| Project/Area Number |
20390192
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
TANAKA Hideo Aichi Cancer Center Research Institute, 疫学・予防部, 部長 (60470168)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Keitaro 愛知県がんセンター(研究所), 疫学・予防部, 室長 (80393122)
SUZUKI Takeshi 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (70416163)
KAWASE Takakazu 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (30463194)
HOSONO Satoyo 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (80402600)
ITO Hidemi 愛知県がんセンター(研究所), 疫学・予防部, 室長 (90393123)
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| Co-Investigator(Renkei-kenkyūsha) |
HIRAKI Akio 岡山大学, 保健管理センター, 助教 (70443455)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 癌 / 社会医学 / 衛生 / 疫学 / 遺伝子多型 / 膵がん / ABO血液型 / 症例対照研究 / ジェノタイプ / 分子疫学 / 胆管細胞癌 / B型肝炎ウイルス / C型肝炎ウイルス / コホート研究 / 予防 / 膵癌 / アルコール / MTHFR / 予防医学 / 葉酸 |
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| Research Abstract |
To elucidate gene-environmental interaction in pancreatic cancer in Asia population, we conducted hospital-based case control studies in Japan. We found that polymorphisms of MTHFR, ADH1B and ALDH2 showed significant interation with alcohol consumption for the development of pancreatic cancer. In addition, we found that ABO blood group alleles was significantly associated with the risk of pancreatic cancer in a Japanese population. We also demonstrated that chronic hepatitis B virus infection was significantly associated with cholangio cellular carcinoma in a cohort study.
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