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Strategy for the personalized medicine of molecular target drug based on the polymorphism information of plasma protein

Research Project

Project/Area Number 20390161
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKumamoto University

Principal Investigator

MARUYAMA Toru  Kumamoto University, 薬学部, 教授 (90423657)

Co-Investigator(Renkei-kenkyūsha) OTAGIRI MASAKI  崇城大学, 薬学部, 教授 (80120145)
WATANABE Hiroshi  熊本大学, 薬学部, 講師 (70398220)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords血清タンパク質 / α1-酸性糖タンパク質 / 多型情報 / 体内動態 / タンパク結合 / α_1-酸性糖タンパク質 / バリアント / リガンド結合 / X線結晶構造解析 / 肝取り込み / α_<1->酸性糖タンパク質 / アルブミン / 分子標的薬
Research Abstract

We determined the crystal structures of complexes of the A variant AGP with some drugs. Comparison of our results with the structure of F1*S variant provides important new insights into the mechanism of the drug-binding selectivity of AGP variants. In addition, we explored the mechanism involved in hepatic cellular uptake of AGP. The findings indicate that hemoglobin beta-subunit contributes to the hepatocellular uptake of AGP, and AGP is incorporated via caveolae/lipid rafts pathway.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (138 results)

All 2011 2010 2009 2008 Other

All Journal Article (55 results) (of which Peer Reviewed: 55 results) Presentation (82 results) Remarks (1 results)

  • [Journal Article] Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients.2011

    • Author(s)
      Anraku M, Takeuchi K, Watanabe H, Kadowaki D, Kitamura K, Tomita K, Kuniyasu A, Suenaga A, Maruyama T, Otagiri M.
    • Journal Title

      J Pharm Sci. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural insights into differences in drug binding selectivity between two forms of human alphal-acid glycoprotein genetic variants, the A and F1*S forms.2011

    • Author(s)
      Nishi K, Ono T, Nakamura T, Fukunaga N, Izumi M, Watanabe H, Suenaga A, Maruyama T, Yamagata Y, Curry S, Otagiri M.
    • Journal Title

      J Biol Chem. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluid resuscitation with hemoglobin-vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model.2011

    • Author(s)
      Taguchi K, Ogaki S, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
    • Journal Title

      J Pharmacol Exp Ther. 337

      Pages: 201-208

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011

    • Author(s)
      Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
    • Journal Title

      Nephrol Dial Transplant. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repeated injection of high doses of hemoglobin encapsulated liposomes (hemoglobin-vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011

    • Author(s)
      Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Dispos. 39

      Pages: 484-489

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin D receptor activator reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism.2011

    • Author(s)
      Tanaka M, Tokunaga K, Komaba H, Itoh K, Matsushita K, Watanabe H, Kadowaki D, Maruyama T, Otagiri M, Fukagawa M.
    • Journal Title

      Ther Apher Dial. 15

      Pages: 129-131

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2011

    • Author(s)
      Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
    • Journal Title

      J Pharm Sci. 100

      Pages: 775-783

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin d receptor activator reduces oxidative stress in hemodialys is patients with secondary hyperparathyroidism.2011

    • Author(s)
      Tanaka M,, Tokunaga K,, Komaba H,, Itoh K,, Matsushita K, Watanabe H,, Kadowaki D, Maruyama T,, Otagiri M,, Fukagawa M.
    • Journal Title

      Ther Apher Dial.

      Volume: 15 Pages: 161-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New insight into the redox properties of uremic solute indoxyl sulfate as a pro- and anti-oxidant.2011

    • Author(s)
      Miyamoto Y,, Watanabe H,, Otagiri M,, Maruyama T.
    • Journal Title

      Ther Apher Dial.

      Volume: 15 Pages: 129-31

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An autoantibody against N(ε)-(carboxyethyl)lysine(CEL) : Possible involvement in the removal of CEL-modified proteins by macrophages.2011

    • Author(s)
      Mera K,, Nagai R,, Takeo K, Izumi M,, Maruyama T,, Otagiri M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural insights into differences in drug binding selectivity between two forms of human{alpha}1-acid glycoprotein genetic variants, the A and F1*S forms.2011

    • Author(s)
      Nishi K,, Ono T,, Nakamura T,, Fukunaga N,, Izumi M,, Watanabe H,, Suenaga A,, Maruyama T,, Yamagata Y,, Curry S, Otagiri M.
    • Journal Title

      J Biol Chem.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.2011

    • Author(s)
      Miyamoto Y, Watanabe H, Noguchi T, Kotani S, Nakajima M, Kadowaki D, Otagiri M, Maruyama T.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichia coli Growth via Complement Activation in a Hemorrhagic Shock Rat Model.2011

    • Author(s)
      Taguchi K, Ogaki S, Watanabe H, Kadowaki.D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
    • Journal Title

      J Pharmacol Exp Ther.

