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Translational research on intractable neuro-metabolic disorders

Research Project

Project/Area Number 20390199
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionKagoshima University

Principal Investigator

INUI Akio  Kagoshima University, 医歯学総合研究科, 教授 (80168418)

Co-Investigator(Renkei-kenkyūsha) ANO Akira  鹿児島大学, 医歯学総合研究科, 教授 (30178800)
AMANAKA Hiroshi  鹿児島大学, 臨床心理学研究科, 教授 (60182581)
HOU De-Xing  鹿児島大学, 農学部, 准教授 (90305160)
HORIUCHI Masahisa  鹿児島大学, 歯学総合研究科, 准教授 (50264403)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords遺伝子 / 医療・福祉 / 神経医学 / トランスレーショナルリサーチ / 臨床 / 神経科学
Research Abstract

The translational research was conducted on intractable nuero-metablic disorders such as congenital diseases including carnitine carrier deficiency, citrin deficiency and chorea acantosis, and maltifactorial diseases including cancer cachexia, eating disorders and mood disorders. JVS mouse and animal models of cancer cachexia and citrin deficiency were created and used on pathological analysis. New treatment methods, such as acetylcarnitine, pyruvic acid, ghrelin agonist and Rikkunshito, were created or applied clinically from this research work.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (38 results)

All 2011 2010 2009 2008

All Journal Article (27 results) (of which Peer Reviewed: 27 results) Presentation (7 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Ghrelin reactive autoantibodies in restrictive anorexia nervosa.2011

    • Author(s)
      Terashi M, Asakawa A, Harada T, Ushikai M, Coquerel Q, Sinno MH, Dechelotte P, Inui A, Fetissov SO.
    • Journal Title

      Nutrition 27(4)

      Pages: 407-413

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of the genes responsible for neuroacanthocytosis in mood disorder and schizophrenia.2011

    • Author(s)
      Shimo H, Nakamura M, Tomiyasu A, Ichiba M, Ueno S, Sano A.
    • Journal Title

      Neurosci Res. Mar 69(3)

      Pages: 196-202

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart.2010

    • Author(s)
      Ushikai M, Horiuchi M, Kobayashi K, Matuda S, Inui A, Takeuchi T, Saheki T.
    • Journal Title

      Mol Genet Metab. 102(3)

      Pages: 349-355

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3.2010

    • Author(s)
      Asakawa A, Fujimiya M, Niijima A, Fujino K, Kodama N, Sato Y, Kato I Nanba H, Laviano A, Meguid MM, Inui A.
    • Journal Title

      Psychoneuroendocrinology 35(8)

      Pages: 1178-1186

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Update on ghrelin.2010

    • Author(s)
      Fetissov SO, Laviano A, Kalra S, Inui A.
    • Journal Title

      Int J Pept. pii:963501

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in acyl ghrelin, des-acyl ghrelin, and ratio of acyl ghrelin to total ghrelin with short-term refeeding in female inpatients with restricting-type anorexia nervosa.2010

    • Author(s)
      Koyama KI, Yasuhara D, Nakahara T, Harada T, Uehara M, Ushikai M, Asakawa A, Inui A.
    • Journal Title

      Horm Metab Res. 42(8)

      Pages: 595-598

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa.2010

    • Author(s)
      Ogiso K, Asakawa A, Amitani H, Nakahara T, Ushikai M, Haruta I, Koyama K, Amitani M, Harada T, Yasuhara D, Inui A.
    • Journal Title

      Peptides 32(1)

      Pages: 150-153

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chorea-acanthocytosis with upper motor neuron degeneration and 3419_3420 delCA and 3970_3973 delAGTC VPS13A mutations.2010

    • Author(s)
      Miki Y, Nishie M, Ichiba M, Nakamura M, Mori F, Ogawa M, Kaimori M, Sano A, Wakabayashi K.
    • Journal Title

      Acta Neuropathol. 119(2)

      Pages: 271-273

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart.2010

    • Author(s)
      Ushikai M, Horiuchi M, Kobayashi K, Matuda S, Inui A, Takeuchi T, Saheki T.
    • Journal Title

      Mol Genet Metab.

