• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A epidemiological study of long-term safety of biological disease-modifying antirheumatic drugs for patients with rheumatoid arthritis and risk factors for adverse drug reactions.

Research Project

Project/Area Number 20390158
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

HARIGAI Masayoshi  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 寄附講座教員 (20238207)

Co-Investigator(Kenkyū-buntansha) MIYASAKA Nobuyuki  東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (30157622)
KOIKE Ryuji  東京医科歯科大学, 医学部附属病院, 准教授 (50250220)
NANKI Toshihiro  東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (00282749)
ATSUMI Tatsuya  北海道大学, 大学院・医学研究科, 准教授 (20301905)
TAKENO Mitsuhiro  横浜市立大学, 医学(系)研究科・大学院, 准教授 (50236494)
KAMEDA Hideto  慶應義塾大学, 医学部, 講師 (00265795)
SAITO Kazuyoshi  産業医科大学, 医学部, 准教授 (30279327)
FUJII Takao  京都大学, 大学院・医学研究科, 准教授 (70255462)
TSUTANI Kiichiro  東京大学, 大学院薬学系研究科, 特任教授 (80142040)
SAWADA Tetsuji  東京医科大学, 医学部, 准教授 (50235470)
TAMURA Naoto  順天堂大学, 医学部, 准教授 (20227284)
TOHMA Shigeto  国立病院機構, 相模原病院, 部長 (50207528)
KAWAKAMI Atsushi  長崎大学, 大学院・医歯薬学総合研究科, 教授 (90325639)
HAYASHI Taichi  筑波大学, 大学院・人間総合科学研究科, 講師 (00466674)
伊藤 聡  筑波大学, 人間総合科学研究科, 准教授 (00334681)
Co-Investigator(Renkei-kenkyūsha) NAKAMURA Takahiro  防衛医科大学校, 医学教育部, 准教授 (60415255)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords生物学的製剤 / TNF阻害薬 / 関節リウマチ / 薬剤疫学 / 安全性 / 患者登録システム / 重篤有害事象 / 薬剤適正使用 / 悪性腫瘍
Research Abstract

We implemented this project to clarify mid- to long-term safety of biological disease modifying antirheumatic drugs (biologics) in Japanese RA patients and to evaluate benefit-risk balance of these drugs. In the REAL study, we identified the use of tumor necrosis factor (TNF) inhibitors as a significant risk factor for serious infection in Japanese RA patients. SECURE study revealed that risks for all malignancies, non-hematopoietic malignancies, and hematopoietic malignancies were not increased in Japanese RA patients given TNF inhibitors. We also performed pharmacoeconomical study to calculate the medical cost for serious adverse events which were observed in the REAL study. These data provided solid and useful evidences for mid- to long-term safety of biologics in Japanese RA patients.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (78 results)

All 2011 2010 2009 2008 Other

All Journal Article (29 results) (of which Peer Reviewed: 17 results) Presentation (43 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Postmarketing surveillance of safety and effectiveness of etanercept in Japanese patients with rheumatoid arthritis.2011

    • Author(s)
      Koike T, Harigai M, Inokuma S, et al.
    • Journal Title

      Mod Rheumatol. (Epub ahead of print)

    • NAID

      10029512752

    • Related Report
      2010 Final Research Report
  • [Journal Article] Tacrolimus-induced Pulmonary Injury in Rheumatoid Arthritis Patients.2011

    • Author(s)
      Koike R, Tanaka M, Komano Y, et al.
    • Journal Title

      Pulmonary Pharmacology and Therapeutics.(20人中20番目) in press.

