The relation between CYP19 haplotypes and breast cancer risk in Japanese women

• Project/Area Number: 20390179
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Aichi Prefectural Institute of Public Health
• Principal Investigator: HIROSE Kaoru Aichi Prefectural Institute of Public Health, 企画情報部・健康科学情報, 室長 (00393124)
• Co-Investigator(Renkei-kenkyūsha): MATSUO Keitaro 愛知県がんセンター研究所, 疫学・予防部, 室長 (80393122)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 乳がん / ハプロタイプ / エストロゲン

Research Abstract

Incidence and death rates of breast cancer in Japan have increased markedly in recently years, especially among postmenopausal women. Many gene polymorphisms of enzymes potentially related to carcinogenesis have been examined for breast cancer risk. Aromatase is one of the key enzymes in estrogen biosynthesis and encoded by CYP19A1. To evaluate impact of CYP19A1 haplotypes on breast cancer risk, we conducted a case-control study. Some haplotyeps in CYP19A1 would influence sex hormones levels, thus suggesting potential importance of CYP19A1 haplotypes on breast cancer risk.

Research Products

• [Journal Article] Association between vitamin D and calcium intake and breast cancerriskaccording tomenopausal status and receptor status in Japan. (2010)
  • Author(s): Kawase T., Matsuo K., Suzuki T., Hirose K., Hosono S., Watanabe M., Inagaki M., Iwata H., TanakaH.,Tajima K.
  • Journal Title: Cancer Sci. 101(5) Pages: 1234-1240
  • Peer Reviewed
• [Journal Article] HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women. (2010)
  • Author(s): Hosono S., Kawase T., Matsuo K., Watanabe M., Kajiyama H., Hirose K., Suzuki T., Kidokoro K., Ito H., Nakanishi T., Yatabe Y., Hamajima N., Kikkawa F., Tajima K.,Tanaka H.
  • Journal Title: J Epidemiology. 20(4) Pages: 295-301
  • NAID: 10027651128
  • Peer Reviewed
• [Journal Article] Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women. (2010)
  • Author(s): Hosono S., Matsuo K., Kajiyama H., Hirose K., Suzuki T., Kawase T., Kidokoro K., NakanishiT.,Hamajima N., Kikkawa F., Tajima K., Tnanaka H.
  • Journal Title: Eur J Clin Nut. 64(4) Pages: 400-409
  • Peer Reviewed
• [Journal Article] Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women (2010)
  • Author(s): Hosono S., et al.
  • Journal Title: Eur J Clin Nut. 64(4) Pages: 400-409
  • Peer Reviewed
• [Journal Article] Association between vitamin D and calcium intake and breast cancerrisk according to menopausal status and receptor status in Japan (2010)
  • Author(s): Kawase T., et al.
  • Journal Title: Cancer Science 101(5) Pages: 1234-1240
  • Peer Reviewed
• [Journal Article] HLA-A alleles and cervical squamous cell carcinoma risk in Japanese women (2010)
  • Author(s): Hosono S., et al.
  • Journal Title: J Epidemiology (in press)
  • Peer Reviewed
• [Journal Article] Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women. (2009)
  • Author(s): KidokoroK.,Ino K.,HiroseK.,Kajiyama H., Hosono S., Suzuki T.,KawaseT., Hiraki A., Hamajima N., Tanaka H., Tajima K., Kikkawa F., Matsuo K.
  • Journal Title: J Hum Genetics 54 Pages: 78-85
  • NAID: 10030729122
  • Peer Reviewed
• [Journal Article] Association between CYP19A1 polymorphisms and sex hormones in postmenopausal Japanese women (2009)
  • Author(s): Kidokoro K., et al.
  • Journal Title: J Hum Genetics 54 Pages: 78-85
  • Peer Reviewed
• [Journal Article] Effect of soybean on breast cancer according to receptor status : a case-control study in Japan. (2008)
  • Author(s): Suzuki T., MatsuoK.,Tsunoda N.,Hirose K., Hiraki A., Kawase T., Yamashita T., Iwata H., Tanaka H., Tajima K.
  • Journal Title: Int J Cancer 123(7) Pages: 1674-1680
  • Peer Reviewed
• [Journal Article] Reduced risk of endometrial cancer from alcohol drinking in Japan. (2008)
  • Author(s): Hosono S., Matsuo K., Kajiyama H., HiorseK., SuzukiT., Hiraki A.,Kawase T., Kidokoro K., Nakanishi T., Hamajima N., Kikkawa F., Tajima K., Tanaka H.
