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Health effects of hazardous factors in the environment and the risk assessment

Research Project

Project/Area Number 20390180
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionAkita University

Principal Investigator

MURATA Katsuyuki  Akita University, 大学院・医学系研究科, 教授 (80157776)

Co-Investigator(Kenkyū-buntansha) IWATA Toyoto  秋田大学, 大学院・医学系研究科, 助教 (00321894)
DAKEISHI Miwako  秋田大学, 大学院・医学系研究科, 助教 (70375236)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywordsリスク評価 / 健康影響 / 有害因子 / 地域保健 / 産業保健 / 有害化学物質 / ベンチマークドース法 / 農薬 / 神経影響 / トリクロロエチレン / 曝露量-影響関係 / 神経運動機能影響 / 身体重心動揺検査 / 手のふるえ検査 / 脳・神経 / 腎機能影響 / 鉛
Research Abstract

The four studies were carried out to clarify human health effects of chronic low-level exposures to hazardous factors in the environment. (1) To assess the neuromotor impact of trichloroethylene objectively, static postural sway and hand tremor parameters, along with urinary trichloroethanol and trichloroacetic acid levels, were investigated in 57 workers without obvious neurological disorders and 60 control subjects. (2) To assess the chronic effect of organophosphorus insecticides in the environment, the urinary dialkylphosphate concentrations and outcome parameters such as cardiac autonomic nervous and neuromotor functions were examined in 339 Japanese adults who were engaged in the food distribution, apple farming and pest control operation. (3) To examine whether the critical level of lead producing adverse effects truly differs between workers and children, an overview of studies addressing the critical level of lead in workers, along with a perspective on lead toxicity in children, was provided by using available data chosen from PubMed. (4) The European Food Safety Authority (EFSA) recommended that the benchmark dose (BMD) approach, as an alternative to the traditionally used no-observed-adverse-effect level approach, be used as the method of choice for the determination of the reference point for deriving health-based guidance values and margins of exposure. As a result, by using the BMD approach recommended by the EFSA, human health safety may be better guaranteed because of the lower reference points for hazardous substances. However, its application to epidemiological data does not always reflect toxicological implications in light of the clinical standard.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (55 results)

All 2011 2010 2009 2008 Other

All Journal Article (34 results) (of which Peer Reviewed: 7 results) Presentation (14 results) Book (3 results) Remarks (4 results)

  • [Journal Article] 生物学的モニタリングのための血漿および赤血球膜リン脂質中長鎖多価不飽和脂肪酸の比較2011

    • Author(s)
      川端輝江,仲井邦彦,萩原千絵,黒川修行,村田勝敬,柳沼梢,佐藤洋
    • Journal Title

      日衛誌 66

      Pages: 108-114

    • NAID

      10029364026

    • Related Report
      2010 Final Research Report
  • [Journal Article] 生物学的モニタリングのための血漿および赤血球膜リン脂質中長鎖多価不飽和脂肪酸の比較2011

    • Author(s)
      川端輝江、村田勝敬, ほか
    • Journal Title

      日本衛生学雑誌

      Volume: 66巻 Pages: 108-114

    • NAID

      10029364026

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ベンチマークドース法の臨床的基準をもつ健康影響指標への適用2011

    • Author(s)
      村田勝敬、苅田香苗, ほか
    • Journal Title

      産業衛生学雑誌

      Volume: 53巻(印刷中)

    • NAID

      10028109155

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanse population.2010

    • Author(s)
      Sakamoto M, Murata K, Kubota M, Nakai K, Satoh H
    • Journal Title

      Ecotoxicol Environ Saf 73

      Pages: 1-6

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cadmium and tubular dysfunction marker levels in urine of residents in non-polluted areas with natural abundance of cadmium in Japan.2010

    • Author(s)
      Moriguchi J, Inoue Y, Kamiyama S, Sakuragi S, Horiguchi M, Murata K, Fukui Y, Ohashi F, Ikeda M
    • Journal Title

