Study on Induction of Th2 response and allergic inflammation by basophils
Project/Area Number |
20390145
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
|
Research Institution | Hyogo College of Medicine |
Principal Investigator |
NAKANISHI Kenji Hyogo College of Medicine, 医学部, 教授 (60172350)
|
Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Tomohiro 兵庫医科大学, 医学部, 教授 (60241171)
NAKAHIRA Masakiyo 兵庫医科大学, 医学部, 助教 (60454758)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
Keywords | 好塩基球 / Th2細胞 / 抗原提示 / アレルギー性炎症 / アレルゲン / IgE複合体 / 抗原提示細胞 / Th2/IgE応答 / アレルゲン/IgE複合体 / 寄生虫感染 / allergen-IgE複合体 / Th2細胞の誘導 / MHC class II / CD80 / 86 |
Research Abstract |
Basophils, accounting for less than 1% of total circulating granulocytes, constitutively express FcεR1, and upon crosslinking of FcεR1-bound IgE with multivalent antigens, immediately release various kinds of effector molecules such as histamine and lipid mediators, and Th2-associated cytokines such as IL-4 and IL-13, causing immediate type hypersensitivity. Furthemore, basophils express IL-18R and IL-33R and very strongly produce IL-4 and IL-13 in response to IL-18 and/or IL-33. We have demonstrated that basophils express MHC class II and CD80/86, have the potential to take-up and process protein antigen (Ag), particularly Ag-IgE complexes, and to present peptide with MHC class II and produce IL-4, revealing that basophils are APC, which selectively induce Th2 cells.
|
Report
(4 results)
Research Products
(95 results)
-
-
-
-
[Journal Article] Granzyme B is a novel interleukin-18 converting enzyme.2010
Author(s)
Omoto Y, Yamanaka K, Tokime K, Kitano S, Kakeda M, Akeda T, Kurokawa I, Gabazza EC, Tsutsui H, Katayama N, Yamanishi K, Nakanishi K, Mizutani H
-
Journal Title
J Dermatol Sci 59
Pages: 129-35
NAID
Related Report
-
[Journal Article] The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.2010
Author(s)
Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S
-
Journal Title
Nat Immunol 11
Pages: 936-44
Related Report
Peer Reviewed
-
[Journal Article] Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins.2010
Author(s)
Kuroda-Morimoto M, Tanaka H, Hayashi N, Nakahira M, Imai Y, Imamura M, Yasuda K, Yumikura-Futatsugi S, Matsui K, Nakashima T, Sugimura K, Tsutsui H, Sano H, Nakanishi K
-
Journal Title
Int Immunol 22
Pages: 561-70
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Contribution of IL-18 to eosinophilic airway inflammation induced by immunization and challenge with Staphylococcus aureus proteins.2010
Author(s)
Kuroda-Morimoto M, Tanaka H, Hayashi N, Nakahira M, Imai Y, Imamura M, Yasuda K, Yumikura-Futatsugi S, Matsui K, Nakashima T, Sugimura K, Tsutsui H, Sano H, Nakanishi K.
-
Journal Title
Int Immunol
Volume: 22
Pages: 561-70
NAID
Related Report
Peer Reviewed
-
-
-
[Journal Article] Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid-enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model.2010
Author(s)
Yoshikawa S, Iijima H, Saito M, Tanaka H, Imanishi H, Yoshimoto N, Yoshimoto T, Futatsugi-Yumikura S, Nakanishi K, Tsujimura T, Nishigami T, Kudo A, Arii S, Nishiguchi S.
-
Journal Title
Hepatol Res
Volume: 40
Pages: 823-31
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Granzyme B is a novel interleukin-18 converting enzyme.2010
Author(s)
Omoto Y, Yamanaka K, Tokime K, Kitano S, Kakeda M, Akeda T, Kurokawa I, Gabazza EC, Tsutsui H, Katayama N, Yamanishi K, Nakanishi K, Mizutani H.
-
Journal Title
J Dermatol Sci
Volume: 59
Pages: 129-35
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.2010
Author(s)
Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, Miyake T, Matsushita K, Okazaki T, Saitoh T, Honma K, Matsuyama T, Yui K, Tsujimura T, Standley DM, Nakanishi K, Nakai K, Akira S.
-
Journal Title
Nat Immunol
Volume: 11
Pages: 936-44
Related Report
Peer Reviewed
-
[Journal Article] A functional polymorphism in IL-18 is associated with severity of bronchial asthma.2009
Author(s)
Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Taniguchi M, Higashi N, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M
-
Journal Title
Am J Respir Crit Care Med 180
Pages: 1048-55
Related Report
Peer Reviewed
-
-
[Journal Article] Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.2009
Author(s)
Imamura M, Tsutsui H, Yasuda K, Uchiyama R, Yumikura-Futatsugi S, Mitani K, Hayashi S, Akira S, Taniguchi S, Van Rooijen N, Tschopp J, Yamamoto T, Fujimoto J, Nakanishi K
-
Journal Title
J Hepatol 51
Pages: 333-41
Related Report
Peer Reviewed
-
-
[Journal Article] A functional polymorphism in IL-18 is associated with severity of bronchial asthma.2009
Author(s)
Harada M, Obara K, Hirota T, Yoshimoto T, Hitomi Y, Sakashita M, Doi S, Miyatake A, Fujita K, Enomoto T, Taniguchi M, Higashi N, Fukutomi Y, Nakanishi K, Nakamura Y, Tamari M.