    • Related Report
      2010 Final Research Report
  • [Journal Article] Methotrexate and trimethoprim-sulfamethoxazole use for PCP prophylaxis2010

    • Author(s)
      Yamazaki H, et al.
    • Journal Title

      J Rheumatol

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The REAL database reveals no significant risk for serious infection during treatment with methotrexate over 8 mg/week in patients with rheumatoid arthritis.2010

    • Author(s)
      Sakai R, et al.
    • Journal Title

      Mod Rheumatol

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 炎症性サイトカイン阻害と感染症(抗体療法 確立された炎症性疾患へのアプローチ)2010

    • Author(s)
      針谷正祥
    • Journal Title

      治療学

      Volume: 44 Pages: 74-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 治療目標・目標達成に向けた治療(Treat to Target)のエビデンスと実際(特集関節リウマヂ治癒をめざず'最新治療コンセンサス)2010

    • Author(s)
      針谷正祥
    • Journal Title

      医学のあゆみ

      Volume: 234 Pages: 14-19

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTLA4-IgによるT細胞共刺激阻害薬-abatacept(関節リウマチの新しい治療)2010

    • Author(s)
      針谷正祥
    • Journal Title

      メディカル・サイエンス・ダイジェスト

      Volume: 36

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF阻害治療と悪性腫瘍一欧米のエビデンスとわが国の取り組み(特集リウマチ性疾患のアウトカム研究)2010

    • Author(s)
      針谷正祥
    • Journal Title

      リウマチ科

      Volume: 43 Pages: 342-346

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 治療のピットフォールー炎症性サイトカイン阻害と感染症一(特集抗体療法●確立された炎症性疾患へのアプローチ)2010

    • Author(s)
      針谷正祥
    • Journal Title

      治療学

      Volume: 44

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的製剤の副作用と使用上の注意点(特集関節リウマチ治療の最前線一現状と展望)2010

    • Author(s)
      野々村美紀, 他
    • Journal Title

      Pharma Medica

      Volume: 28 Pages: 39-42

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的製剤大規模試験のエビデンスー我が国における試験を中心に-REAL研究2010

    • Author(s)
      針谷正祥, 他
    • Journal Title

      日本臨床増刊号 関節リウマチ(第2版)

      Volume: 68 Pages: 339-342

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ステロイドはリウマチに良い?悪い?(特集関節リウマチの治療~ベーシックな治療薬と最新薬のハーモニー~)2010

    • Author(s)
      長坂憲治, 他
    • Journal Title

      Modern Physician

      Volume: 30 Pages: 1042-1045

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的製剤の安全使用に向けて。(関節リウマチ・治療/実地診療における薬の使いかたと留意点)2010

    • Author(s)
      田中みち, 他
    • Journal Title

      Medical Practice

      Volume: 27 Pages: 2121-2127

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 関節リウマチにおけるMTXの安全性一REAL研究より (特集関節リウマチ治療におけるメトトレキサートMTXの新たな位置づけ)2010

    • Author(s)
      酒井良子, 他
    • Journal Title

      リウマチ科

      Volume: 44 Pages: 520-524

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的製剤の副作用と使用上の注意点(特集 関節リウマチ治療の最前線-現状と展望)2010

    • Author(s)
      野々村美紀、針谷正祥
    • Journal Title

      Pharma Medica 28

      Pages: 39-42

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab : A retrospective review and case-control study of 21 patients.2009

    • Author(s)
      Komano Y, Harigai M, Koike R, et al.
    • Journal Title

      Arthritis Rheum. 61(3)

      Pages: 305-312

    • Related Report
      2010 Final Research Report
  • [Journal Article] Postmarketing surveillance of the safety and effectiveness of etanercept in Japan.2009

    • Author(s)
      Koike T, Harigai M, Inokuma S, et al.
    • Journal Title

      J Rheumatol.May 36(5)

      Pages: 898-906

    • Related Report
      2010 Final Research Report
  • [Journal Article] Japan College of Rheumatology 2009 guidelines for the use of tocilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis.2009

    • Author(s)
      Koike R, Harigai M, Atsumi T, et al.
    • Journal Title

      Mod Rheumatol (19)

      Pages: 351-357

    • NAID

      10025113303

    • Related Report
      2010 Final Research Report
  • [Journal Article] Postmarketing surveillance of the safety and effectiveness of etanercept in Japan.2009