      Int Arch Occup Environ Health 83

      Pages: 455-466

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intervention study on cardiac autonomic nervous effects of methylmercury from seafood.2010

    • Author(s)
      Yaginuma-Sakurai K, Murata K, Shimada M, Nakai K, Kurokawa N, Kameo S, Satoh
    • Journal Title

      Neurotoxicol Teratol 32

      Pages: 240-245

    • Related Report
      2010 Final Research Report
  • [Journal Article] Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides.2010

    • Author(s)
      Harari R, Julvez J, Murata K, Barr D, Bellinger DC, Debes F, Grandjean P
    • Journal Title

      Environ Health Perspect 118

      Pages: 890-896

    • Related Report
      2010 Final Research Report
  • [Journal Article] Adverse effects of methylmercury : environmental health research implications.2010

    • Author(s)
      Grandjean P, Satoh H, Murata K, Eto K
    • Journal Title

      Environ Health Perspect 118

      Pages: 1137-1145

    • Related Report
      2010 Final Research Report
  • [Journal Article] neuromotor effects of short-term and long-term exposures to trichloroethylene in workers.2010

    • Author(s)
      Murata K, Inoue O, Akutsu M, Iwata T
    • Journal Title

      Am J Ind Med 53

      Pages: 915-921

    • Related Report
      2010 Final Research Report
  • [Journal Article] Neurobehavioral effects of prenatal exposure to methylmercury and PCBs and seafood intake : Neonatal Behavioral Assessment Scale results of Tohoku Study of Child Development.2010

    • Author(s)
      Suzuki K, Nakai K, Sugawara T, Nakamura T, Ohba T, Shimada M, Hosokawa T, Okamura K, Sakai T, Kurokawa N, Murata K, Satoh C, Satoh H
    • Journal Title

      Environ Res 110

      Pages: 699-704

    • Related Report
      2010 Final Research Report
  • [Journal Article] Retrospective study on temporal and regional variations of methylmercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area, Japan.2010

    • Author(s)
      Sakamoto M, Murata K, Tsuruta K, Miyamoto K, Akagi H
    • Journal Title

      Ecotoxicol Environ Saf 73

      Pages: 1144-1149

    • Related Report
      2010 Final Research Report
  • [Journal Article] 3次元画面テレビの将来2010

    • Author(s)
      村田勝敬
    • Journal Title

      公衆衛生 74

      Pages: 352-353

    • Related Report
      2010 Final Research Report
  • [Journal Article] 世界における先行出生コホート研究の教訓2010

    • Author(s)
      村田勝敬,間正理恵
    • Journal Title

      医学のあゆみ 235

      Pages: 1127-1132

    • Related Report
      2010 Final Research Report
  • [Journal Article] メチル水銀曝露の多様性と健康リスク2010

    • Author(s)
      村田勝敬,坂本峰至,佐藤洋
    • Journal Title

      公衆衛生 74

      Pages: 747-748

    • Related Report
      2010 Final Research Report
  • [Journal Article] 3Dゲーム使用の視覚系神経機能に及ぼす影響2010

    • Author(s)
      西村雄宏,岩田豊人,村田勝敬
    • Journal Title

      秋田医学 37

      Pages: 85-91

    • NAID

      110007873842

    • Related Report
      2010 Final Research Report
  • [Journal Article] Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides.2010

    • Author(s)
      Harari R, Murata K, et al
    • Journal Title

      Environmental Health Perspectives

      Volume: 118巻 Pages: 1001-1007

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mercury and heavy metal profiles of maternal and umbilical cord RBCs in Japanese population2010

    • Author(s)
      Sakamoto M, Murata K, et al
    • Journal Title

      Ecotoxicology and Environmental Safety 73

      Pages: 1-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylmercury exposure and adverse cardiovascular effects in Faroese whaling men.2009

