: J Biol Chem. 284 Pages: 18923-18931
• [Journal Article] Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr irus replication compartments (2009)
  • Author(s): Kudoh A, Iwahori S, Sato Y, Nakayama S, Isomura HH, Murata T Tsurumi T.
  • Journal Title: J Virol. 83 Pages: 6641-6651
• [Journal Article] ORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein. (2009)
  • Author(s): Murata T, Sato Y, Nakayama S, Kudoh A, Iwahori S, Isomura HH, Tajima M, Hishiki T, Ohshima T, Hijikata M, Shimotohno K Tsurumi T
  • Journal Title: J Biol Chem. 284 Pages: 8033-8041
• [Journal Article] Efficient Production of infectious viruses requires enzymatic activity of Epstein-Barr virus protein kinase. (2009)
  • Author(s): Murata T, Isomura HH, Yamashita Y, Toyama S, Sato Y, Nakayama S, Kudoh A, Iwahori S, Kanda T Tsurumi T
  • Journal Title: Virology 389 Pages: 75-81
• [Journal Article] Homologous recombinational repair factors are recruited and loaded onto the viral DNA genome in Epstein-Barr virus replication compartments. (2009)
  • Author(s): Kudoh A, Iwahori S, Sato Y, Nakayama S, Isomura HH, Murata T Tsurumi T.
  • Journal Title: J Virol. 83 Pages: 6641-6651
• [Journal Article] Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2, leading to repression of p53-mediated transcription. (2009)
  • Author(s): Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata T, Isomura HH, Nishiyama Y Tsurumi T.
  • Journal Title: Virology. 388 Pages: 204-211
• [Journal Article] TORC2, a Coactivator of cAMP-response Element-binding Protein, Promotes Epstein-Barr Virus Reactivation from Latency through Interaction with Viral BZLF1 Protein. (2009)
  • Author(s): Murata T, et al
  • Journal Title: J.Biol.Chem. 284 Pages: 8033-8041
  • Peer Reviewed
• [Journal Article] Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex. (2009)
  • Author(s): Sato Y, et al.
  • Journal Title: PLoS Pathog 5
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus polymerase processivity factor enhances BALF2 promoter transcription as a coactivator for the BZLF1 immediate-early protein. (2009)
  • Author(s): Nakayama S, et al.
  • Journal Title: J.Biol.Chem. 284 Pages: 21557-21568
  • Peer Reviewed
• [Journal Article] TORC2, a Coactivator of cAMP-response Element-binding Protein, Promotes Epstein-Barr Virus Reactivation from Latency through Interaction with Viral BZLF1 Protein (2009)
  • Author(s): Murata T, et al
  • Journal Title: J. Biol. Chem. 284 Pages: 8033-8041
  • Peer Reviewed
• [Journal Article] Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites. (2008)
  • Author(s): Iwahori S, Yasui Y, Kudoh A, Sato Y, Nakayama S, Murata T, Isomura HH, Tsurumi T.
  • Journal Title: Cell Signal. 10 Pages: 1795-803
• [Journal Article] A cis element between the TATA Box and the transcription start site of the major immediate-early promoter of human cytomegalovirus determines efficiency of viral replication. (2008)
  • Author(s): Isomura HH, Stinski MF, Kudoh A, Nakayama S, Murata T, Sato Y, Iwahori S, Tsurumi T.
  • Journal Title: J Virol 82 Pages: 849-858
• [Journal Article] Noncanonical TATA Sequence in the UL44 Late Promoter of Human Cytomegalovirus is required for the accumulation of late viral transcripts. (2008)
  • Author(s): Isomura HH, Stinski MF, Kudoh A, Murata T, Nakayama S, Sato Y, Iwahori S, Tsurumi T.
  • Journal Title: J Virol 82 Pages: 1638-1646
• [Journal Article] Cell cycle arrest and lytic induction of EBV-transformed B lymphoblastoid cells by a histone deacetylase inhibitor, Trichostatin A. (2008)
  • Author(s): Seo JS, Cho NY, Kim HR, Tsurumi T, Jang YS, Lee WK, Lee SK.