    • Author(s)
      Koike T,針谷正祥, Inokuma S, Inoue K, Ishiguro N, Ryu J, Takeuchi T, Tanaka Y, Yamanaka H, Fujii K, Freundlich B, Suzukawa M.
    • Journal Title

      Journal of Rheumatology 36

      Pages: 898-906

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japan College of Rheumatology 2009 guidelines for the use of to cilizumab, a humanized anti-interleukin-6 receptor monoclonal antibody, in rheumatoid arthritis.2009

    • Author(s)
      Koike R, 針谷正祥, Atsumi T, Amano K, Kawai S, Saito K, Saito T, Yamamura M, Matsubara T, Miyasaka N.
    • Journal Title

      Modern Rheumatology 19

      Pages: 351-357

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的製剤による副作用 予防とリスクマネージメント ニューモシスチス肺炎2009

    • Author(s)
      駒野有希子、針谷正祥
    • Journal Title

      内科 103

      Pages: 711-714

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      針谷正祥
    • Journal Title

      よくわかる関節リウマチのすべて(分担執筆)(永井書店)

      Pages: 186-201

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      針谷正祥
    • Journal Title

      正しい生物学的製剤の使い方(関節リウマチ)(分担執筆)(医薬ジャーナル社)

      Pages: 53-61

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Pneumocystis jiroveci pneumonia in patients with rheumatoid arthritis treated with infliximab : A retrospective review and case-control study of 21 patients2009

    • Author(s)
      Komano Y, Harigai M, Koike R, et al.
    • Journal Title

      Arthritis & Rheumatism 61

      Pages: 305-12

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis.2008

    • Author(s)
      Takeuchi T, Tatsuki Y, Nogami Y, Ishiguro N, Tanaka Y, Yamanaka H, Kamatani N, Harigai M, Ryu J, Inoue K, Kondo H, Inokuma S, Ochi T, Koike T
    • Journal Title

      Annals of the Rheumatic Diseases 67

      Pages: 189-94

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of antibody titers 1 year after influenza vaccination in patients with rheumatoid arthritis receiving TNF blockers. 2008 Nov 18.2008

    • Author(s)
      Nii T, Kubota T, Nanki T, Komano Y, Harigai M, et al.
    • Journal Title

      Modern Rheumatology (On linefirst)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methotrexate and trimethoprim-sulfamethoxazole use for PCP prophylaxis.

    • Author(s)
      Yamazaki H, Nanki T, Miyasaka N, Harigai, M.
    • Journal Title

      J Rheumatol in press.

    • Related Report
      2010 Final Research Report
  • [Journal Article] The REAL database reveals no significant risk for serious infection during treatment with methotrexate over 8 mg/week in patients with rheumatoid arthritis.

    • Author(s)
      Sakai R, Komano Y, Tanaka M, et al.
    • Journal Title

      Mod Rheumatol(19人中19番目) (Epub ahead of print)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Incidence and risk factors for serious infection in rheumatoid arthritis patients treated with tumor necrosis factor (TNF) inhibitors ; a report from the Registry of Japanese Rheumatoid Arthritis Patients for Long-Term Safety (REAL).

    • Author(s)
      Komano Y, Tanaka M, Nanki T, et al.
    • Journal Title

      J Rheumatol(24人中24番目) in press.

