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Neuroscientific studies on the effect of moxibustion on chronic diseases

Research Project

Project/Area Number 20390200
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionFujita Health University

Principal Investigator

USUDA Nobuteru  Fujita Health University, 医学部, 教授 (30135123)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Satoshi  藤田保健衛生大学, 医学部, 教授 (50340229)
NAGATSU Toshiharu  藤田保健衛生大学, 医学部, 名誉教授 (40064802)
MURAKAMI Kazuo  国際科学振興財団, バイオ研究所, 研究所長 (70110517)
NAKAI Sachiko  藤田保健衛生大学, 医学部, 研究員 (30257836)
WATARI Nakazou  藤田保健衛生大学, 医学部, 客員教授 (40079976)
NAGATSU Ikuko  藤田保健衛生大学, 医学部, 名誉教授 (80084573)
NAKAHARA Daiichirou  浜松医科大学, 医学部, 教授 (80128389)
HIGUCHI Susumu  藤田保健衛生大学, 医学部, 客員教授 (40156576)
TAKAHASHI Hisahide  藤田保健衛生大学, 名誉教授 (80084606)
HATA Toshimichi  同志社大学, 心理学部, 准教授 (50399044)
HAYASHI Takashi  国際科学振興財団, バイオ研究所, 研究員 (80399328)
FUKASAWA Motoaki  藤田保健衛生大学, 医学部, 助教 (70387728)
ATSUZAWA Kimie  藤田保健衛生大学, 医学部, 助教 (60387727)
MATSUZAWA Ayami  藤田保健衛生大学, 医学部, 客員講師 (90273078)
YAMAZAKI Masao  藤田保健衛生大学, 医療科学部, 教授 (10192395)
NAGAOKA Toshiharu  藤田保健衛生大学, 医療科学部, 教授 (20021420)
OKAWARA Takeshi  藤田保健衛生大学, 医学部, 助教 (20469034)
Co-Investigator(Renkei-kenkyūsha) SETOU Mitsutoshi  大学共同利用機関法人自然科学研究機構(共通施設), 統合バイオサイエンスセンター, 准教授 (20302664)
OOSUKA Kouzi  愛知医科大学, 医学部, 准教授 (40378013)
KANEKO Rina  藤田保健衛生大学, 医学部, 助教 (70367697)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords東洋医学 / 施灸の脳科学
Research Abstract

Subjective evidence of the brain reactions for moxibustion was attempted. Moxibustion treatment was done on rats, and measurements of brain functions based on neurotransmitter secretion by microdialysis; electrophysiological changes including EEG ; and gene expression analyses by DNA microarray, were performed. As all the reaction measured was very weak, high S/N ratio was required. Dopamine secretion, elevated gene expression, the elevation of body temperature, changes of hippocampal θwave in EEG, were shown in the experiments. As these are considered to affect brain functions including emotion, memory, etc, moxibustion may have possible curative effects on chronic diseases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (60 results)

All 2011 2010 2009 2008 Other

All Journal Article (41 results) (of which Peer Reviewed: 40 results) Presentation (16 results) Remarks (3 results)

  • [Journal Article] Activation of PI3 kinase/Akt signaling in chronic subdural hematoma outer membranes.2011

    • Author(s)
      Funai M, Osuka K, Usuda N, Atsuzawa K, Inukai T, Yasuda M, Watanabe Y, Takayasu M.
    • Journal Title

      J Neurotrauma. 28(in press)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.2011

    • Author(s)
      Nakashima A, Mori K, Kaneko YS, Hayashi N, Nagatsu T, Ota A.
    • Journal Title

      Biochem Biophys Res Commun. 407(in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrathecal cocaine delivery enables long-access self-administration with binge-like behavior in mice.2011

    • Author(s)
      Nakamura M, Gao S, Okamura H, Nakahara D.
    • Journal Title

      Psychopharmacology. 213

      Pages: 119-129

    • NAID

      120005305473

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.2011

    • Author(s)
      Nakashima A, et al.
    • Journal Title

      Biochemical and Biophysical Research Communication

      Volume: 407(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrathecal cocaine delivery enables long-access self-administration with binge-like behavior in mice.2011

    • Author(s)
      Nakamura M, et al.
    • Journal Title

      Psychopharmacology

      Volume: 213 Pages: 119-129

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of PI3 kinase/Akt signaling in chronic subdural hematoma outer membranes.2011

