| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
To identify gene sets for prediction of prognosis or for prediction of efficacy of anticancer drugs in metastatic colorectal cancer (mCRC), mRNA were extracted from tumor tissues of mCRC and were analyzed for oligonucleotide microarray. We found that mCRC were clustered into 3 large clusters. Further, these clusters were correlated with KRAS status and efficacy of chemotherapy with or without anti-EGFR antibody. We are now extracting gene sets for prediction of efficacy of specific anticancer drug or regimen.
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