  • Journal Title: Oncol Rep. 19 Pages: 93-98
• [Journal Article] Identification of phosphorylation sites on transcription factor Sp1 in response to DNA damage and its accumulation at damaged sites (2008)
  • Author(s): Iwahori S, et al.
  • Journal Title: Cell Signal 20 Pages: 1795-1803
  • Peer Reviewed
• [Journal Article] Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts (2008)
  • Author(s): Isomura H, et al.
  • Journal Title: J. Virol. 82 Pages: 1638-1646
  • Peer Reviewed
• [Presentation] Utilizing WT1-expressing lymphoblastoid cell lines for the induction of WT1-specific cell immunity (2010)
  • Author(s): 神田輝、越智俊元、安川正貴、岡本幸子、峰野純一、葛島清隆、鶴見達也
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] Screening of cellular factors that enhance reactivation of Epstein-Barr virus from latency (2010)
  • Author(s): 村田貴之、鶴見達也
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Tail to tail contact for tetrameric ring formation of EBV BMRF1 is crucial for viral replication (2010)
  • Author(s): 中山早苗、村田貴之、鶴見達也
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Screening of cellular factors that enhance reactivation from Epstein-Barr virus latency (2010)
  • Author(s): 村田貴之, 鶴見達也
  • Organizer: 14th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases
  • Place of Presentation: Birmingham
  • Year and Date: 2010-09-07
• [Presentation] The impact of viral repetitive sequences on the biological properties of Epstein-Barr virus recombinants1 (2010)
  • Author(s): Kanda T., Tsurumi T.
  • Organizer: 4th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases
  • Place of Presentation: Birmingham
  • Year and Date: 2010-09-06
• [Presentation] Tail to tail contact for tetrameric ring formation of EBV processivity factor is crucial for viral replication The EMBO meeting 2010 (2010)
  • Author(s): 鶴見達也, 中山早苗, 村田貴之
  • Place of Presentation: Barcelona
  • Year and Date: 2010-09-05
• [Presentation] Tail to tail contact for tetrameric ring formation of EBV BMRF 1 is crucial for viral replication. (2010)
  • Author(s): Tatsuya Tsurumi
  • Organizer: EMBO Meeting 2010
  • Place of Presentation: Palau de Congressos de Catalunya(Spain)
  • Year and Date: 2010-09-05
• [Presentation] Human Cytomegalovirus Late Transactivators Recruited to the Replication Compartments (2010)
  • Author(s): Isomura H., Stinski M.F., Murata T., Kanda T., Tsurumi T
  • Organizer: 35th Annua International Herpesvirus Workshop
  • Place of Presentation: Salt Lake City
  • Year and Date: 2010-07-24
• [Presentation] 潜伏感染細胞中でEBNA1蛋白質と相互作用する細胞性因子の解析 (2010)
  • Author(s): 神田輝、鶴見達也
  • Organizer: 第7回EBウイルス研究会
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-09
• [Presentation] EBウイルスBZLF1はSUMO 化によりその転写活性を強く抑制される (2010)
  • Author(s): 村田貴之、鶴見達也
  • Organizer: 第7回EBウイルス研究会
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-09
• [Presentation] 潜伏感染EB ウイルスエピゾームの宿主染色体付着機構の解析 (2010)
  • Author(s): 神田輝、鶴見達也
  • Organizer: 第25回ヘルペスウイルス研究会
  • Place of Presentation: 浜松
  • Year and Date: 2010-05-27
• [Presentation] 純粋な組換えEBV を用いたエピトープタグ付加EBNA1蛋白質発現リンパ芽球様細胞株の樹立 (2009)