      Volume: 337 Pages: 201-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated injection of high doses of hemoglobin-encapsulated liposomes (hemoglobin vesicles) induces accelerated blood clearance in a hemorrhagic shock rat model.2011

    • Author(s)
      Taguchi K, Iwao Y, Watanabe H, Kadowaki D, Sakai H, Kobayashi K, Horinouchi H, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Dispos.

      Volume: 39 Pages: 484-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander.2010

    • Author(s)
      Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Dispos. 38

      Pages: 2124-2129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin-vesicles, can be safely used under conditions of hepatic impairment.2010

    • Author(s)
      Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
    • Journal Title

      Toxicol Appl Pharmacol. 248

      Pages: 234241-234241

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Albumin fusion of thioredoxin-the production and evaluation of its biological activity for potential therapeutic applications.2010

    • Author(s)
      Ikuta S, Chuang VTG, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
    • Journal Title

      J Control Release. 147

      Pages: 17-23

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.2010

    • Author(s)
      Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
    • Journal Title

      J Control Release. 145

      Pages: 9-16

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.2010

    • Author(s)
      Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
    • Journal Title

      FEBS Lett. 584

      Pages: 2816-2820

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an expression system for human?acid glycoprotein in E.coli : the role of oligosaccharide moieties on structural and functional properties.2010

    • Author(s)
      Nishi K, Fukunaga N, Ono T, Akuta T, Yumita N, Watanabe H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Pharmacokinet. 25

      Pages: 200-207

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-mediated uptake of human?acid glycoprotein into liver parenchymal cells in mice.2010

    • Author(s)
      Matsumoto K, Nishi K, Kikuchi M, Watanabe H, Nakajou K, Komori H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Pharmacokinet. 25

      Pages: 101-107

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander.2010

    • Author(s)
      Taguchi K, Urata Y, Anraku M, Watanabe H, Kawai K, Komatsu T, Tsuchida E, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Dispos.

      Volume: 38 Pages: 2124-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.2010

    • Author(s)
      Taguchi K, Miyasato M, Watanabe H, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
    • Journal Title

      J Pharm Sci.

      Volume: 100 Pages: 775-83

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatically-metabolize and -excreted artificial oxygen carrier hemoglobin vesicles, can be safely used under conditions of hepatic impairment.2010

    • Author(s)
      Taguchi K, Miyasato M, Ujihira H, Watanabe H, Kadowaki D, Sakai H, Tsuchida E, Horinouchi H, Kobayashi K, Maruyama T, Otagiri M.
    • Journal Title

      Toxicol Appl Pharmacol.

      Volume: 248 Pages: 234-41

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Albumin fusion of thioredoxin-the production and evaluation, of its biological activity for potential therapeutic applications.2010

    • Author(s)
      Ikuta S, Chuang VT, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M.
    • Journal Title

      J Control Release.

      Volume: 147 Pages: 17-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an expression system for human alpha(1)-acid glycoprotein in E.coli : The roles of oligosaccharide moieties in structural and functional properties.2010

    • Author(s)
      Nishi K, Fukunaga N, Ono T, Akuta T, Yumita N, Watanabe H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Pharmacokinet.

      Volume: 25 Pages: 200-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-step preparation of S-nitrosated human serum albumin with high biological activities.2010

    • Author(s)
      Ishima Y, Hiroyama S, Kragh-Hansen U, Maruyama T, Sawa T, Akaike T, Kai T, Otagiri M.
    • Journal Title

      Nitric Oxide.

      Volume: 23 Pages: 121-7

    • NAID

      120002971552

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.2010

    • Author(s)
      Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M.
    • Journal Title

      FEBS Lett.

      Volume: 584 Pages: 2816-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.2010

    • Author(s)
      Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M.
    • Journal Title

      J Control Release.

