Preventive medical evaluation for the illness risk of genetic polymorphism related to metabolic syndrome

• Project/Area Number: 20390181
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Chiba University
• Principal Investigator: SUWAZONO Yasushi Chiba University, 大学院・医学研究院, 准教授 (90302546)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Etsuko 千葉大学, 大学院・医学研究院, 講師 (80097427) ; NAKAGAWA Hideaki 金沢医科大学, 医学部, 教授 (00097437) ; UETANI Mirei 千葉大学, 大学院・医学研究院, 講師 (30376371)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 成人保健 / メタボリック症候群 / アディポカイン / レジスチン / アディポネクチン / 遺伝子多型 / 縦断調査 / 多変量解析 / ペルオキシソーム増殖剤活性化受容体 / 高脂血症 / 糖尿病 / 追跡調査 / アデイポカイン

Research Abstract

The aim of this study was to evaluate the illness risk for metabolic syndrome of genetic polymorphism in a large Japanese cohort. This study suggested that the genetic polymorphisms for resistin(-420C/G), adiponectin(45T>G) and peroxisome proliferator-activated receptor gamma(161C>T) are associated with the risk for the diseases constituting the metabolic syndrome.