Anaylisis of immunological alterations affecting asbestos-induced carcinogenesis

• Project/Area Number: 20390178
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Kawasaki Medical School
• Principal Investigator: OTSUKI Takemi Kawasaki Medical School, 医学部, 教授 (40160551)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Yasumitsu 川崎医科大学, 医学部, 准教授 (90360271) ; MAEDA Megumi 川崎医科大学, 医学部, 助教 (20434988) ; KUMAGAI Naoko 川崎医科大学, 医学部, 助教 (00509276) ; MURAKAMI Shuko 川崎医科大学, 医学部, 助教 (50454848)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2009: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: アスベスト / 珪酸 / 免疫担当細胞 / 腫瘍免疫 / 発癌 / 制御性T細胞 / シリカ / 悪性中皮腫 / 曝露 / 細胞株 / 自己免疫疾患

Research Abstract

Since so-called "Kubota-Shock" in 2005, the issue regarding carcinogenesis among the patients exposed to asbestos has been medical and social problem. The aim of this project is to elucidate whether or not asbestos exposure affect on human immune system to tend to induce carcinogenesis. As the results, most of our findings indicate immune alteration caused by asbestos exposure using human cell lines and freshly isolated immune cells proceed to reducing tumor immunity. To find molecular preventive targets regarding immunological effects of asbestos should be performed in the future.

Research Products

• [Journal Article] Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients. (2011)
  • Author(s): Maeda M, et al
  • Journal Title: Am J Resp Cell Mol Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Reduction of CXCR3 in an in vitro model of continuous asbestos exposure on a human T-cell line, MT-2. (2011)
  • Author(s): Maeda M, et al
  • Journal Title: Am J Resp Cell Mol Biol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients. (2011)
  • Author(s): Otsuki T, et al
  • Journal Title: Int J Immunopath Pharmacol Volume: 24(in press)
  • Peer Reviewed
• [Journal Article] Suppressive effect of asbestos on cytotoxicity of human NK cells. (2011)
  • Author(s): Nishimura Y
  • Journal Title: Int J Immunopath Pharmacol Volume: 24(in press)
  • Peer Reviewed
• [Journal Article] Dysregulation of the Immune System Caused by Silica and Asbestos. (2010)
  • Author(s): Maeda M, Nishimura Y, Kumagai N, Hayashi H, Hatayama T, Katoh M, Miyahara N, Yamamoto S, Otsuki T.
  • Journal Title: J Immunotoxicol 7(4) Pages: 268-278
  • Peer Reviewed
• [Journal Article] Reductive alteration of the regulatory function of the CD4+CD25+ T cell fraction in silicosis patients. (2010)
  • Author(s): Hayashi H, Miura Y, Maeda M, Murakami S, Kumagai N, Nishimura M, Kusaka M, Uragami K, Fujimoto W, Otsuki T.
  • Journal Title: Int J Immunopathol Pharmacol 23(4) Pages: 1099-1109
  • Peer Reviewed
• [Journal Article] Peripheral regulatory T cell from silicosis patients is susceptible to CD95-mediated apoptosis. (2010)
  • Author(s): Hayashi H.
  • Journal Title: Kawasaki Med J 36(1) Pages: 13-21
  • Peer Reviewed
• [Journal Article] 珪酸・アスベストの免疫影響(ミニ特集:繊維・粒子状物質研究会(仙台) (2010)
  • Author(s): 熊谷直子,西村泰光,前田恵,林宏明,大槻剛巳
  • Journal Title: 日本衛生学会誌 64(4) Pages: 93-499
  • Peer Reviewed
• [Journal Article] 珪肺症例における自己免疫異常の検出-血清可溶性インターロイキン2受容体と可溶性CD40リガンドの濃度の意義- (2010)
  • Author(s): 林宏明,西村泰光,前田恵,熊谷直子,村上周子,三浦由恵,草加勝康,浦上更三,大槻剛巳
  • Journal Title: 日本職業・災害医学会会誌 58(2) Pages: 45-51
  • NAID: 10029837869
  • Peer Reviewed
• [Journal Article] Dysregulation of the Immune System Caused by Silica and Asbestos. (2010)
  • Author(s): Maeda M., et al
  • Journal Title: J Immunotoxicol Volume: 7 Pages: 268-278
  • Peer Reviewed
• [Journal Article] Reductive alteration of the regulatory function of the CD4+CD25+ T cell fraction in silicosis patients. (2010)
  • Author(s): Hayashi H, et al
  • Journal Title: Int J Immunopathol Pharmacol Volume: 23 Pages: 1099-1109
  • Peer Reviewed
• [Journal Article] Peripheral regulatory T cell from silicosis patients is susceptible to CD95-mediated apoptosis (2010)
  • Author(s): Hayashi H
  • Journal Title: Kawasaki Med J 36 Pages: 13-21
  • Peer Reviewed
• [Journal Article] Impairment in cytotoxicity and expression of NK-cell activating receptors on human NK cells following exposure to asbestos fibers. (2009)
  • Author(s): Nishimura Y, Miura Y, Maeda M, Kumagai N, Murakami S, Hayashi H, Fukuoka K, Nakano T, Otsuki T.
  • Journal Title: Int J Immunopathol Pharmacol 22(3) Pages: 579-90
  • Peer Reviewed
• [Journal Article] Decrease in phosphorylation of ERK following decreased expression of NK-cell activating receptors in human NK cell line exposed to asbestos. (2009)
  • Author(s): Nishimura Y, Maeda M, Kumagai N, Hayashi H, Miura Y, Otsuki T.
  • Journal Title: Int J Immunopathol Pharmacol 22(4) Pages: 879-88
  • Peer Reviewed
• [Journal Article] Soluble interleukin-2 receptor as an indicator of immunological disturbance found in silicosis patients (2009)
  • Author(s): Hayashi H, Maeda M, Murakami S, Kumagai N, Chen Y, Hatayama T, Katoh M, Miyahara N, Yamamoto S, Yoshida Y, Nishimura Y, Kusaka M, Fujimoto W, Otsuki T.
  • Journal Title: Int J Imminopathol Pharmacol 22(1) Pages: 53-62
  • Peer Reviewed
• [Journal Article] Is soluble CD40 ligand an indicator of immunopathological disturbance in silicosis patients? (2009)
  • Author(s): Hayashi H, Nishimura Y, Maeda M, Murakami S, Kumagai N, ChenY, Kusaka M, Uragami K, Fujimoto W, Otsuki T.
  • Journal Title: Kawasaki Med J 35(2) Pages: 129-138
  • NAID: 110007150517
  • Peer Reviewed
• [Journal Article] Cytokine alteration and speculated immunological patho physiology in silicosis and asbestos-related diseases. (2009)
  • Author(s): Murakami S, Nishimura Y, Maeda M, Kumagai N, Hayashi H, Chen Y, Kusaka K, Kishimoto T, Otsuki T.