-
Journal Title
Am J Respir Crit Care Med 180
Pages: 1048-1055
Related Report
Peer Reviewed
-
[Journal Article] Association of serum IL-33 level and the IL-33 genetic variant with Japanese cedar pollinosis.2008
Author(s)
Sakishita M., Yoshimoto T., Hirota T., Harada M., Okubo K., Osawa Y., Fujieda S., Nakamura Y., Yasuda K., Nakanishi K., Tamari M.
-
Journal Title
Clin.Exp.Allergy 38
Pages: 1875-1881
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Demonstration of cooperative contribution of MET-and EGFR-mediated STAT3 phosphorylation to liver regeneration by exogenous suppressor of cytokine signalings.2008
Author(s)
Seki, E., Kondo, Y., Iimuro, Y., Naka, T., Son, G., Kishimoto, T., Fujimoto, J., Tsutsui, H., Nakanishi, K.
-
Journal Title
J. Hepatol 48
Pages: 237-245
Related Report
Peer Reviewed
-
[Journal Article] Protective effect of IL-18 on kainate-and IL-1 β-induced cerebellar ataxia in mice.2008
Author(s)
Andoh, T., Kishi, H., Motoki, K., Nakanishi, K., Kuraishi, Y., Muraguchi, A.
-
Journal Title
J. Immunol 180
Pages: 437-441
Related Report
Peer Reviewed
-
-
[Journal Article] Freshly isolated Langerhans cells negatively regulate naive T cell activation in response to peptide antigen through cell-to-cell contact.2008
Author(s)
Imai, Y., Hayashi, N., Yasuda. K., Tsutsui, H., Mizutani, H., Nakanishi, K.
-
Journal Title
J. Dermatol. Sci 51
Pages: 19-29
NAID
Related Report
Peer Reviewed
-
[Journal Article] Interferon-γ is a therapeutic target molecule for prevention of postoperative adhesion formation.2008
Author(s)
Kondo, Y., Yoshimoto, T., Yasuda, K., Futatsugi, Yumikura, S., Morimoto, M., Hayashi, N., Hoshino, T., Fujimoto, J., Nakanishi, K.
-
Journal Title
Int. Immunol 20
Pages: 791-800
Related Report
Peer Reviewed
-
[Journal Article] Association of serum IL-33 level and the IL-33 genetic variant with Japanese cedar pollinosis.2008
Author(s)
Sakishita, M., Yoshimoto, T., Hirota, T., Harada, M., Okubo, K., Osawa, Y., Fujieda, S., Nakamura, Y., Yasuda, K., Nakanishi, K., Tamari, M.
-
Journal Title
Clin. Exp. Allergy 38
Pages: 1875-1881
Related Report
Peer Reviewed
-
[Journal Article] Class-specific regulation of pro-inflammatory genes by MyD88 pathways and Ikappa Bzeta.2008
Author(s)
Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T., Takeda, K.
-
Journal Title
J. Biol. Chem 283
Pages: 12468-12477
Related Report
Peer Reviewed
-
[Journal Article] Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.2008
Author(s)
Saiga, H., Nishimura, J., Kuwata, H., Okuyama, M., Matsumoto, S., Sato, S., Matsumoto, M., Akira, S., Yoshikai, Y., Honda, K., Yamamoto, M., Takeda, K.
-
Journal Title
J. Immunol 181
Pages: 8521-8527
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] In vivo administration of IL-33 induces goblet cells capable of expelling Nippostrongylus brasiliensis in the absence of adaptive immune system.2008
Author(s)
Yasuda, K., Sasaki, Y., Kondo, Y., Matsumoto, M., Yoshimoto, T. Nakanishi, K.
Organizer
第38回日本免疫学会総会・学術集会
Place of Presentation
京都
Year and Date
2008-12-03
Related Report
-
-
[Presentation] New DC immunization : Intracellular adjubant plus Ag immunization induces prompt and striking Ag-specific Th2 response.2008
Author(s)
Imai, Y., Yasuda, K., Havashi, N., Yoshimoto, T., Mizutani, H., Nakanishi, K.
Organizer
第38回日本免疫学会総会・学術集会
Place of Presentation
京都
Year and Date
2008-12-01
Related Report
-
-
-
-
-
[Presentation] In vivo administration of IL-33 induces goblet cells capable of expelling Nippostrongylus brasiliensis in the absence of adaptive immune system.2008
Author(s)
Yasuda, K., Sasaki, Y., Kondo, Y., Matsumoto, M., Yoshimoto, T., Nakanishi, K.
Organizer
The 8^<th> Awaji International Forum on Infection and Immunity
Place of Presentation
Hyogo
Year and Date
2008-09-07
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Requirement of MyD88 and TRIF but not ATP signaling for TLR4-mediated caspase-1 activation.2008
Author(s)
Imamura, M., Tsutsui, H., Yasuda, K., Akira, S., Fujimoto, J., Nakanishi, K.
Organizer
The 8th Awaji International Forum on Infection and Immunity
Place of Presentation
Hyogo
Related Report
-
-
-
-
-
-
-