| Project/Area Number |
20390175
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
|
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
SATOH Masahiko Aichi Gakuin University, 薬学部, 教授 (20256390)
|
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Yasuyuki 愛知学院大学, 薬学部, 准教授 (40247482)
HASEGAWA Tatsuya 山梨県環境科学研究所, 環境健康研究部, 主任研究員 (90208489)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | 環境保健 / 毒性学 / カドミウム / 鉄輸送 / 非ヘム鉄 / ヘム / マウス / ヒト小腸上皮細胞 / 妊娠マウス / 胎仔毒性 |
|---|
| Research Abstract |
Cadmium inhibited iron absorption through suppression of the expression of genes (DMT1、FPN1、DCYTB) related to iron transport in the duodenum of pregnant mice. As a result, it was shown that fetal growth was inhibited. Furthermore, cadmium was found to suppress the expression of genes (DMT1, FPN1, DCYTB, HEPH, HCP1) related to iron transport in the duodenum of adult mice and to affect on the intestinal iron absorption. In addition, cadmium was also shown to inhibit the expression of genes (DMT1, FPN1, DCYTB, HEPH) related to iron transport in cultured intestinal epithelial cells.
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