  • Journal Title: Environ Health Prev Med 14(4) Pages: 216-222
  • NAID: 10026958932
  • Peer Reviewed
• [Journal Article] Impairment in cytotoxicity and expression of NK-cell activating receptors on human NK cells following exposure to asbestos fibers (2009)
  • Author(s): Nishimura Y, et al
  • Journal Title: Int J Immunopathol Pharmacol 22 Pages: 579-590
  • Peer Reviewed
• [Journal Article] Decrease in phosphorylation of ERK following decreased expression of NK cell-activating receptors in human NK cell line exposed to asbestos (2009)
  • Author(s): Nishimura Y, et al
  • Journal Title: Int J Immunopathol Pharmacol. 22 Pages: 879-888
  • Peer Reviewed
• [Journal Article] Soluble interleukin-2 receptor as an indicator of immunological disturbance found in silicosis patients (2009)
  • Author(s): Hayashi H, et al
  • Journal Title: Int J Immunopathol Pharmacol. 22 Pages: 53-62
  • Peer Reviewed
• [Journal Article] Is soluble CD40 ligand an indicator of immunopathological disturbance in silicosis patients? (2009)
  • Author(s): Hayashi H, et al
  • Journal Title: Kawasaki Med J 35 Pages: 129-138
  • Peer Reviewed
• [Journal Article] Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases (2009)
  • Author(s): Murakami S, et al
  • Journal Title: Environ Health Prev Med 14 Pages: 216-222
  • Peer Reviewed
• [Journal Article] Nova Science Publishers, Inc. (2009)
  • Author(s): Otsuki T, et al.
  • Journal Title: Immunological effects of Asbestos.In Asbestos : Risks, Environment and Impact.Eds : Antonio Soto and Gael Salazar, ISBN 978-1-60692-053-4, (C) 2009 Pages: 185-193
• [Journal Article] (2009)
  • Author(s): Nishimura Y, et al.
  • Journal Title: Suppressive effect of asbestos-exposure on cytotoxicity of human NK cells, and the possibility of NKp46 as a marker to monitor immune status in people exposed to asbestos.Industrial Hygiene and Occupational Diseases Section, Chinese Preventive Medical Association, In Proceeding of The 2nd China-Japan Joint Asbestos Symposium(Japan Asbestos Mesothelioma Study Group) Pages: 129-135
• [Journal Article] (2009)
  • Author(s): 林宏明, 他
  • Journal Title: アスベストーシス.In炎症・再生医学事典.(編:松島綱治, 西脇徹)(朝倉書店, 東京, 2009(ISBN978-4-254-30099-4C3547)) Pages: 269-271
• [Journal Article] Immunological alterations found in mesothelioma patients and their experimental evidences (2008)
  • Author(s): Miura Y, Nishimura Y, Maeda M, Murakami S, Hayashi H, Fukuoka K, Kishimoto T, Nakano T, Otsuki T.
  • Journal Title: Environ Health Prev Med 13 Pages: 55-59
  • Peer Reviewed
• [Journal Article] Immunological changes in mesothelioma patients and their experimental detection (2008)
  • Author(s): Maeda M, Miura Y, Nishimua Y, Murakami S, Hayashi H, Kumagai N, Hatayama T, Katoh M, Miyahara N, Yamamoto S, Fukuoka K, Kishimoto T, Nakano T, Otsuki T.
  • Journal Title: Clin Med : Circ, Resp Pulm Med 2 Pages: 11-17
  • Peer Reviewed
• [Journal Article] 珪肺症例CD4+25+分画における活性化T細胞の混入と制御性T細胞早期細胞死の可能性 (2008)
  • Author(s): 林宏明, 三浦由恵, 前田恵, 村上周子, 熊谷直子, 西村泰光, 草加勝康, 大槻剛巳.
  • Journal Title: 日本職業・環境アレルギー学会雑誌 15 Pages: 42-50
  • Peer Reviewed
• [Journal Article] Decreased CXCR3 expression in CD4+ T cells exposed to asbestos or derived from asbestos-exposed patients.
  • Author(s): Maeda M, Nishimura Y, Hayashi H, Kumagai N, Chen Y, Murakami S, Miura Y, Hiratsuka J, Kishimoto T, Otsuki T.
  • Journal Title: Am J Resp Cell Mol Biol (in press)
  • Peer Reviewed
• [Journal Article] Reduction of CXCR3 in an in vitro model of continuous asbestos exposure on a human T-cell line, MT-2.
  • Author(s): Maeda M, Nishimura Y, Hayashi H, Kumagai N, Chen Y, Murakami S, Miura Y, Hiratsuka J, Kishimoto T, Otsuki T.
  • Journal Title: Am J Resp Cell Mol Biol (in press)
  • Peer Reviewed
• [Journal Article] Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients.
  • Author(s): Otsuki T, Hayashi H, Nishimura Y, Hyodo F, Maeda M, Kumagai N, Miura Y, Kusaka M, Urakami K
  • Journal Title: Int J Immunopath Pharmacol 24(1)(in press)
  • Peer Reviewed
• [Journal Article] Suppressive effect of asbestos on cytotoxicity of human NK cells.
  • Author(s): Nishimura Y, Kumagai N, Maeda M, Hayashi H, Fukuoka K, nakano T, Miura Y, HIratsuka J, Otsuki T.
  • Journal Title: Int J Immunopath Pharmacol 24(1)(in press)
  • Peer Reviewed
• [Presentation] 症例登録制度,基礎研究(細胞株を用いた中皮腫細胞特性およびアスベストの免疫影響.シンポジウム2(繊維・粒子状物質研究会)科学技術振興調整費「アスベスト関連疾患への総括的取り組み」班研究の成果と総括 (2011)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 震災による中止も誌上発表:日本衛生学会誌6682), 273, 2011
  • Year and Date: 2011-03-26
• [Presentation] アスベスト低濃度長期曝露制御性T細胞株でのFoxP3遺伝子メチル化の変化 (2011)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 震災による中止も誌上発表:日本衛生学会誌6682), 503, 2011
  • Year and Date: 2011-03-26
• [Presentation] 石綿曝露時NK傷害性低下に関わるサイトカイン産生プロファイルの解析 (2011)
  • Author(s): 西村泰光, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 震災による中止も誌上発表:日本衛生学会誌6682), 421, 2011
  • Year and Date: 2011-03-26
• [Presentation] アスベスト慢性曝露CD4陽性T細胞におけるT細胞増殖抑制活性の解析 (2011)
  • Author(s): 前田恵, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 震災による中止も誌上発表:日本衛生学会誌6682), 420, 2011
  • Year and Date: 2011-03-26
• [Presentation] 胸膜プラーク陽性石綿曝露者の末梢血CD8+リンパ球の機能解析 (2011)
  • Author(s): 熊谷直子, 他
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 震災による中止も誌上発表:日本衛生学会誌6682), 420, 2011
  • Year and Date: 2011-03-26
• [Presentation] Continuous and low-dose exposure to asbestos enhances TGF-β1 production in a human adult T cell leukemia virus-immortalized T cell line, MT-2. (2011)
  • Author(s): Otsuki T, 他
  • Organizer: The 50th Anniversary Annual Meating of Society of Toxicology (U.S.A).
