a study and new treatment of lung cancer stem cells
Project/Area Number |
20390229
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Hirosaki University |
Principal Investigator |
SAIJO Yasuo Hirosaki University, 大学院・医学研究科, 教授 (10270828)
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Co-Investigator(Kenkyū-buntansha) |
ITH JUGOH 弘前大学, 大学院・医学研究科, 准教授 (10333717)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2009: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2008: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
Keywords | 肺がん / がん幹細胞 / CD133 / 肺癌 / 肺幹細胞 / 肺胞上皮細胞 / SP-C / CCSP / 肺がん幹細胞 / SCIDマウス / 肺前駆細胞 |
Research Abstract |
We identified lung cancer stem cells using CD133 as a marker. A small fraction of all 19 cell lines examined expressed CD133. Resistant cells against gefitinib showed high % of CD133 positive cells. Lung stem cells at brochiolalveolar duct junction amplified after birth and naphthalene treatment, but no after bleomycin treatment.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] For the North-East Japan Study Group : Gefitinib or Chemotherapy for Non-Small Cell Lung Cancer with Mutated EGFR.2010
Author(s)
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita K, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Ogura T, Ando M, Morita S, Nukiwa T
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Journal Title
New Engl J Med 362
Pages: 2380-8
Related Report
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[Journal Article] Randomized phase II trial of weekly paclitaxel combined with carboplatin versus standard paclitaxel combined with carboplatin for elderly patients with advanced non-small-cell lung cancer.2010
Author(s)
Sakakibara T, Inoue A, Sugawara S, Maemondo M, Ishida T, Usui K, Abe T, Kanbe M, Watanabe H, Saijo Y, Nukiwa T
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Journal Title
Ann Oncol. 21
Pages: 795-9
Related Report
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[Journal Article] Randomized phase II trial of weekly paclitaxel combined with carboplatin versus standard paclitaxel combined with carboplatin for elderly patients with advanced non-small-cell lung cancer.2010
Author(s)
Sakakibara T, Inoue A, Sugawara S, Maemondo M, Ishida T, Usui K, Abe T, Kanbe M, Watanabe H, Saijo Y., Nukiwa T
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Journal Title
Annals of Oncology 21
Pages: 795-799
Related Report
Peer Reviewed
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[Journal Article] First-line gefitinib for advanced non-small cell lung cancer patients having epidermal growth factor receptor mutations without indication for chemotherapy.2009
Author(s)
Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y, Genma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K
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Journal Title
J Clin Oncol 27
Pages: 1394-400
Related Report
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[Journal Article] First-line gefitinib for advanced non-small cell lung cancer patients having epidermal growth factor receptor mutations without indication for chemotherapy.2009
Author(s)
Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y, Genma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K.
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Journal Title
Journal of Clinical Oncology 27
Pages: 1394-1400
Related Report
Peer Reviewed
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[Journal Article] Nukiwa Randomized Phase II Trial Comparing Amrubicin With Topotecan in Patients With Previously Treated Small-Cell Lung Cancer : North Japan Lung Cancer Study Group Trial 0402.2008
Author(s)
Inoue A, Sugawara S, Yamazaki K, Maemondo M, Suzuki T, Gomi K, Takanashi S, Inoue C, Inage M, Yokouchi H, Watanabe H, Tsukamoto T, Saijo Y, Ishimoto O, Hommura F
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Journal Title
J Clin Oncol 26
Pages: 5401-6
Related Report
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