Immunologic response to Helicobacter involved in the development of chronic gastritis
Project/Area Number |
20390207
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kyoto University |
Principal Investigator |
WATANABE Norihiko Kyoto University, 医学研究科, 准教授 (50419446)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
|
Keywords | 内科学 / 免疫学 / 細胞・組織 / 生体分子 / 感染症 |
Research Abstract |
H. pylori CagA in the stomach plays an important role in the migration of H. pylori-primed CM4^+ T cells in the gastric mucosa from the Peyer's patches. In addition, H. pylori CagA can directly trigger epithelial cells to produce TSLP and TSLP-mediated DC activation may be involved in Th2 responses triggering B cell activation in H. pylori-induced gastritis.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Analysis of Humoral Immune Response in Experimental Autoimmune Pancreatitis in Mice.2010
Author(s)
Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K, Kido M, Watanabe N, Uchida K, Fukui T, Okazaki K, Chiba T.
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Journal Title
Pancreas. 39
Pages: 224-231
Related Report
Peer Reviewed
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[Journal Article] Analysis of humoral immune response in experimental autoimmune pancreatitis inmice2010
Author(s)
Asada M, Nishio A, Akamatsu T, Tanaka J, Saga K, Kido M, Watanabe N, Uchida K, Fukui T, Okazaki K, Chiba T
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Journal Title
Pancreas 39
Pages: 224-231
Related Report
Peer Reviewed
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[Presentation] Role of Peyer patches in H. pylori immunity2009
Author(s)
渡部則彦
Organizer
XXIst International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
Place of Presentation
Fundacao Eng. Antoniode Almeida, Porto, Portugal
Year and Date
2009-09-18
Related Report
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