      Volume: 145 Pages: 9-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice.2010

    • Author(s)
      Matsumoto K, Nishi K, Kikuchi M, Watanabe H, Nakajou K, Komori H, Kadowaki D, Suenaga A, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Pharmacokinet.

      Volume: 25 Pages: 101-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an expression system for human alfa_1-acid glycoprotein in E.coli : the role of oligosaccharide moieties on structural and functional properties2010

    • Author(s)
      Nishi K
    • Journal Title

      Drug Metab Pharmacokinet (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics2010

    • Author(s)
      Hirata K
    • Journal Title

      J Control Release (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice2010

    • Author(s)
      Matsumoto K
    • Journal Title

      Drug Metab Pharmacokinet 25

      Pages: 101-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitrosylated human serum albumin(SNO-HSA)induces apoptosis in tumor cells2010

    • Author(s)
      Katayama N
    • Journal Title

      Nitric Oxide 22

      Pages: 259-265

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of reactive-aldehydes on the modification and dysfunction of human serum albumin2010

    • Author(s)
      Mera K
    • Journal Title

      J Pharm Sci 99

      Pages: 1614-1625

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemoglobin vesicles, polyethylene glycol (PEG) ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice.2009

    • Author(s)
      Taguchi K, Urata Y, Anraku M, Watanabe H, Kadowaki D, Sakai H, Horinouchi H, Kobayashi K, Tsuchida E, Maruyama T, Otagiri M.
    • Journal Title

      Drug Metab Dispos. 37

      Pages: 2197-2203

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin-vesicles as an artificial oxygen carrier.2009

    • Author(s)
      Taguchi K, Urata Y, Anraku M, Maruyama T, Watanabe H, Sakai H, Horinouchi H, Kobayashi K, Tsuchida E, Kai T, Otagiri M.
    • Journal Title

      Drug Metab Dispos. 37

      Pages: 1456-1463

    • NAID

      130004639499

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha (1)-acid glycoprotein.2009

    • Author(s)
      Nishi K, Ueno M, Murakami Y, Fukunaga N, Akuta T, Kadowaki D, Watanabe H, Suenaga A, Maruyama T, Otagiri M.
    • Journal Title

      J Pharm Sci. 98

      Pages: 4316-4326

    • NAID

      130005024241

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation for antioxidant and renoprotective activity of olmesartan using nephrectomy rats2009

    • Author(s)
      Kadowaki D
    • Journal Title

      Biol Pharm Bull 32

      Pages: 2041-2045

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Updates on contemporary protein binding techniques2009

    • Author(s)
      Chuang VT
    • Journal Title

      Drug Metab Pharmacokinet 24

      Pages: 358-364

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Albumin as a nitric oxide-traffic protein : characterization, biochemistry and possible future therapeutic applications2009

    • Author(s)
      Ishima Y
    • Journal Title

      Drug Metab Pharmacokinet 24

      Pages: 308-317

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemoglobin vesicles, polyethylene glycol(PEG)ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice2009

    • Author(s)
      Taguchi K
    • Journal Title

      Drug Metab Dispos 37

      Pages: 2197-2203

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant properties of some different molecular weight chitosans2009

    • Author(s)
      Tomida H
    • Journal Title

      Carbohydr Res 344

      Pages: 1690-1696

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin vesicles as an artificial oxygen carrier2009

    • Author(s)
      Taguchi K
    • Journal Title

      Drug Metab Dispos 37

      Pages: 1456-1463

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model2009

    • Author(s)
      Taguchi K
    • Journal Title

      J Control Release 136

      Pages: 232-239

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha(1)-acid glycoprotein2009

    • Author(s)
      Nishi K
    • Journal Title

      J Pharm Sci 98

      Pages: 4316-4326

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered chain-length and glycosylation modify the pharmacokinetics of human serum albumin2009

    • Author(s)
      Iwao Y
    • Journal Title

      Biochim Biophys Acta 1794

      Pages: 634-641

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha(l)-acid glycoprotein2009

    • Author(s)
      Nishi K
    • Journal Title

      J Pharm Sci (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant effects of a dietary supplement : reduction of indices of oxidative stress in normal subjects by water-soluble chitosan2009

    • Author(s)
      Anraku M
    • Journal Title

      Food Chem Toxicol 47

      Pages: 104-109

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products2008

    • Author(s)
      Iwao Y
    • Journal Title

      Am J Physiol Renal Physiol 295

      Pages: 1871-1880

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding2008

    • Author(s)
      Ishima Y
    • Journal Title

      J Biol Chem 283

      Pages: 34966-34975

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidant protection of human serum albumin by chitosan2008

    • Author(s)
      Anraku M
    • Journal Title

      Int J Biol Macromol 43

      Pages: 159-164

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutaraldehyde is an effective cross-linker for production of antibodies against advanced glycation end-products2008

    • Author(s)
      Mera K
    • Journal Title

      J Immunol Methods 334

      Pages: 82-90

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and evaluation of S-nitrosylated human serum albumin as a novel anticancer drug2008

    • Author(s)
      Katayama N
    • Journal Title

      J Pharmacol Exp Ther 325

      Pages: 69-79

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetic properties of hemoglobin vesicles as a substitute for red blood cells.

    • Author(s)
      Taguchi K,, Maruyama T,, Otagiri M.
    • Journal Title

      Drug Metab Rev.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 尿毒症物質CMPFの酸化ストレス誘発メカニズム2011

    • Author(s)
      宮本洋平、岩尾康範、米良克美、渡邊博志、門脇大介、異島優、佐藤圭創、小田切優樹、丸山徹
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      ツインメッセ静岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 一酸化炭素結合型赤血球による肝CYP保護効果2011

    • Author(s)
      大柿滋、田口和明、渡邊博志、門脇大介、小田切優樹、丸山徹
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡,グランシップ
    • Related Report
      2010 Final Research Report
  • [Presentation] 尿毒症物質p-cresyl sulfateの酸化ストレスに及ぼす影響2011

    • Author(s)
      本田大輔、宮本洋平、渡邊博志、門脇大介、丸山徹、小田切優樹
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      ツインメッセ静岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 尿毒症物質フランジカルボン酸CMPFのレドックス特性2010

    • Author(s)
      宮本洋平
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ファージディスプレイ法を用いたHSA分子上のBR結合部位の探索2010

    • Author(s)
      蓑毛藍
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] α1-酸性糖タンパク質のヘモグロビンβ鎖を介した肝実質細胞取り込み機構の解明2010

    • Author(s)
      小森久和
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 慢性肝障害時におけるヘモグロビン小胞体(HbV)の体内動態特性2010

    • Author(s)
      田口和明
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺障害モデルマウスに対するアルブミンチオレドキシン融合タンパク質の有用性評価2010

    • Author(s)
      丸山徹
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖鎖付加アルブミンを用いたクッパー細胞へのNOターゲティング2010

    • Author(s)
      平田憲史朗
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] S-ニトロソアルブミンによる細胞内NO輸送におけるNO修飾率の影響2010

    • Author(s)
      渡邊博志
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト血清アルブミンの非酵素的糖化修飾における各中間体アルデヒドの役割2010

    • Author(s)
      末永綾香
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血中における内因性S-cGMP化血清アルブミンの検出と機能評価2010

    • Author(s)
      異島優
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] α_1-酸性糖タンパク質の薬物結合部位に関する構造生物学的研究2010

    • Author(s)
      和泉実代子、中村照也、小野知実、渡邊博志、山縣ゆり子、小田切優樹、丸山徹
    • Organizer
      第27回日本薬学会九州支部大会
    • Place of Presentation
      長崎大学薬学部
    • Related Report
      2010 Final Research Report
  • [Presentation] BLM誘発肺線維症に対するアルブミン-チオレドキシン融合タンパク質の有用性評価2010

    • Author(s)
      田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹
    • Organizer
      第27回日本薬学会九州支部大会
    • Place of Presentation
      長崎大学薬学部
    • Related Report
      2010 Final Research Report
  • [Presentation] 一酸化炭素を付加した赤血球は大量出血時における肝チトクロームP450を保護する2010

    • Author(s)
      大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
    • Organizer
      第27回日本薬学会九州支部大会
    • Place of Presentation
      長崎大学薬学部
    • Related Report
      2010 Final Research Report
  • [Presentation] 尿毒症物質CMPFの生体内レドックス特性2010

    • Author(s)
      宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
    • Organizer
      第27回臨床フリーラジカル会議
    • Place of Presentation
      京都,烟川
    • Related Report
      2010 Final Research Report
  • [Presentation] 1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling2010

    • Author(s)
      Komori H, Watanabe H, Syuto T, Maruyama T, Otagiri M
    • Organizer
      第4回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京大学武田先端知ビル
    • Related Report
      2010 Final Research Report
  • [Presentation] Involvement of hemoglobin beta-chain on plasma membrane in uptake of human alfal-acid glycoprotein into liver2010

    • Author(s)
      Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
    • Organizer
      The Pharmaceutical Sciences World Congress 2010
    • Place of Presentation
      New Orleans
    • Related Report
      2010 Final Research Report
  • [Presentation] 出血性ショックモデルラットにおける一酸化炭素結合型赤血球のチトクロームP450の保護効果2010

    • Author(s)
      大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
    • Organizer
      第17回日本血液代替物学会
    • Place of Presentation
      熊本国際交流会館
    • Related Report
      2010 Final Research Report
  • [Presentation] X-RAY CRYSTALLOGRAPHIC STUDY OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND DRUG COMPLEX2010

    • Author(s)
      Miyoko Izumi, Tomomi Ono, Teruya Nakamura, Koji Nishi, Hiroshi Watanabe, Toru Maruyama, Yuriko Yamagata, Masaki Otagiri
    • Organizer
      日本薬物動態学会 第25回年会
    • Place of Presentation
      大宮ソニックシティ
    • Related Report
      2010 Final Research Report
  • [Presentation] CHARACTERIZATION OF STRUCTURE AND FUNCTION OF HUMAN SERUM ALBUMIN IN PATIENTS WITH LIVER DISEASE2010

    • Author(s)
      Kohei Nagumo, Tsuyoshi Sugimori, Motohiko Tanaka, Yutaka Sasaki, Yu Ishima, Hiroshi Watanabe, Kazuyuki Kubota, Naoyuki Yamada, Masaki Otagiri, Toru Maruyama.
    • Organizer
      日本薬物動態学会 第25回年会
    • Place of Presentation
      大宮ソニックシティ
    • Related Report
      2010 Final Research Report
  • [Presentation] IMPROVED THERAPEUTIC EFFECT OF THIOREDOXIN BY FUSION TO HUMAN SERUM ALBUMIN AGAINST BLEOMYCIN-INDUCED PULMONARY FIBROSIS2010

    • Author(s)
      田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹
    • Organizer
      日本薬物動態学会 第25回年会
    • Place of Presentation
      大宮ソニックシティ
    • Related Report
      2010 Final Research Report
  • [Presentation] Hepatic uptake of alfal-acid glycoprotein through hemoglobin beta-chain-mediated endocytic pathway2010

    • Author(s)
      Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
    • Organizer
      9^<th> International ISSX meeting
    • Place of Presentation
      Istanbul
    • Related Report
      2010 Final Research Report
  • [Presentation] alfal-酸性糖タンパク質によるCD163の発現誘導2010

    • Author(s)
      Komori H, Watanabe H, Syuto T, Maruyama T, Otagiri M
    • Organizer
      第35回西日本薬剤学研究会
    • Place of Presentation
      大分,九重共同研修所
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトalfal-酸性糖タンパク質/薬物複合体のX線結晶構造解析2010

    • Author(s)
      和泉実代子、小野知実、中村照也、西弘二、渡邊博志、丸山徹、山縣ゆり子、小田切優樹
    • Organizer
      第25回日本薬剤学会
    • Place of Presentation
      あわぎんホール 徳島県郷土文化会館
    • Related Report
      2010 Final Research Report
  • [Presentation] 尿毒症物質CMPFの酸化ストレス誘発機序解明2010

    • Author(s)
      宮本洋平、岩尾康範、渡邊博志、門脇大介、佐藤圭創、小田切優樹、丸山徹
    • Organizer
      第25回日本薬剤学会
    • Place of Presentation
      あわぎんホール 徳島県郷土文化会館
    • Related Report
      2010 Final Research Report
  • [Presentation] 一酸化炭素結合型赤血球による肝チトクロームP450の保護効果2010

    • Author(s)
      大柿滋、田口和明、渡邊博志、小田切優樹、丸山徹
    • Organizer
      第25回日本薬剤学会
    • Place of Presentation
      あわぎんホール徳島県郷土文化会館
    • Related Report
      2010 Final Research Report
  • [Presentation] α_1-酸性糖タンパク質の薬物結合部位に関する構造生物学的研究2010

    • Author(s)
      和泉実代子、中村照也、小野知実、渡邊博志、山縣ゆり子、小田切優樹、丸山徹
    • Organizer
      第26回日本薬学会九州支部大会
    • Place of Presentation
      長崎大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトα_1-酸性糖タンパク質/薬物複合体のX線結晶構造解析2010

    • Author(s)
      和泉実代子、中村照也、小野知実、渡邊博志、山縣ゆり子、小田切優樹、丸山徹
    • Organizer
      日本薬剤学会第25年会
    • Place of Presentation
      あわぎんホール徳島郷土文化会館
    • Related Report
      2010 Annual Research Report
  • [Presentation] X-RAY CRYSTALLOGRAPHIC STUDY OF HUMAN ALPHA1-ACID GLYCOPROTEIN AND DRUG COMPLEX2010

    • Author(s)
      Miyoko Izumi., Tomomi Ono, Teruya Nakamura, Koji Nishi, Hiroshi Watanabe, Toru Maruyama, Yuriko Yamagata, Masaki Otagiri
    • Organizer
      日本薬物動態学会第25回年会
    • Place of Presentation
      大宮ソニックシティ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hepatic uptake of alfa1-acid glycoprotein through hemoglobin b-chain-mediated endocytic pathway2010

    • Author(s)
      Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
    • Organizer
      9^<th> International ISSX meeting
    • Place of Presentation
      Istanbul, Turkey Convention and Exhibition Center-Harbiye
    • Related Report
      2010 Annual Research Report
  • [Presentation] Involvement of hemoglobin b-chain on plasma membrane in uptake of human al-acid glycoprotein into liver2010

    • Author(s)
      Komori H, Uehara N, Nishi K, Watanabe H, Maruyama T, Otagiri M
    • Organizer
      The Pharmaceutical Sciences World Congress 2010
    • Place of Presentation
      New Orleans, LA, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] alfa1-酸性糖タンパク質によるCD163の発現誘導2010

    • Author(s)
      小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
    • Organizer
      第35回西日本薬剤学研究会
    • Place of Presentation
      九重共同研修所
    • Related Report
      2010 Annual Research Report
  • [Presentation] alfa1-acid glycoprotein enhances the expression of hemoglobin scavenge receptor CD163 through the activation of TLR4 signaling2010

    • Author(s)
      小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹
    • Organizer
      第4回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      東京大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝障害モデルラットにおけるヘモグロビン小胞体の体内動態特性2009

    • Author(s)
      宮里麻友美
    • Organizer
      第26回日本薬学会九州支部大会
    • Place of Presentation
      九州大学
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of bilirubin binding site in human serum albumin via construction and bilirubin binding screening of a phage library2009

    • Author(s)
      蓑毛藍
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Involvement of hemoglobin β-chain mediated endocytic pathway in hepatic uptake of α1-acid glycoprotein2009

    • Author(s)
      小森久和
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪大学
    • Year and Date
      2009-11-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transferring from Poly-S-Nitrosylated Human Serum Albumin is Involved in Cell-Surface Protein Disulfide Isomerase2009

    • Author(s)
      Yoshida F
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪大学
    • Year and Date
      2009-11-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 3-carboxy-4-metyl-5- propyl-2-furan propionate, an uremic toxin, increase oxidative stress through over-generation of super-oxide anion radical2009

    • Author(s)
      宮本洋平
    • Organizer
      第31回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      大阪大学
    • Year and Date
      2009-11-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] REACTIVE ALDEHYDES INDUCE STRUCTUAL CHANGE AND DISFUNCTION OF HUMAN SERUM ALBUMIN2009

    • Author(s)
      Takeo K
    • Organizer
      第24回日本薬物動態学会年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] EFFECT OF ALBUMIN BINDING AND ANTIOXIDATIVE ACTIVITY ON TRANSTHYRETIN AMYLOID FORMATION2009

    • Author(s)
      Kugimiya T
    • Organizer
      第24回日本薬物動態学会年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] IMPROVED THERAPEUTIC EFFECT OF THIOREDOXIN BY FUSION TO HUMAN SERUM ALBUMIN AGAINST OVALBUMIN-INDUCED LUNG INJURY2009