  • Place of Presentation: Walter E.Washington Convention Center, Washington D.C. U.S.A
  • Year and Date: 2011-03-07
• [Presentation] Asbestos exposure causes decrease in production of cytokines related to Nk cell activation. (2011)
  • Author(s): Nishimura Y, 他
  • Organizer: The 50th Anniversary Annual Meating of Society of Toxicology (U.S.A).
  • Place of Presentation: Walter E.Washington Convention Center, Washington D.C. U.S.A.
  • Year and Date: 2011-03-07
• [Presentation] Enhanced suppressive function on regulatory T cell-like cell line, MT-2, by continuous exposure to asbestos. (2011)
  • Author(s): Maeda M, 他
  • Organizer: The 50th Anniversary Annual Meating of Society of Toxicology (U.S.A.).
  • Place of Presentation: Walter E.Washington Convention Center, Washington D.C. U.S.A.
  • Year and Date: 2011-03-07
• [Presentation] Effect of asbestos exposure on production of cytokines, apoptosis, and cell prolifertion related with differentiation of human CTL. (2011)
  • Author(s): Kumagai N, 他
  • Organizer: The 50th Anniversary Annual Meating of Society of Toxicology (U.S.A.).
  • Place of Presentation: Walter E.Washington Convention Center, Washington D.C. U.S.A
  • Year and Date: 2011-03-07
• [Presentation] アスベストによる免疫防御機構の破綻の解明.シンポジウム「環境発癌から分子標的予防まで」 (2011)
  • Author(s): 大槻剛巳
  • Organizer: 第10回分子予防環境医学研究会大会
  • Place of Presentation: 京都府立医科大学医学部旧図書館棟3階講堂
  • Year and Date: 2011-01-21
• [Presentation] 混合リンパ球培養法を用いた細胞障害性T細胞の分化における石綿曝露影響 (2011)
  • Author(s): 熊谷直子, 他
  • Organizer: 第10回分子予防環境医学研究会大会
  • Place of Presentation: 京都府立医科大学医学部旧図書館棟3階講堂
  • Year and Date: 2011-01-21
• [Presentation] Continuous and low-dose exposure to asbestos enhances TGF-β1 production in a human adult T cell leukemia virus-immortalized T cell line, MT-2. (2011)
  • Author(s): Otsuki T, Maeda M, Kumagai N, Miyahara N, Katoh M, Yamamoto S, hatayama T, Nishimura Y
  • Organizer: The 50th Anniversary Annual Meating of Society of Toxicology (U.S.A.).
  • Place of Presentation: Walter E. Washington Convention Center, Washington D.C. U.S.A.
• [Presentation] Asbestos exposure causes decrease in production of cytokines related to Nk cell activation. (2011)
  • Author(s): Nishimura Y, Kumagai N, Maeda M, Hayashi H, Otsuki T
  • Organizer: The 50th Anniversary Annual Meating of Society of Toxicology (U.S.A.).
  • Place of Presentation: Walter E. Washington Convention Center, Washington D.C. U.S.A.
• [Presentation] Enhanced suppressive function on regulatory T cell-like cell line, MT-2, by continuous exposure to asbestos. (2011)
  • Author(s): Maeda M, Chen Y, Nishimura Y, Kumagai N, Hayashi H, Miura Y, Otsuki T
  • Organizer: The 50th Anniversary Annual Meating of Society of Toxicology (U.S.A.).
  • Place of Presentation: Walter E. Washington Convention Center, Washington D.C. U.S.A.
• [Presentation] Effect of asbestos exposure on production of cytokines, apoptosis, and cell prolifertion related with differentiation of human CTL. (2011)
  • Author(s): Kumagai N, Nishimura Y, Maeda M, Hayashi H, Otsuki T
  • Organizer: The 50th Anniversary Annual Meating of Society of Toxicology (U.S.A.).
  • Place of Presentation: Walter E. Washington Convention Center, Washington D.C. U.S.A.
• [Presentation] アスベスト曝露MT-2細胞におけるT細胞増殖抑制機能亢進とDNAメチル化変化 (2010)
  • Author(s): 大槻剛巳, 他
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-07
• [Presentation] 珪肺症例における免疫異常:症例および末梢血CD4+25+分画の機能 (2010)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第54回中国四国合同日本産業衛生学会
  • Place of Presentation: 海峡メッセ下関
  • Year and Date: 2010-11-28
• [Presentation] 科学技術振興調整費「アスベスト関連疾患への総括的取り組み」班 悪中皮腫集学的治療に関する安全性確認試験ならびに基礎研究の進捗状況 (2010)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第58回日本職業・災害医学会
  • Place of Presentation: サンルートプラザ東京(舞浜)
  • Year and Date: 2010-11-05
• [Presentation] アスベストの免疫影響:クリソタイルとクロシドライトの低濃度長期曝露によるヒトT細胞株への影響の相違 (2010)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第51回日本肺癌学会
  • Place of Presentation: 広島国際会議場・ANAクラウンプラザホテル広島
  • Year and Date: 2010-11-04
• [Presentation] CXCR3発現とIFN-γ産生を指標としたアスベスト関連疾患の抗腫瘍免疫機能予測 (2010)
  • Author(s): 前田恵, 他
  • Organizer: 第51回日本肺癌学会
  • Place of Presentation: 広島国際会議場・ANAクラウンプラザホテル広島
  • Year and Date: 2010-11-04
• [Presentation] 石綿曝露によるIFN-γとTNF-α産生低下を伴う細胞障害性T細胞分化の抑制 (2010)
  • Author(s): 熊谷直子, 他
  • Organizer: 第51回日本肺癌学会
  • Place of Presentation: 広島国際会議場・ANAクラウンプラザホテル広島
  • Year and Date: 2010-11-04
• [Presentation] NK細胞障害性低下に関連した石綿曝露下PBMC培養時サイトカイン産生プロファイルの変化 (2010)
  • Author(s): 西村泰光, 他
  • Organizer: 第51回日本肺癌学会