    • Related Report
      2010 Final Research Report
  • [Presentation] アダリムマブ全例使用成績調査中間解析報告-安全性データを中心に-2011

    • Author(s)
      針谷正祥
    • Organizer
      ヒュミラ インターネットライブセミナー
    • Place of Presentation
      東京
    • Year and Date
      2011-01-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] TNF阻害薬の継続投与と重篤感染症発現リスク-REALデータベースを用いた解析-2010

    • Author(s)
      針谷正祥
    • Organizer
      厚生労働科学研究費補助金 免疫アレルギー疾患等予防・治療研究事業平成22年度リウマチ関連三班合同研究発表会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節リウマチの診断と治療の新潮流2010

    • Author(s)
      針谷正祥
    • Organizer
      第7回島根東部リウマチセミナー
    • Place of Presentation
      松江市
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節リウマチの薬物療法一注意すべき副作用と対策一2010

    • Author(s)
      針谷正祥
    • Organizer
      熊本地区リウマチ教育研修会
    • Place of Presentation
      熊本
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節炎の診断と薬物治療の進歩~beyond the paradigm~2010

    • Author(s)
      針谷正祥
    • Organizer
      第14回北九州リウマチ薬物治療懇話会
    • Place of Presentation
      北九州市
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] REALデータベースからみたACR/Ei1LAR RA新分類基準の検証2010

    • Author(s)
      針谷正祥
    • Organizer
      第25回日本臨床リウマチ学会 シンポジウム1
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Post-Marketing Surveillance Program of Tocilizumab for RA in Japan-Interim Analyses of 3, 881 Patients.2010

    • Author(s)
      Koike T, Harigai M, et al.
    • Organizer
      American College of Rheumatology 74th Annual Scientific Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Golimumab, a Human Anti-TNF a Monoclonal Antibody Administered Subcutaneoulsy Every Four Weeks as Monotherapyin Patients with Active Rheumatoid Arthritis Despite DMARD Therapy : 24-Week Results of Clinical and Radiographic Assessments.2010

    • Author(s)
      Takeuchi T, Harigai M, et al.
    • Organizer
      American College of Rheumatology 74th Annual Scientific Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Golimumab, a Human Anti-TNF a Monoclonal Antibody Administered Subcutaneously Every Four Weeks in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy : 24-Week Results of Clinical and Radiographic Assessments.2010

    • Author(s)
      Tanaka Y, Harigai M, et al.
    • Organizer
      American College of Rheumatology 74th Annual Scientific Meeting
    • Place of Presentation
      Atlanta
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節リウマチにおける生物学的製剤エビデンスからプラクティスへ2010

    • Author(s)
      針谷正祥
    • Organizer
      静岡炎症研究会2010
    • Place of Presentation
      静岡
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節リウマチにおけるTNF阻害薬と悪性腫瘍のリスク-SECURE研究からの報告-2010

    • Author(s)
      針谷正祥
    • Organizer
      関節リウマチ患者における生物学的製剤の安全性に関する国際シンポジウム-日本および海外の大規模コホート研究からのエビデンス-
    • Place of Presentation
      東京
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] アダリムマブ前例使用成績調査中間解析報告2010

    • Author(s)
      針谷正祥
    • Organizer
      ヒュミラ2周年記念講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 関節リウマチにおける生物学的製剤の薬剤疫学2010

    • Author(s)
      針谷正祥
    • Organizer
      薬剤疫学セミナー
    • Place of Presentation
      東京
    • Year and Date
      2010-07-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 我が国のエビデンスに基づく生物学的製剤の安全性2010

    • Author(s)
      針谷正祥
    • Organizer
      第8回湘南西部リウマチ性疾患症例検討会
    • Place of Presentation
      厚木市
    • Year and Date
      2010-06-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 正しく知ろう関節リウマチー診断と治療の最新知識一2010

    • Author(s)
      針谷正祥
    • Organizer
      2010年度日本女性薬剤師会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生物学的製剤の長期安全性に関する国内外のエビデンス2010

    • Author(s)
      針谷正祥
    • Organizer
      第2回KOCS小児リウマチ研究会
    • Place of Presentation
      博多
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 我が国のエビデンスに基づくトシリズマプ治療の最適化2010

    • Author(s)
      針谷正祥
    • Organizer
      第5回トシリズマブ適正使用研究会
    • Place of Presentation
      長崎
    • Year and Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 日本人関節リウマチ患者のエビデンスに基づく分子標的治療の最適化2010