    • Author(s)
      Furukawa M
    • Organizer
      第24回日本薬物動態学会年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] IMPACT OF CINACALCET ON SERUM OXIDATIVE STRESS IN SECONDARY HYPERPARATHYROIDISM2009

    • Author(s)
      Tokunaga K
    • Organizer
      第24回日本薬物動態学会年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] PHARMACOKINETIC STUDY OF ENCLOSED HEMOGLOBIN AND OUTER LIPID COMPONENT AFTER THE ADMINISTRATION OF HEMOGLOBIN VESICLES AS AN ARTIFICIAL OXYGEN CARRIER2009

    • Author(s)
      田口和明
    • Organizer
      第24回日本薬物動態学会年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] THE DETECTION OF ENDOGENOUS S-GUANYLATED HUMAN SERUM ALBUMIN2009

    • Author(s)
      Hoshino H
    • Organizer
      第24回日本薬物動態学会年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-11-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] α1-酸性糖タンパク質のヘモグロビンβ鎖を介した肝細胞取り込み機構2009

    • Author(s)
      小森久和
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      九州大学
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 強力な臓器保護剤としての新規S-ニトロソヒト血清アルブミンの開発2009

    • Author(s)
      異島優
    • Organizer
      第16回血液代替物学会年次大会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 出血性ショックモデルラットにおけるヘモグロビン小胞体頻回投与時の体内動態解析2009

    • Author(s)
      田口和明
    • Organizer
      第16回血液代替物学会年次大会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 四塩化炭素誘発肝障害モデルラットにおけるヘモグロビン小胞体の体内動態の評価2009

    • Author(s)
      宮里麻友美
    • Organizer
      第16回血液代替物学会年次大会
    • Place of Presentation
      慶應義塾大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] HUMAN ALBUMIN BASED DRUG DELIVERY : ALBUMIN FUSION OF THIOREDOXIN2009

    • Author(s)
      Chuang VTG
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      九州大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] MODIFICATION WITH REACTIVE ALDEHYDES ALTERS THE STRUCTURE AND FUNCTION OF HUMAN SERUM ALBUMIN2009

    • Author(s)
      Mera K
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      九州大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] PROPOSED DOSE OF HEMOGLOBIN VESICLES, PEGYLATED LIPOSOMES DEVELOPED AS A RED BLOOD SUBSTITUTE, DOES NOT INDUCE THE ACCELERATED BLOOD CLEARANCE PHENOMENON IN MICE2009

    • Author(s)
      田口和明
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      九州大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] EVALUATION FOR ANTIOXIDANT AND RENOPROTECTIVE ACTIVITY OF OLMESARTAN USING NEPHRECTOMY RATS2009

    • Author(s)
      Kadowaki D
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      九州大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] ANTIOXIDANT PROPERTY OF SEVERAL MOLECULAR WEIGHT CHITOSANS IN IN VITRO AND IN VIVO STUDIES2009

    • Author(s)
      Anraku M
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      九州大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] FATTY ACIDS COULD BE A NOVEL TYPE OF MEDIATOR OF S-DENITROSATION FROM S-NITROSYLATED HUMAN SERUM ALBUMIN2009

    • Author(s)
      Ishima Y
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      九州大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] GENETICALLY ENGINEERED MANNOSY- LATED-HUMAN SERUM ALBUMIN AS A VERSATILE CARRIER FOR LIVER-SELECTIVE THERPEUTICS2009

    • Author(s)
      平田憲史郎
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      九州大学
    • Year and Date
      2009-10-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pharmacokinetic profiles of hemoglobin-vesicles as an artificial oxygen carrier2009

    • Author(s)
      田口和明
    • Organizer
      XII Symposium on Blood Substitute
    • Place of Presentation
      Camera di Commercio, Via Verdi 2, Parma
    • Year and Date
      2009-08-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mannosylated- Recombinant albumin as a NO traffic protein for the treatment of hepatic ischemia/reperfusion injury2009

    • Author(s)
      平田憲史郎
    • Organizer
      XII Symposium on Blood Substitute
    • Place of Presentation
      Camera di Commercio, Via Verdi 2, Parma
    • Year and Date
      2009-08-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] DDS担体としての組換え型アルブミン二量体の有用性評価2009