  • Place of Presentation: 広島国際会議場・ANAクラウンプラザホテル広島
  • Year and Date: 2010-11-04
• [Presentation] 基礎研究の進展と登録制度.科学技術振興調整費中皮腫研究班特別報告 (2010)
  • Author(s): 大槻剛巳
  • Organizer: 第51回日本肺癌学会
  • Place of Presentation: 広島国際会議場・ANAクラウンプラザホテル広島
  • Year and Date: 2010-11-04
• [Presentation] アスベスト低濃度長期曝露によるT細胞のメチル化の変化 (2010)
  • Author(s): 前田恵, 他
  • Organizer: 第17回石綿・中皮腫研究会
  • Place of Presentation: 埼玉医科大学川越ビル大会議室(埼玉)
  • Year and Date: 2010-10-16
• [Presentation] 石綿曝露下のNK細胞機能低下に介在する作用機上の解析 (2010)
  • Author(s): 西村泰光, 他
  • Organizer: 第17回石綿・中皮腫研究会
  • Place of Presentation: 埼玉医科大学川越ビル大会議室(埼玉)
  • Year and Date: 2010-10-16
• [Presentation] Soluble interleukin-2 receptor as a marker of immunological disturbance found in silicosis patients. (2010)
  • Author(s): Otsuki T, et al
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-09-25
• [Presentation] アスベスト繊維(クリソタイルとクロシドライト)による免疫影響の比較 (2010)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第17回日本免疫毒性学会学術大会
  • Place of Presentation: 独立行政法人国立環境研究所大山記念ホール
  • Year and Date: 2010-09-09
• [Presentation] 石綿曝露時NK細胞上NKp46低下に関連するサイトカイン産生の変化および単球系細胞の減少 (2010)
  • Author(s): 西村泰光, 他
  • Organizer: 第17回日本免疫毒性学会学術大会
  • Place of Presentation: 独立行政法人国立環境研究所大山記念ホール
  • Year and Date: 2010-09-09
• [Presentation] アスベスト曝露MT-2細胞のFoxP3発現とDNAメチル化解析 (2010)
  • Author(s): 前田恵, 他
  • Organizer: 第17回日本免疫毒性学会学術大会
  • Place of Presentation: 独立行政法人国立環境研究所大山記念ホール
  • Year and Date: 2010-09-09
• [Presentation] 胸膜プラーク陽性者の末梢血CD8+細胞の機能解析 (2010)
  • Author(s): 熊谷直子, 他
  • Organizer: 第17回日本免疫毒性学会学術大会
  • Place of Presentation: 独立行政法人国立環境研究所大山記念ホール
  • Year and Date: 2010-09-09
• [Presentation] Decrease in NKp46 in NK cells upon exposure to asbestos, a possible marker tomonitor anti-tumor immunity. (2010)
  • Author(s): Nishimura Y, 他
  • Organizer: The 10th International Congress of the iMiG (International Mesotheloma Intereat Group)
  • Place of Presentation: Kyoto International Conference Center
  • Year and Date: 2010-09-02
• [Presentation] Down-regulation of CXCR3 in CD4+T cells exposed to asbestos and peripheral CD4+ T cells in patients with malignant mesothelioma. (2010)
  • Author(s): 前田恵, 他
  • Organizer: 文科省科研費「がん研究分野の特性等を踏まえた支援活動」平成22年度がん若手研究者ワークショップ
  • Place of Presentation: アートランドホテル蓼科(長野)
  • Year and Date: 2010-09-02
• [Presentation] Reduced alteration of the regulatory function of CD4+25+ T cell fraction in silicosis patients (2010)
  • Author(s): Hayashi H, et al
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe International Exhibition Hall
  • Year and Date: 2010-08-23
• [Presentation] 珪肺症例の制御性T細胞のCD95媒介アポトーシスに対する高感受性 (2010)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第41回日本職業・環境アレルギー学会総会・学術大会/第57回日本産業衛生学会アレルギー・免疫毒性研究会 合同大会
  • Place of Presentation: 高崎ビューホテル
  • Year and Date: 2010-07-16
• [Presentation] 珪肺症におけるsIL-2R・sCD40L測定と免疫異常との関連 (2010)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第19回日本臨床環境医学会学術集会
  • Place of Presentation: 北里大学白金キャンパス
  • Year and Date: 2010-07-02
• [Presentation] アスベスト曝露による腫瘍免疫減衰と,その回復 (2010)
  • Author(s): 大槻剛巳
  • Organizer: バイオアカデミックフォーラム/バイオテクノロジー国際会議/国際バイオエキスポ
  • Place of Presentation: 東京ビッグサイト
  • Year and Date: 2010-07-01
• [Presentation] アスベスト曝露影響を測る免疫関連遺伝子の同定,新規診断法開発への試行 (2010)
  • Author(s): 西村泰光
  • Organizer: バイオアカデミックフォーラム/バイオテクノロジー国際会議/国際バイオエキスポ
  • Place of Presentation: 東京ビッグサイト
  • Year and Date: 2010-07-01
• [Presentation] アスベスト曝露下NK細胞機能低下に関わるサイトカイン産生量の変化 (2010)
  • Author(s): 西村泰光, 他
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2010-06-25
• [Presentation] IL-10およびTGF-β1を高産生するアスベスト耐性T細胞株のT細胞増殖抑制活性について (2010)
  • Author(s): 前田恵, 他
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2010-06-25
• [Presentation] ヒトCTL分化誘導に関わるサイトカイン産生・アポトーシス・細胞増殖への石綿曝露影響 (2010)
  • Author(s): 熊谷直子, 他
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2010-06-25
• [Presentation] Nishimura Y, Maeda M, Hayashi H, Otsuki T. Exposure O Asbestos Suppressed the Differentiation of Human Cytotoxic T Lymphocytes. (2010)
  • Author(s): Kumagai N, et al
  • Organizer: The 21st Japan China Korea Joint Conference on Occupational Health.
  • Place of Presentation: Tochigi-ken Sogo Bunka Center, Utsunomiya, JAPAN
  • Year and Date: 2010-06-11
• [Presentation] Nishimura Y, Kumagai N, Hayashi H, Miura Y, Kishimoto T, Otsuki T. Application of CXCR3 expression in CD4+ T cells to the diagnosis of asbestos-related diseases. (2010)
  • Author(s): Maeda M, et al
  • Organizer: The 21st Japan China Korea Joint Conference on Occupational Health.