    • Author(s)
      針谷正祥
    • Organizer
      Rheumatology Cpdate 2010
    • Place of Presentation
      札幌
    • Year and Date
      2010-05-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 我が国のエビデンスに基づいた生物学的製剤の安全かつ有効な使用方法2010

    • Author(s)
      針谷正祥
    • Organizer
      生物学的製剤の適正使用について語る会~in Hiroshima~
    • Place of Presentation
      広島市
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒュミラの安全性情報~関節リウマチにおける使用経験から~2010

    • Author(s)
      針谷正祥
    • Organizer
      ヒュミラ適応追加記念講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-03-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 我が国のエビデンスに基づく♂アダリムマブの適正使用2010

    • Author(s)
      針谷正祥
    • Organizer
      抗TNF製剤適応追加勉強会
    • Place of Presentation
      東京都
    • Year and Date
      2010-03-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチにおけるトシリズマブの安全性-国内外のエビデンス2010

    • Author(s)
      針谷正祥
    • Organizer
      第2回RA Sunriseフォーラム大阪
    • Place of Presentation
      大阪市
    • Year and Date
      2010-02-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evidence, experience and perspective of the treatment of rheumatoid arthritis patients with tocilizumab2010

    • Author(s)
      針谷正祥
    • Organizer
      Hong Kong Pharmacy Conference 2010
    • Place of Presentation
      Hong Kong
    • Year and Date
      2010-01-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Post-Marketing Surveillance Program of Tocilizumab for RA in Japan-Interim Analyses of 3,881 Patients., American College of Rheumatology2010

    • Author(s)
      Koike T, Harigai M, et al.
    • Organizer
      74th Annual Scientific Meeting An Official Journal of the American College of Rheumatology, 62, 168
    • Place of Presentation
      Atlanta, Georgia
    • Related Report
      2010 Final Research Report
  • [Presentation] Evidence, experience and perspective of the treatment of rheumatoid arthritis patients with tocilizuamb.2010

    • Author(s)
      Harigai M
    • Organizer
      Hong Kong Pharmacy Conference 2010
    • Place of Presentation
      Hong Kong
    • Related Report
      2010 Final Research Report
  • [Presentation] TNF antagonists in rheumatoid arthritis and risk of malignancy. results from the SECURE study.2010

    • Author(s)
      Harigai M.
    • Organizer
      International Symposium for Safety of Biologics in Patients with Rheumatoid Arthritis -Merging evidence from large-scale cohort studies in Japan and overseas-
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] 関節リウマチに対するBiologics治療下における感染症の診断と治療2009

    • Author(s)
      針谷正祥
    • Organizer
      第82回福岡リウマチ懇話会
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] リウマチ性疾患における生物学的製剤と重症感染症2009

    • Author(s)
      針谷正祥
    • Organizer
      第58回日本感染症学会(東日本地方会学術集会)、第56回日本科学療法学会(東日本支部総会)
    • Place of Presentation
      東京
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Tacrolimus-Induced Pulmonary Injury in Patients with Rheumatoid Arthritis.2009

    • Author(s)
      Koike R, 針谷正祥, et al.
    • Organizer
      American College of Rheumatology
    • Place of Presentation
      Philadelphia
    • Year and Date
      2009-10-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチ薬物療法の現状と展望2009

    • Author(s)
      針谷正祥
    • Organizer
      第19回東三河リウマチ研究会 症例検討会及び学術講演会
    • Place of Presentation
      豊橋市
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Biological Eraにおける関節リウマチの最新治療戦略2009

    • Author(s)
      針谷正祥
    • Organizer
      第6回都城リウマチ研究会
    • Place of Presentation
      都築市
    • Year and Date
      2009-08-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pneumocystis jiroveci pneumonia(PCP)associated with etanercept in patients with rheumatoid arthritis2009