  • Journal Title: Cancer Sci 99 Pages: 1195-1201
  • Peer Reviewed
• [Journal Article] Tajima K. Soy consumption reduces the risk of non-small cell lung cancers with epidermal growth factor receptor mutationsamong Japanese. (2008)
  • Author(s): Matsuo K., HirakiA., Ito H.,KosakaT., Suzuki T.,Hirose K.,Wakai K.,Yatabe Y., Mitsudomi T.
  • Journal Title: Cancer Sci 99 Pages: 1202-1208
  • Peer Reviewed
• [Journal Article] One-carbon metabolism-related gene polymorphisms and risk of breast cancer. (2008)
  • Author(s): Suzuki T., Matsuo K., Hirose K., Hiraki A., Kawase T., Watanabe M., Yamashita T., Yatabe Y., Iwata H., Tajima K.
  • Journal Title: Carcinogenesis 29 Pages: 356-362
  • Peer Reviewed
• [Journal Article] Effect of soybean on breast cancer according to receptor status : a case-control study in Japan (2008)
  • Author(s): Suzuki T., et al.
  • Journal Title: Int J Cancer 123 Pages: 1674-1680
  • Peer Reviewed
• [Journal Article] Reduced risk of endometrial cancer from alcohol drinking in Japan (2008)
  • Author(s): Hosono S., et al.
  • Journal Title: Cancer Sci 99 Pages: 1195-1201
  • Peer Reviewed
• [Journal Article] Soy consumption reduces the risk of non-small cell lung cancers with epidermal growth factor receptor mutations among Japanese (2008)
  • Author(s): Matsuo K., et al.
  • Journal Title: Cancer Sci 99 Pages: 1202-1208
  • NAID: 10024007506
  • Peer Reviewed
• [Presentation] 日本人女性におけるDNA修復遺伝子多型と子宮体がんリスクとの関連 (2011)
  • Author(s): 細野覚代, 他
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 札幌市
  • Year and Date: 2011-01-22
• [Presentation] 日本人におけるCYP19A1遺伝子多型と閉経後子宮内膜癌リスクとの関連 (2010)
  • Author(s): 細野覚代, 他
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-23
• [Presentation] Association between CYP19A1 polymorphisms and the risk for postmenopausal endometrial cancer in Japanese women (2010)
  • Author(s): Hosono S, et al.
  • Organizer: 69th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-23
• [Presentation] 日本人閉経後女性における生殖歴関連要因および身体要因と血清ホルモンレベルとの関連 (2009)
  • Author(s): 広瀬かおる, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-03
• [Presentation] 日本人女性における飲酒と乳がん発症との関連 (2009)
  • Author(s): 川瀬孝和, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-03
• [Presentation] 日本人女性におけるBody Mass Indexの変化と子宮内膜癌リスクについての検討 (2009)
  • Author(s): 細野覚代, 他
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2009-10-03
• [Presentation] 日本人閉経後女性における身体特性・生活習慣およびその介入の女性ホルモンレベルに与える影響 (2009)
  • Author(s): 広瀬かおる, 他
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市
  • Year and Date: 2009-01-23
• [Presentation] 愛知県がんセンターにおける大規模病院疫学研究参加非がん女性における初潮年齢の推移の検討 (2009)
  • Author(s): 城所久美子, 他
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市
  • Year and Date: 2009-01-23
• [Presentation] 日本人女性における食事からのカルシウム、ビタミンD摂取と子宮頸がんリスクとの関連 (2009)
  • Author(s): 細野覚代, 他
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市
  • Year and Date: 2009-01-23
• [Presentation] 日本人女性における食事からのカルシウム、ビタミンD摂取と子宮頚がんリスクとの関連 (2009)
  • Author(s): 細野覚代, 他
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢市
  • Year and Date: 2009-01-23
• [Presentation] 初経年齢の乳がん罹患リスクへの影響は、HER2・ホルモン受容体発現の有無によって異なる (2008)
  • Author(s): 松尾恵太郎, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-30
• [Presentation] 日本人におけるHuman-Leukocyte-Antigen-Aアレルと子宮頸がんリスクとの関連 (2008)
  • Author(s): 細野覚代, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-30
• [Presentation] 日本人における Human-Leukocyte-Antigen-Aアレルと子宮頚がんリスクとの関連 (2008)
  • Author(s): 細野覚代, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-30
• [Presentation] 閉経後女性の血清ホルモン濃度と生活習慣、CYP19A1 の遺伝子多型の関連 (2008)
  • Author(s): 城所久美子, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29
• [Presentation] 閉経後女性の血清ホルモン濃度と生活習慣、CYP19A1の遺伝子多型の関連 (2008)
  • Author(s): 城所久美子, 他
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-29