  • Place of Presentation: Tochigi-ken Sogo Bunka Center, Utsunomiya, JAPAN
  • Year and Date: 2010-06-11
• [Presentation] クリソタイル低濃度長期曝露ヒトT細胞株における制御性T細胞機能の解析 (2010)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第83回日本産業衛生学会
  • Place of Presentation: フェニックスプラザ(福井市),福井県国際交流会館
  • Year and Date: 2010-05-27
• [Presentation] 石綿曝露によるNK細胞上NKp46発現量低下における非リンパ系細胞の関わり (2010)
  • Author(s): 西村泰光, 他
  • Organizer: 第83回日本産業衛生学会
  • Place of Presentation: フェニックスプラザ(福井市),福井県国際交流会館
  • Year and Date: 2010-05-27
• [Presentation] 石綿曝露によるNK細胞上NKp46発現量低下におけるサイトカインの関与 (2010)
  • Author(s): 西村泰光, 他
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2010-05-10
• [Presentation] アスベスト低濃度長期曝露による制御性T細胞様MT-2細胞株の抑制機能亢進 (2010)
  • Author(s): 前田恵, 他
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2010-05-10
• [Presentation] CTL分化に関わるサイトカイン産生および細胞増殖とアポトーシスへの石綿曝露影響 (2010)
  • Author(s): 熊谷直子, 他
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2010-05-10
• [Presentation] 珪肺症例でのCD4+CD25+分画および血清IL-17の検討 (2010)
  • Author(s): 林宏明, 他
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2010-05-10
• [Presentation] Immunological effects of silica and asbestos. (2010)
  • Author(s): Otsuki T, et al
  • Organizer: ISOEAID'10 in KYOTO (International symposium on Occupational and Environmental Allergy and Immune Diseases 2010 in KYOTO
  • Place of Presentation: KYODAI-KAIKAN (Kyoto, Japan)
  • Year and Date: 2010-04-08
• [Presentation] Suppressive effect of asbestos on cytotoxicity of human NK cells. (2010)
  • Author(s): Nishimura Y, et al
  • Organizer: ISOEAID'10 in KYOTO (International symposium on Occupational and Environmental Allergy and Immune Diseases 2010 in KYOTO
  • Place of Presentation: KYODAI-KAIKAN (Kyoto, Japan)
  • Year and Date: 2010-04-08
• [Presentation] Analysis of immune index in asbesots-related disease. (2010)
  • Author(s): Maeda M, et al
  • Organizer: ISOEAID'10 in KYOTO (International symposium on Occupational and Environmental Allergy and Immune Diseases 2010 in KYOTO
  • Place of Presentation: KYODAI-KAIKAN (Kyoto, Japan)
  • Year and Date: 2010-04-08
• [Presentation] Differentiation into human cytotoxic T lymphocytes are suppressed under exposure to asbestos. (2010)
  • Author(s): Kumagai N., et al
  • Organizer: ISOEAID'10 in KYOTO (International symposium on Occupational and Environmental Allergy and Immune Diseases 2010 in KYOTO
  • Place of Presentation: KYODAI-KAIKAN (Kyoto, Japan)
  • Year and Date: 2010-04-08
• [Presentation] Effects of asbestos on T-lymphocytes and NK cells in the development of tumor immunity (2010)
  • Author(s): Otsuki T, et al
  • Organizer: The Society of Toxicology(SOT)Annual Meeting
  • Place of Presentation: Salt Lake City, Utah
  • Year and Date: 2010-03-10
• [Presentation] Asbestos-exposure causes suppressed expression of NKp46 with low cytotoxicity in NK cells, related with malignant mesothelioma (2010)
  • Author(s): 西村泰光, et al
  • Organizer: The Society of Toxicology(SOT)Annual Meeting
  • Place of Presentation: Salt Lake City, Utah
  • Year and Date: 2010-03-10
• [Presentation] functional analysis of human CD4+ T cells with decreased CXCR3 expression by long-term, low-dose exposure to asbestos (2010)
  • Author(s): 前田恵, et al
  • Organizer: The Society of Toxicology(SOT)Annual Meeting
  • Place of Presentation: Salt Lake City, Utah
  • Year and Date: 2010-03-10
• [Presentation] suppressive effects of asbestos-exposure on the differentiation into human cytotoxic T lymphocytes (2010)
  • Author(s): 熊谷直子, et al
  • Organizer: The Society of Toxicology(SOT)Annual Meeting
  • Place of Presentation: Salt Lake City, Utah
  • Year and Date: 2010-03-10
• [Presentation] アスベスト曝露CD4+T細胞と抗腫瘍免疫機能の低下について (2010)
  • Author(s): 前田恵, 他
  • Organizer: 第9回分子予防環境医学研究会
  • Place of Presentation: 東京大学大学院医学系研究科1号館1階講堂
  • Year and Date: 2010-01-23
• [Presentation] Decreased cytotoxity of human NK cells with low expression of NK cell-activating receptors upon exposure to asbestos, related with malignant mesotheioma. (2010)
  • Author(s): Nishimura Y, Kumagai N, Maeda M, Hayashi H, fukuoka K, Nakano T, Kishimoto T, Otsuki T
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe International Exhibition Hall
• [Presentation] Decreased induction of human CTL upon exposure to asbestos fibers (2010)
  • Author(s): Kumagai N, Nishimura Y, Maeda M, Hayashi H, Otsuki T.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe International Exhibition Hall
• [Presentation] REduced alteration of the regulatory function of CD4+25+ T cell fraction in silicosis patients. (2010)
  • Author(s): Hayashi H, Maeda M, Nishimura Y, Kumagai N, Miura Y, Otsuki T.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe International Exhibition Hall
• [Presentation] Alteration of cellular characteristics of HTLV-1 immortalized human T cell line, MT-2, by continuous long-term exposre to asbestos, chrysotile and crocidolite. (2010)
  • Author(s): Otsuki T, Miura Y, Maeda M, Kumagai N, Hayahsi H, Nishimura Y
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe International Exhibition Hall
• [Presentation] Relevance of chemokine receptor CXCR3 in asbestos-related diseases. (2010)
  • Author(s): Maeda M, Nishimura Y, Kumagai N, Hayashi H, Miura Y, Kishimoto T, Otsuki T
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe International Exhibition Hall
• [Presentation] The effects of cntinuous long-term exposure to asbestos, chrysotile and crocidolite on HTLV=1 immortalized human T cell line, MT-2. (2010)
  • Author(s): Otsuki T, Maeda M, Miura Y, Kumagai N, Hayashi H, Yamamoto S, Nishimura Y
  • Organizer: The 10th International Congress of the iMiG (International Mesotheloma Interest Group)
  • Place of Presentation: Kyoto International Conference Center
• [Presentation] Decrease in NKp46 in NK cells upon exposure to asbestos, a possible marker tomonitor anti-tumor immunity. (2010)
  • Author(s): Nishimura Y, Kumagai N, Maeda M, Hayashi H, Kishimoto T, Otsuki T
  • Organizer: The 10th International Congress of the iMiG (International Mesotheloma Interest Group)
  • Place of Presentation: Kyoto International Conference Center
• [Presentation] Human MT-2 cell line displays enhanced suppressive function by chronic exposure to asbestos. (2010)
  • Author(s): Maeda M, Nishimura Y, Kumagai N, Hayashi H, Miura Y, Otsuki T
  • Organizer: The 10th International Congress of the iMiG (International Mesotheloma Interest Group)
  • Place of Presentation: Kyoto International Conference Center
• [Presentation] Suppressive effects of asbestos-exposure on the differentiation of human cytotoxic T lymphocytes, accompanied with decrease in IFN-γ and TNF-α. (2010)
  • Author(s): Kumagai N, Nishimura Y, Maeda M, Hayashi H, Kishimoto T, Otsuki T
  • Organizer: The 10th International Congress of the iMiG (International Mesotheloma Interest Group)
  • Place of Presentation: Kyoto International Conference Center
• [Presentation] Decreased Cytotoxicity of NK Cells with Low NKp46 Caused by Exposure to Asbestos, Observed in Patients with Mesothelioma. (2010)
  • Author(s): Nishimura Y, Kumagai N, Maeda M, Hayashi H, Kishimoto T, Otsuki T
  • Organizer: The 21st Japan China Korea Joint Conference on Occupational Health.
  • Place of Presentation: Tochigi-ken Sogo Bunka Center, Utsunomiya, JAPAN
• [Presentation] Exposure to Asbestos Suppressed the Differentiation of Human Cytotoxic T Lymphocytes. (2010)
  • Author(s): Kumagai N, Nishimura Y, Maeda M, Hayashi H, Otsuki T
  • Organizer: The 21st Japan China Korea Joint Conference on Occupational Health.