    • Author(s)
      田中みち, 針谷正祥, 他
    • Organizer
      The 9th World Congress on Inflammation
    • Place of Presentation
      東京
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of serious adverse events in patients with rheumatoid arthritis under the treatment with biologics ; a report from the Registry of Japanese Rheumatoid Arthritis Patients for Long-term Safety2009

    • Author(s)
      Komano Y, 針谷正祥, et al.
    • Organizer
      Annual European Congress of Rheumatology
    • Place of Presentation
      Copenhagen
    • Year and Date
      2009-06-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pneumocystis jiroveci pneumonia associated with etanercept in patients with rheumatoid arthritis2009

    • Author(s)
      田中みち, 針谷正祥, 他
    • Organizer
      Annual European Congress of Rheumatology
    • Place of Presentation
      Copenhagen
    • Year and Date
      2009-06-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチにおける生物学的製剤-有効かつ安全な治療を目指して2009

    • Author(s)
      針谷正祥
    • Organizer
      第4回Biological Meeting in Tottori(BMT)
    • Place of Presentation
      米子市
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] アダリムマブ全例市販後調査における安全性と有効性2009

    • Author(s)
      針谷正祥
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチ患者におけるメトトレキサートの安全性:8mg/週以下と8mg/週超の比較2009

    • Author(s)
      酒井良子、針谷正祥, 他
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] エタネルセプト投与下での関節リウマチ患者におけるニューモシスチス肺炎2009

    • Author(s)
      田中みち、針谷正祥, 他
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 国内におけるアダリムマブのエビデンス2009

    • Author(s)
      針谷正祥
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 日本人関節リウマチ患者におけるタクロリムスの安全性2009

    • Author(s)
      針谷正祥
    • Organizer
      第53回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of serious adverse events in patients with rheumatoid arthritis under the treatment with biologics ; a report from the Registry of Japanese Rheumatoid Arthritis Patients for Long-term Safety.2009

    • Author(s)
      Komano Y, et al.
    • Organizer
      Annual European Congress of Rheumatology
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2010 Final Research Report
  • [Presentation] Pneumocystis jiroveci pneumonia associated with etanercept in patients with rheumatoid arthritis.2009

    • Author(s)
      Tanaka M, et al.
    • Organizer
      Annual European Congress of Rheumatology
    • Place of Presentation
      Copenhagen, Denmark
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本における生物学的製剤使用関節リウマチ患者に関する疫学研究(REAL研究)による生物学的製剤の安全性の検討(中間報告)2008

    • Author(s)
      駒野有希子, 針谷正祥, 他
    • Organizer
      第52回日本リウマチ学会総会・学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-22
    • Related Report
      2008 Annual Research Report
  • [Book] ニューモシスチス肺炎。リウマチ・膠原病内科 クリニカルスタンダード(必携ベッドサイドで必ず役立つリウマチ・膠原病学のエッセンス)2010

    • Author(s)
      長坂憲治, 他(編集 三森経世)
    • Total Pages
      331
    • Publisher
      文光堂
    • Related Report
      2010 Annual Research Report
  • [Book] 生物学的製剤の標的分子からみたRAの病態(ファーマナビゲーターリウマチ~生物学的製剤編~)2010

    • Author(s)
      針谷正祥(編集竹内勤)
    • Total Pages
      246
    • Publisher
      メジカルレビュー社
    • Related Report
      2010 Annual Research Report
  • [Book] 副作用・合併症への対応と対策(生物学的製剤によるリウマチ治療マニュアル)2010

    • Author(s)
      田中みち, 他(監修日本リウマチ実地医会)
    • Total Pages
      217
    • Publisher
      日本医学館
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.tmd.ac.jp/grad/phv/

    • Related Report
      2010 Final Research Report
  • [Remarks] 東京医科歯科大学薬害監視学講座ホームページ

    • URL

      http://www.tmd.ac.jp/grad/phv/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks] 東京医科歯科大学薬害監視学講座ホームページ

    • URL

      http://www.tmd.ac.jp/grad/phv/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2018-01-05  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi