Translational research on intractable neuro-metabolic disorders

• Project/Area Number: 20390199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kagoshima University
• Principal Investigator: INUI Akio Kagoshima University, 医歯学総合研究科, 教授 (80168418)
• Co-Investigator(Renkei-kenkyūsha): ANO Akira 鹿児島大学, 医歯学総合研究科, 教授 (30178800) ; AMANAKA Hiroshi 鹿児島大学, 臨床心理学研究科, 教授 (60182581) ; HOU De-Xing 鹿児島大学, 農学部, 准教授 (90305160) ; HORIUCHI Masahisa 鹿児島大学, 歯学総合研究科, 准教授 (50264403)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 遺伝子 / 医療・福祉 / 神経医学 / トランスレーショナルリサーチ / 臨床 / 神経科学

Research Abstract

The translational research was conducted on intractable nuero-metablic disorders such as congenital diseases including carnitine carrier deficiency, citrin deficiency and chorea acantosis, and maltifactorial diseases including cancer cachexia, eating disorders and mood disorders. JVS mouse and animal models of cancer cachexia and citrin deficiency were created and used on pathological analysis. New treatment methods, such as acetylcarnitine, pyruvic acid, ghrelin agonist and Rikkunshito, were created or applied clinically from this research work.

Research Products

• [Journal Article] Ghrelin reactive autoantibodies in restrictive anorexia nervosa. (2011)
  • Author(s): Terashi M, Asakawa A, Harada T, Ushikai M, Coquerel Q, Sinno MH, Dechelotte P, Inui A, Fetissov SO.
  • Journal Title: Nutrition 27(4) Pages: 407-413
  • Peer Reviewed
• [Journal Article] Comprehensive analysis of the genes responsible for neuroacanthocytosis in mood disorder and schizophrenia. (2011)
  • Author(s): Shimo H, Nakamura M, Tomiyasu A, Ichiba M, Ueno S, Sano A.
  • Journal Title: Neurosci Res. Mar 69(3) Pages: 196-202
  • Peer Reviewed
• [Journal Article] Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart. (2010)
  • Author(s): Ushikai M, Horiuchi M, Kobayashi K, Matuda S, Inui A, Takeuchi T, Saheki T.
  • Journal Title: Mol Genet Metab. 102(3) Pages: 349-355
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3. (2010)
  • Author(s): Asakawa A, Fujimiya M, Niijima A, Fujino K, Kodama N, Sato Y, Kato I Nanba H, Laviano A, Meguid MM, Inui A.
  • Journal Title: Psychoneuroendocrinology 35(8) Pages: 1178-1186
  • Peer Reviewed
• [Journal Article] Update on ghrelin. (2010)
  • Author(s): Fetissov SO, Laviano A, Kalra S, Inui A.
  • Journal Title: Int J Pept. pii:963501
  • Peer Reviewed
• [Journal Article] Changes in acyl ghrelin, des-acyl ghrelin, and ratio of acyl ghrelin to total ghrelin with short-term refeeding in female inpatients with restricting-type anorexia nervosa. (2010)
  • Author(s): Koyama KI, Yasuhara D, Nakahara T, Harada T, Uehara M, Ushikai M, Asakawa A, Inui A.
  • Journal Title: Horm Metab Res. 42(8) Pages: 595-598
  • Peer Reviewed
• [Journal Article] Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa. (2010)
  • Author(s): Ogiso K, Asakawa A, Amitani H, Nakahara T, Ushikai M, Haruta I, Koyama K, Amitani M, Harada T, Yasuhara D, Inui A.
  • Journal Title: Peptides 32(1) Pages: 150-153
  • Peer Reviewed
• [Journal Article] Chorea-acanthocytosis with upper motor neuron degeneration and 3419_3420 delCA and 3970_3973 delAGTC VPS13A mutations. (2010)
  • Author(s): Miki Y, Nishie M, Ichiba M, Nakamura M, Mori F, Ogawa M, Kaimori M, Sano A, Wakabayashi K.
  • Journal Title: Acta Neuropathol. 119(2) Pages: 271-273
  • Peer Reviewed
• [Journal Article] Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart. (2010)
  • Author(s): Ushikai M, Horiuchi M, Kobayashi K, Matuda S, Inui A, Takeuchi T, Saheki T.
  • Journal Title: Mol Genet Metab. Volume: 102(3) Pages: 349-355
  • Peer Reviewed
