Roles of cytokines and TLRs in lymphocyte activation and differentiation
Project/Area Number |
20390141
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
|
Research Institution | University of Toyama |
Principal Investigator |
TAKATSU Kiyoshi University of Toyama, 大学院・医学薬学研究部(医学), 教授 (10107055)
|
Co-Investigator(Kenkyū-buntansha) |
NAGAI Yoshinori 富山大学, 大学院・医学薬学研究部(医学), 准教授 (30431761)
IKUTANI Masashi 富山大学, 大学院・医学薬学研究部(医学), 助教 (40513718)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
Keywords | リンパ球 / IL-5 / TLR / 抗原交叉提示 / 免疫学 / 自然免疫 / IFN-γ / Iigp1 |
Research Abstract |
To investigate IL-5-producing cells in the peripheral tissues, we succeeded to generate IL-5/GFP knock-in mice. IL-5/GFP^+ cells were distributed mainly in the lung and intestinal tissues and they were CD3^- c-kit^- cells but not CD3^+ T cells. We also analyzed RP105 signals in B cell activation and found that RP105 was required for TLR4-dependent plasma cell differentiation and IgM production. Finally, we demonstrated that an interferon-inducible gene Iigp1 had a crucial role in Th1-dependent antigen cross-presentation.
|
Report
(4 results)
Research Products
(62 results)