Genetic factors and gene-environmental interaction in pancreatic cancer in Asia population.

• Project/Area Number: 20390192
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: TANAKA Hideo Aichi Cancer Center Research Institute, 疫学・予防部, 部長 (60470168)
• Co-Investigator(Kenkyū-buntansha): MATSUO Keitaro 愛知県がんセンター(研究所), 疫学・予防部, 室長 (80393122) ; SUZUKI Takeshi 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (70416163) ; KAWASE Takakazu 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (30463194) ; HOSONO Satoyo 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (80402600) ; ITO Hidemi 愛知県がんセンター(研究所), 疫学・予防部, 室長 (90393123)
• Co-Investigator(Renkei-kenkyūsha): HIRAKI Akio 岡山大学, 保健管理センター, 助教 (70443455)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
• Keywords: 癌 / 社会医学 / 衛生 / 疫学 / 遺伝子多型 / 膵がん / ABO血液型 / 症例対照研究 / ジェノタイプ / 分子疫学 / 胆管細胞癌 / B型肝炎ウイルス / C型肝炎ウイルス / コホート研究 / 予防 / 膵癌 / アルコール / MTHFR / 予防医学 / 葉酸

Research Abstract

To elucidate gene-environmental interaction in pancreatic cancer in Asia population, we conducted hospital-based case control studies in Japan. We found that polymorphisms of MTHFR, ADH1B and ALDH2 showed significant interation with alcohol consumption for the development of pancreatic cancer. In addition, we found that ABO blood group alleles was significantly associated with the risk of pancreatic cancer in a Japanese population. We also demonstrated that chronic hepatitis B virus infection was significantly associated with cholangio cellular carcinoma in a cohort study.

