| Project/Area Number |
20390220
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MANABBE Ichiro The University of Tokyo, 医学部附属病院, 特任准教授 (70359628)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIU Katsuhito 東京大学, 医学部附属病院, 特任助教 (30422306)
西村 剛 東京大学, 医学部附属病院, 特任助教 (20422305)
大石 由美子 東京大学, 医学部附属病院, 特任助教 (80435734)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIMURA Go 東京大学, 医学部附属病院, 助教 (20422305)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | メタボリックシンドローム / 動脈硬化 / 転写因子 / 小胞体ストレス / 翻訳後修飾 |
|---|
| Research Abstract |
Metabolic syndrome is an clinically important risk factor for cardiovascular disease. However, it is insufficiently understood how atherosclerosis in induced in metabolic syndrome. In the present study, we analyzed molecular pathogenic mechanisms of cardiovascular and metabolic diseases in obesity. A particular focus was on the signaling and transcriptional regulatory mechanisms of vascular responses to metabolic stress, such as free fatty acids (FFAs). We found that free saturated fatty acids induce endoplasmic reticulum (ER) stress in smooth muscle cells and pancreatic ・ cells, resulting in dysfunction of those cell types. The response is mediated by TLR4. We also found that FFAs activated inflammatory processes in the heart and kidney. These results suggest that FFAs are the common factors that induce inflammatory processes in the cardiovascular, metabolic and renal systems.
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