Development of cell, gene and drug delivery system to the cardiovascular tissue using a novel cell-surface lectin.
Project/Area Number |
20390222
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Shinshu University |
Principal Investigator |
IKEDA Uichi Shinshu University, 医学系研究科, 教授 (30221063)
|
Co-Investigator(Kenkyū-buntansha) |
KOYAMA Jun 信州大学, 医学系研究科, 准教授 (10303463)
IZAWA Atsushi 信州大学, 医学系研究科, 助教 (50464095)
高橋 将文 信州大学, 医学系研究科, 准教授 (40296108)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
Keywords | 再生医療 / 糖鎖 / 遺伝子 / 心筋梗塞 / 動脈硬化 / 心筋細胞 |
Research Abstract |
We found a novel function of vimentin and desmin of cardiovascular tissues by which these proteins interact with physiological GlcNAc-bearing ligands on the cell surface through their GlcNAc-binding lectin-like properties. Cell surface coating of bone marrow cells with GlcNAc promoted adhesion of these cells to cardiac myocytes and their regeneration to cardiac myocytes, and this would be useful for the treatment of cardiovascular disease with bone marrow implantation.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury.2011
Author(s)
Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
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Journal Title
Circulation 123
Pages: 594-604
Related Report
Peer Reviewed
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[Journal Article]2010
Author(s)
伊澤淳、池田宇一
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Journal Title
心筋梗塞の再発予防(循環器疾患最新の治療)(南江堂)
Pages: 126-128
Related Report
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[Journal Article] Therapeutic neovascularization by the implantation of autologous mononuclear cells in patients with connective tissue diseases.2009
Author(s)
Takahashi M, Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Horie T, Aizawa Y, Amano J, Minota S, Murohara T, Matsubara H, Ikeda U.
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Journal Title
Curr Pharm Design 15
Pages: 2778-2783
Related Report
Peer Reviewed
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[Journal Article] Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation.2009
Author(s)
Doi H, Iso T, Shiba Y, Sato H, Yamazaki M, Oyama Y, Akiyama H, Tanaka T, Tomita T, Arai M, Takahashi M, Ikeda U, Kurabayashi M.
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Journal Title
Biochem Biophys Res Commun 381
Pages: 654-659
Related Report
Peer Reviewed
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[Journal Article] Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat.2009
Author(s)
Nomoto T, Okada T, Shimazaki K, Yoshioka T, Nonaka-Sarukawa M, Ito T, Takeuchi K, Katsura KI, Mizukami H, Kume A, Ookawara S, Ikeda U, Katayama Y, Ozawa K.
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Journal Title
Gene Ther 16
Pages: 383-391
Related Report
Peer Reviewed
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[Journal Article] Therapeutic neovascularization by the implantation of autologous mononu clear cells in patients with connective tissue diseases.2009
Author(s)
Takahashi M, Izawa A, Ishigatsubo Y, Fujimoto K, Miyamoto M, Horie T, Aizawa Y, Amano J, Minota S, Murohara T, Matsubara H, Ikeda U
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Journal Title
Curr Pharm Des 15
Pages: 2778-2783
Related Report
Peer Reviewed
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[Journal Article] Noninvasive evaluation of coronary endothelial function following sirolimus-eluting stent implantation by using positron emission tomography.2009
Author(s)
Horigome M, Kumazaki S, Hattori N, Kasai H, Horigome M, Aizawa K, Izawa A, Tomita T, Tsutsui H, Koyama J, Sakurai S, Ikeda U.
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Journal Title
Cardiology 114
Pages: 157-163
Related Report
Peer Reviewed
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[Journal Article] Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation.2009
Author(s)
Doi H, Iso T, Shiba Y, Sato H, Yamazaki M, Oyama Y, Akiyama H, Tanaka T, Tomita T, Arai M, Takahashi M, Ikeda U, Kurabayashi M
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Journal Title
Biochem Biophys Res Commun 381
Pages: 654-659
Related Report
Peer Reviewed
-
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[Journal Article] Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat.2009
Author(s)
Nomoto T, Okada T, Shimazaki K, Yoshioka T, Nonaka-Sarukawa M, Ito T, Takeuchi K, Katsura KI, Mizukami H, Kume A, Ookawara S, Ikeda U, Katayama Y, Ozawa K
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Journal Title
Gene Ther 16
Pages: 383-391
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
池田宇一
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Journal Title
動脈疾患(内科確定診断完全マスター)(メディカルビュー社)
Pages: 124-130
Related Report
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[Journal Article]2009
Author(s)
伊澤淳、池田宇一
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Journal Title
コレステロールと末梢動脈(コレステロール-基礎から臨床へ-)(ライフサイエンス出版)
Pages: 81-87
Related Report
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[Journal Article] Critical role of bone marrow-derived ASC, an inflammasome adaptor molecule, in neolntimal formation after vascular injuryin mice.2008
Author(s)
Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara, Nakayama J, Taniguchi S, Ikeda U
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Journal Title
Circulation 117
Pages: 3079-3087
Related Report
Peer Reviewed
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