  • Author(s): 神田輝、鶴見達也
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-27
• [Presentation] EB ウイルスの再活性化-EBウイルスBZLF1 遺伝子産物はSUMO化によりその転写活性を抑制される (2009)
  • Author(s): 村田貴之、鶴見達也
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-27
• [Presentation] EBウイルス産生感染に伴うp27Kip1分解の分子機構 (2009)
  • Author(s): 岩堀聡子、村田貴之、藤田雅俊、清野透、鶴見達也
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-27
• [Presentation] EB ウイルスの再活性化-TORC2はBZLF1 蛋白質と共同してEBウイルスの再活性化を促進する (2009)
  • Author(s): 村田貴之、鶴見達也
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] ヒトサイトメガロウイルスUL76ORF内に存在するinternalentry ribosome site (2009)
  • Author(s): 磯村寛樹、鶴見達也
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-25
• [Presentation] 変異EBV BMRF1蛋白質のウイルス産生感染に与える影響 (2009)
  • Author(s): 中山早苗、鶴見達也
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-25
• [Presentation] Human cytomegalovirus L76 gene regulates the level of xpression of the UL77 gene (2009)
  • Author(s): Isomura H, Stinski MF, Murata T, Nakayama S, Chiba S, Akatsuka Y, Kanda T, Tsurumi T
  • Organizer: 14th nternational Conference on mmunobiology and Prophylaxis of Human erpesvirus Infections
  • Place of Presentation: Kobe
  • Year and Date: 2009-10-06
• [Presentation] Sumoylation of pstein-Barr virus BZLF1 viral protein ramatically inhibits its ranscriptional activity (2009)
  • Author(s): 村田貴之, 鶴見達也
  • Organizer: 14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections
  • Place of Presentation: Kobe
  • Year and Date: 2009-10-06
• [Presentation] Single-step conversion of peripheral B-lymphocytes into B-lymphoblastoid cell lines expressing WT1 tumor antigen (末梢血Bリンパ球を材料としたWT1蛋白質高発現Bリンパ芽球様細胞株ワンステップ樹立法) (2009)
  • Author(s): Kanda T, Tsurumi T
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Human cytomegalovirus UL76 contains an internal ribosome entry site to facilitate UL77 translation (2009)
  • Author(s): 磯村寛樹、鶴見達也
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Sumoylation of Epstein-Barr virus BZLF1 viral protein dramatically inhibits its transcriptional activity (2009)
  • Author(s): 村田貴之、鶴見達也
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Epstein-Barr Virus Polymerase Processivity Factor Enhances BALF2 Promoter Transcription as a Coactivator for the BZLF1 Immediate-Early Protein. (2009)
  • Author(s): 中山早苗、鶴見達也
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Phosphorylation of p27Kip1 by Epstein-Barr virus protein kinase induces its degradation through SCF/Skp2 ubiquitin ligase (2009)
  • Author(s): 岩堀聡子、村田貴之、藤田雅俊、清野透、鶴見達也
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Epstein-Barr virus polymerase processivity factor enhances BALF2 Promoter transcription as a coactivator for the BZLF1 (2009)
  • Author(s): 中山早苗
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-10-01
• [Presentation] Phosphorylation of p27Kip1 by Epstein-Barr Virus Protein Kinase Induces its Degradation through SCFSkp2 Ubiquitin Ligase Actions during Viral Lytic Replication (2009)
  • Author(s): Tsurumi T, Iwahori S., Murata T.