      Volume: 102(3) Pages: 349-355

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Appetite and gastrointestinal motility : Role of ghrelin-family peptides.2010

    • Author(s)
      Perboni S, Inui A.
    • Journal Title

      Clin Nutr.

      Volume: 29(2) Pages: 227-234

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3.2010

    • Author(s)
      Asakawa A, Fujimiya M, Niijima A, Fujino K, Kodama N, Sato Y, Kato I, Nanba H, Laviano A, Meguid MM, Inui A.
    • Journal Title

      Psychoneuroendocrinology

      Volume: 35(8) Pages: 1178-1186

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin gene products and the regulation of food intake and gut motility.2009

    • Author(s)
      Chen CY, Asakawa A, Fujimiya M, Lee SD, Inui A.
    • Journal Title

      Pharmacol Rev. 61(4)

      Pages: 430-481

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the anorexigenic activity of CRF Family peptides.2009

    • Author(s)
      Tanaka C, Asakawa A, Ushikai M, Sakoguchi T, Amitani H, Terashi M, Cheng K, Chaolu H, Nakamura N, Inui A.
    • Journal Title

      Bicochem Biophys Res Commun. 390(3)

      Pages: 887-891

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Failure of the feeding response to fasting in carnitie-deficient juvenile visecal steatosis (JVS) mice : involvement of defective acly-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus.2009

    • Author(s)
      Sakoguchi T, Horiuchi M, Asakawa A, Ushikai M, Yoshida G, Fujimiya M, Kato I, Nakazato M, Takeuchi T, Saheki T, Inui A.
    • Journal Title

      Biochim Biophys Acta. 1792(11)

      Pages: 1087-1093

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] New method of manometric measurement of gasroduodenal motility in conscious mice : Effects of ghrelin and Y2 depletion.2009

    • Author(s)
      Tanaka R, Inui A, Asakawa, Atsuchi K, Ataka K, Fujimiya M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 297(5)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population.2009

    • Author(s)
      Numata S, Iga J, Nakataki M, Tayoshi S, Taniguchi K, Sumitani S, Tomotake M, Tanahashi T, Itakura M, Kamegaya Y, Tatsumi M, Sano A, Asada T, Kunugi H, Ueno S, Ohmori T.
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet. 50B(4)

      Pages: 527-534

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin gene products and the regulation of food intake and gut motility2009

    • Author(s)
      Chen CY, Asakawa A, Fujimiya M, Lee SD, Inui A
    • Journal Title

      Pharmacol Rev 61(4)

      Pages: 430-81

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the anorexigenic activity of CRF family peptides2009

    • Author(s)
      Tanaka C, Asakawa A, Ushikai M, Sakoguchi T, Amitani H, Terashi M, Cheng K, Chaolu H, Nakamura N, Inui A
    • Journal Title

      Biochem Biophys Res Commun 390(3)

      Pages: 887-91

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis(JVS)mice : involvement of defective acylghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus2009

    • Author(s)
      Sakoguchi T, Horiuchi M, Asakawa A, Ushikai M, Yoshida G, Fujimiya M, Kato I, Nakazato M, Takeuchi T, Saheki T, Inui A
    • Journal Title

      Biochim Biophys Acta 1792(11)

      Pages: 1087-93

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New mathod of manometric measurement of gastroduodenal motility in conscious mice : Effects of ghrelin and Y2 depletion2009

    • Author(s)
      Tanaka R, Inui A, Asakawa A, Atsuchi K, Ataka K, Fujimiya M
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 390(3)

      Pages: 887-91

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural control of the anorexia-cachexia syndrome.2008

    • Author(s)
      Laviano A, Inui A, Marks DL, Meguid MM, Pichard C, Rossi Fanelli F, Seelaender M.
    • Journal Title

      Am J Physiol Endocrinol Metab. 295(5)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats.2008

    • Author(s)
      Fujimiya M, Asakawa A, Ataka K, Kato I, Inui A.
    • Journal Title

      World J Gastroenterol. 14(41)

      Pages: 6318-6326

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin Treatment of Chronic Kidney Disease : Improvements in Lean Body Mass and Cytokine Profile.2008

