Basic studies on drug development targeting for brain NCX
| Project/Area Number |
20390159
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUDA Toshio Osaka University, 大学院・薬学研究科, 教授 (00107103)
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| Co-Investigator(Kenkyū-buntansha) |
AGO Yukio 大阪大学, 大学院・薬学研究科, 助教 (50403027)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 脳神経疾患 / 薬理学 / Na^+ / Ca^<2+>交換系(NCX) / 一酸化窒素(NO) / アストロサイト / MPTP / パーキンソン病 / Na^+/Ca^<2+>交感系(NCX) / SH-SY5Y細胞 / Ca^<2+> / SEA0400 / Ca^<2+>exchanger(NCX) / Parkinson / ドパモン神経 / nitric oxide(NO) / microdialysis / Ca^<2+> exchanger (NCX) / ドパミン神経 / nitric oxide (NO) |
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| Research Abstract |
The present study was performed, using a specific inhibitor of NCX, to clarify the pathological role of the Na^+/Ca^<2+> exchanger (NCX), which is involved in the regulation of intracellular Ca^<2+> concentrations. We found that NCX is involved in nitric oxide (NO)-induced cytotoxicity in cultured cells and in dopaminergic dysfunction in a mouse model of Parkinson's disease. These findings suggest that NCX has a potential as a candidate molecule for treatment of NO-related disorders.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Excessive Na^+/H^+ exchange in disruption of dendritic Na^+ and Ca^<2+> homeostasis and mitochondrial dysfunction following in vitro ischemia.2010
Author(s)
Douglas B. Kintner, Xinzhi Chen, Julia Currie, Vishal Chanana, Peter Ferrazzano, Akemichi Baba, Toshio Matsuda, Mike Cohen, John Orlowski, Shing-Yan Chiu, Jack Taunton, Dandan Sun
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Journal Title
J.Biol.Chem. 285(45)
Pages: 35155-35168
Related Report
Peer Reviewed
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[Journal Article] A Na^+/Ca^<2+> exchanger isoform, NCX1, involves in retinal cell death after N-methyl-D-aspartate and ischemia-reperfusion.2009
Author(s)
Yuta Inokuchi, Masamitsu Shimazawa, Yoshimi Nakajima, Issei Komuro, Toshio Matsuda, Akemichi Baba, Makoto Araie, Satomi Kita, Takahiro Iwamoto, Hideaki Hara
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Journal Title
J.Neurosci.Res. 87(4)
Pages: 906-917
Related Report
Peer Reviewed
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[Journal Article] A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothio-phen-5-yl)ethoxy]propyl}azetidin-3-ol maleate), prevents 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice.2008
Author(s)
Toshiyuki Kawasaki, Yukio Ago, Tatsuya Kitao, Tetsuaki Nashida, Akiko Takagi, Kazuhiro Takuma, Toshio Matsuda
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Journal Title
Neuro-pharmacology 55(5)
Pages: 654-660
Related Report
Peer Reviewed
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