| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Research Abstract |
This study investigated the cytotoxicity of arsenobataine (AsB) and discusses future detoxication treatment of inorganic arsenic for prevention and improvement of environmental arsenic poisoning. AsB was synthesized from arsenic trioxide and arsenic chemical warfare agent. The toxicity of all AsB was clearly decreased. Apoptosis and oxidant stress were induced by reactive oxygen species in arsenic trioxide, but not in AsB. Thus, synthesis of AsB from different inorganic arsenics appears to result in detoxified arsenic. Although this synthesis involves problems related to efficiency and economic potential, the back-to-nature treatment of AsB with no requirement of repository is expected. An awareness campaign on the international level and further research on AsB is required.
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