| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Research Abstract |
We determined the crystal structures of complexes of the A variant AGP with some drugs. Comparison of our results with the structure of F1*S variant provides important new insights into the mechanism of the drug-binding selectivity of AGP variants. In addition, we explored the mechanism involved in hepatic cellular uptake of AGP. The findings indicate that hemoglobin beta-subunit contributes to the hepatocellular uptake of AGP, and AGP is incorporated via caveolae/lipid rafts pathway.
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