• [Journal Article] Appetite and gastrointestinal motility : Role of ghrelin-family peptides. (2010)
  • Author(s): Perboni S, Inui A.
  • Journal Title: Clin Nutr. Volume: 29(2) Pages: 227-234
  • Peer Reviewed
• [Journal Article] Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 3. (2010)
  • Author(s): Asakawa A, Fujimiya M, Niijima A, Fujino K, Kodama N, Sato Y, Kato I, Nanba H, Laviano A, Meguid MM, Inui A.
  • Journal Title: Psychoneuroendocrinology Volume: 35(8) Pages: 1178-1186
  • Peer Reviewed
• [Journal Article] Ghrelin gene products and the regulation of food intake and gut motility. (2009)
  • Author(s): Chen CY, Asakawa A, Fujimiya M, Lee SD, Inui A.
  • Journal Title: Pharmacol Rev. 61(4) Pages: 430-481
  • Peer Reviewed
• [Journal Article] Comparison of the anorexigenic activity of CRF Family peptides. (2009)
  • Author(s): Tanaka C, Asakawa A, Ushikai M, Sakoguchi T, Amitani H, Terashi M, Cheng K, Chaolu H, Nakamura N, Inui A.
  • Journal Title: Bicochem Biophys Res Commun. 390(3) Pages: 887-891
  • Peer Reviewed
• [Journal Article] Failure of the feeding response to fasting in carnitie-deficient juvenile visecal steatosis (JVS) mice : involvement of defective acly-ghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus. (2009)
  • Author(s): Sakoguchi T, Horiuchi M, Asakawa A, Ushikai M, Yoshida G, Fujimiya M, Kato I, Nakazato M, Takeuchi T, Saheki T, Inui A.
  • Journal Title: Biochim Biophys Acta. 1792(11) Pages: 1087-1093
  • Peer Reviewed
• [Journal Article] New method of manometric measurement of gasroduodenal motility in conscious mice : Effects of ghrelin and Y2 depletion. (2009)
  • Author(s): Tanaka R, Inui A, Asakawa, Atsuchi K, Ataka K, Fujimiya M.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. 297(5)
  • Peer Reviewed
• [Journal Article] Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (2009)
  • Author(s): Numata S, Iga J, Nakataki M, Tayoshi S, Taniguchi K, Sumitani S, Tomotake M, Tanahashi T, Itakura M, Kamegaya Y, Tatsumi M, Sano A, Asada T, Kunugi H, Ueno S, Ohmori T.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. 50B(4) Pages: 527-534
  • Peer Reviewed
• [Journal Article] Ghrelin gene products and the regulation of food intake and gut motility (2009)
  • Author(s): Chen CY, Asakawa A, Fujimiya M, Lee SD, Inui A
  • Journal Title: Pharmacol Rev 61(4) Pages: 430-81
  • Peer Reviewed
• [Journal Article] Comparison of the anorexigenic activity of CRF family peptides (2009)
  • Author(s): Tanaka C, Asakawa A, Ushikai M, Sakoguchi T, Amitani H, Terashi M, Cheng K, Chaolu H, Nakamura N, Inui A
  • Journal Title: Biochem Biophys Res Commun 390(3) Pages: 887-91
  • Peer Reviewed
• [Journal Article] Failure of the feeding response to fasting in carnitine-deficient juvenile visceral steatosis(JVS)mice : involvement of defective acylghrelin secretion and enhanced corticotropin-releasing factor signaling in the hypothalamus (2009)
  • Author(s): Sakoguchi T, Horiuchi M, Asakawa A, Ushikai M, Yoshida G, Fujimiya M, Kato I, Nakazato M, Takeuchi T, Saheki T, Inui A
  • Journal Title: Biochim Biophys Acta 1792(11) Pages: 1087-93
  • Peer Reviewed
• [Journal Article] New mathod of manometric measurement of gastroduodenal motility in conscious mice : Effects of ghrelin and Y2 depletion (2009)
  • Author(s): Tanaka R, Inui A, Asakawa A, Atsuchi K, Ataka K, Fujimiya M
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 390(3) Pages: 887-91
  • Peer Reviewed
• [Journal Article] Neural control of the anorexia-cachexia syndrome. (2008)
  • Author(s): Laviano A, Inui A, Marks DL, Meguid MM, Pichard C, Rossi Fanelli F, Seelaender M.