  • Organizer: 9th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Awaji
  • Year and Date: 2009-09-09
• [Presentation] TORC2 promotes EBV reactivation from latency through interaction with viral BZLF1 protein (2009)
  • Author(s): 村田貴之, 鶴見達也
  • Organizer: 4th International Symposium on Nasopharyngeal Carcinoma
  • Place of Presentation: Marrakech, Morocco
  • Year and Date: 2009-06-19
• [Presentation] EBウイルスの再活性化:TORC2はBZLF1 蛋白質と共同してEBウイルスの再活性化を促進する (2009)
  • Author(s): 村田貴之、鶴見達也
  • Organizer: 第6回EBウイルス研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-05
• [Presentation] Calcineurin Promotes EBV Reactivation from Latency via TORC2 8th International Conference on Protein Phosphatases (2008)
  • Author(s): 村田貴之, 鶴見達也
  • Place of Presentation: Maebashi
  • Year and Date: 2008-11-12
• [Presentation] ECS Ubiquitin complex is recruited by Epstein-Barr virus BZLF1 IE protein for degradation of the p53 tumor suppressor (2008)
  • Author(s): 佐藤好隆、鶴見達也
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] TORC2 promotes EBV reactivation from latency by interacting with BZLF1 (2008)
  • Author(s): 村田貴之、鶴見達也
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] TORC2 promotes EBV reactivation from latency by interacting with BZLF1 (2008)
  • Author(s): 村田貴之
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2008-10-29
• [Presentation] EBV BMRF1蛋白質は一本鎖DNA結合蛋白質をコードするBALF2遺伝子の発現を促進する (2008)
  • Author(s): 中山早苗、岩堀聡子、鶴見達也
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2008-10-26
• [Presentation] Epstein-BarrウイルスBZLF1蛋白質は溶解感染期においてECSユビキチンE3リガーゼ複合体をリクルートしてp53を分解する (2008)
  • Author(s): 佐藤好隆、西山幸廣、鶴見達也
  • Organizer: 第56回日本ウイルス学会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2008-10-26
• [Presentation] Degradation of phosphorylated p53 occurs through viral protein-ECS E3 ligase complex during Epstein-Barr virus lytic replication (2008)
  • Author(s): Tsurumi T, Yoshitaka S
  • Organizer: The 8th Awaji International Forum on Infection and Immunity
  • Place of Presentation: Hyogo
  • Year and Date: 2008-09-09
• [Presentation] Open Reading frame 76 of human cytomegalovirus contains an internal ribosome entry site. (2008)
  • Author(s): Isomura H, Stinski M.F., Kumimoto H, Tsurumi T
  • Organizer: 33th International Herpesvirus Workshop, 2008
  • Place of Presentation: Estoril, Portugal
  • Year and Date: 2008-07-29
• [Presentation] EBウイルス溶解感染時にp53はBZLF1-ECSユビキチンリガーゼによって分解される (2008)
  • Author(s): 佐藤好隆、鶴見達也
  • Organizer: 第5回EBウイルス研究会
  • Place of Presentation: 鳥取
  • Year and Date: 2008-07-18
• [Presentation] Expression of Epstein-Barr virus BZLF1 immediate-early protein induces p53 degradation independent of MDM2
  • Author(s): Sato Y., Tsurumi T.
  • Organizer: leading to repression of p53-mediated transcription. American Society for Microbiology Conference on Manipulation of Nuclear Processes by DNA Viruses Charleston
• [Presentation] TORC promotes EBV reactivation from latency by interacting with BZLF1.
  • Author(s): 村田貴之, 鶴見達也
  • Organizer: American Society for Microbiology Conference on Manipulation of Nuclear Processes by DNA Viruses Charleston
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• [Patent(Industrial Property Rights)] 弱毒ヒトサイトメガロウイルス及びそのワクチンとしての使用 (2011)
  • Inventor(s): 鶴見達也, 磯村寛樹
  • Industrial Property Rights Holder: 愛知県
  • Filing Date: 2011-01-26
• [Patent(Industrial Property Rights)] 弱毒ヒトサイトメガロウイルス及びそのワクチンとしての使用 (2011)
  • Inventor(s): 鶴見達也, 磯村寛樹
  • Industrial Property Rights Holder: 愛知県
  • Industrial Property Number: 2011-014548
  • Filing Date: 2011-03-26
• [Patent(Industrial Property Rights)] 弱毒HCMV及びそのワクチンとしての使用 (2010)
  • Inventor(s): 鶴見達也, 磯村寛樹
  • Industrial Property Rights Holder: 愛知県
  • Industrial Property Number: 2010-042936
  • Filing Date: 2010-02-26