Research Products

• [Journal Article] ABO blood group alleles and the risk of pancreatic cancer in Japanese population. (2011)
  • Author(s): Nakao M, Matsuo K, Hosono S, Ogata S, Ito H, Watanabe M, Mizuno N, Iida S, Satoh S, Yatabe Y, Yamao K, Ueda R, Tajima K, Tanaka H
  • Journal Title: Cancer Sci. 102(5) Pages: 1076-1080
  • NAID: 10029293868
  • Peer Reviewed
• [Journal Article] 膵がんの疫学 (2011)
  • Author(s): 田中英夫
  • Journal Title: 綜合臨牀 60 Pages: 668-672
• [Journal Article] ABO blood group alleles and the risk of pancreatic cancer in Japanese population. (2011)
  • Author(s): Nakao M
  • Journal Title: Cancer Sci Volume: 102 Pages: 1076-1080
  • Peer Reviewed
• [Journal Article] Risk factors for intrahepatic cholangiocarcinoma : A possible role of hepatitis B virus. (2010)
  • Author(s): Tanaka M, Tanaka H, Tsukuma H, Ioka A, Oshima A, Nakahara T.
  • Journal Title: Journal of Viral Hepatitis. 17 Pages: 742-748
  • Peer Reviewed
• [Journal Article] 大阪府における性差から見たHCV関連肝細胞癌発症の動向 (2010)
  • Author(s): 今井康陽, 田中英夫, 平松直樹, 林紀夫
  • Journal Title: Epidemiology of hepatitis C virus-related hepatocellular carcinoma in Osaka with special reference to sex difference 消化器内科 50 Pages: 331-336
• [Journal Article] Risk factors for intrahepatic cholangiocarcinoma : a possible role of hepatitis B virus. (2010)
  • Author(s): Tanaka M
  • Journal Title: J Viral Hepat Volume: 17 Pages: 742-748
  • Peer Reviewed
• [Journal Article] Risk factors for intrahepatic cholangiocarcinoma : A possible role of hepatitis B virus (2010)
  • Author(s): Tanaka M
  • Journal Title: Journal of Viral Hepatitis (in press)
  • Peer Reviewed
• [Journal Article] Reduced risk of hepatocellular carcinoma after interferon therapy in aged patients with chronic hepatitis C is limited to sustained virological responders (2010)
  • Author(s): Imai Y
  • Journal Title: Journal of Viral Hepatitis 17 Pages: 185-191
  • Peer Reviewed
• [Journal Article] Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. (2009)
  • Author(s): Kanda J, Matsuo K, Suzuki T, Kawase T, Hiraki A, Watanabe M, Mizuno N, Sawaki A, Yamao K, Tajima K, Tanaka H
  • Journal Title: Cancer Sci 100 Pages: 296-302
  • NAID: 10025142499
  • Peer Reviewed
• [Journal Article] Impact of multiple alcohol dehydrogenase (ADH) gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese Population. (2009)
  • Author(s): Oze I, Matsuo K, Suzuki T, Kawase T, Watanabe M, Hiraki A, Ito H, Hosono S, Ozawa T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Kiura K, Tajima K, Tanimoto M, Tanaka H
  • Journal Title: Cancer Epidemiol Biomarker Prev 18 Pages: 3097-3102
  • Peer Reviewed
• [Journal Article] Proposal for a Cooperative Study on Population-based Cancer Survival in Selected Registries in East Asia. (2009)
  • Author(s): Tanaka H, Tanaka M, Chen W, Park S, Jung KW, Chiang CJ, Lai MS, Mirasol-Lumague MR, Laudico AS, Sinuraya ES, Nishino Y, Shibata A, Fujita M, Soda M, Naito M, Tsukuma H, Moore MA, Ajiki W.
  • Journal Title: Asian Pac J Cancer Prev. 10 Pages: 1191-1198
  • Peer Reviewed
• [Journal Article] Reduced risk of hepatocellular carcinoma after interferon therapy in aged patients with chronic hepatitis C is limited to sustained virological responders. (2009)
  • Author(s): Imai Y, Tamura S, Tanaka H, Hiramatsu N, Kiso S, Doi Y, Inada M, Nagase T, Kitada T, Imanaka K, Fukuda K, Takehara T, Kasahara A, Hayashi N.
  • Journal Title: J Viral Hepat. 17 Pages: 185-191
  • Peer Reviewed
• [Journal Article] 我が国における肝細胞癌の疫学動向 (2009)
  • Author(s): 田中英夫
  • Journal Title: 日本臨牀 67 Pages: 263-267
• [Journal Article] Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese (2009)
  • Author(s): Kanda J
  • Journal Title: Cancer Sci 100 Pages: 296-302
  • Peer Reviewed
• [Journal Article] Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk. (2008)
  • Author(s): Suzuki T, Matsuo K, Sawaki A, Mizuno N, Hiraki A, Kawase T, Watanabe M, Nakamura T, Yamao K, Tajima K, Tanaka H
  • Journal Title: Cancer Epidemiol Biomarkers Prev 17 Pages: 2742-2747
  • Peer Reviewed
• [Journal Article] Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer risk (2008)
  • Author(s): Suzuki T
  • Journal Title: Cancer Epidemiol Biomarkers Prev 17 Pages: 2742-2747
  • Peer Reviewed
• [Journal Article] Declining incidence of hepatocellular carcinoma in Osaka, Japan, from 1990 to 2003 (2008)
  • Author(s): Tanaka H
  • Journal Title: Ann Intern Med 148 Pages: 820-826
  • Peer Reviewed
• [Presentation] 日本人集団におけるABO血液型と膵臓がん発症リスクの検討 (2011)
  • Author(s): 中尾心人
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: かでる2.7(札幌市)
  • Year and Date: 2011-01-21
• [Presentation] Attributions of alcohol drinking to cancer incidence/mortality in the Japanese population (2010)
  • Author(s): Tanaka H
  • Organizer: Cancer Biology, Epidemiology, and Policy Making for Tobacco and Alcohol Control
  • Place of Presentation: メルパルクNAGOYA(愛知県名古屋市)
  • Year and Date: 2010-03-26
• [Presentation] Changing impact of hepatitis B and C virus infection for development of primary liver cancer in Japanese population (2010)
  • Author(s): Tanaka H
  • Organizer: International symposium on hepatocellular carcinoma
  • Place of Presentation: 鹿児島大学(鹿児島県鹿児島市)
  • Year and Date: 2010-02-19
• [Presentation] Current status of population-based cancer registries in Japan. (2009)
  • Author(s): 田中英夫
  • Organizer: 20th Asia Pacific Cancer Conference
  • Place of Presentation: Tsukuba.
  • Year and Date: 2009-11-12
• [Presentation] Current status of population-based cancer registries in Japan. (2009)
  • Author(s): Tanaka, H.
  • Organizer: 20th Asia Pacific Cancer Conference.
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2009-11-12
• [Presentation] 日本における肝細胞癌罹患率の急激な減少-C型肝炎の変化の特徴- (2008)
  • Author(s): 田中英夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Declining incidence of Liver cancer in Japan from 1990-2003-a role of Hepatitis C virus infection (2008)
  • Author(s): Tanaka H
  • Organizer: The 4^<th> APOCP
  • Place of Presentation: 北京
  • Year and Date: 2008-10-11
• [Remarks] 愛知県がんセンター研究所疫学・予防部webページ
  • URL: http://www.pref.aichi.jp/cancer-center/400/420/421/421-01.html