Pharmacogenetic studies on the influence of ALDH2 gene polymorphisms on the vasodilation induced by organic nitrates
| Project/Area Number |
20390160
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
SASAGURI Toshiyuki Kyushu University, 大学院・医学研究院, 教授 (30261209)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Fumi 九州大学, 大学院・医学研究院, 助教 (50274436)
MATSUMURA Kiyoshi 九州大学, 病院, 助教 (70285469)
三輪 宜一 九州大学, 大学院・医学研究院, 助教 (60346773)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 硝酸薬 / ニトログリセリン / 二硝酸イソソルビド / 狭心症 / 血管拡張 / 2型アルデヒド脱水素酵素 / 遺伝子多型 / ゲノム薬理学 / 薬理遺伝学 / 硝酸イソソルビド |
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| Research Abstract |
To examine whether polymorphisms at codon 487 of aldehyde dehydrogenase 2 (ALDH2) influence nitroglycerin (GTN)-induced vasodilation, and whether GTN or isosorbide dinitrate (ISDN) is more effective in each genotype, we performed a crossover trial using sublingual spray of GTN and ISDN. Maximal artery diameter increase in response to GTN or ISDN did not differ among genotypes. However, the time required for dilation was longer in the ^*1/^*2 and ^*2/^*2 genotypes than ^*1/^*1. In contrast, ISDN-induced dilation did not differ among genotypes. The time required for GTN dilation was shorter than that for ISDN dilation among ^*1 allele carriers, whereas GTN and ISDN dilation did not differ among participants carrying ^*2/^*2. These results suggested that the response to GTN was significantly delayed in ^*2 allele carriers. GTN dilated the artery more quickly than ISDN in ^*1/^*1 and ^*1/^*2, but not in ^*2/^*2.
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Report
(4 results)
Research Products
(47 results)
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[Presentation] 2型アルデヒド脱水素酵素の遺伝子多型ガニトログリセリンおとび二硝酸イソソルビドの血管拡張作用に印ぼす効果2010
Author(s)
吉原達也, 坂田智子, 白石富美恵, 鬼木秀幸, 市島久仁彦, 大坪俊夫, 三輪宜一, 高橋富美, 有馬久富, 松村潔, 笹栗俊之
Organizer
第31回日本臨床薬理学会年会
Place of Presentation
京都
Related Report
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[Presentation] Effect of aldehyde dehydrogenase-2 gene polymorphism on vasodilatory response of brachial artery induced by nitroglycerin.2010
Author(s)
Sakata S, Matsumura K, Miwa Y, Oniki H, Ichishima K, Arima H, Takahashi-Yanaga F, Yoshihara T, Shiraishi F, Iida M, Sasaguri T
Organizer
23rd Scientific Meeting of the International Society of Hypertension
Place of Presentation
バンクーバー
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