    • Author(s)
      Funai M, et al.
    • Journal Title

      Journal of Neurotrauma

      Volume: 28(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of blood purification and bortezomib plus dexamethasone therapy for the treatment of acute renal failure due to myeloma cast nephropathy.2010

    • Author(s)
      Hasegawa M, Sugiyama S, Yuzawa Y., 他
    • Journal Title

      Ther Apher Dial. 14

      Pages: 451-456

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurogenesis in the dentate gyrus of the rat hippocampus enhanced by tickling stimulation with positive emotion.2010

    • Author(s)
      Yamamuro T, Senzaki K, Iwamoto S, Nakagawa Y, Hayashi T, Hori M, Sakamoto S, Murakami K, Shiga T, Urayama O.
    • Journal Title

      Neurosci Res. 68

      Pages: 285-289

    • NAID

      120007137819

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the serum bone metabolism markers of elderly alcoholics during abstinence.2010

    • Author(s)
      Matsui T, Yokoyama A, Matsushita S, Mori S, Arai H, Higuchi S, Maruyama K.
    • Journal Title

      J Am Geriatr Soc. 58

      Pages: 984-986

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage.2010

    • Author(s)
      Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Wakabayashi T, Takayasu M.
    • Journal Title

      Brain Res. 1332

      Pages: 12-19

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of mitochondrial fatty acid beta-oxidation enzymes in rat testis.2010

    • Author(s)
      Fukasawa M, Atsuzawa K, Mizutani K, Nakazawa (Matsuzawa) A, Usuda N.
    • Journal Title

      J Histochem Cytochem. 58

      Pages: 195-206

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective and neurotoxic phenotypes of activated microglia in neonatal mice with respective MPTP- and ethanol-induced brain injury.2010

    • Author(s)
      Sawada H, Suzuki H, Nagatsu T, Sawada M.
    • Journal Title

      Neurodegener Dis. 7

      Pages: 64-67

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a comprehensive lifestyle modification program on the bone density of male heavy drinkers.2010

    • Author(s)
      Matsui T, Higuchi S, Maruyama K., 他
    • Journal Title

      Alcohol Clin Exp Res. 34

      Pages: 869-875

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic approach for Alzheimer's disease by removing amyloid beta protein from the brain with an extracorporeal removal system.2010

    • Author(s)
      Kawaguchi K, Kitaguchi N, Nakai S, Murakami K, Asakura K, Mutoh T, Fujita Y, Sugiyama S.
    • Journal Title

      J Artif Organs. 13

      Pages: 31-37

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of blood purification and bortezomib plus dexamethasone therapy for the treatment of acute renal failure due to myeloma cast nephropathy.2010

    • Author(s)
      Hasegawa M, et al.
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 14 Pages: 450-456

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurogenesis in the dentate gyrus of the rat hippocampus enhanced by tickling stimulation with positive emotion.2010

    • Author(s)
      Yamamuro T, et al.
    • Journal Title

      Neuroscience Research

      Volume: 68 Pages: 285-259

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the serum bone metabolism markers of elderly alcoholics during abstinence.2010

    • Author(s)
      Matsui T, et al.
    • Journal Title

      Journal of the American Geriatrics Society

      Volume: 58 Pages: 984-986

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress activates STAT1 in basilar arteries after subarachnoid hemorrhage.2010

    • Author(s)
      Osuka K, et al.
    • Journal Title

      Brain Research

      Volume: 1332 Pages: 12-19

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical localization of mitochondrial fatty acid β-oxidation enzymes in rat testis2010

    • Author(s)
      Fukasawa M, et al.
    • Journal Title

      Journal of Histochemistry and Cytochemistry 58

      Pages: 195-206

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective and neurotoxic phenotypes of activated microglia in neonatal mice with respective MPTP-and ethanol-induced brain injury.2010

    • Author(s)
      Sawada H, et al.
    • Journal Title

      Neuro-digenerative Disorder 18

      Pages: 64-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of a comprehensive lifestyle modification program on the bone dinsity of male heavy drinker2010

    • Author(s)
      Matsui T, et al.
    • Journal Title

      Alcoholism : Clinical and Experimental Research (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic approach for Alzheimer's disease by removing amyloid β protein from the brain with an extracorporeal removal system2010