  • Place of Presentation: Tochigi-ken Sogo Bunka Center, Utsunomiya, JAPAN
• [Presentation] Application of CXCR3 expression in CD4+ T cells to the diagnosis of asbestos-related diseases. (2010)
  • Author(s): Maeda M, Nishimura Y, Kumagai N, Hayashi H, Miura Y, Kishimoto T, Otsuki T
  • Organizer: The 21st Japan China Korea Joint Conference on Occupational Health.
  • Place of Presentation: Tochigi-ken Sogo Bunka Center, Utsunomiya, JAPAN
• [Presentation] Immunological effects of silica and asbestos. (2010)
  • Author(s): Otsuki T, Maeda M, Miura Y, Hayashi H, Kumagai N, Fukuoka K, Nakano T, Kishimoto T, Kusaka M, Uragami K, Nishimura Y.
  • Organizer: ISOEAID'10 in KYOTO (International symposium on Occupational and Environmental Allergy and Immune Diseases 2010 in KYOTO (Local Organizer: Otsuki T)
  • Place of Presentation: KYODAI-KAIKAN (Kyoto, Japan)
• [Presentation] Suppressive effect of asbestos on cytotoxicity of human NK cells. (2010)
  • Author(s): Nishimura Y, Kumagai N, Maeda M, Hayashi H, Fukuoka K, Nakano T, Kishimoto T, Otsuki T
  • Organizer: ISOEAID'10 in KYOTO (International symposium on Occupational and Environmental Allergy and Immune Diseases 2010 in KYOTO (Local Organizer: Otsuki T)
  • Place of Presentation: KYODAI-KAIKAN (Kyoto, Japan)
• [Presentation] Analysis of immune index in asbesots-related disease. (2010)
  • Author(s): Maeda M, Nishimura Y, Kumagai N< Hayashi H, Miura Y, Kishimoto T, Otsuki T
  • Organizer: ISOEAID'10 in KYOTO (International symposium on Occupational and Environmental Allergy and Immune Diseases 2010 in KYOTO (Local Organizer: Otsuki T)
  • Place of Presentation: KYODAI-KAIKAN (Kyoto, Japan)
• [Presentation] Differentiation into human cytotoxic T lymphocytes are suppressed under exposure to asbestos. (2010)
  • Author(s): Kumagai N, Nishimura Y, Maeda M, Hayashi H, Otsuki T
  • Organizer: ISOEAID'10 in KYOTO (International symposium on Occupational and Environmental Allergy and Immune Diseases 2010 in KYOTO (Local Organizer: Otsuki T)
  • Place of Presentation: KYODAI-KAIKAN (Kyoto, Japan)
• [Presentation] Effects of asbestos on T-lymphocytes and NK cells in the development of tumor immunity. (2010)
  • Author(s): Otsuki T, Maeda M, Kumagai N, Hayashi H, Nishimura Y
  • Organizer: The Society of Toxicology (SOT) The 49th Annual Meeting in Salt Lake City, Utah
• [Presentation] Asbestos-exposure causes suppressed expression of NKp46 with low cytotoxicity in NK cells, related with malignant mesothelioma. (2010)
  • Author(s): Nishimura Y, Kumagai N, Maeda M, Hayashi H, Kishimoto Y, Otsuki T
  • Organizer: The Society of Toxicology (SOT) The 49th Annual Meeting in Salt Lake City, Utah
• [Presentation] functional analysis of human CD4+ T cells with decreased CXCR3 expression by long-term, low-dose exposure to asbestos. (2010)
  • Author(s): Maeda M, Nishimura Y, Kumagai N, Hayashi H, Miura Y, Kishimoto T, Otsuki T
  • Organizer: The Society of Toxicology (SOT) The 49th Annual Meeting in Salt Lake City, Utah
• [Presentation] suppressive effects of asbestos-exposure on the differentiation into human cytotoxic T lymphocytes (2010)
  • Author(s): Kumagai N, Nishimura Y, Maeda M, Hayashi H, Otsuki T
  • Organizer: The Society of Toxicology (SOT) The 49th Annual Meeting in Salt Lake City, Utah
• [Presentation] Soluble IL-2 receptor as an indicator of immunological disturbance found in silicosis, scleroderma and silica-induced scleroderma (2009)
  • Author(s): 林宏明, etal
  • Organizer: 日本研究皮膚科学会第34回年次学術大会・総会
  • Place of Presentation: JALリゾートシーホークホテル福岡
  • Year and Date: 2009-12-06
• [Presentation] Suppressed expression of NKp46 genein NK cells caused by exposure to asbestos but not mesothelioma cells, possible marker for impaired anti-tumor immunity in asbestos-exposed (2009)
  • Author(s): 西村泰光, et al
  • Organizer: 第39回日本免疫学会学術大会
  • Place of Presentation: 大阪国際会議場(グランキューブ大阪)
  • Year and Date: 2009-12-03
• [Presentation] Long-term and low-level exposure to asbestos enhances cell contact-dependent T-ell suppression function of MT-2 (2009)
  • Author(s): 前田恵, 他
  • Organizer: 第39回日本免疫学会学術大会
  • Place of Presentation: 大阪国際会議場(グランキューブ大阪)
  • Year and Date: 2009-12-03
• [Presentation] Analysis for effect of asbestos-exposure on production of cytokines related with differentiation into human CTL. (2009)
  • Author(s): 熊谷直子, et al
  • Organizer: 第39回日本免疫学会学術大会
  • Place of Presentation: 大阪国際会議場(グランキューブ大阪)
  • Year and Date: 2009-12-03
• [Presentation] Detection of dysregulated self-torelance in silicosis : The significance of soluble IL-2 receptor and soluble CD40 ligand in serum (2009)
  • Author(s): 林宏明, 他
  • Organizer: 第39回日本免疫学会学術大会.
