| Project/Area Number |
20390145
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
NAKANISHI Kenji Hyogo College of Medicine, 医学部, 教授 (60172350)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Tomohiro 兵庫医科大学, 医学部, 教授 (60241171)
NAKAHIRA Masakiyo 兵庫医科大学, 医学部, 助教 (60454758)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 好塩基球 / Th2細胞 / 抗原提示 / アレルギー性炎症 / アレルゲン / IgE複合体 / 抗原提示細胞 / Th2/IgE応答 / アレルゲン/IgE複合体 / 寄生虫感染 / allergen-IgE複合体 / Th2細胞の誘導 / MHC class II / CD80 / 86 |
|---|
| Research Abstract |
Basophils, accounting for less than 1% of total circulating granulocytes, constitutively express FcεR1, and upon crosslinking of FcεR1-bound IgE with multivalent antigens, immediately release various kinds of effector molecules such as histamine and lipid mediators, and Th2-associated cytokines such as IL-4 and IL-13, causing immediate type hypersensitivity. Furthemore, basophils express IL-18R and IL-33R and very strongly produce IL-4 and IL-13 in response to IL-18 and/or IL-33. We have demonstrated that basophils express MHC class II and CD80/86, have the potential to take-up and process protein antigen (Ag), particularly Ag-IgE complexes, and to present peptide with MHC class II and produce IL-4, revealing that basophils are APC, which selectively induce Th2 cells.
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