The study of detoxication of inorganic arsenic to aim at preventative and eradication of arsenic poisoning
| Project/Area Number |
20390174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kitasato University |
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Principal Investigator |
YAMAUCHI Hiroshi Kitasato University, 医療衛生学部, 教授 (90081661)
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| Co-Investigator(Kenkyū-buntansha) |
HISAEDA Yoshio 九州大学, 大学院・工学研究院, 教授 (70150498)
TAKATA Ayako 聖マリアンナ医科大学, 医学部, 教授 (30321897)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | ヒ素 / ヒ素中毒 / 無毒化 / アルセノベタイン / メチル化 / ビタミンB12 / 人工的化学合成 / 細胞毒性試験 / 酸化的DNA損傷 / 廃棄処理技術 |
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| Research Abstract |
This study investigated the cytotoxicity of arsenobataine (AsB) and discusses future detoxication treatment of inorganic arsenic for prevention and improvement of environmental arsenic poisoning. AsB was synthesized from arsenic trioxide and arsenic chemical warfare agent. The toxicity of all AsB was clearly decreased. Apoptosis and oxidant stress were induced by reactive oxygen species in arsenic trioxide, but not in AsB. Thus, synthesis of AsB from different inorganic arsenics appears to result in detoxified arsenic. Although this synthesis involves problems related to efficiency and economic potential, the back-to-nature treatment of AsB with no requirement of repository is expected. An awareness campaign on the international level and further research on AsB is required.
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Report
(4 results)
Research Products
(44 results)
