A systematic research on immunomodulation in autoimmune pulumonary alveolar proteinpsis.
| Project/Area Number |
20390230
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
NAKATA Koh Niigata University, 医歯学総合病院, 教授 (80207802)
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| Co-Investigator(Kenkyū-buntansha) |
TAZAWA Ryushi 新潟大学, 医歯学総合病院, 講師 (70301041)
TAKIZAWA Jun 新潟大学, 医歯学系, 助教 (70463990)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
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| Keywords | 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / その他 / 肺胞蛋白症 / GM-CSF / T-リンパ球 / PDLD / 自己抗体 / 自己免疫性肺胞蛋白症 / 抗GM-CSF抗体 / アイソタイプ / EBウイルス / メモリーB細胞 / ELISPOT / 抗GM-CSF自己抗体 / リンパ球サブセット / T細胞 / アポトーシス / B細胞分化 |
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| Research Abstract |
High avidity GM-CSF autoantibodies (GMAb) with IgG isotype are now considered to be the etiology for autoimmune pulmonary alveolar proteinsosis (aPAP). We detected low concentrations of IgM-GMAb in more than 80% of 71 aPAP patients and 22% of 23 healthy subjects. The frequencies and concentrations of IgM type in culture supernatants were even between aPAP and controls. In contrast, the frequency of IgG-GMAb producing B cells was higher in aPAP than those in controls. The present results suggest that the isotype switch from IgM to IgG is accelerated in patients with aPAP.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Comparative Study of High-Resolution CT Findings Between Autoimmune and Secondary Pulmonary Alveolar Proteinosis.2009
Author(s)
Ishii H, Trapnell BC, Tazawa R, Inoue Y, Akira M, Kogure Y, Tomii K, Takada ; T, Hojo M, Ichiwata T, Goto H, Nakata K.
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Journal Title
Chest. 136巻
Pages: 1348-1355
Related Report
Peer Reviewed
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[Journal Article] Comparative Study of High-Resolution CT Findings Between Autoimmune and Secondary Pulmonary Alveolar Proteinosis2009
Author(s)
Ishii H, Trapnell BC, Tazawa R, Inoue Y, Akira M, Kogure Y, Tomii K, Takada ; T, Hojo M, Ichiwata T, Goto H, Nakata K
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Journal Title
Chest 136
Pages: 1348-1355
Related Report
Peer Reviewed
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[Journal Article] Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. http://www.ncbi.nlm.nih.gov/pubmed/19282464?log$=activity2009
Author(s)
Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JR Yamada Y, Trapnell BC.
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Journal Title
BLOOD 113
Pages: 2547-2556
Related Report
Peer Reviewed
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[Journal Article] Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects.2008
Author(s)
Uchida K, Nakata K, Suzuki T, Luisetti M, Watanabe M, Koch DE, Stevens CA, Beck DC, Denson LA, Carey BC, Keicho N, Krischer JP, Yamada Y, Trapnell BC.
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Journal Title
Blood. 113巻
Pages: 2547-2556
Related Report
Peer Reviewed
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[Journal Article] A combination therapy of whole lung lavage and GM-CSF inhalation in pulmonary alveolar proteinosis.2008
Author(s)
Yamamoto H, Yamaguchi E, Agata H, Kandatsu N, Komatsu T, Kawai S, Baba K, Awaya T, Nishikomori R, Tsurusawa M, Nakata K.
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Journal Title
Pediatric Pneumocology 43巻
Pages: 828-830
Related Report
Peer Reviewed
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[Journal Article] A combination therapy of whole lung lavage and GM-CSF inhalation in pulmonary alveolar proteinosis.2008
Author(s)
Yamamoto H, Yamaguchi E, Agata H, Kandatsu N, Komatsu T, Kawai s, Baba K, Awaya T, Nishikomori R, Tsurusawa M, Nakata K
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Journal Title
Pediatric Pneumocology 43
Pages: 828-830
Related Report
Peer Reviewed
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