Strategy for the personalized medicine of molecular target drug based on the polymorphism information of plasma protein
| Project/Area Number |
20390161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
MARUYAMA Toru Kumamoto University, 薬学部, 教授 (90423657)
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| Co-Investigator(Renkei-kenkyūsha) |
OTAGIRI MASAKI 崇城大学, 薬学部, 教授 (80120145)
WATANABE Hiroshi 熊本大学, 薬学部, 講師 (70398220)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 血清タンパク質 / α1-酸性糖タンパク質 / 多型情報 / 体内動態 / タンパク結合 / α_1-酸性糖タンパク質 / バリアント / リガンド結合 / X線結晶構造解析 / 肝取り込み / α_<1->酸性糖タンパク質 / アルブミン / 分子標的薬 |
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| Research Abstract |
We determined the crystal structures of complexes of the A variant AGP with some drugs. Comparison of our results with the structure of F1*S variant provides important new insights into the mechanism of the drug-binding selectivity of AGP variants. In addition, we explored the mechanism involved in hepatic cellular uptake of AGP. The findings indicate that hemoglobin beta-subunit contributes to the hepatocellular uptake of AGP, and AGP is incorporated via caveolae/lipid rafts pathway.
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Report
(4 results)
Research Products
(138 results)
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[Journal Article] Structural insights into differences in drug binding selectivity between two forms of human alphal-acid glycoprotein genetic variants, the A and F1*S forms.2011
Author(s)
Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Vitamin d receptor activator reduces oxidative stress in hemodialys is patients with secondary hyperparathyroidism.2011
Author(s)
Tanaka M,, Tokunaga K,, Komaba H,, Itoh K,, Matsushita K, Watanabe H,, Kadowaki D, Maruyama T,, Otagiri M,, Fukagawa M.
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Journal Title
Ther Apher Dial.
Volume: 15
Pages: 161-8
Related Report
Peer Reviewed
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[Journal Article] Structural insights into differences in drug binding selectivity between two forms of human{alpha}1-acid glycoprotein genetic variants, the A and F1*S forms.2011
Author(s)
Nishi K,, Ono T,, Nakamura T,, Fukunaga N,, Izumi M,, Watanabe H,, Suenaga A,, Maruyama T,, Yamagata Y,, Curry S, Otagiri M.
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Journal Title
J Biol Chem.
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin-vesicles, can be safely used under conditions of hepatic impairment.2010
Author(s)
Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
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Journal Title
Toxicol Appl Pharmacol. 248
Pages: 234241-234241
Related Report
Peer Reviewed
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[Journal Article] Hepatically-metabolize and -excreted artificial oxygen carrier hemoglobin vesicles, can be safely used under conditions of hepatic impairment.2010
Author(s)
Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
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Journal Title
Toxicol Appl Pharmacol.
Volume: 248
Pages: 234-41
Related Report
Peer Reviewed
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[Journal Article] Hemoglobin vesicles, polyethylene glycol (PEG) ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice.2009
Author(s)
Taguchi K, Urata Y, Anraku M, Watanabe H, Kadowaki D, Sakai H, Horinouchi H, Kobayashi K, Tsuchida E, Maruyama T, Otagiri M.
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Journal Title
Drug Metab Dispos. 37
Pages: 2197-2203
Related Report
Peer Reviewed
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[Journal Article] Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin-vesicles as an artificial oxygen carrier.2009
Author(s)
Taguchi K, Urata Y, Anraku M, Maruyama T, Watanabe H, Sakai H, Horinouchi H, Kobayashi K, Tsuchida E, Kai T, Otagiri M.
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Journal Title
Drug Metab Dispos. 37
Pages: 1456-1463
NAID
Related Report
Peer Reviewed
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