  • Place of Presentation: 大阪国際会議場(グランキューブ大阪)
  • Year and Date: 2009-12-03
• [Presentation] アスベストの免疫影響. 奈良県立医科大学 (2009)
  • Author(s): 大槻剛巳
  • Organizer: 住居医学研究会
  • Place of Presentation: 奈良県立医科大学 基礎医学校舎5階 会議室
  • Year and Date: 2009-11-20
• [Presentation] 珪肺症を合併した全身性強皮症の1例 (2009)
  • Author(s): 林宏明, 他
  • Organizer: 第37回日本臨床免疫学会総会
  • Place of Presentation: 東京ステーシオンコンファレンス(丸の内)
  • Year and Date: 2009-11-14
• [Presentation] アスベスト低濃度継続曝露T細胞株における制御性T細胞機能の増強 (2009)
  • Author(s): 大槻剛巳, 他
  • Organizer: 第50回日本肺癌学会総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2009-11-12
• [Presentation] 胸膜プラーク陽性者NK細胞のNKp46発現量による細胞障害性の差異, 石綿曝露後NKp46発現抑制機構 (2009)
  • Author(s): 西村泰光, 他
  • Organizer: 第50回日本肺癌学会総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2009-11-12
• [Presentation] アスベスト曝露の細胞傷害性T細胞分化への影響.「集まれ!理系女子 (2009)
  • Author(s): 熊谷直子
  • Organizer: 第1回女子生徒による科学研究発表交流会」について(ポスター発表募集)(女性研究者ポスター発表)
  • Place of Presentation: 福山大学社会連携研究推進センター.(宮地茂記念館)
  • Year and Date: 2009-10-30
• [Presentation] effects of environmental substances on human immunocompetent cells : An asbestos (2009)
  • Author(s): Otsuki T, et al
  • Organizer: 第71回日本血液学会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2009-10-23
• [Presentation] ヒトポリクローナルT細胞(株)MT-2へのクロシドライト曝露とアポトーシス誘導について (2009)
  • Author(s): 前田恵, 他
  • Organizer: 第16回石綿・中皮腫研究会
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2009-10-03
• [Presentation] 石綿曝露影響を受けるNK細胞活性化受容体の中皮腫予防指標としての可能性 (2009)
  • Author(s): 西村泰光, 他
  • Organizer: 第16回石綿・中皮腫研究会
  • Place of Presentation: 長良川国際会議場
  • Year and Date: 2009-10-03
• [Presentation] 石綿曝露影響を受けるNK細胞受容体発現量の中皮腫予防指標としての可能性 (2009)
  • Author(s): 西村泰光
  • Organizer: 第28回生体と金属・化学物質に関する研究会
  • Place of Presentation: 古牧温泉 青森屋
  • Year and Date: 2009-09-01
• [Presentation] 珪酸やアスベスト曝露疾患におけるサイトカインの変化と想定される免疫異常/Cytokine alteration and speculated immunological pathology in silicosis and asbestos-related diseases (2009)
  • Author(s): Otsuki T, et al
  • Organizer: 第16回日本免疫毒性学会学術大会
  • Place of Presentation: 旭川市民文化会館
  • Year and Date: 2009-08-28
• [Presentation] 石綿曝露後NK細胞上NKp46発現抑制機構の解析, NKp46の抗腫瘍免疫機能予測分子指標としての可能性 (2009)
  • Author(s): 西村泰光, 他
  • Organizer: 第16回日本免疫毒性学会学術大会
  • Place of Presentation: 旭川市民文化会館
  • Year and Date: 2009-08-28
• [Presentation] アスベスト低濃度長期曝露によるT細胞株MT-2のT細胞増殖抑制活性の亢進 (2009)
  • Author(s): 前田恵, 他
  • Organizer: 第16回日本免疫毒性学会学術大会
  • Place of Presentation: 旭川市民文化会館
  • Year and Date: 2009-08-28
• [Presentation] 石綿曝露によるCTL分化抑制に関わるサイトカイン産生について (2009)
  • Author(s): 熊谷直子, 他
  • Organizer: 第16回日本免疫毒性学会学術大会
  • Place of Presentation: 旭川市民文化会館
  • Year and Date: 2009-08-28
• [Presentation] 珪酸曝露によるCD4+25+T細胞への免疫影響 (2009)
  • Author(s): 林宏明, 他
  • Organizer: 第16回日本免疫毒性学会学術大会
  • Place of Presentation: 旭川市民文化会館
  • Year and Date: 2009-08-28
• [Presentation] 珪肺症を有し特異な皮膚症状を呈した全身性強皮症 (2009)
  • Author(s): 林宏明, 他
  • Organizer: 第40回日本職業・環境アレルギー学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2009-07-20
• [Presentation] アスベスト曝露によるT細胞株MT-2のTGF-β1産生機構について (2009)
  • Author(s): 前田恵, 他
  • Organizer: 第18回日本臨床環境医学会
  • Place of Presentation: さん太ホール(岡山市)
  • Year and Date: 2009-07-04
• [Presentation] 珪肺症例における活性化T細胞(CD4+CD25+)と(制御性T細胞(CD4+CD25+Foxp3+)の動態 (2009)
  • Author(s): 林宏明, 他
  • Organizer: 第18回日本臨床環境医学会
  • Place of Presentation: さん太ホール(岡山市)
  • Year and Date: 2009-07-04
• [Presentation] アスベスト曝露の免疫抑制的影響を測る分子指標の可能性 (2009)
  • Author(s): 西村泰光
  • Organizer: 大学・国公立研究所による研究成果発表フォーラム～バイオアカデミックフォーラム～
  • Place of Presentation: 東京ビッグサイト
  • Year and Date: 2009-07-01
• [Presentation] 石綿曝露によるヒト細胞傷害性T細胞分化抑制におけるサイトカインの関わり (2009)
  • Author(s): 熊谷直子, 他
  • Organizer: 第74回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 京都大学芝蘭会館(本館)2階
  • Year and Date: 2009-06-26
• [Presentation] アスベスト耐性T細胞株のMAPK活性化を介するTGF-b1産生促進について (2009)
  • Author(s): 前田恵, 他
  • Organizer: 第74回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 京都大学芝蘭会館(本館)2階
  • Year and Date: 2009-06-26
• [Presentation] 環境と生体反応:健康被害から健康増進へ (2009)
  • Author(s): 大槻剛巳
  • Organizer: 岡山県医用工学研究会平成21年度第1回セミナー
  • Place of Presentation: 岡山大学鹿田キャンパス附属図書館3階情報実習室
  • Year and Date: 2009-06-18
• [Presentation] 珪肺症を合併した全身性強皮症 (2009)
  • Author(s): 林宏明, 他
  • Organizer: 第26回岡山膠原病研究会
  • Place of Presentation: 岡山全日空ホテル
  • Year and Date: 2009-06-16
• [Presentation] HTLV-1不死化T細胞株MT-2の青石綿低濃度長期曝露によるアポトーシス抵抗性獲得について (2009)
  • Author(s): 前田恵, 他
  • Organizer: 日本農芸化学会中四国支部第24回講演会
  • Place of Presentation: くにびきメッセ(松江)
  • Year and Date: 2009-05-23
• [Presentation] ヒトポリクローナルT細胞株MT-2におけるクロシドライト依存的なアポトーシスについて (2009)
  • Author(s): 前田恵, 他
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-05-22
• [Presentation] ヒト細胞傷害性T細胞分化を抑制する石綿曝露の影響について (2009)
  • Author(s): 熊谷直子, 他
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-05-22
• [Presentation] 悪性中皮腫予防分子指標としてのNK細胞上NKp46発現量低下の検討、および石綿曝露後NKp46発現抑制機構の解析 (2009)
  • Author(s): 西村泰光, 他
  • Organizer: 第82回日本産業衛生学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2009-05-22
• [Presentation] アスベスト曝露による免疫監視機構の障害.シンポジウム「アスベスト関連疾患・病態から治療まで」 (2009)
  • Author(s): 大槻剛巳
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国際会館(京都)
  • Year and Date: 2009-05-01
• [Presentation] Suppressive effect of asbestos-exposure on cytotoxicity of human NK cells, and the possibility of NKp46 as a marker to monitor immune status in people exposed to asbestos., -18 (2009)
  • Author(s): 西村泰光, et al
  • Organizer: 第2回日中石綿シンポジウム
  • Place of Presentation: New CEntury Zhijiang Resort Hangzhou, Hangzhou, China
  • Year and Date: 2009-04-17
• [Presentation] Suppressive effect of asbestos-exposure on cytotoxicity of human NK cells, and the possibility of NKp46 as a marker to monitor immune status in people exposed to asbestos. (2009)
  • Author(s): Nishimura Y, Maeda M, Kumagai N, Murakami S, Hayashi H, Kishimoto T, Fukuoka K, Nakano T, Otsuki T
  • Organizer: 第2回日中石綿シンポジウム, New CEntury Zhijiang Resort Hangzhou
  • Place of Presentation: Hangzhou, China
• [Presentation] Immunotoxicological effects of asbestos on human T cells. (2009)
  • Author(s): Otsuki T, Maeda M, Murakami S, Miura Y, Kumagai N, Chen Y, Hayashi H, Nakano T, Fukuoka K, Kishimoto T, Nishimura Y
  • Organizer: The 48th Society of Toxicology (USA)
  • Place of Presentation: Baltimore Convention Center in Baltimore, Maryland
• [Presentation] Keynote Speach (3). Achivement of Research Project "Comprehensive approach on asbestos-related diseases (sponsered by SCFPST)" and immunological effects of asbestos (2008)
  • Author(s): Takemi Otsuki.