    • Author(s)
      Kawaguchi K, et al.
    • Journal Title

      Journal of Aftificial Organs 13

      Pages: 31-37

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of laughter on post-prandial glucose levels and gene expression in type 2 diabetic patients.2009

    • Author(s)
      Hayashi T, Murakami K.
    • Journal Title

      Life Sci. 85

      Pages: 185-187

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Consortium for Alzheimer Disease. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.2009

    • Author(s)
      Takei N, Higuchi S, Kuwano R., 他
    • Journal Title

      Genomics. 93

      Pages: 441-448

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in the prevalence of adolescent alcohol use and its possible causes in Japan : periodical nationwide cross-sectional surveys.2009

    • Author(s)
      Osaki Y, Tanihata T, Ohida T, Kanda H, Suzuki K, Higuchi S, Kaneita Y, Minowa M, Hayashi K.
    • Journal Title

      Alcohol Clin Exp Res. 33

      Pages: 247-254

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessing multidimensional cognitions of drinking among alcohol-dependent patients : development and validation of a drinking-related cognitions scale (DRCS).2009

    • Author(s)
      Sawayama T, Yoneda J, Tanaka K, Shirakawa N, Sawayama E, Higuchi S, Miyaoka H.
    • Journal Title

      Addict Behav. 34

      Pages: 82-85

    • NAID

      10021950602

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of laughter on post-prandial glucose levels and gene expression in type-2 diabetic patients.Review.2009

    • Author(s)
      Hayashi T, et al.
    • Journal Title

      Life Science 85

      Pages: 185-187

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of tumor necrosis factor receptors on granulocytes in patients with myeloperoxidase anti-neutrophil cytoplasmic autoantibody-associated vasculitis2009

    • Author(s)
      Hasegawa M, et al.
    • Journal Title

      Nephron Clinical Practice 113

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese2009

    • Author(s)
      Takei N, et al.
    • Journal Title

      Genomics 93

      Pages: 441-448

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in the prevalence of adolescent alcohol use and its possible causesin Japan : periodical nationwide cross-sectional surveys.2009

    • Author(s)
      Osaki, Y
    • Journal Title

      Alcohol Clin Exp Res 33

      Pages: 247-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessing multidimensional cognitions of drinking among alcohol-dependentpatients : development and validation of a drinking-related cognitions scale(DRCS).2009

    • Author(s)
      Sawayama, T
    • Journal Title

      Addict Behav 34

      Pages: 82-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy.2008

    • Author(s)
      Matsushita S, Miyakawa T, Maesato H, Matsui T, Yokoyama A, Arai H, Higuchi S, Kashima H.
    • Journal Title

      Alcohol Clin Exp Res. 32

      Pages: 1091-1095

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The HLA-DRB1^*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease.2008

    • Author(s)
      Kitagawa W, Imai H, Komatsuda A, Maki N, Wakui H, Hiki Y, Sugiyama S.
    • Journal Title

      Nephrol Dial Transplant. 23

      Pages: 3126-3129

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral lipopolysaccharide administration affects the olfactory dopamine system in mice.2008

    • Author(s)
      Ota A, Mori K, Kaneko YS, Nakashima A, Nagatsu I, Nagatsu T.
    • Journal Title

      Ann N Y Acad Sci. 1148

      Pages: 127-135

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A link between stress and depression : shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression.2008

    • Author(s)
      Miura H, Ozaki N, Sawada M, Isobe K, Ohta T, Nagatsu T.
    • Journal Title

      Stress. 11

      Pages: 198-209

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease.2008

    • Author(s)
      Kitagawa, W
    • Journal Title

      Nephrol Dial Transplant 23

      Pages: 3126-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral lipopolysaccharide administration affects the olfactory dopaminesystem in mice.2008

    • Author(s)
      Ota, A
    • Journal Title

      Ann NYAcad Sci 1148

      Pages: 127-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A link between stress and depression : shifts in the balance between thekynurenine and serotonin pathways of tryptophan metabolism and theetiology and pathophysiology of depression.2008

    • Author(s)
      Miura, H
    • Journal Title

      Stress 11

      Pages: 198-209

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perinatal asphyxia reduces dentate granule cells and exacerbatesmethamphetamine-induced hyperlocomotion in adulthood.2008