    • Author(s)
      異島優
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヘモグロビン小胞体の体内動態の検討2009

    • Author(s)
      田口和明
    • Organizer
      第25回日本DDS学会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2009-07-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] α1-酸性糖タンパク質のヘモグロビンβ鎖を介した肝細胞取り込み機構の解析2009

    • Author(s)
      小森久和
    • Organizer
      日本薬剤学会第24年会
    • Place of Presentation
      グランシップ静岡
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] イヌアルブミン分子上のケトプロフェン結合部位のトポロジー解析2009

    • Author(s)
      小田切優樹
    • Organizer
      第9回日本蛋白質科学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] S-ニトロソヒト血清アルブミンの臓器保護作用は、脂肪酸結合により増強される2009

    • Author(s)
      異島優
    • Organizer
      第9回日本蛋白質科学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] S-ニトロソヒト血清アルブミンの臓器保護作用は、脂肪酸結合により増強される2009

    • Author(s)
      異島優
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡グランシップ
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 組換え型糖鎖付加アルブミンの肝ターゲティング担体としての有用性評価2009

    • Author(s)
      平田憲史郎
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡グランシップ
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト血清アルブミンの薬物結合能に及ぼす中間体アルデヒド修飾の影響2009

    • Author(s)
      米良克己
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規血液浄化法の開発を目的としたファージディスプレイライブラリ法を用いた高親和性ビリルビン捕獲型アルブミン変異体の探索2009

    • Author(s)
      蓑毛 藍
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗酸化能に富むアルブミンの設計 : 抗酸化活性に関与するアミノ酸残基の探索2009

    • Author(s)
      末永綾香
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Binding of a1-acid glycoprotein, a member of the lipocalin family. to membrane results in a unique structural change and ligand release2009

    • Author(s)
      丸山 徹
    • Organizer
      揺らぎが機能を決める生命分子の科学-第二回公開シンポジウム-
    • Place of Presentation
      岡崎コンファレンスセンター
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] a1-酸性糖タンパク質の立体構造に関する基礎的検討2008

    • Author(s)
      小野 知美
    • Organizer
      第25回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝細胞膜上におけるa1-酸性糖タンパク質とhemoglobin p-chainの相互作用解析2008

    • Author(s)
      小森 久和
    • Organizer
      第25回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学
    • Year and Date
      2008-12-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規血液浄化法の開発を目的としたファージディスプレイ法を用いた高ビリルビン親和性アルブミン変異体の探索2008

    • Author(s)
      蓑毛 藍
    • Organizer
      第25回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト血清アルブミンの抗酸化活性に関与するアミノ酸残基の探索2008

    • Author(s)
      山田 純嗣
    • Organizer
      第25回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] NMRを用いたアルブミン分子におけるN-B転移の機構解明2008

    • Author(s)
      渡 健太
    • Organizer
      第25回日本薬学会九州支部大会
    • Place of Presentation
      九州保健福祉大学
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] alphal-acid glycoprotein (AGP)と細胞膜上のhemoglobin beta chainの相互作用はAGPの肝取り込みに関与する2008

    • Author(s)
      小森久和
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトa1-酸性糖タンパク質の薬物結合特性におけるペプチド部分の重要性2008

    • Author(s)
      小野知実
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] a1-酸性糖タンパク質分子上の薬物結合部位のトポロジー解析2008

    • Author(s)
      西弘二
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 高ビリルビン結合親和性を有する組換えヒト血清アルブミン変異体のファージライブラリーの構築とそのスクリーニング2008

    • Author(s)
      蓑毛 藍
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 家族性ポリアミロイドニューロパチーにおけるアルブミンの抗酸化作用2008

    • Author(s)
      釘宮 智江
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト血清アルブミンの構造・機能に及ぼす反応性アルデヒド修飾の影響2008

    • Author(s)
      竹尾和寛
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト血清アルブミンの抗酸化活性に関与するアミノ酸残基の探索2008

    • Author(s)
      山田純嗣
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本市民会館
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ファージディスプレイ法を用いた高ビリルビン親和性アルブミン変異体の探索と結合性評価2008

    • Author(s)
      蓑毛 藍
    • Organizer
      第21回バイオメディカル分析科学シンポジウム
    • Place of Presentation
      札幌コンペンションセンター
    • Year and Date
      2008-08-07
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/Yakuzai/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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