| Budget Amount *help |
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Research Abstract |
We tried to find the genetic polymorphisms useful for the predictive diagnosis of the development or the prognosis of autoimmune thyroid disease on the basis of the possibilities that the induction factors for peripheral self-tolerance and the regulatory factors for target organ development are related to the pathogenesis of autoimmune thyroid disease (AITD). As a result, we found that SNPs of GITR, Foxp3, HHHEX, Foxel and CTLA-4 were related to the prognosis or the development of AITD, and were useful for the predictive diagnostic methods for AITD.
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