    • Author(s)
      Wakuda, T
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Model mice for mild-form glycine encephalopathy : behavioral andbiochemical characterizations and efficacy of antagonists for the glycinebinding site of N-methyl D-aspartate receptor.2008

    • Author(s)
      Kojima-ishii, K
    • Journal Title

      Pediatr Res 64

      Pages: 228-33

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathy.2008

    • Author(s)
      Matsushita, S
    • Journal Title

      Alcohol Clin Exp Ees 32

      Pages: 1091-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 施灸による前頭前野と線条体におけるドーパミン分泌2011

    • Author(s)
      深澤元晶
    • Organizer
      第116回日本解剖学会全国学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 施灸による体温上昇2011

    • Author(s)
      臼田信光
    • Organizer
      第116回日本解剖学会全国学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 施灸による体温上昇2011

    • Author(s)
      臼田信光, 他
    • Organizer
      第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会 合同大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 東洋医学研究におけるマイクロダイアリシスの適用:施灸の脳反応2010

    • Author(s)
      深澤元晶, 他
    • Organizer
      第21回マイクロダイアリシス研究会
    • Place of Presentation
      昭和女子大学(東京)
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 施灸による脳内ドーパミン分泌に関するマイクロダイアリシス2010

    • Author(s)
      深澤元晶
    • Organizer
      Neuro 2010(第33回日本神経科学会大会・第53回日本神経化学会大会・第20回日本神経回路学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 施灸による脳内ドーパミン分泌に関するマイクロダイアリシス2010

    • Author(s)
      深澤元晶, 他
    • Organizer
      第33回日本神経科学会大会・第53回日本神経化学会大会・第20回日本神経回路学会大会 合同大会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場(神戸)
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 施灸によるラット大脳基底核におけるドパミン分泌2010

    • Author(s)
      深澤元晶
    • Organizer
      第25回日本大脳基底核研究会
    • Place of Presentation
      福島
    • Year and Date
      2010-08-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 施灸による線条体におけるドーパミン分泌2010

    • Author(s)
      深澤元晶
    • Organizer
      第115回日本解剖学会全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 施灸による線条体におけるドーパミン分泌2010

    • Author(s)
      深澤元晶
    • Organizer
      第115回日本解剖学会全国学術集会
    • Place of Presentation
      岩手県民会館(岩手県)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 施灸によるマイクロダイアリシスにおける線条体の免疫組織化学2009

    • Author(s)
      深澤元晶
    • Organizer
      第50回日本組織細胞化学会学術集会
    • Place of Presentation
      ピアザ淡海(滋賀県)
    • Year and Date
      2009-09-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effective detection of histochemical reaction products by phase contrast electron microscopy2009

    • Author(s)
      Usuda N, et al.
    • Organizer
      Experimental Biology 2009
    • Place of Presentation
      Ernest N.Morial Convention Center, New Orleans, LA, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 非晶質凍結状態細胞内超微小構造の位相差電子顕微鏡観察2008

    • Author(s)
      臼田, 信光
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 位相差電子顕微鏡による、樹脂包埋した動物組織の高コントラストイメージング2008

    • Author(s)
      厚沢, 季美江
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 氷包埋で微生物を観る2008

    • Author(s)
      臼田, 信光
    • Organizer
      日本顕微鏡学会第52回シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 位相差電子顕微鏡観察における生物試料作製2008

    • Author(s)
      臼田, 信光
    • Organizer
      日本顕微鏡学会関西支部特別講演会
    • Place of Presentation
      尼崎
    • Year and Date
      2008-07-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 位相差電子顕微鏡による生物電顕の最先端を目指して2008

    • Author(s)
      臼田, 信光
    • Organizer
      日本顕微鏡学会第64回学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2008-05-21
    • Related Report
      2008 Annual Research Report
  • [Remarks] 研究開発支援総合ディレクトリReaDに登録済

    • URL

      http://read.jst./go.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks] 研究開発支援総合ディレクトリ ReaD に登録済

    • URL

      http://read.jst./go.jp/

    • Related Report
      2009 Annual Research Report
  • [Remarks] 研究開発支援総合ディレクトリReaDに登録済。

    • URL

      http://read.jst./go.jp/

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2019-05-27  

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