| Project/Area Number |
20390221
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
SHINDO Takayuki Shinshu University, 医学系研究科, 教授 (90345215)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Takayuki 信州大学, 医学系研究科, 准教授 (80317825)
SHIMOZAWA Tatsuo 東京大学, 医学部附属病院, 講師 (90231365)
MURATA Toshinori 信州大学, 医学部, 教授 (50253406)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | アドレノメデュリン / RAMP / 血管 / 動脈硬化 / メタボリックシンドローム / 生活習慣病 / 治療 |
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| Research Abstract |
Recently, various humoral factors have attracted much attention in terms of being a common molecular basis that links the onset of metabolic syndrome with that of vascular complications. These factors play important roles in the maintenance of metabolic and vascular homeostasis. In contrast, an imbalance between the factors may cause the onset of metabolic syndrome and cardiovascular diseases.
Adrenomedullin (AM), originally identified as a potent vasodilatory peptide produced by vascular cells, has been shown to be synthesized by a variety of cell types and possesses various biological functions. AM has been shown to be involved in both metabolic and vascular homeostasis.
In this study, by using gene-engineered mice of RAMP2 (a receptor activity-modifying protein of AM' s receptor), we proved that RAMP2 is the key molecule of the AM' s metabolic and vascular regulation. RAMP2 could be a novel therapeutic target for metabolic syndrome and cardiovascular diseases.
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