| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Research Abstract |
The present study was performed, using a specific inhibitor of NCX, to clarify the pathological role of the Na^+/Ca^<2+> exchanger (NCX), which is involved in the regulation of intracellular Ca^<2+> concentrations. We found that NCX is involved in nitric oxide (NO)-induced cytotoxicity in cultured cells and in dopaminergic dysfunction in a mouse model of Parkinson's disease. These findings suggest that NCX has a potential as a candidate molecule for treatment of NO-related disorders.
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