    • Author(s)
      Deboer MD, Zhu X, Levasseur PR, Inui A, Hu Z, Han G, Mitch WE, Taylor JE, Halem HA, Dong JZ, Datta R, Culler MD, Marks DL.
    • Journal Title

      Endocrinology 149(2)

      Pages: 827-835

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin.2008

    • Author(s)
      Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A.
    • Journal Title

      Biol Psychiatry. 65(9)

      Pages: 748-759

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neural control of the anorexia-chachexia syndrome.2008

    • Author(s)
      Laviano A, Inui A, Marks DL, Meguid MM, Pichard C, Rossi Fanneli F, Seelaender MC
    • Journal Title

      Am J Physiol Endocrinol Metab 295(5)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] At the Cutting Edge : ghrelin gene products in food intake and gut motility.2008

    • Author(s)
      Chen CY, Fujimiya M, Asakawa A, Chang FY, Cheng JT, Lee SD, Inui A
    • Journal Title

      Neuroendocrinology 89(1)

      Pages: 9-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different effects of ghrelin, des-acyl ghrel in and obestat in on gastroduodenal motility in consc ious rats.2008

    • Author(s)
      Fujimiya M, Asakawa A, Ataka K, Kato I, Inui A
    • Journal Title

      World J Gastroenterol 14(41)

      Pages: 6318-6326

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ペプチドはどこまでわれわれの行動を規定しているか2010

    • Author(s)
      乾明夫
    • Organizer
      第51回日本心身医学総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 特に神経性食欲不振症の基礎と臨床2009

    • Author(s)
      乾明夫、摂食障害
    • Organizer
      第62回日本自律神経学会総会
    • Place of Presentation
      和歌山
    • Year and Date
      2009-11-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪液質のトランスレーショナルリサーチ2009

    • Author(s)
      乾明夫
    • Organizer
      第11回日本神経消化器病学会イブニングセミナー
    • Place of Presentation
      仙台
    • Year and Date
      2009-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪液質の病態と治療における最新の進歩-特に食欲調節の立場から-2009

    • Author(s)
      乾明夫
    • Organizer
      第1回日本心身医学5学会合同集会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 食欲・体重調節からみた消化管ホルモン2009

    • Author(s)
      乾明夫、浅川明弘、上野尚彦、藤宮峯子
    • Organizer
      第72回消化器心身医学研究会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-05-09
    • Related Report
      2010 Final Research Report
  • [Presentation] A central serotonin 2C receptor pathway regulates gastrointestinal motor activity via ghrelin-neuropeptide Y signaling, but does not downstream activation of melanocortin 3/4 receptors in rats.2009

    • Author(s)
      Asakawa A
    • Organizer
      5thCACHEXIA CONFERENCE
    • Place of Presentation
      スペイン(バルセロナ)
    • Related Report
      2010 Final Research Report
  • [Presentation] A central serotonin 2C receptor pathway regulates gastrointestinal motor activity via ghrelin-neuropeptide Y signaling, but does not downstream activation of melanocortin 3/4 receptors in rats2009

    • Author(s)
      Asakawa A
    • Organizer
      5th CACHEXIA CONFERENCE
    • Place of Presentation
      スペイン(バルセロナ)
    • Related Report
      2009 Annual Research Report
  • [Book] 日本臨床(肥満症)(第2版)-基礎・臨床研究の進歩、NPY/AgRP2010

    • Author(s)
      乾明夫, 他
    • Related Report
      2010 Final Research Report
  • [Book] 基礎・臨床研究の進歩NPY/AgRP2010

    • Author(s)
      乾明夫
    • Publisher
      日本臨床(肥満症 第2版)(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 悪液質改善剤2010

    • Inventor(s)
      乾明夫、浅川明弘、藤塚直樹
    • Industrial Property Rights Holder
      鹿児島大学
    • Filing Date
      2010-12-09
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 悪液質改善剤2010

    • Inventor(s)
      乾明夫, 浅川明弘, 藤塚直樹
    • Industrial Property Rights Holder
      鹿児島大学
    • Industrial Property Number
      2010-274339
    • Filing Date
      2010-12-09
    • Related Report
      2010 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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