    • Author(s)
      Choi AL, Weihe P, Budtz-Jorgensen E, Jorgensen PJ, Salonen JT, Tuomainen T-P, Murata K, Nielsen HP, Petersen MS, Askham J, Grandjean P
    • Journal Title

      Environ Health Perspect 117

      Pages: 367-372

    • Related Report
      2010 Final Research Report
  • [Journal Article] Paradoxical increases in serum levels of highly chlorinated PCBs in aged women in clear contrast to robust decreases in dietary intakes from 1980 to 2003 in Japan.2009

    • Author(s)
      Koizumi A, Harada KH, Eslami B, Fujimine Y, Hachiya N, Hirosawa I, Inoue K, Inoue S, Koda S, Kusaka Y, Murata K, Omae K, Saito N, Shimbo S, Takenaka K, Takeshita T, Todoriki H, Wada Y, Watanabe T, Ikeda M
    • Journal Title

      Environ Health Pre Med 14

      Pages: 235-246

    • NAID

      10026959024

    • Related Report
      2010 Final Research Report
  • [Journal Article] N-acetyl-beta-D-glucosaminidase (NAG) as the most sensitive marker of tubular dysfunction for monitoring residents in non-polluted areas.2009

    • Author(s)
      Moriguchi J, Inoue Y, Kamiyama S, Horiguchi M, Murata K, Sakuragi S, Fukui Y, Ohashi F, Ikeda M
    • Journal Title

      Toxicol Lett 190

      Pages: 1-8

    • Related Report
      2010 Final Research Report
  • [Journal Article] Lead toxicity : Does the critical level of lead resulting in adverse effects differ between adults and children?2009

    • Author(s)
      Murata K, Iwata T, Dakeishi M, Karita K
    • Journal Title

      J Occup Health 51

      Pages: 1-12

    • NAID

      110007055445

    • Related Report
      2010 Final Research Report
  • [Journal Article] 東北コホート調査と曝露評価2009

    • Author(s)
      仲井邦彦,中村朋之,村田勝敬,佐藤洋
    • Journal Title

      日衛誌 64

      Pages: 749-758

    • Related Report
      2010 Final Research Report
  • [Journal Article] 健康障害予防の原点2009

    • Author(s)
      村田勝敬
    • Journal Title

      産業医学ジャーナル 32-3

      Pages: 56-57

    • Related Report
      2010 Final Research Report
  • [Journal Article] 安全基準に関連する動物実験のジレンマ2009

    • Author(s)
      村田勝敬,佐藤洋
    • Journal Title

      日衛誌 64

      Pages: 824-825

    • NAID

      10026249455

    • Related Report
      2010 Final Research Report
  • [Journal Article] 小児環境保健に関する疫学調査の取り組みと課題2009

    • Author(s)
      村田勝敬,佐藤洋
    • Journal Title

      化学物質と環境 No.96

      Pages: 6-10

    • Related Report
      2010 Final Research Report
  • [Journal Article] Lead toxicity : Does the critical level of lead resulting in adverse effects differ between adults and children2009

    • Author(s)
      Murata K, Iwata T, Dakeishi M, et.al.
    • Journal Title

      Journal of Occupational Health 51

      Pages: 1-12

    • NAID

      110007055445

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in mercury concentrations of segmental maternal hair during gestation and their correlations with other biomarkers of fetal exposure to methylmercury in the Japanese population.2008

    • Author(s)
      Sakamoto M, Kubota M, Murata K, Nakai K, Sonoda I, Satoh H
    • Journal Title

      Environ Res 106

      Pages: 270-276

    • Related Report
      2010 Final Research Report
  • [Journal Article] Assessment of DNA damage in Japanese nurses handling antineoplastic drugs by the Comet assay.2008

    • Author(s)
      Sasaki M, Dakeishi M, Hoshi S, Ishii N, Murata K
    • Journal Title