  • Organizer: AAI (Asian Asebestos Initiative) International Conference in Kitakyushu
  • Place of Presentation: 産業医大
  • Year and Date: 2008-10-02
• [Presentation] Immunological changes in mesothelioma patients and their experimental detection. (2008)
  • Author(s): Otsuki T,Maeda M, Murakami S,Hayashi H, Kumagai N,Miura Y,Ying C,Kuribayashi K,Fukuoka K,Kishimoto T,Nakano T,Nishimura Y
  • Organizer: Inetrnational Mesothelioma Interest Group. Congress 2008
  • Place of Presentation: Amsterdam
• [Presentation] Impairment in cytotoxicity and expression of NK-cell activating receptors on human NK cells caused by exposure to asbestos fibers. (2008)
  • Author(s): Nishimura Y, Maeda M, Murakami S, Hayashi H, Miura Y, fukuoka K, Nakano T, Otsuki T
  • Organizer: Inetrnational Mesothelioma Interest Group. Congress 2008
  • Place of Presentation: Amsterdam
• [Presentation] Down-regulation of chemokine receptor CXCR3 in peripheral T lymphocytes from patients with asbestos-related disease. (2008)
  • Author(s): Maeda M, Nishimura Y, Murakami S, Kumagai N, Hayashi H, Ying C, Miura Y, Nakano T, Kishimoto T, Otsuki T
  • Organizer: Inetrnational Mesothelioma Interest Group. Congress 2008
  • Place of Presentation: Amsterdam
• [Presentation] Keynote Speach (3). Achivement of Research Project "Comprehensive approach on asbestos-related diseases (sponsered by SCFPST)" and immunological effects of asbestos. (2008)
  • Author(s): Otsuki T.
  • Organizer: AAI (Asian Asebestos Initiative) International Conference in Kitakyushu
  • Place of Presentation: Japan
• [Book] Immunological effects of silica and related dysregulation of autoimmunity. Autoimmune Disorder/Book 1, ISBN : 978-953-308-70-9 (2011)
  • Author(s): Kumagai N, et al.
  • Publisher: InTech Open Access Publisher (in press)
• [Book] 平成20年度両備てい園記念財団研究所製金による研究報告書(アスベスト曝露が誘導するヒトT細胞のTGF-β産生促進と制御性T細胞の関連性 生物学に関する試験論叢 第25集) (2010)
  • Author(s): 前田恵
• [Book] 住居医学(IV)(筏義人,吉田修(編著))(アスベストの免疫影響) (2010)
  • Author(s): 大槻剛巳,西村泰光,前田恵,三浦由恵,熊谷直子,林宏明
  • Publisher: 米田出版 千葉県市川市
• [Book] Dysregulation of Autoimmunity Caused by Silica Exposure : Fas-Mediated Apoptosis in T Lymphocy tes Derived from Silicosis Patients. IN. Autoimmune Disorders : Symptoms, Diagnosis and Treatment. Editors : Maria E. Petro ISBN : 978-1-61761-698-3. (2010)
  • Author(s): Hayashi H,, et al.
  • Publisher: Nova Science Publishers, Inc.. Hauppauge, NY
• [Book] アスベストーシス,シリコーシス.In改訂版 分子予防環境医学.編:分子予防環境医学研究会 (2010)
  • Author(s): 西村泰光, 他
  • Publisher: 大槻剛巳, 前田恵, 熊谷直子, 本の泉社, 東京(in press)
• [Book] アスベストの免疫影響.In住居医学(IV).筏義人,吉田修(編著) (2010)
  • Author(s): 大槻剛巳, 他
  • Publisher: 米田出版 千葉県市川市
• [Book] Asbestos : Risks, Environment and Impact.(Eds : Antonio Soto, Gael Salazar)(Immunological effects of Asbestos. ISBN978-1-60692-053-4) (2009)
  • Author(s): Otsuki T, Maeda M, Miura Y, Hayashi H, Murakami S, Kumagai N, Nishimura Y
  • Publisher: [○!C]2009 Nova Science Publishers, Inc.
• [Book] 炎症・再生医学事典(編:松島綱治,西脇徹)(アスベストーシス ISBN978-4-254-30099-4C3547) (2009)
  • Author(s): 林宏明,西村泰光,前田恵,大槻剛巳
  • Publisher: 朝倉書店,東京
• [Book] Autoimmune Disorder/Book 1(Inech Open Access Publisher Immunological effects of silica and related dysregulation of autoimmunity. ISBN:978-953-308-70-9)
  • Author(s): Kumagai N, Hayashi H, Maeda M, Miura Y, Nishimura Y, Fujimoto W, Otsuki T.
  • Publisher: (in press)
• [Book] Autoimmune Disorders : Symptoms, Diagnosis and Treatment.(Editors : Maria E. Petro)(Dysregulation of Autoimmunity Caused by Silica Exposure : Fas-Mediated Apoptosis in T Lymphocytes Derived from Silicosis Patients. ISBN:978-1-61761-698-3)
  • Author(s): Hayashi H, Nishimura Y, Hyodo F, Maeda M, Kumagai N, Miura Y, Kusaka M, Uragami K, Otsuki T.
  • Publisher: Nova Science Publishers, Inc.. Hauppauge, NY
• [Book] 分子予防環境医(アスベストーシス,シリコーシス 松島綱治)
  • Author(s): 西村泰光,大槻剛巳,前田恵,熊谷直子
  • Publisher: 本の泉社 東京
• [Remarks] 川崎医科大学衛生学教室HPに研究概要を紹介
  • URL: http://www.kawasaki-m.ac.jp/hygiene/
• [Remarks]
  • URL: http://www.kawasaki-m.ac.jp/hygiene/
• [Remarks]
  • URL: http://www.kawasaki-m.ac.jp/hygiene/
• [Remarks] (教室HP)
  • URL: http://www.kawasaki-m.ac.jp/hygiene/