  • Journal Title: Am J Physiol Endocrinol Metab. 295(5)
  • Peer Reviewed
• [Journal Article] Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats. (2008)
  • Author(s): Fujimiya M, Asakawa A, Ataka K, Kato I, Inui A.
  • Journal Title: World J Gastroenterol. 14(41) Pages: 6318-6326
  • Peer Reviewed
• [Journal Article] Ghrelin Treatment of Chronic Kidney Disease : Improvements in Lean Body Mass and Cytokine Profile. (2008)
  • Author(s): Deboer MD, Zhu X, Levasseur PR, Inui A, Hu Z, Han G, Mitch WE, Taylor JE, Halem HA, Dong JZ, Datta R, Culler MD, Marks DL.
  • Journal Title: Endocrinology 149(2) Pages: 827-835
  • Peer Reviewed
• [Journal Article] Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin. (2008)
  • Author(s): Fujitsuka N, Asakawa A, Hayashi M, Sameshima M, Amitani H, Kojima S, Fujimiya M, Inui A.
  • Journal Title: Biol Psychiatry. 65(9) Pages: 748-759
  • Peer Reviewed
• [Journal Article] Neural control of the anorexia-chachexia syndrome. (2008)
  • Author(s): Laviano A, Inui A, Marks DL, Meguid MM, Pichard C, Rossi Fanneli F, Seelaender MC
  • Journal Title: Am J Physiol Endocrinol Metab 295(5)
  • Peer Reviewed
• [Journal Article] At the Cutting Edge : ghrelin gene products in food intake and gut motility. (2008)
  • Author(s): Chen CY, Fujimiya M, Asakawa A, Chang FY, Cheng JT, Lee SD, Inui A
  • Journal Title: Neuroendocrinology 89(1) Pages: 9-17
  • Peer Reviewed
• [Journal Article] Different effects of ghrelin, des-acyl ghrel in and obestat in on gastroduodenal motility in consc ious rats. (2008)
  • Author(s): Fujimiya M, Asakawa A, Ataka K, Kato I, Inui A
  • Journal Title: World J Gastroenterol 14(41) Pages: 6318-6326
  • Peer Reviewed
• [Presentation] ペプチドはどこまでわれわれの行動を規定しているか (2010)
  • Author(s): 乾明夫
  • Organizer: 第51回日本心身医学総会
  • Place of Presentation: 仙台
  • Year and Date: 2010-06-26
• [Presentation] 特に神経性食欲不振症の基礎と臨床 (2009)
  • Author(s): 乾明夫、摂食障害
  • Organizer: 第62回日本自律神経学会総会
  • Place of Presentation: 和歌山
  • Year and Date: 2009-11-05
• [Presentation] 悪液質のトランスレーショナルリサーチ (2009)
  • Author(s): 乾明夫
  • Organizer: 第11回日本神経消化器病学会イブニングセミナー
  • Place of Presentation: 仙台
  • Year and Date: 2009-09-24
• [Presentation] 悪液質の病態と治療における最新の進歩-特に食欲調節の立場から- (2009)
  • Author(s): 乾明夫
  • Organizer: 第1回日本心身医学5学会合同集会
  • Place of Presentation: 東京
  • Year and Date: 2009-06-06
• [Presentation] 食欲・体重調節からみた消化管ホルモン (2009)
  • Author(s): 乾明夫、浅川明弘、上野尚彦、藤宮峯子
  • Organizer: 第72回消化器心身医学研究会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2009-05-09
• [Presentation] A central serotonin 2C receptor pathway regulates gastrointestinal motor activity via ghrelin-neuropeptide Y signaling, but does not downstream activation of melanocortin 3/4 receptors in rats. (2009)
  • Author(s): Asakawa A
  • Organizer: 5thCACHEXIA CONFERENCE
  • Place of Presentation: スペイン(バルセロナ)
• [Presentation] A central serotonin 2C receptor pathway regulates gastrointestinal motor activity via ghrelin-neuropeptide Y signaling, but does not downstream activation of melanocortin 3/4 receptors in rats (2009)
  • Author(s): Asakawa A
  • Organizer: 5th CACHEXIA CONFERENCE
  • Place of Presentation: スペイン(バルセロナ)
• [Book] 日本臨床(肥満症)(第2版)-基礎・臨床研究の進歩、NPY/AgRP (2010)
  • Author(s): 乾明夫, 他
• [Book] 基礎・臨床研究の進歩NPY/AgRP (2010)
  • Author(s): 乾明夫
  • Publisher: 日本臨床(肥満症 第2版)(印刷中)
• [Patent(Industrial Property Rights)] 悪液質改善剤 (2010)
  • Inventor(s): 乾明夫、浅川明弘、藤塚直樹
  • Industrial Property Rights Holder: 鹿児島大学
  • Filing Date: 2010-12-09
• [Patent(Industrial Property Rights)] 悪液質改善剤 (2010)
  • Inventor(s): 乾明夫, 浅川明弘, 藤塚直樹
  • Industrial Property Rights Holder: 鹿児島大学
  • Industrial Property Number: 2010-274339
  • Filing Date: 2010-12-09