      J Occup Health 50

      Pages: 7-12

    • NAID

      110006570663

    • Related Report
      2010 Final Research Report
  • [Journal Article] Association of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes with fasting plasma glucose levels in Japanese male and female workers.2008

    • Author(s)
      Dakeishi M, Murata K, Sasaki M, Tamura A, 岩田豊人
    • Journal Title

      Alcohol Alcoholism 43

      Pages: 143-147

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effects of acute alcohol ingestion on neuromotor functions.2008

    • Author(s)
      Ando S, Iwata T, Ishikawa H, Dakeishi M, 村田勝敬
    • Journal Title

      Neurotoxicology 29

      Pages: 735-739

    • Related Report
      2010 Final Research Report
  • [Journal Article] 意味の異なる2つの"予防."2008

    • Author(s)
      村田勝敬
    • Journal Title

      日衛誌 63

      Pages: 662-662

    • NAID

      10024477911

    • Related Report
      2010 Final Research Report
  • [Journal Article] ベンチマークドース法の臨床的基準をもつ健康影響指標への適用

    • Author(s)
      村田勝敬,苅田香苗,堀口兵剛,岩田豊人,広瀬明彦
    • Journal Title

      産衛誌 (印刷中)

    • NAID

      10028109155

    • Related Report
      2010 Final Research Report
  • [Journal Article] Neuromotor effects of short-term and long-term exposures to trichloroethylene in workers

    • Author(s)
      Murata K, Iwata T, et al
    • Journal Title

      American Journal of Industrial Medicine (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurobehavioral deficits and increased blood pressure in school-age children prenatally exposed to pesticides

    • Author(s)
      Harari R, Murata K, et al.
    • Journal Title

      Environmental Health Perspectives (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胎児期・乳児期別における母親由来金属の児体内蓄積に関する研究2011

    • Author(s)
      坂本峰至,村田勝敬,仲井邦彦,佐藤洋
    • Organizer
      第81回日本衛生学会学術総会
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本人における有機リン系殺虫剤尿中代謝物量の特徴2011

    • Author(s)
      上山純,斎藤勲,斎藤峻,近藤高明,柴田英治,五藤雅博,岩田豊人,村田勝敬,湧澤伸哉,上島通浩
    • Organizer
      第81回日本衛生学会学術総会
    • Related Report
      2010 Final Research Report
  • [Presentation] 環境由来化学物質曝露の体内蓄積量低減を目指した介入研究2011

    • Author(s)
      仲井邦彦,黒川修行,川端輝江,佐々木裕子,柳沼梢,島田美幸,白石彩,中塚晴夫,村田勝敬
    • Organizer
      第81回日本衛生学会学術総会
    • Related Report
      2010 Final Research Report
  • [Presentation] 環境由来化学物質の胎児期曝露と新生児の行動発達の関連姓NBASによる解析から2011

    • Author(s)
      龍田希,仲井邦彦,鈴木恵太,柳沼梢,島田美幸,黒川修行,村田勝敬,佐藤洋
    • Organizer
      第81回日本衛生学会学術総会
    • Related Report
      2010 Final Research Report
  • [Presentation] 親の収入と児の体格や知能指数との関連性について2011

    • Author(s)
      黒川修行,龍田希,鈴木恵太,柳沼梢,島田美幸,村田勝敬,仲井邦彦,佐藤洋
    • Organizer
      第81回日本衛生学会学術総会
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship between methylmercury and DHA in pregnant women and fetuses : the risks and benefits of fish consumption.2010

    • Author(s)
      Sakamoto M, Murata K, Kawakami S, Domingo J, Nakai K, Satoh H
    • Organizer
      XII International Congress of Toxicology
    • Place of Presentation
      Barcelona (Spain)
    • Related Report
      2010 Final Research Report
  • [Presentation] トリクロロエチレンの神経運動機能に及ぼす影響2010

    • Author(s)
      岩田豊人,福岡敦子,阿久津雅典,村田勝敬,井上修
    • Organizer
      第69回産業衛生学会東北地方会
    • Related Report
      2010 Final Research Report
  • [Presentation] Relationship between methyl mercury and docosahexaenoic acids in pregnant women and fetuses.2009

    • Author(s)
      Sakamoto M, Kawakami S, Murata K, Nakai K, Satoh H
    • Organizer
      9th International Conference on Mercury as a Global Pollutant
    • Place of Presentation
      Guiyang (China)
    • Related Report
      2010 Final Research Report
  • [Presentation] Methylmercury exposure, fish consumption, and cardiovascular function in Faroese whalingmen.2009

    • Author(s)
      Choi AL, Weihe P, Budtz-Jorgensen E, Jorgensen PJ, Salonen J, Tuomainen TP, Murata K, Nielsen HP, Petersen MS, Askham J, Grandjean P
    • Organizer
      9^<th> International Conference on Mercury as a Global Pollutant
    • Place of Presentation
      Guiyang (China)
    • Related Report
      2010 Final Research Report
  • [Presentation] Methylmercury and the fetal brain : The Faroe Islands Studies.2009

    • Author(s)
      Weihe P, Grandjean P, Murata K, Debes F, Ludvig A, Steuerwald U, Budtz-Jorgensen E, Choi AL
    • Organizer
      9^<th> International Conference on Mercury as a Global Pollutant
    • Place of Presentation
      Guiyang (China)
    • Related Report
      2010 Final Research Report
  • [Presentation] Contribution of NIMD to mercury research in Guizhou, China, II. Human exposure research : high exposure of Chinese mercury mine workers to mercury vapor and increased methylmercury levels in the hair.2009

    • Author(s)
      Sakamoto M, Feng X, Yoshida M, Murata K, Yasutake A
    • Organizer
      9^<th> International Conference on Mercury as a Global Pollutant
    • Place of Presentation
      Cuiyang (China)
    • Related Report
      2010 Final Research Report
  • [Presentation] 小規模金鉱山における水銀による作業者の健康影響の現状について2009

    • Author(s)
      吉田稔,村田勝敬,佐藤洋
    • Organizer
      第68回産業衛生学会東北地方会
    • Place of Presentation
      秋田市
    • Related Report
      2010 Final Research Report
  • [Presentation] 秋田県の職域におけるメンタルヘルス実態調査について2009

    • Author(s)
      伏見雅人,工藤康嗣,村田勝敬,清水徹男
    • Organizer
      第68回産業衛生学会東北地方会
    • Related Report
      2010 Final Research Report
  • [Presentation] 鉛作業者における鉛の許容濃度に関する研究2008

    • Author(s)
      岩田豊人,嶽石美和子,村田勝敬
    • Organizer
      第67回産業衛生学会東北地方会
    • Place of Presentation
      青森市
    • Related Report
      2010 Final Research Report
  • [Book] Minamata disease.(In : Nriagu JO (ed) Encyclopedia of Environmental Health (Vol 3))2011

    • Author(s)
      Murata K, Sakamoto M
    • Publisher
      Elsevier, Burlington
    • Related Report
      2010 Final Research Report
  • [Book] Methylmercury neruotoxicology : from rare poisonings to silent pandemic.(In : Wang C, Slikker W (ed) Developmental Neurotoxicology Research : Principles, Models, Techniques, Strategies, and Mechanisms).2011

    • Author(s)
      Grandjean P, Choi AL, Weihe P, Murata K
    • Publisher
      Jon Wiley & Sons, Inc, Hoboken
    • Related Report
      2010 Final Research Report
  • [Book] Minamata disease(In : Encyclopedia of Environmental Health)volume 32011

    • Author(s)
      Murata K, Sakamoto M
    • Publisher
      Elsevier B.V.
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.akita-u.ac.jp/~eisei/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/-eisei/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~eisei/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~eisei/achievement.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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